iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-045785

Ensembl Protein ID

ENSP00000317891.7

UniProt Accession

Q15025; A4F1W8; A4F1W9; A4F1X2; A4F1X4; A4F1X5; A4F1X6; A4F1X7; A4F1X9; B7Z699; E7EPY1; E7ET96; O76008; Q05KP3; Q05KP4; Q6N077; Q96EL9; Q99833; Q9H1J3; TNIP1_HUMAN

Genbank Protein ID

CAA09855.1; CAA09856.1; AAG42154.1; BAF34946.1; BAF34947.1; BAF48787.1; BAF48788.1; BAF48789.1; BAF48790.1; BAF48791.1; BAF48792.1; BAF48793.1; BAF48794.1; BAF48795.1; BAF48796.1; BAF48797.1; BAF48798.1; BAA06416.2; BAH13185.1; CAE45793.1; EAW61688.1; EAW61689.1; EAW61690.1; EAW61691.1; AAH12133.1; AAH14008.1; AAC99999.1; AAB41438.1

Protein Name

TNFAIP3-interacting protein 1; A20-binding inhibitor of NF-kappa-B activation 1; HIV-1 Nef-interacting protein; Nef-associated factor 1; Nip40-1; Virion-associated nuclear shuttling protein

Genbank Nucleotide ID

AJ011895; AJ011896; AY012155; AB177543; AB177544; AB252970; AB252971; AB252972; AB252973; AB252974; AB252975; AB252976; AB252977; AB252978; AB252979; AB252980; AB252981; D30755; AK299975; BX640647; AC008641; CH471062; CH471062; CH471062; BC012133; BC014008; U39403; U83844

Gene Name

TNIP1; KIAA0113; NAF1; ABIN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000145901.14	ENST00000517504.5	ENSP00000430739.1
ENSG00000145901.14	ENST00000315050.11	ENSP00000317891.7
ENSG00000145901.14	ENST00000523338.5	ENSP00000428243.1
ENSG00000145901.14	ENST00000519339.5	ENSP00000427854.1
ENSG00000145901.14	ENST00000524280.5	ENSP00000429912.1
ENSG00000145901.14	ENST00000523200.5	ENSP00000431105.1
ENSG00000145901.14	ENST00000389378.6	ENSP00000374029.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBAN	UBAN	18212736

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBAN	2.40e-24	86.7	452	512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkask 61
           k+el++++e+LkqQv+i++eDFq+ER+dREr+neekeeL++qveklq+qv+++n++lka+k
   Q: 452  KQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFK 512
           699*******************************************************986 PP

Organism

Homo sapiens

Functional Description
(View)

Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Protein Sequence
(Fasta)

MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE ESQMEATRLR 60
QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP TAPACPSDKP APVQKPPSSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATACATACTG TTCTGTGACT CCCCGAAAGA GGGATTCTCT CTACATTCTG AAATTTGTTG 60
TCCCTATCCT GGTATTGAGA AGTCACCTTC CTGATACAAA AAGAAGGAAC AAGTTGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0395--Inflammatory response
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR033372--TNIP1

Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005654--C:nucleoplasm
GO:0042802--F:identical protein binding
GO:0051019--F:mitogen-activated protein kinase binding
GO:0006952--P:defense response
GO:0009101--P:glycoprotein biosynthetic process
GO:0006954--P:inflammatory response
GO:0007159--P:leukocyte cell-cell adhesion
GO:0085032--P:modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071--P:negative regulation of viral genome replication
GO:0050729--P:positive regulation of inflammatory response
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0006412--P:translation

KEGG

hsa:10318

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002103	Ailuropoda melanoleuca	89.18	0.00e+00	886.00
IUUC-Apl-004176	Anas platyrhynchos	55.56	1.00e-159	556.00
IUUC-Aca-004362	Anolis carolinensis	57.16	1.00e-155	543.00
IUUC-Ame-011307	Astyanax mexicanus	41.23	1.00e-95	343.00
IUUC-Bta-012620	Bos taurus	87.04	0.00e+00	779.00
IUUC-Cja-018996	Callithrix jacchus	95.76	0.00e+00	1058.00
IUUC-Cfa-020274	Canis familiaris	88.56	0.00e+00	875.00
IUUC-Cpo-021786	Cavia porcellus	86.34	0.00e+00	929.00
IUUC-Csa-023236	Chlorocebus sabaeus	97.02	0.00e+00	996.00
IUUC-Cho-024535	Choloepus hoffmanni	76.61	3.00e-54	206.00
IUUC-Cin-025355	Ciona intestinalis	27.01	2.00e-11	64.30
IUUC-Dre-028725	Danio rerio	47.62	9.00e-123	434.00
IUUC-Dno-028967	Dasypus novemcinctus	88.39	6.00e-116	410.00
IUUC-Dor-030761	Dipodomys ordii	82.11	4.00e-109	389.00
IUUC-Ete-032695	Echinops telfairi	73.21	0.00e+00	816.00
IUUC-Eca-033655	Equus caballus	88.87	0.00e+00	939.00
IUUC-Eeu-035335	Erinaceus europaeus	66.85	3.00e-104	372.00
IUUC-Fca-035597	Felis catus	89.50	0.00e+00	951.00
IUUC-Fal-037020	Ficedula albicollis	52.67	1.00e-143	503.00
IUUC-Gga-040812	Gallus gallus	55.35	1.00e-152	533.00
IUUC-Ggo-045345	Gorilla gorilla	98.58	0.00e+00	1102.00
IUUC-Itr-048029	Ictidomys tridecemlineatus	86.88	0.00e+00	957.00
IUUC-Lch-049745	Latimeria chalumnae	54.21	2.00e-120	426.00
IUUC-Loc-052635	Lepisosteus oculatus	50.90	2.00e-143	502.00
IUUC-Laf-053625	Loxodonta africana	83.02	0.00e+00	858.00
IUUC-Mcc-055730	Macaca mulatta	97.02	0.00e+00	1036.00
IUUC-Meu-056550	Macropus eugenii	71.88	5.00e-116	411.00
IUUC-Mpo-057394	Magnaporthe poae	38.00	3.10e-02	34.70
IUUC-Mga-059948	Meleagris gallopavo	66.51	3.00e-70	258.00
IUUC-Mmr-060900	Microcebus murinus	89.32	0.00e+00	1036.00
IUUC-Mdo-061805	Monodelphis domestica	71.18	0.00e+00	817.00
IUUC-Mmu-063749	Mus musculus	82.28	0.00e+00	852.00
IUUC-Mpu-065979	Mustela putorius furo	87.46	0.00e+00	962.00
IUUC-Mlu-067100	Myotis lucifugus	84.94	0.00e+00	890.00
IUUC-Nle-069667	Nomascus leucogenys	99.21	0.00e+00	1084.00
IUUC-Opr-070478	Ochotona princeps	82.00	0.00e+00	921.00
IUUC-Ont-071777	Oreochromis niloticus	46.61	3.00e-109	389.00
IUUC-Oan-073239	Ornithorhynchus anatinus	66.03	0.00e+00	740.00
IUUC-Ocu-073879	Oryctolagus cuniculus	88.09	0.00e+00	899.00
IUUC-Oga-088900	Otolemur garnettii	92.31	0.00e+00	1085.00
IUUC-Oar-089444	Ovis aries	84.08	0.00e+00	845.00
IUUC-Ptr-090641	Pan troglodytes	99.53	0.00e+00	1117.00
IUUC-Pan-092283	Papio anubis	97.44	0.00e+00	1016.00
IUUC-Psi-092967	Pelodiscus sinensis	54.12	7.00e-163	567.00
IUUC-Pma-094726	Petromyzon marinus	32.96	6.00e-53	202.00
IUUC-Pfo-096085	Poecilia formosa	46.79	2.00e-113	402.00
IUUC-Pab-097976	Pongo abelii	92.16	0.00e+00	1018.00
IUUC-Pca-100215	Procavia capensis	73.51	0.00e+00	763.00
IUUC-Pva-102258	Pteropus vampyrus	82.76	0.00e+00	889.00
IUUC-Pte-104050	Pyrenophora teres	25.93	3.10e-02	35.00
IUUC-Rno-105833	Rattus norvegicus	80.95	0.00e+00	823.00
IUUC-Sly-111729	Solanum lycopersicum	26.96	4.00e-04	40.40
IUUC-Stu-112653	Solanum tuberosum	25.58	2.00e-04	41.20
IUUC-Ssc-115652	Sus scrofa	86.03	0.00e+00	885.00
IUUC-Tgu-116648	Taeniopygia guttata	53.54	1.00e-136	480.00
IUUC-Tru-118455	Takifugu rubripes	45.19	4.00e-110	392.00
IUUC-Tbe-128129	Tupaia belangeri	86.42	1.00e-104	373.00
IUUC-Ttr-128305	Tursiops truncatus	81.63	0.00e+00	796.00
IUUC-Xtr-131842	Xenopus tropicalis	50.16	7.00e-131	461.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence