• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046191
UUCD1 version UUC-HoS-00798
Ensembl Protein ID ENSP00000295317.3
UniProt Accession Q8NC42; Q53S14; Q8N5I8; Q8NBY5; Q8WUU3; RN149_HUMAN
Genbank Protein ID AAR21083.1; BAC11334.1; BAC11430.1; CAL37444.1; AAY14775.1; AAH19355.2; AAH32328.2; AAH45743.1
Protein Name E3 ubiquitin-protein ligase RNF149; DNA polymerase-transactivated protein 2; RING finger protein 149; RING-type E3 ubiquitin transferase RNF149
Genbank Nucleotide ID AY450390; AK074985; AK075141; AM392566; AC013722; BC019355; BC032328; BC045743
Gene Name RNF149; DNAPTP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163162.8 ENST00000424632.5 ENSP00000399090.1
ENSG00000163162.8 ENST00000295317.3 ENSP00000295317.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 9.60e-06 27.7 269 310
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e f  kd  ++lpC+H+fh+ C+  w         + +CP C+
   Q: 269  CAVCIENFkvKDIIRILPCKHIFHRICIDPW------LLDHRTCPMCK 310
           ********8866699****************......9999******6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
 E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Protein Sequence
(Fasta)
MAWRRREASV GARGVLALAL LALALCVPGA RGRALEWFSA VVNIEYVDPQ TNLTVWSVSE 60
SGRFGDSSPK EGAHGLVGVP WAPGGDLEGC APDTRFFVPE PGGRGAAPWV ALVARGGCTF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046191|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACCCCGCCT CAGTCTTCCA GGGCGGCGGT GGGTGTCCGC TTCTCTCTGC TCTTCGACTG 60
CACCGCACTC GCGCGTGACC CTGACTCCCC CTAGTCAGCT CAGCGGTGCT GCCATGGCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046191|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF02225--PA
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035690--P:cellular response to drug
GO:0043409--P:negative regulation of MAPK cascade
GO:0031647--P:regulation of protein stability
KEGG hsa:284996
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001968 Ailuropoda melanoleuca 83.87 4.00e-175 607.00
IUUC-Apl-004109 Anas platyrhynchos 71.16 1.00e-100 359.00
IUUC-Bta-012340 Bos taurus 81.54 7.00e-165 573.00
IUUC-Cja-019566 Callithrix jacchus 91.25 0.00e+00 674.00
IUUC-Cfa-020289 Canis familiaris 84.94 3.00e-109 387.00
IUUC-Cpo-021916 Cavia porcellus 66.67 5.00e-73 267.00
IUUC-Csa-024084 Chlorocebus sabaeus 96.00 0.00e+00 685.00
IUUC-Cho-024305 Choloepus hoffmanni 81.94 7.00e-134 469.00
IUUC-Cgl-026578 Colletotrichum gloeosporioides 48.08 3.00e-12 66.20
IUUC-Cne-026985 Cryptococcus neoformans 29.91 4.00e-11 63.90
IUUC-Dno-030098 Dasypus novemcinctus 82.00 1.00e-178 619.00
IUUC-Dor-030620 Dipodomys ordii 74.42 4.00e-141 494.00
IUUC-Ete-032306 Echinops telfairi 82.62 6.00e-166 577.00
IUUC-Fca-035950 Felis catus 82.11 1.00e-114 405.00
IUUC-Fal-037429 Ficedula albicollis 67.47 1.00e-133 469.00
IUUC-Fso-038141 Fusarium solani 41.25 1.00e-15 77.80
IUUC-Gga-041201 Gallus gallus 65.97 6.00e-131 460.00
IUUC-Ggo-045429 Gorilla gorilla 98.89 0.00e+00 687.00
IUUC-Itr-048018 Ictidomys tridecemlineatus 80.11 6.00e-158 550.00
IUUC-Lch-049498 Latimeria chalumnae 62.16 5.00e-128 451.00
IUUC-Laf-054239 Loxodonta africana 69.17 7.00e-129 453.00
IUUC-Meu-056382 Macropus eugenii 73.61 1.00e-149 523.00
IUUC-Mor-056917 Magnaporthe oryzae 43.94 9.00e-13 68.60
IUUC-Mga-059435 Meleagris gallopavo 68.25 7.00e-66 243.00
IUUC-Mmr-061513 Microcebus murinus 85.48 1.00e-172 598.00
IUUC-Mdo-063028 Monodelphis domestica 74.04 2.00e-151 528.00
IUUC-Mmu-063545 Mus musculus 77.01 8.00e-153 533.00
IUUC-Mpu-066370 Mustela putorius furo 82.70 1.00e-170 592.00
IUUC-Mlu-067271 Myotis lucifugus 68.94 3.00e-131 461.00
IUUC-Nle-069207 Nomascus leucogenys 98.00 0.00e+00 717.00
IUUC-Opr-070704 Ochotona princeps 68.42 6.00e-92 330.00
IUUC-Oan-072837 Ornithorhynchus anatinus 69.31 1.00e-136 479.00
IUUC-Ocu-074671 Oryctolagus cuniculus 78.67 2.00e-121 427.00
IUUC-Oga-089083 Otolemur garnettii 83.25 1.00e-175 608.00
IUUC-Oar-089254 Ovis aries 81.22 1.00e-108 385.00
IUUC-Ptr-090940 Pan troglodytes 99.19 0.00e+00 710.00
IUUC-Pan-092636 Papio anubis 95.89 0.00e+00 678.00
IUUC-Psi-093435 Pelodiscus sinensis 74.48 1.00e-93 335.00
IUUC-Pab-098525 Pongo abelii 98.45 0.00e+00 697.00
IUUC-Pva-102395 Pteropus vampyrus 80.82 4.00e-169 587.00
IUUC-Pgr-103263 Puccinia graminis 36.56 1.00e-11 65.50
IUUC-Rno-105789 Rattus norvegicus 77.47 7.00e-151 526.00
IUUC-Sha-107305 Sarcophilus harrisii 71.01 6.00e-91 326.00
IUUC-Ssc-115598 Sus scrofa 81.87 3.00e-167 581.00
IUUC-Tgu-116463 Taeniopygia guttata 68.06 1.00e-129 456.00
IUUC-Tsy-118915 Tarsius syrichta 87.40 4.00e-109 387.00
IUUC-Tre-121978 Trichoderma reesei 48.98 3.00e-12 67.00
IUUC-Tme-126970 Tuber melanosporum 49.06 1.00e-12 68.20
IUUC-Tbe-127906 Tupaia belangeri 64.90 5.00e-77 280.00
IUUC-Xtr-131821 Xenopus tropicalis 61.66 3.00e-127 447.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved