iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000020882.7	ENSRNOT00000028348.7	ENSRNOP00000028348.4
ENSRNOG00000020882.7	ENSRNOT00000084586.1	ENSRNOP00000075019.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-06	28.5	429	461
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.20e-09	37.4	22	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclafsd.tllvsGsdDgtikvWDlrtg 33
           H ++vt + +s+ +l+++++d++ ++ W+++++
   Q: 429  HRSPVTKIMLSEkHLISVCADNNHVRTWSVTRF 461
           99******9988566677888888*****9976 PP

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 4    ilvvggeeffahkivLaas.SsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkld 66
            l+vgg++f++ + +L+    s+F++l+++  +  +++++ + i+ ++p+vf  +l+Fl+t++ld
   Q: 22   HLNVGGKRFSTSRQTLTWIpDSFFSSLLSGRIStLKDETGAIFID-RDPTVFAPILNFLRTKELD 85
           69****************99*************9999********.*****************98 PP

Organism

Rattus norvegicus

Functional Description
(View)

Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.

Protein Sequence
(Fasta)

MAVPTTAVEG VRSRGAPGEV IHLNVGGKRF STSRQTLTWI PDSFFSSLLS GRISTLKDET 60
GAIFIDRDPT VFAPILNFLR TKELDPRGVH GSSLLHEAQF YGLTPLVRRL QVREELDRSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGTCC CGACGACTGC AGTGGAGGGG GTCCGGAGTC GGGGAGCGCC CGGGGAAGTG 60
ATTCATCTGA ACGTAGGGGG CAAGCGGTGA GTGTGGGAGA CCTCCGAGGC CCCATCCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50097--BTB
PS00678--WD_REPEATS_1

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0045742--P:positive regulation of epidermal growth factor receptor signaling pathway
GO:0051260--P:protein homooligomerization

KEGG

rno:292735

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002379	Ailuropoda melanoleuca	87.93	0.00e+00	1108.00
IUUC-Aca-004906	Anolis carolinensis	72.12	0.00e+00	943.00
IUUC-Ath-006820	Arabidopsis thaliana	38.54	5.00e-09	55.50
IUUC-Afl-008395	Aspergillus flavus	26.80	7.00e-05	42.00
IUUC-Ame-011252	Astyanax mexicanus	68.46	0.00e+00	870.00
IUUC-Bta-012690	Bos taurus	92.71	0.00e+00	1141.00
IUUC-Bci-013656	Botrytis cinerea	38.46	6.00e-10	57.40
IUUC-Cja-018763	Callithrix jacchus	91.19	0.00e+00	1268.00
IUUC-Cfa-020543	Canis familiaris	91.72	0.00e+00	1136.00
IUUC-Cpo-021962	Cavia porcellus	88.92	0.00e+00	1162.00
IUUC-Dre-027729	Danio rerio	72.95	0.00e+00	959.00
IUUC-Dno-028972	Dasypus novemcinctus	88.34	0.00e+00	1068.00
IUUC-Dor-030553	Dipodomys ordii	92.06	0.00e+00	1103.00
IUUC-Dme-031935	Drosophila melanogaster	50.60	0.00e+00	664.00
IUUC-Eca-033315	Equus caballus	89.77	0.00e+00	1127.00
IUUC-Eeu-035311	Erinaceus europaeus	87.68	0.00e+00	969.00
IUUC-Fca-036552	Felis catus	92.05	0.00e+00	1150.00
IUUC-Fso-038119	Fusarium solani	33.70	6.00e-06	45.80
IUUC-Gmo-039368	Gadus morhua	74.41	0.00e+00	900.00
IUUC-Gac-041846	Gasterosteus aculeatus	69.73	0.00e+00	932.00
IUUC-Ggo-045623	Gorilla gorilla	71.87	0.00e+00	856.00
IUUC-Hsa-045915	Homo sapiens	91.94	0.00e+00	1253.00
IUUC-Itr-048663	Ictidomys tridecemlineatus	94.66	0.00e+00	1155.00
IUUC-Loc-051959	Lepisosteus oculatus	73.04	0.00e+00	974.00
IUUC-Laf-054452	Loxodonta africana	83.70	0.00e+00	997.00
IUUC-Mcc-055544	Macaca mulatta	92.08	0.00e+00	1211.00
IUUC-Meu-056159	Macropus eugenii	88.12	0.00e+00	1036.00
IUUC-Mmr-061709	Microcebus murinus	92.90	0.00e+00	1168.00
IUUC-Mdo-062553	Monodelphis domestica	82.18	0.00e+00	1047.00
IUUC-Mmu-063367	Mus musculus	97.30	0.00e+00	1289.00
IUUC-Mpu-066614	Mustela putorius furo	93.13	0.00e+00	1127.00
IUUC-Nle-069872	Nomascus leucogenys	87.55	0.00e+00	1148.00
IUUC-Opr-070600	Ochotona princeps	80.26	0.00e+00	942.00
IUUC-Ont-071375	Oreochromis niloticus	73.98	0.00e+00	941.00
IUUC-Oga-088526	Otolemur garnettii	92.61	0.00e+00	1182.00
IUUC-Oar-089898	Ovis aries	91.15	0.00e+00	1135.00
IUUC-Ptr-091353	Pan troglodytes	88.12	0.00e+00	1184.00
IUUC-Pan-091730	Papio anubis	92.56	0.00e+00	1202.00
IUUC-Pfo-097224	Poecilia formosa	73.41	0.00e+00	943.00
IUUC-Pab-098142	Pongo abelii	88.76	0.00e+00	1157.00
IUUC-Pca-100847	Procavia capensis	80.82	0.00e+00	943.00
IUUC-Pva-102652	Pteropus vampyrus	93.44	0.00e+00	1157.00
IUUC-Stu-112405	Solanum tuberosum	39.18	2.00e-10	60.10
IUUC-Sar-113577	Sorex araneus	80.12	0.00e+00	912.00
IUUC-Tru-118507	Takifugu rubripes	68.85	0.00e+00	963.00
IUUC-Tni-120814	Tetraodon nigroviridis	73.50	0.00e+00	930.00
IUUC-Tre-121919	Trichoderma reesei	32.32	1.00e-05	44.30
IUUC-Tvi-122427	Trichoderma virens	33.33	4.00e-06	46.20
IUUC-Xtr-132155	Xenopus tropicalis	70.40	0.00e+00	951.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence