iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105363

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 48; Deubiquitinating enzyme 48; Synaptic ubiquitin-specific protease; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48

Genbank Nucleotide ID

AB073880

Gene Name

Usp48

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000013602.6	ENSRNOT00000077933.1	ENSRNOP00000069188.1
ENSRNOG00000013602.6	ENSRNOT00000031855.5	ENSRNOP00000030008.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	14535949
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	14535949

Classification

Family	E-value	Score	Start	End
DUB/USP	3.20e-73	247.2	89	419
ULD/UDP/UBQ/UBQ_Other	1.30e-10	41.4	946	1008

Active Site

Position(s)	Description	Evidence
98	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10093}
353	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp........kepkgellkslqklfeelwkskkkavsprellkalkkea 81
           +Gl+Nlg+tCY+N  LQ+ +   elr++l    ++++++  +        + + ++++++lq lf+ l++s++++++p+ ++kal+   
   Q: 89   VGLTNLGATCYVNTFLQVWFLNLELRQALYL-CPSTCSDYTKgdgirggkDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALG--- 173
           6*****************************9.88888776666666666677778******************************9... PP
   S: 82   eefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
             +++ +qqDaqEf + +++ le++l                       +++k+   ++++++ F g++   ++c +c+++s+  ++f+
   Q: 174  --LDTGQQQDAQEFSKLFMSLLEDTL-----------------------SKQKNPDVRNVVQQQFCGEYAYVTVCSQCGRESKLVSKFY 237
           ..78899*******************.......................457889999******************************* PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleL 259
           +l+l+++g++     +l+dc+++f kee+leg+n+y+ce+c++kq+a++k++l +lP +L l+L+Rf f++++++++k+n ++ f ++L
   Q: 238  ELELNIQGHK-----QLTDCISEFLKEERLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESL 321
           **********.....9************************************************************************* PP
   S: 260  dlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetg................... 327
           d++p+++++      +  YeL+av++H G s+ sGHY+a+vk+ + + W++f+D+ +++++ ++ +   +                   
   Q: 322  DMEPYVEHKGG----SFVYELSAVLIHRGvSAYSGHYIAHVKDPQSGdWYKFNDEDIEKMEGKKLQLGIEedlaepsksqtrkpkcgkg 406
           ******99554....68**************************66555************9999998665999**************** PP
   S: 328  ....staYvlfYk 336
               ++aY+l+Y+
   Q: 407  thcsRNAYMLVYR 419
           ************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 16   k...vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihllekks 74
           k   v+   t +eLK +i +++++ p +q+L ++GkiL +d+ tL+ +g+ ++s+i+l  +++
   Q: 946  KallVSANQTLKELKIQIMHAFSVAPFDQNLSIDGKILnDDCATLGTLGVIPESVILLKADEP 1008
           334489999************************************************988775 PP

Organism

Rattus norvegicus

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.

Protein Sequence
(Fasta)

MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCRG NPNCLVGIGE 60
HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV NTFLQVWFLN LELRQALYLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGCACACG CGCGCGCGTT TGTGAGTCCT GACACACTAC ACTCTGAGAT CTTTGTGTTT 60
TTTATTTTCA ACCTAAATGT CAACCGAACC ACAAAACCAA ATCTTGCTTT CCTTTAGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR033841--USP48
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS50053--UBIQUITIN_2
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0045211--C:postsynaptic membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:362636

