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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046350
UUCD1 version UUC-HoS-01260
Ensembl Protein ID ENSP00000330753.2
UniProt Accession Q9NSI6; C9JK25; O43721; Q5R2V0; Q5R2V1; Q6P2D1; Q8TCV3; Q96QG9; Q96QH0; Q9NUK1; BRWD1_HUMAN
Genbank Protein ID CAC37033.2; CAC44371.1; CAC44372.1; BAD74071.1; BAD74072.1; AAH64602.1; CAB90452.1; CAA10896.1; ENSP00000330753
Protein Name Bromodomain and WD repeat-containing protein 1; WD repeat-containing protein 9
Genbank Nucleotide ID AJ238214; AJ292465; AJ292466; AB080586; AB080587; AF064861; AL163279; AJ222636; AK002177
Gene Name BRWD1; C21orf107; WDR9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000185658.13 ENST00000333229.6 ENSP00000330753.2
ENSG00000185658.13 ENST00000446924.5 ENSP00000391014.1
ENSG00000185658.13 ENST00000342449.7 ENSP00000344333.3
ENSG00000185658.13 ENST00000380800.7 ENSP00000370178.3
ENSG00000185658.13 ENST00000424441.1 ENSP00000415066.1
ENSG00000185658.13 ENST00000445668.5 ENSP00000395575.1
ENSG00000185658.13 ENST00000430093.5 ENSP00000393702.1
ENSG00000185658.13 ENST00000445245.5 ENSP00000390684.1
ENSG00000185658.13 ENST00000455867.5 ENSP00000389882.1
ENSG00000185658.13 ENST00000412604.1 ENSP00000398900.1
ENSG00000185658.13 ENST00000341322.4 ENSP00000342106.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdb
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.40e-35 118.9 184 221
UBD/Beta-Prp 2.80e-54 186.0 286 543
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH + v+c+af  + +++ +GsdD+ +k+W+++ g+ll
   Q: 184  GHLSAVYCVAFdRTgHRIFTGSDDCLVKIWSTHNGRLL 221
           8**********955599***************999987 PP
   

   UBD/Beta-Prp
   S: 22   ksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlslsfs 103
           +++++++++dgt+  w+++ ++l      l+  ++  ++v+ ++  fs  g +l+tgs+D++i+ +   +++++ +  l+ h+d+v s++f+
   Q: 286  QRYMVSTGADGTVCFWQWDLESLkfsprpLKFTEKPRPGVQMLCssFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSIQFC 377
           689*****************99999988777778888888755522888888**************99999********************* PP
   S: 104  psgdklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
            +gd+++sGs+d t+r+w  e+ ++ +                 ++  +  v++++++++++++v++ +D ++++W++ tg+ll+ l g h 
   Q: 378  NNGDRFLSGSRDGTARIWRFEQLEWRSIlldmatrisgdlsseEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMG-HA 468
           ***********************99998999********998877777888*************************************9.** PP
   S: 181  dsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           d v  l+   fds  + ++s+++dg++ +wd+ +g+ ++ + +         v + +fs+++++++++ s+g + i+
   Q: 469  DEVFVLEthpFDS--RIMLSAGHDGSIFIWDITKGTKMKHYFNMIegqghGAVFDCKFSQDGQHFACTDSHGHLLIF 543
           *******555555..99****************999977766544444456677789999*****999999998886 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
 May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Protein Sequence
(Fasta)
MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 60
RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046350|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGAGGCCA GATCGTGTGG ACTTGGCCTT TTCCTCTGGG TCTGATGGGA GCCTCTGGAG 60
GATTTTGAGA GAGGAAGGAC AAGTCCGTCT TTAGTTTGTT TTTTTTTTTT TCTTGAGATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046350|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00439--Bromodomain
PF00400--WD40
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0006325--P:chromatin organization
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG hsa:54014
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002332 Ailuropoda melanoleuca 84.56 0.00e+00 3316.00
IUUC-Apl-004083 Anas platyrhynchos 69.45 0.00e+00 1964.00
IUUC-Aca-004348 Anolis carolinensis 72.67 0.00e+00 1954.00
IUUC-Aly-006517 Arabidopsis lyrata 30.58 3.00e-73 271.00
IUUC-Ame-010718 Astyanax mexicanus 71.21 0.00e+00 1175.00
IUUC-Bta-013217 Bos taurus 88.76 0.00e+00 3713.00
IUUC-Bdi-014797 Brachypodium distachyon 29.25 3.00e-59 224.00
IUUC-Bol-015737 Brassica oleracea 30.00 6.00e-74 273.00
IUUC-Bra-017961 Brassica rapa 29.96 3.00e-73 271.00
IUUC-Cja-019966 Callithrix jacchus 95.17 0.00e+00 4004.00
IUUC-Cfa-021037 Canis familiaris 88.25 0.00e+00 3627.00
IUUC-Cpo-021934 Cavia porcellus 92.14 0.00e+00 2781.00
IUUC-Cre-023003 Chlamydomonas reinhardtii 34.15 9.00e-35 142.00
IUUC-Csa-023352 Chlorocebus sabaeus 97.62 0.00e+00 3847.00
IUUC-Cho-024690 Choloepus hoffmanni 80.34 0.00e+00 1381.00
IUUC-Dno-028938 Dasypus novemcinctus 85.01 0.00e+00 3576.00
IUUC-Dme-031752 Drosophila melanogaster 49.84 0.00e+00 671.00
IUUC-Eca-034349 Equus caballus 89.48 0.00e+00 3552.00
IUUC-Fca-035485 Felis catus 82.67 0.00e+00 3099.00
IUUC-Fal-037307 Ficedula albicollis 77.67 0.00e+00 2298.00
IUUC-Gma-043340 Glycine max 30.36 6.00e-71 263.00
IUUC-Ggo-045500 Gorilla gorilla 99.05 0.00e+00 4145.00
IUUC-Itr-047962 Ictidomys tridecemlineatus 95.71 0.00e+00 1173.00
IUUC-Lch-049662 Latimeria chalumnae 57.91 0.00e+00 2115.00
IUUC-Lpe-051619 Leersia perrieri 31.23 1.00e-70 262.00
IUUC-Laf-053848 Loxodonta africana 87.28 0.00e+00 3565.00
IUUC-Mcc-054638 Macaca mulatta 97.89 0.00e+00 4116.00
IUUC-Meu-056739 Macropus eugenii 79.91 0.00e+00 1117.00
IUUC-Mga-060165 Meleagris gallopavo 77.82 0.00e+00 2306.00
IUUC-Mmr-061227 Microcebus murinus 92.21 0.00e+00 3848.00
IUUC-Mdo-062074 Monodelphis domestica 70.44 0.00e+00 2795.00
IUUC-Mmu-064075 Mus musculus 82.83 0.00e+00 3020.00
IUUC-Mac-065343 Musa acuminata 31.02 2.00e-75 278.00
IUUC-Mpu-066643 Mustela putorius furo 90.31 0.00e+00 3011.00
IUUC-Mlu-067735 Myotis lucifugus 86.48 0.00e+00 3506.00
IUUC-Nle-069402 Nomascus leucogenys 96.14 0.00e+00 3148.00
IUUC-Oan-072954 Ornithorhynchus anatinus 69.87 0.00e+00 2859.00
IUUC-Ocu-074456 Oryctolagus cuniculus 88.38 0.00e+00 3700.00
IUUC-Oba-075709 Oryza barthii 30.17 1.00e-60 229.00
IUUC-Oru-085195 Oryza rufipogon 30.17 1.00e-60 229.00
IUUC-Olu-087745 Ostreococcus lucimarinus 28.57 2.00e-56 214.00
IUUC-Oga-087938 Otolemur garnettii 82.97 0.00e+00 3282.00
IUUC-Oar-090214 Ovis aries 87.78 0.00e+00 3566.00
IUUC-Ptr-091213 Pan troglodytes 99.35 0.00e+00 4135.00
IUUC-Pan-092444 Papio anubis 97.16 0.00e+00 4084.00
IUUC-Psi-093271 Pelodiscus sinensis 60.60 0.00e+00 2216.00
IUUC-Pma-094427 Petromyzon marinus 66.98 4.00e-133 467.00
IUUC-Ppa-095793 Physcomitrella patens 29.84 2.00e-74 275.00
IUUC-Pfo-097318 Poecilia formosa 62.84 0.00e+00 1792.00
IUUC-Pab-097573 Pongo abelii 97.61 0.00e+00 4012.00
IUUC-Pop-099672 Populus trichocarpa 31.03 8.00e-73 269.00
IUUC-Pca-100759 Procavia capensis 70.97 0.00e+00 1162.00
IUUC-Pva-102782 Pteropus vampyrus 88.13 0.00e+00 3591.00
IUUC-Rno-105687 Rattus norvegicus 79.01 0.00e+00 3301.00
IUUC-Sly-111348 Solanum lycopersicum 30.56 7.00e-76 280.00
IUUC-Sar-113519 Sorex araneus 80.54 0.00e+00 1787.00
IUUC-Tgu-116513 Taeniopygia guttata 77.55 0.00e+00 2311.00
IUUC-Tsy-118921 Tarsius syrichta 90.27 0.00e+00 2043.00
IUUC-Tca-121615 Theobroma cacao 29.89 7.00e-68 253.00
IUUC-Tbe-127663 Tupaia belangeri 80.20 0.00e+00 1361.00
IUUC-Ttr-128561 Tursiops truncatus 86.95 0.00e+00 3467.00
IUUC-Vpa-130444 Vicugna pacos 85.78 0.00e+00 3351.00
IUUC-Vvi-131362 Vitis vinifera 30.99 6.00e-74 273.00
Created Date 25-Jun-2017

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