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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106228
Ensembl Protein ID YCR088W
UniProt Accession P15891; D6VR88; ABP1_YEAST
Genbank Protein ID CAA36075.1; CAA42253.1; DAA07557.1
Protein Name Actin-binding protein
Genbank Nucleotide ID X51780; X59720; BK006937
Gene Name ABP1; YCR088W; YCR88W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YCR088W YCR088W YCR088W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.20e-12 46.1 539 589
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           + ydy+a++d+eLt+ + d++  i  e  d +W+ g+ e  g +GlfP+n+v 
   Q: 539  AEYDYDAAEDNELTFVENDKIINI--EFVDDDWWLGELEKDGSKGLFPSNYVS 589
           67*******************999..99***********************95 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.
 Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.
Protein Sequence
(Fasta)
MALEPIDYTT HSREIDAEYL KIVRGSDPDT TWLIISPNAK KEYEPESTGS SFHDFLQLFD 60
ETKVQYGLAR VSPPGSDVEK IIIIGWCPDS APLKTRASFA ANFAAVANNL FKGYHVQVTA 120
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Protein Fasta Sequence


>IUUC-Sce-106228|UBD,SH3|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGCTTTGG AACCTATTGA TTATACTACT CACTCGAGAG AGATCGACGC AGAGTACCTG 60
AAGATTGTCA GAGGCTCCGA TCCTGACACC ACCTGGTTGA TTATTTCACC CAATGCGAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106228|UBD,SH3|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0832--Ubl conjugation
Interpro

IPR002108--ADF-H
IPR029006--ADF-H/Gelsolin-like_dom
IPR001452--SH3_domain
PROSITE

PS51263--ADF_H
PS50002--SH3
Pfam

PF00241--Cofilin_ADF
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00102--ADF
SM00326--SH3
Gene Ontology

GO:0030479--C:actin cortical patch
GO:0005938--C:cell cortex
GO:0051015--F:actin filament binding
GO:0000147--P:actin cortical patch assembly
GO:0051016--P:barbed-end actin filament capping
GO:2000601--P:positive regulation of Arp2/3 complex-mediated actin nucleation
GO:0044379--P:protein localization to actin cortical patch
KEGG sce:YCR088W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002064 Ailuropoda melanoleuca 53.70 2.00e-11 61.60
IUUC-Apl-003494 Anas platyrhynchos 46.00 6.00e-12 62.40
IUUC-Aca-004462 Anolis carolinensis 46.00 8.00e-12 62.00
IUUC-Ago-007760 Ashbya gossypii 44.64 3.00e-77 280.00
IUUC-Acl-008295 Aspergillus clavatus 64.91 3.00e-17 81.60
IUUC-Afu-008895 Aspergillus fumigatus 62.30 3.00e-17 81.60
IUUC-Ani-009403 Aspergillus nidulans 61.54 5.00e-17 77.40
IUUC-Ang-009722 Aspergillus niger 66.67 1.00e-15 76.60
IUUC-Aor-010021 Aspergillus oryzae 32.61 2.00e-15 75.50
IUUC-Ate-010587 Aspergillus terreus 66.67 4.00e-16 78.20
IUUC-Ame-011634 Astyanax mexicanus 54.00 2.00e-10 58.20
IUUC-Bgr-012041 Blumeria graminis 62.50 4.00e-15 74.70
IUUC-Bta-012469 Bos taurus 44.00 1.00e-11 61.20
IUUC-Bci-013690 Botrytis cinerea 61.11 8.00e-15 73.90
IUUC-Cel-018413 Caenorhabditis elegans 41.03 1.00e-06 45.10
IUUC-Cfa-020718 Canis familiaris 53.70 2.00e-11 61.60
IUUC-Cpo-022244 Cavia porcellus 44.00 1.00e-11 61.20
IUUC-Csa-023039 Chlorocebus sabaeus 46.00 1.00e-11 61.60
IUUC-Cin-025315 Ciona intestinalis 43.90 2.00e-07 48.10
IUUC-Csv-026276 Ciona savignyi 44.23 3.00e-11 62.40
IUUC-Cgl-026571 Colletotrichum gloeosporioides 23.27 3.00e-14 71.60
IUUC-Cne-027017 Cryptococcus neoformans 58.00 2.00e-12 65.90
IUUC-Dre-028279 Danio rerio 27.61 4.00e-11 60.80
IUUC-Dno-029332 Dasypus novemcinctus 53.70 3.00e-11 61.20
IUUC-Dor-031101 Dipodomys ordii 44.00 2.00e-11 60.10
IUUC-Dse-031182 Dothistroma septosporum 55.56 4.00e-14 71.60
IUUC-Dme-031718 Drosophila melanogaster 50.00 1.00e-10 59.30
IUUC-Eca-033966 Equus caballus 44.00 2.00e-11 60.80
IUUC-Fca-035699 Felis catus 46.00 1.00e-11 61.20
IUUC-Fal-036775 Ficedula albicollis 53.70 2.00e-11 62.40
IUUC-Fox-037778 Fusarium oxysporum 35.42 4.00e-15 74.70
IUUC-Fso-038435 Fusarium solani 57.41 1.00e-14 73.20
IUUC-Gmo-039493 Gadus morhua 37.84 1.00e-06 44.70
IUUC-Ggr-039882 Gaeumannomyces graminis 57.41 1.00e-13 69.70
IUUC-Gga-040335 Gallus gallus 50.00 2.00e-10 58.50
IUUC-Gac-042632 Gasterosteus aculeatus 43.59 3.00e-07 47.00
IUUC-Ggo-044835 Gorilla gorilla 44.00 2.00e-11 60.50
IUUC-Hsa-046818 Homo sapiens 53.70 2.00e-11 62.40
IUUC-Itr-048833 Ictidomys tridecemlineatus 55.56 4.00e-12 64.30
IUUC-Kpa-049215 Komagataella pastoris 38.10 4.00e-40 157.00
IUUC-Lch-050221 Latimeria chalumnae 48.33 7.00e-11 60.10
IUUC-Loc-052855 Lepisosteus oculatus 50.00 1.00e-10 59.30
IUUC-Lma-053035 Leptosphaeria maculans 66.00 2.00e-15 75.50
IUUC-Laf-053866 Loxodonta africana 53.70 2.00e-11 62.00
IUUC-Mcc-055650 Macaca mulatta 46.00 1.00e-11 61.20
IUUC-Meu-056479 Macropus eugenii 42.31 1.00e-11 61.60
IUUC-Mor-057105 Magnaporthe oryzae 60.00 3.00e-14 72.00
IUUC-Mpo-057325 Magnaporthe poae 56.00 4.00e-13 65.50
IUUC-Mla-059134 Melampsora laricipopulina 33.83 2.00e-15 75.50
IUUC-Mga-059763 Meleagris gallopavo 46.00 5.00e-12 62.40
IUUC-Mvi-060304 Microbotryum violaceum 47.37 3.00e-10 58.50
IUUC-Mmr-061147 Microcebus murinus 53.70 2.00e-11 61.60
IUUC-Mdo-061979 Monodelphis domestica 42.31 1.00e-11 61.60
IUUC-Mmu-063302 Mus musculus 44.00 1.00e-11 61.60
IUUC-Mpu-066114 Mustela putorius furo 44.00 7.00e-12 62.00
IUUC-Mlu-067704 Myotis lucifugus 53.70 1.00e-11 62.40
IUUC-Nfi-068448 Neosartorya fischeri 28.48 1.00e-18 86.70
IUUC-Ncr-068730 Neurospora crassa 57.89 3.00e-15 75.10
IUUC-Nle-069636 Nomascus leucogenys 44.00 1.00e-11 61.20
IUUC-Opr-070892 Ochotona princeps 44.00 2.00e-11 60.50
IUUC-Ont-072280 Oreochromis niloticus 40.00 6.00e-07 45.40
IUUC-Oan-073528 Ornithorhynchus anatinus 53.70 2.00e-11 61.60
IUUC-Ocu-073804 Oryctolagus cuniculus 44.00 2.00e-11 60.50
IUUC-Oga-088028 Otolemur garnettii 53.70 2.00e-11 62.00
IUUC-Oar-089771 Ovis aries 44.00 1.00e-11 61.20
IUUC-Ptr-091237 Pan troglodytes 44.00 2.00e-11 60.50
IUUC-Pan-092656 Papio anubis 46.00 1.00e-11 61.20
IUUC-Psi-093785 Pelodiscus sinensis 51.85 2.00e-11 62.00
IUUC-Pma-094207 Petromyzon marinus 55.56 2.00e-12 64.70
IUUC-Pno-095096 Phaeosphaeria nodorum 59.65 2.00e-15 75.90
IUUC-Pfo-096624 Poecilia formosa 44.00 5.00e-12 62.80
IUUC-Pab-097913 Pongo abelii 53.70 2.00e-11 61.60
IUUC-Pca-100691 Procavia capensis 44.00 2.00e-11 60.50
IUUC-Pva-102270 Pteropus vampyrus 44.00 2.00e-11 60.50
IUUC-Pgr-103652 Puccinia graminis 25.42 1.00e-14 72.80
IUUC-Ptt-103703 Puccinia triticina 54.55 6.00e-10 56.60
IUUC-Pte-104156 Pyrenophora teres 60.00 1.00e-13 69.70
IUUC-Pyt-104742 Pyrenophora triticirepentis 28.38 8.00e-15 73.90
IUUC-Rno-105489 Rattus norvegicus 53.70 2.00e-11 61.60
IUUC-Sha-107134 Sarcophilus harrisii 42.31 1.00e-11 61.20
IUUC-Sja-107956 Schizosaccharomyces japonicus 28.96 3.00e-15 75.10
IUUC-Spo-108101 Schizosaccharomyces pombe 30.89 2.00e-16 79.30
IUUC-Sit-109972 Setaria italica 36.36 1.40e+00 26.20
IUUC-Sar-113072 Sorex araneus 37.04 5.00e-10 58.20
IUUC-Sre-115023 Sporisorium reilianum 56.60 3.00e-14 71.60
IUUC-Ssc-115305 Sus scrofa 37.04 4.00e-10 58.50
IUUC-Tgu-117049 Taeniopygia guttata 53.70 2.00e-11 62.00
IUUC-Tru-118693 Takifugu rubripes 39.62 3.00e-12 63.50
IUUC-Tsy-119452 Tarsius syrichta 37.04 6.00e-10 57.80
IUUC-Tni-120393 Tetraodon nigroviridis 38.46 1.00e-07 47.80
IUUC-Tre-122167 Trichoderma reesei 55.56 6.00e-14 70.90
IUUC-Tvi-122614 Trichoderma virens 55.56 6.00e-14 70.90
IUUC-Tme-127196 Tuber melanosporum 29.92 2.00e-14 72.00
IUUC-Tbe-127585 Tupaia belangeri 37.04 6.00e-10 57.80
IUUC-Ttr-128639 Tursiops truncatus 44.00 2.00e-11 60.80
IUUC-Uma-129649 Ustilago maydis 58.49 1.00e-14 72.80
IUUC-Vda-129766 Verticillium dahliae 66.67 1.00e-16 80.10
IUUC-Vpa-130114 Vicugna pacos 40.43 2.00e-10 56.20
IUUC-Xtr-131827 Xenopus tropicalis 46.00 1.00e-11 61.60
IUUC-Xma-133290 Xiphophorus maculatus 53.57 3.00e-11 60.80
Created Date 25-Jun-2017

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