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000130	Aegilops tauschii	32.19	2.00e-80	293.00
IUUC-Aml-001357	Ailuropoda melanoleuca	94.02	0.00e+00	1986.00
IUUC-Atr-002976	Amborella trichopoda	32.38	6.00e-79	289.00
IUUC-Apl-003773	Anas platyrhynchos	85.45	0.00e+00	1645.00
IUUC-Aca-004466	Anolis carolinensis	80.28	0.00e+00	862.00
IUUC-Aly-006249	Arabidopsis lyrata	29.92	1.00e-71	265.00
IUUC-Ath-006700	Arabidopsis thaliana	30.87	8.00e-80	292.00
IUUC-Ame-011554	Astyanax mexicanus	68.33	0.00e+00	1442.00
IUUC-Bta-012573	Bos taurus	93.16	0.00e+00	1986.00
IUUC-Bdi-014149	Brachypodium distachyon	32.22	6.00e-82	299.00
IUUC-Bol-016289	Brassica oleracea	26.99	3.00e-83	303.00
IUUC-Bra-017205	Brassica rapa	26.10	5.00e-73	269.00
IUUC-Cel-018662	Caenorhabditis elegans	28.02	1.00e-28	122.00
IUUC-Cja-019991	Callithrix jacchus	93.24	0.00e+00	2003.00
IUUC-Cfa-020294	Canis familiaris	94.11	0.00e+00	2023.00
IUUC-Cpo-021706	Cavia porcellus	91.73	0.00e+00	1888.00
IUUC-Cre-022636	Chlamydomonas reinhardtii	32.13	1.00e-42	169.00
IUUC-Csa-023931	Chlorocebus sabaeus	94.31	0.00e+00	2016.00
IUUC-Cho-024566	Choloepus hoffmanni	92.42	3.00e-152	533.00
IUUC-Cin-025307	Ciona intestinalis	47.49	2.00e-75	275.00
IUUC-Csv-026006	Ciona savignyi	37.03	3.00e-150	526.00
IUUC-Cne-027065	Cryptococcus neoformans	28.00	3.00e-68	254.00
IUUC-Dre-027624	Danio rerio	69.30	0.00e+00	1491.00
IUUC-Dno-029633	Dasypus novemcinctus	92.95	0.00e+00	1263.00
IUUC-Dor-030809	Dipodomys ordii	73.12	0.00e+00	1166.00
IUUC-Ete-032818	Echinops telfairi	88.74	0.00e+00	930.00
IUUC-Eca-033692	Equus caballus	94.31	0.00e+00	2012.00
IUUC-Eeu-035185	Erinaceus europaeus	71.74	0.00e+00	770.00
IUUC-Fca-035676	Felis catus	93.62	0.00e+00	2015.00
IUUC-Fal-036913	Ficedula albicollis	85.05	0.00e+00	1793.00
IUUC-Gmo-038532	Gadus morhua	64.63	0.00e+00	1384.00
IUUC-Gga-041041	Gallus gallus	85.34	0.00e+00	1790.00
IUUC-Gac-042570	Gasterosteus aculeatus	66.05	0.00e+00	1432.00
IUUC-Gma-044136	Glycine max	27.77	1.00e-96	347.00
IUUC-Ggo-045367	Gorilla gorilla	89.88	0.00e+00	1889.00
IUUC-Hsa-046019	Homo sapiens	94.59	0.00e+00	2019.00
IUUC-Hvu-047303	Hordeum vulgare	33.40	5.00e-65	242.00
IUUC-Itr-048319	Ictidomys tridecemlineatus	92.23	0.00e+00	1996.00
IUUC-Lch-049989	Latimeria chalumnae	75.55	0.00e+00	1626.00
IUUC-Lpe-051612	Leersia perrieri	32.55	8.00e-80	292.00
IUUC-Loc-052756	Lepisosteus oculatus	70.16	0.00e+00	1530.00
IUUC-Laf-054043	Loxodonta africana	92.60	0.00e+00	1997.00
IUUC-Mcc-054986	Macaca mulatta	92.86	0.00e+00	1998.00
IUUC-Meu-056228	Macropus eugenii	73.85	0.00e+00	825.00
IUUC-Mtr-058762	Medicago truncatula	27.48	5.00e-92	332.00
IUUC-Mga-059896	Meleagris gallopavo	84.82	0.00e+00	1691.00
IUUC-Mvi-060269	Microbotryum violaceum	37.75	1.00e-62	235.00
IUUC-Mmr-060887	Microcebus murinus	94.11	0.00e+00	2008.00
IUUC-Mdo-062506	Monodelphis domestica	90.25	0.00e+00	1929.00
IUUC-Mmu-063642	Mus musculus	96.39	0.00e+00	2074.00
IUUC-Mac-064896	Musa acuminata	31.84	6.00e-79	289.00
IUUC-Mpu-066194	Mustela putorius furo	93.82	0.00e+00	1999.00
IUUC-Mlu-067233	Myotis lucifugus	93.30	0.00e+00	1991.00
IUUC-Nle-069052	Nomascus leucogenys	93.23	0.00e+00	1999.00
IUUC-Opr-070890	Ochotona princeps	92.86	0.00e+00	1226.00
IUUC-Ont-071450	Oreochromis niloticus	65.05	0.00e+00	1377.00
IUUC-Oan-073252	Ornithorhynchus anatinus	86.67	0.00e+00	1026.00
IUUC-Ocu-073796	Oryctolagus cuniculus	93.61	0.00e+00	1708.00
IUUC-Oba-075563	Oryza barthii	32.04	1.00e-80	295.00
IUUC-Obr-076394	Oryza brachyantha	31.72	3.00e-80	293.00
IUUC-Ogl-077339	Oryza glaberrima	38.57	1.00e-40	160.00
IUUC-Ogu-079007	Oryza glumaepatula	33.04	2.00e-74	274.00
IUUC-Oin-079997	Oryza indica	32.04	5.00e-81	296.00
IUUC-Olo-080364	Oryza longistaminata	32.04	9.00e-81	295.00
IUUC-Ome-081165	Oryza meridionalis	33.05	4.00e-75	276.00
IUUC-Oni-083026	Oryza nivara	32.04	6.00e-81	296.00
IUUC-Opu-083284	Oryza punctata	34.04	2.00e-74	274.00
IUUC-Oru-084797	Oryza rufipogon	32.04	6.00e-81	295.00
IUUC-Osa-086221	Oryza sativa	38.57	1.00e-40	160.00
IUUC-Ola-086568	Oryzias latipes	66.20	0.00e+00	1429.00
IUUC-Oga-088687	Otolemur garnettii	92.37	0.00e+00	1985.00
IUUC-Oar-090345	Ovis aries	93.16	0.00e+00	1890.00
IUUC-Ptr-090734	Pan troglodytes	94.40	0.00e+00	2016.00
IUUC-Pan-091704	Papio anubis	90.67	0.00e+00	1919.00
IUUC-Psi-092937	Pelodiscus sinensis	85.15	0.00e+00	1565.00
IUUC-Ppa-095808	Physcomitrella patens	27.70	1.00e-70	262.00
IUUC-Pab-098129	Pongo abelii	94.50	0.00e+00	2017.00
IUUC-Pop-099494	Populus trichocarpa	27.78	8.00e-85	308.00
IUUC-Pca-100647	Procavia capensis	95.45	0.00e+00	671.00
IUUC-Ppe-102091	Prunus persica	29.87	6.00e-84	305.00
IUUC-Pva-102719	Pteropus vampyrus	93.63	0.00e+00	1992.00
IUUC-Sha-107620	Sarcophilus harrisii	86.52	0.00e+00	1786.00
IUUC-Smo-109487	Selaginella moellendorffii	28.71	5.00e-83	302.00
IUUC-Sit-110683	Setaria italica	32.65	1.00e-81	298.00
IUUC-Sly-111377	Solanum lycopersicum	29.45	1.00e-80	295.00
IUUC-Stu-111969	Solanum tuberosum	31.42	6.00e-70	258.00
IUUC-Sar-113099	Sorex araneus	92.87	0.00e+00	1682.00
IUUC-Sbi-113833	Sorghum bicolor	41.81	3.00e-56	212.00
IUUC-Ssc-115279	Sus scrofa	86.62	0.00e+00	1309.00
IUUC-Tgu-117519	Taeniopygia guttata	82.39	0.00e+00	1640.00
IUUC-Tru-117651	Takifugu rubripes	65.24	0.00e+00	1410.00
IUUC-Tsy-119201	Tarsius syrichta	90.72	0.00e+00	1762.00
IUUC-Tni-120840	Tetraodon nigroviridis	66.45	0.00e+00	1435.00
IUUC-Tca-121674	Theobroma cacao	28.87	3.00e-86	313.00
IUUC-Tae-125247	Triticum aestivum	25.92	2.00e-82	301.00
IUUC-Tur-126599	Triticum urartu	32.54	1.00e-79	291.00
IUUC-Tbe-127782	Tupaia belangeri	83.09	0.00e+00	1696.00
IUUC-Ttr-128312	Tursiops truncatus	92.37	0.00e+00	1965.00
IUUC-Vpa-130348	Vicugna pacos	93.44	0.00e+00	1902.00
IUUC-Vvi-131353	Vitis vinifera	32.52	9.00e-85	308.00
IUUC-Xtr-132172	Xenopus tropicalis	70.36	0.00e+00	1351.00
IUUC-Xma-133263	Xiphophorus maculatus	67.36	0.00e+00	1404.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence