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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045723
Ensembl Protein ID ENSP00000346671.3
UniProt Accession P06241; B5BU57; E1P557; H0UI48; Q16248; Q5R3A6; Q5R3A7; Q8N5D7; FYN_HUMAN
Genbank Protein ID AAA36615.1; AAC08285.1; AAB33113.2; BAG70107.1; BAG70240.1; CAI22300.1; CAI22301.1; EAW48278.1; EAW48279.1; EAW48281.1; EAW48282.1; EAW48283.1; AAH32496.1
Protein Name Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; p59-Fyn
Genbank Nucleotide ID M14676; M14333; S74774; AB451293; AB451426; Z97989; Z97989; CH471051; CH471051; CH471051; CH471051; CH471051; BC032496
Gene Name FYN
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000010810.17 ENST00000368682.7 ENSP00000357671.3
ENSG00000010810.17 ENST00000354650.7 ENSP00000346671.3
ENSG00000010810.17 ENST00000229471.8 ENSP00000229471.4
ENSG00000010810.17 ENST00000462598.7 ENSP00000429590.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarmiRNAMapSomamiR
miRcodeRAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Drug and target
TTDGRACPDTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDPhosphoBasemUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.90e-15 56.2 87 142
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ +++  ++ +++W+++ + ++g  G +P+n+v+ ++
   Q: 87   FVALYDYEARTEDDLSFHKGEKFQIL--NSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
           789***********************..89999*********************9987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
 Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Protein Sequence
(Fasta)
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045723|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGAGCATCAG CAAGAGTAGC AGCGAGCAGC CGCGCTGGTG GCGGCGGCGC GTCGTTGCAG 60
TTGCGCCATC TGTCAGGAGC GGAGCCGGCG AGGAGGGGGC TGCCGCGGGC GAGGAGGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045723|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0005524--F:ATP binding
GO:0046875--F:ephrin receptor binding
GO:0001948--F:glycoprotein binding
GO:0070851--F:growth factor receptor binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0046934--F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005088--F:Ras guanyl-nucleotide exchange factor activity
GO:0004871--F:signal transducer activity
GO:0050798--P:activated T cell proliferation
GO:0002250--P:adaptive immune response
GO:0007411--P:axon guidance
GO:0007596--P:blood coagulation
GO:0006816--P:calcium ion transport
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0071375--P:cellular response to peptide hormone stimulus
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0007417--P:central nervous system development
GO:0048813--P:dendrite morphogenesis
GO:0050966--P:detection of mechanical stimulus involved in sensory perception of pain
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0007631--P:feeding behavior
GO:0030900--P:forebrain development
GO:0045087--P:innate immune response
GO:0035556--P:intracellular signal transduction
GO:0007612--P:learning
GO:0050900--P:leukocyte migration
GO:0000165--P:MAPK cascade
GO:1902951--P:negative regulation of dendritic spine maintenance
GO:2001240--P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0010629--P:negative regulation of gene expression
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0042177--P:negative regulation of protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001764--P:neuron migration
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0030168--P:platelet activation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1901216--P:positive regulation of neuron death
GO:0010976--P:positive regulation of neuron projection development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0090314--P:positive regulation of protein targeting to membrane
GO:0042523--P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0006468--P:protein phosphorylation
GO:0042981--P:regulation of apoptotic process
GO:1905664--P:regulation of calcium ion import across plasma membrane
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0050690--P:regulation of defense response to virus by virus
GO:0014066--P:regulation of phosphatidylinositol 3-kinase signaling
GO:1904645--P:response to beta-amyloid
GO:0042493--P:response to drug
GO:0045471--P:response to ethanol
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0042110--P:T cell activation
GO:0031295--P:T cell costimulation
GO:0050852--P:T cell receptor signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016032--P:viral process
KEGG hsa:2534
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002009 Ailuropoda melanoleuca 99.81 0.00e+00 1090.00
IUUC-Apl-003716 Anas platyrhynchos 92.76 0.00e+00 1003.00
IUUC-Aca-005065 Anolis carolinensis 98.88 0.00e+00 1080.00
IUUC-Ame-011533 Astyanax mexicanus 94.95 0.00e+00 912.00
IUUC-Bta-012645 Bos taurus 99.63 0.00e+00 1088.00
IUUC-Cel-018682 Caenorhabditis elegans 57.68 9.00e-150 523.00
IUUC-Cja-019027 Callithrix jacchus 99.81 0.00e+00 1090.00
IUUC-Cfa-021163 Canis familiaris 99.81 0.00e+00 1090.00
IUUC-Cpo-022315 Cavia porcellus 99.81 0.00e+00 1090.00
IUUC-Csa-023721 Chlorocebus sabaeus 100.00 0.00e+00 1092.00
IUUC-Cho-025014 Choloepus hoffmanni 99.63 0.00e+00 1088.00
IUUC-Dre-027985 Danio rerio 92.36 0.00e+00 1056.00
IUUC-Dno-030043 Dasypus novemcinctus 90.66 0.00e+00 1062.00
IUUC-Dor-031035 Dipodomys ordii 98.51 0.00e+00 1071.00
IUUC-Dme-031976 Drosophila melanogaster 60.65 2.00e-164 572.00
IUUC-Eca-033928 Equus caballus 90.21 0.00e+00 830.00
IUUC-Eeu-034582 Erinaceus europaeus 99.14 0.00e+00 687.00
IUUC-Fca-035582 Felis catus 99.81 0.00e+00 1090.00
IUUC-Fal-037320 Ficedula albicollis 93.11 0.00e+00 1007.00
IUUC-Gmo-038992 Gadus morhua 90.72 0.00e+00 1033.00
IUUC-Gga-041262 Gallus gallus 93.11 0.00e+00 1007.00
IUUC-Gac-042461 Gasterosteus aculeatus 90.50 0.00e+00 1036.00
IUUC-Ggo-044469 Gorilla gorilla 99.07 0.00e+00 1087.00
IUUC-Itr-048519 Ictidomys tridecemlineatus 99.81 0.00e+00 1090.00
IUUC-Lch-049825 Latimeria chalumnae 92.92 0.00e+00 1013.00
IUUC-Loc-052531 Lepisosteus oculatus 91.43 0.00e+00 1045.00
IUUC-Laf-053659 Loxodonta africana 99.63 0.00e+00 1087.00
IUUC-Mcc-055039 Macaca mulatta 93.91 0.00e+00 1019.00
IUUC-Mga-060067 Meleagris gallopavo 98.70 0.00e+00 1077.00
IUUC-Mmr-061194 Microcebus murinus 99.81 0.00e+00 1090.00
IUUC-Mdo-062628 Monodelphis domestica 99.63 0.00e+00 1088.00
IUUC-Mmu-063896 Mus musculus 99.44 0.00e+00 1087.00
IUUC-Mpu-066333 Mustela putorius furo 99.44 0.00e+00 1086.00
IUUC-Mlu-067315 Myotis lucifugus 99.81 0.00e+00 1090.00
IUUC-Nle-068978 Nomascus leucogenys 94.41 0.00e+00 1021.00
IUUC-Ont-072516 Oreochromis niloticus 91.81 0.00e+00 1051.00
IUUC-Oan-073714 Ornithorhynchus anatinus 99.56 0.00e+00 948.00
IUUC-Ocu-074284 Oryctolagus cuniculus 100.00 0.00e+00 1092.00
IUUC-Ola-087431 Oryzias latipes 91.62 0.00e+00 1047.00
IUUC-Oga-088789 Otolemur garnettii 94.04 0.00e+00 1016.00
IUUC-Oar-089408 Ovis aries 99.63 0.00e+00 1088.00
IUUC-Ptr-091068 Pan troglodytes 100.00 0.00e+00 1092.00
IUUC-Pan-092217 Papio anubis 100.00 0.00e+00 1092.00
IUUC-Psi-093602 Pelodiscus sinensis 98.70 0.00e+00 1079.00
IUUC-Pfo-097084 Poecilia formosa 92.18 0.00e+00 1054.00
IUUC-Pab-097673 Pongo abelii 99.63 0.00e+00 1088.00
IUUC-Pca-100245 Procavia capensis 97.53 0.00e+00 971.00
IUUC-Pva-102645 Pteropus vampyrus 97.95 0.00e+00 1052.00
IUUC-Rno-105372 Rattus norvegicus 99.63 0.00e+00 1088.00
IUUC-Sha-107637 Sarcophilus harrisii 99.26 0.00e+00 1075.00
IUUC-Sar-113016 Sorex araneus 88.45 0.00e+00 944.00
IUUC-Ssc-116389 Sus scrofa 99.44 0.00e+00 1083.00
IUUC-Tgu-117206 Taeniopygia guttata 93.11 0.00e+00 1007.00
IUUC-Tru-118241 Takifugu rubripes 90.94 0.00e+00 1043.00
IUUC-Tni-120031 Tetraodon nigroviridis 91.62 0.00e+00 1043.00
IUUC-Tbe-127707 Tupaia belangeri 96.75 0.00e+00 971.00
IUUC-Ttr-129145 Tursiops truncatus 99.81 0.00e+00 1090.00
IUUC-Vpa-130815 Vicugna pacos 97.00 0.00e+00 1034.00
IUUC-Xtr-132293 Xenopus tropicalis 90.32 0.00e+00 979.00
Created Date 25-Jun-2017

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