iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103363.14	ENST00000262306.11	ENSP00000262306.7
ENSG00000103363.14	ENST00000409906.8	ENSP00000386652.4
ENSG00000103363.14	ENST00000494946.6	ENSP00000458213.1
ENSG00000103363.14	ENST00000572954.1	ENSP00000458443.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/Elon-B_C	Elon-B_C	17361105; 9606976
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	10224134; 15209385

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	1.60e-09	39.1	18	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 17   vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyg 60
            ++s+tV eLK+ +e+ l+ pp++qrL+ ++++L+d+ktL+++g
   Q: 18   AKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECG 61
           3799***************************************8 PP

Organism

Homo sapiens

Functional Description
(View)

The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Protein Sequence
(Fasta)

MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC 60
GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVQ 118

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGAACGGG GCGGAGCGCG GCTGCGCCGG CGCGTCGAGG GGAGAGGCAG CAGCCGCGAT 60
GGTGAGCGGG CGTGGGGGAG GGGCGGCCGG GCCGGGCCGG GGGCGGCGGG GGGCGGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0070449--C:elongin complex
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0030891--C:VCB complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006461--P:protein complex assembly
GO:0016567--P:protein ubiquitination
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter

KEGG

hsa:6923

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001280	Ailuropoda melanoleuca	95.80	2.00e-62	229.00
IUUC-Atr-002796	Amborella trichopoda	27.83	1.00e-05	41.20
IUUC-Apl-003979	Anas platyrhynchos	87.88	3.00e-12	63.20
IUUC-Aca-004530	Anolis carolinensis	88.14	3.00e-56	209.00
IUUC-Aly-005974	Arabidopsis lyrata	29.03	2.00e-05	40.00
IUUC-Ath-007691	Arabidopsis thaliana	26.88	2.00e-05	40.00
IUUC-Ame-011292	Astyanax mexicanus	87.39	1.00e-57	214.00
IUUC-Bta-012458	Bos taurus	97.46	8.00e-64	234.00
IUUC-Bdi-014917	Brachypodium distachyon	28.57	2.00e-07	46.60
IUUC-Cel-018575	Caenorhabditis elegans	38.53	7.00e-17	79.00
IUUC-Cja-019950	Callithrix jacchus	99.15	7.00e-65	238.00
IUUC-Cfa-020172	Canis familiaris	97.44	1.00e-40	158.00
IUUC-Cpo-022344	Cavia porcellus	98.29	2.00e-63	233.00
IUUC-Csa-024213	Chlorocebus sabaeus	100.00	2.00e-65	239.00
IUUC-Csv-026001	Ciona savignyi	57.26	2.00e-35	140.00
IUUC-Dre-027429	Danio rerio	85.71	9.00e-56	207.00
IUUC-Dno-029254	Dasypus novemcinctus	97.44	6.00e-63	231.00
IUUC-Dme-031644	Drosophila melanogaster	56.78	8.00e-32	128.00
IUUC-Eeu-034507	Erinaceus europaeus	67.07	5.00e-27	112.00
IUUC-Fca-036342	Felis catus	98.29	2.00e-63	233.00
IUUC-Gmo-039577	Gadus morhua	86.55	2.00e-46	177.00
IUUC-Gac-041732	Gasterosteus aculeatus	84.87	9.00e-56	208.00
IUUC-Gma-044029	Glycine max	31.18	2.00e-06	45.10
IUUC-Ggo-044725	Gorilla gorilla	99.15	8.00e-65	239.00
IUUC-Hvu-047856	Hordeum vulgare	32.20	3.00e-06	42.70
IUUC-Lpe-051645	Leersia perrieri	30.43	1.00e-07	47.40
IUUC-Laf-054303	Loxodonta africana	96.58	1.00e-62	231.00
IUUC-Mcc-054748	Macaca mulatta	99.15	3.00e-65	239.00
IUUC-Mtr-058736	Medicago truncatula	32.26	4.00e-07	46.20
IUUC-Mmr-061528	Microcebus murinus	98.29	2.00e-63	234.00
IUUC-Mdo-062545	Monodelphis domestica	93.16	3.00e-60	223.00
IUUC-Mmu-064363	Mus musculus	97.46	1.00e-63	234.00
IUUC-Mpu-066915	Mustela putorius furo	97.44	4.00e-63	232.00
IUUC-Mlu-067606	Myotis lucifugus	94.05	1.00e-40	157.00
IUUC-Nle-069340	Nomascus leucogenys	99.15	5.00e-65	238.00
IUUC-Ont-071550	Oreochromis niloticus	85.59	5.00e-56	209.00
IUUC-Oan-073548	Ornithorhynchus anatinus	94.96	3.00e-52	196.00
IUUC-Ocu-074024	Oryctolagus cuniculus	98.23	4.00e-61	226.00
IUUC-Obr-076724	Oryza brachyantha	28.26	2.00e-06	43.50
IUUC-Oin-080167	Oryza indica	28.26	8.00e-06	41.60
IUUC-Opu-084014	Oryza punctata	28.26	6.00e-06	42.00
IUUC-Osa-085650	Oryza sativa	28.26	8.00e-06	41.60
IUUC-Ola-086438	Oryzias latipes	87.29	3.00e-56	210.00
IUUC-Oar-090425	Ovis aries	97.44	4.00e-63	232.00
IUUC-Ptr-090487	Pan troglodytes	99.15	2.00e-65	241.00
IUUC-Pan-092779	Papio anubis	99.15	1.00e-65	242.00
IUUC-Pfo-097197	Poecilia formosa	85.71	3.00e-56	209.00
IUUC-Pab-098035	Pongo abelii	99.15	1.00e-65	241.00
IUUC-Pop-099504	Populus trichocarpa	27.47	6.00e-05	38.90
IUUC-Rno-105121	Rattus norvegicus	97.46	1.00e-63	234.00
IUUC-Sha-107566	Sarcophilus harrisii	94.07	3.00e-61	226.00
IUUC-Sar-113663	Sorex araneus	44.58	1.00e-17	80.90
IUUC-Sbi-114447	Sorghum bicolor	27.47	8.00e-06	41.20
IUUC-Ssc-115270	Sus scrofa	97.46	8.00e-64	234.00
IUUC-Tru-118420	Takifugu rubripes	84.03	1.00e-55	208.00
IUUC-Tni-120611	Tetraodon nigroviridis	84.21	1.00e-52	197.00
IUUC-Tca-121839	Theobroma cacao	27.96	1.00e-05	41.20
IUUC-Tae-125514	Triticum aestivum	31.11	2.00e-09	53.50
IUUC-Ttr-128410	Tursiops truncatus	96.61	3.00e-63	233.00
IUUC-Vvi-130839	Vitis vinifera	29.03	2.00e-05	41.20
IUUC-Xtr-132615	Xenopus tropicalis	82.20	5.00e-54	202.00
IUUC-Xma-133408	Xiphophorus maculatus	84.03	7.00e-55	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence