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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045721
Ensembl Protein ID ENSP00000393313.1
UniProt Accession Q9UBC2; A2RRF3; A5PL29; B4DKA3; EP15R_HUMAN
Genbank Protein ID AAF21930.1; BAA88118.1; BAG51266.1; BAG59115.1; EAW84542.1; AAI31591.1; AAI42717.1
Protein Name Epidermal growth factor receptor substrate 15-like 1; Eps15-related protein
Genbank Nucleotide ID AF110265; AB015346; AK024166; AK296473; AC008764; BC131590; BC142716
Gene Name EPS15L1; EPS15R
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000127527.13 ENST00000594851.5 ENSP00000469495.1
ENSG00000127527.13 ENST00000602022.5 ENSP00000471981.1
ENSG00000127527.13 ENST00000455140.6 ENSP00000393313.1
ENSG00000127527.13 ENST00000592031.5 ENSP00000465286.2
ENSG00000127527.13 ENST00000248070.10 ENSP00000248070.5
ENSG00000127527.13 ENST00000594975.5 ENSP00000471662.1
ENSG00000127527.13 ENST00000599790.1 ENSP00000473242.1
ENSG00000127527.13 ENST00000597937.5 ENSP00000472267.1
ENSG00000127527.13 ENST00000593760.5 ENSP00000472958.1
ENSG00000127527.13 ENST00000596037.5 ENSP00000472135.1
ENSG00000127527.13 ENST00000602151.1 ENSP00000468866.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Other/Other UBD/Other/Other 16159959
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/Alpha-Helix/UIM 92.63 0.00e+00 1413.00 IUUC-Mmu-064123
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
 Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Protein Sequence
(Fasta)
MAAPLIPLSQ QIPTGNSLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA 60
DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSNLNLSMPP PKFHDTSSPL MVTPPSAEAH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045721|UBD,UBD/Other/Other;UBD,UIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACATGCGTGG CCCTGTCTAC GGCCCCGCCC TCTCCCGGGA CAGGCGGCCT GCGCACCGCC 60
CTCCCGTCGT CCCAGTGCGC ACGCGTGGCT GCAGCCCCGC CCCCGTTCCC CCGGCGCTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045721|UBD,UBD/Other/Other;UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0106--Calcium
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
Pfam

PF12763--EF-hand_4
SMART

SM00054--EFh
SM00027--EH
Gene Ontology

GO:0030132--C:clathrin coat of coated pit
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0045296--F:cadherin binding
GO:0005509--F:calcium ion binding
GO:0006897--P:endocytosis
GO:0061024--P:membrane organization
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
KEGG hsa:58513
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002190 Ailuropoda melanoleuca 94.02 0.00e+00 1498.00
IUUC-Atr-002491 Amborella trichopoda 21.05 1.00e-13 72.80
IUUC-Apl-003895 Anas platyrhynchos 85.67 0.00e+00 1326.00
IUUC-Aly-006045 Arabidopsis lyrata 42.50 4.00e-14 73.90
IUUC-Ath-007330 Arabidopsis thaliana 42.50 4.00e-14 73.90
IUUC-Acl-008193 Aspergillus clavatus 29.73 1.00e-23 105.00
IUUC-Afl-008603 Aspergillus flavus 33.16 2.00e-43 171.00
IUUC-Afu-008916 Aspergillus fumigatus 32.00 5.00e-46 180.00
IUUC-Ani-009469 Aspergillus nidulans 29.97 2.00e-42 168.00
IUUC-Ang-009642 Aspergillus niger 29.80 4.00e-39 157.00
IUUC-Aor-009997 Aspergillus oryzae 32.20 2.00e-40 161.00
IUUC-Ate-010517 Aspergillus terreus 31.96 8.00e-44 172.00
IUUC-Ame-011472 Astyanax mexicanus 70.29 0.00e+00 993.00
IUUC-Bgr-012135 Blumeria graminis 31.79 2.00e-43 171.00
IUUC-Bta-013308 Bos taurus 93.99 0.00e+00 1295.00
IUUC-Bci-013666 Botrytis cinerea 30.61 2.00e-42 168.00
IUUC-Cel-018526 Caenorhabditis elegans 28.43 1.00e-51 198.00
IUUC-Cja-019827 Callithrix jacchus 98.14 0.00e+00 1489.00
IUUC-Cfa-020227 Canis familiaris 94.06 0.00e+00 1494.00
IUUC-Cpo-021877 Cavia porcellus 83.64 0.00e+00 1192.00
IUUC-Csa-023659 Chlorocebus sabaeus 98.06 0.00e+00 1553.00
IUUC-Cin-025645 Ciona intestinalis 40.19 2.00e-119 423.00
IUUC-Csv-025925 Ciona savignyi 56.21 9.00e-40 155.00
IUUC-Cgl-026390 Colletotrichum gloeosporioides 24.65 6.00e-38 153.00
IUUC-Cne-027039 Cryptococcus neoformans 39.64 5.00e-15 77.80
IUUC-Cme-027270 Cyanidioschyzon merolae 30.23 3.00e-21 97.40
IUUC-Dre-028630 Danio rerio 69.25 0.00e+00 1014.00
IUUC-Dse-031409 Dothistroma septosporum 31.28 6.00e-42 166.00
IUUC-Dme-031851 Drosophila melanogaster 33.33 4.00e-58 220.00
IUUC-Ete-033018 Echinops telfairi 67.16 2.00e-152 533.00
IUUC-Eca-033480 Equus caballus 95.22 0.00e+00 1453.00
IUUC-Fca-035983 Felis catus 96.14 0.00e+00 1352.00
IUUC-Fal-037211 Ficedula albicollis 82.35 0.00e+00 1284.00
IUUC-Fox-037755 Fusarium oxysporum 31.95 1.00e-43 172.00
IUUC-Fso-038230 Fusarium solani 31.91 5.00e-43 170.00
IUUC-Gmo-039045 Gadus morhua 68.83 0.00e+00 917.00
IUUC-Ggr-039734 Gaeumannomyces graminis 31.85 5.00e-43 170.00
IUUC-Gga-040471 Gallus gallus 84.84 0.00e+00 1347.00
IUUC-Gac-041817 Gasterosteus aculeatus 70.21 0.00e+00 1037.00
IUUC-Gma-043381 Glycine max 21.64 3.00e-12 68.20
IUUC-Ggo-044868 Gorilla gorilla 97.58 0.00e+00 1460.00
IUUC-Itr-048698 Ictidomys tridecemlineatus 97.72 3.00e-149 520.00
IUUC-Kpa-049396 Komagataella pastoris 32.79 4.00e-46 181.00
IUUC-Lch-049746 Latimeria chalumnae 77.23 0.00e+00 1237.00
IUUC-Loc-052757 Lepisosteus oculatus 74.40 0.00e+00 1162.00
IUUC-Lma-053198 Leptosphaeria maculans 29.69 4.00e-42 167.00
IUUC-Laf-054236 Loxodonta africana 81.07 0.00e+00 1051.00
IUUC-Mcc-055213 Macaca mulatta 99.54 0.00e+00 1494.00
IUUC-Meu-056373 Macropus eugenii 74.59 0.00e+00 1090.00
IUUC-Mor-056953 Magnaporthe oryzae 34.01 4.00e-48 187.00
IUUC-Mpo-057429 Magnaporthe poae 39.66 5.00e-19 90.50
IUUC-Mtr-057705 Medicago truncatula 35.24 6.00e-13 70.10
IUUC-Mla-059188 Melampsora laricipopulina 24.32 7.00e-39 156.00
IUUC-Mga-059308 Meleagris gallopavo 85.02 0.00e+00 1347.00
IUUC-Mvi-060354 Microbotryum violaceum 30.24 3.00e-40 161.00
IUUC-Mmr-061497 Microcebus murinus 96.04 0.00e+00 1519.00
IUUC-Mdo-063032 Monodelphis domestica 85.32 0.00e+00 1352.00
IUUC-Mmu-064123 Mus musculus 92.63 0.00e+00 1369.00
IUUC-Mpu-066896 Mustela putorius furo 95.33 0.00e+00 1317.00
IUUC-Mlu-067715 Myotis lucifugus 95.13 0.00e+00 1466.00
IUUC-Nfi-068419 Neosartorya fischeri 31.64 1.00e-44 175.00
IUUC-Ncr-068851 Neurospora crassa 30.03 3.00e-41 164.00
IUUC-Nle-069851 Nomascus leucogenys 96.16 0.00e+00 1464.00
IUUC-Opr-070476 Ochotona princeps 82.64 0.00e+00 1238.00
IUUC-Ont-071263 Oreochromis niloticus 70.21 0.00e+00 1019.00
IUUC-Ocu-074170 Oryctolagus cuniculus 87.68 0.00e+00 1385.00
IUUC-Obr-076871 Oryza brachyantha 33.94 2.00e-12 68.90
IUUC-Ola-086518 Oryzias latipes 69.75 0.00e+00 932.00
IUUC-Oga-088628 Otolemur garnettii 96.14 0.00e+00 1499.00
IUUC-Oar-089507 Ovis aries 92.21 0.00e+00 1394.00
IUUC-Ptr-091492 Pan troglodytes 97.22 0.00e+00 1460.00
IUUC-Pan-092868 Papio anubis 96.00 0.00e+00 1548.00
IUUC-Psi-093247 Pelodiscus sinensis 84.57 0.00e+00 1389.00
IUUC-Pma-094109 Petromyzon marinus 53.09 0.00e+00 743.00
IUUC-Pno-094814 Phaeosphaeria nodorum 29.41 3.00e-42 167.00
IUUC-Pfo-097520 Poecilia formosa 56.83 0.00e+00 644.00
IUUC-Pab-098751 Pongo abelii 99.67 0.00e+00 1545.00
IUUC-Pca-100272 Procavia capensis 77.26 0.00e+00 1056.00
IUUC-Pva-102235 Pteropus vampyrus 88.98 0.00e+00 1239.00
IUUC-Pgr-103392 Puccinia graminis 29.74 2.00e-36 148.00
IUUC-Ptt-103746 Puccinia triticina 29.45 2.00e-28 122.00
IUUC-Pte-104059 Pyrenophora teres 29.44 6.00e-41 163.00
IUUC-Pyt-104816 Pyrenophora triticirepentis 29.44 4.00e-41 164.00
IUUC-Rno-105454 Rattus norvegicus 92.85 0.00e+00 1404.00
IUUC-Sha-106549 Sarcophilus harrisii 84.65 0.00e+00 1338.00
IUUC-Sja-107675 Schizosaccharomyces japonicus 28.04 9.00e-36 145.00
IUUC-Ssl-108463 Sclerotinia sclerotiorum 29.79 6.00e-39 156.00
IUUC-Sre-114981 Sporisorium reilianum 32.26 9.00e-49 189.00
IUUC-Tgu-117217 Taeniopygia guttata 84.56 0.00e+00 1292.00
IUUC-Tru-117670 Takifugu rubripes 67.92 0.00e+00 1025.00
IUUC-Tsy-119464 Tarsius syrichta 79.80 2.00e-162 566.00
IUUC-Tni-119871 Tetraodon nigroviridis 55.48 0.00e+00 816.00
IUUC-Tre-122064 Trichoderma reesei 31.48 6.00e-40 160.00
IUUC-Tvi-122351 Trichoderma virens 32.73 3.00e-44 174.00
IUUC-Tur-126672 Triticum urartu 23.99 3.00e-13 71.60
IUUC-Tme-126877 Tuber melanosporum 31.68 3.00e-44 174.00
IUUC-Ttr-129235 Tursiops truncatus 96.24 0.00e+00 1454.00
IUUC-Uma-129336 Ustilago maydis 31.53 3.00e-49 191.00
IUUC-Vda-129921 Verticillium dahliae 33.02 4.00e-40 160.00
IUUC-Vvi-130856 Vitis vinifera 41.10 2.00e-12 68.60
IUUC-Xtr-131940 Xenopus tropicalis 75.35 0.00e+00 1235.00
IUUC-Xma-134262 Xiphophorus maculatus 55.65 2.00e-108 387.00
Created Date 25-Jun-2017

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