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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Cel-018641
UUCD1 version UUC-CaE-00329
Ensembl Protein ID Y108G3AL.1a.1
UniProt Accession Q17391; Q95Y32; CUL3_CAEEL
Genbank Protein ID AAC47122.1; CCD74336.1
Protein Name Cullin-3
Genbank Nucleotide ID U58085; FO081768
Gene Name cul-3; Y108G3AL.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000838 Y108G3AL.1a.1 Y108G3AL.1a.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 4.30e-163 544.6 34 675
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefikqvkkkveesedeq.lLktynreWekfreqlkvlrkifayldrtyvk 96
    l++a+++i+r++++ ++eely+++y+++l+k+g++lY+ lk v++++++ v+ ++ es+++ +L+t+ + W +++ +++++r+i++y+dr yv
   Q: 34 LKRAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGERLYNGLKDVIQDHMASVRIRIIESMNSGsFLETVAESWADHTVAMVMIRDILMYMDRIYVA 129
    799*********************************************************9999******************************** PP
   S: 97 kskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefykaesaeflqe 190
    ++++v +v++L+ld++r+ei+++ i +r+ ++ll+li+ +Rk ++++ + +++++ +l++L+++++++y++ FE + l++t+ +y+ ++ l+
   Q: 130 QNNHVLPVYNLGLDAYRTEILRQngIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRTVYEDEFERPLLKETSDYYRDVCKNWLSG 225
    **********************99*********************************************************************999 PP
   S: 191 .nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykLlsrvln.......gleellk 274
    n+ Yl +ve ++++e +ra+ryl++ te k+l+v++ +++a+h+++++ +++ +l++kk edl+r++++++r+ + gl+ llk
   Q: 226 dNDACFYLAQVEIAMHDEASRASRYLDKMTEAKILQVMDDVMVAEHIQTIVymqnGGVKFMLEHKKIEDLTRIFRIFKRIGDsvtvpggGLKALLK 321
    9**************************************************9998899*********************9888888999******* PP
   S: 275 eleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspEllAryiDqlLrksskgltee 370
    +++++e g++++ +e k+p+++V++ll+lk+ +++l+ +aF +d+ F + +++fetf+n n +spE++A y+D+ Lr+++k + ++
   Q: 322 AVSEYLNETGSNIVKNEDLLKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSN-----RQSPEFVALYMDDMLRSGLKCVSDA 412
    ******************************************************************.....99*********************** PP
   S: 371 eleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeekenteesesvel 466
    e++++ld+v+++f+y++ekdvFeky+k++LakRLl++ks s++ E++++ kLk+ecg++ft+kLe+Mf+d ++ +l + F++ +e++ + s+++
   Q: 413 EMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQFTQKLENMFRDKELWLTLATSFRDWREAQPTKMSIDI 508
    ************************************************************************************************ PP
   S: 467 svlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael...........................kkgkyelqV 535
    s +vL+ag+Wpt + + v LP+el+ ++e+f+++Y ekh+gRkL+ + lg+a++ka++ k +++lqV
   Q: 509 SLRVLTAGVWPTVQCNP-VVLPQELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFypppkasmsneengpgpsssgesmkerKPEHKILQV 603
    *************6657.9****************************************************99999999998886655559***** PP
   S: 536 stfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkepeske.ieeedlfsvNqef 604
    t Qm++LL+fn+++++s ++l ++ ++pe+eL+r lqsL+ +k +++l ++++k+ i++ d f vN++f
   Q: 604 NTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKasQRILVRKNKGKDaIDMSDEFAVNDNF 675
    ********************************************9***********999***********99 PP
   

Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:13679922). Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:13679922). Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation (PubMed:12781129). Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation (PubMed:12781129). Regulates microtubule stability in the early embryo (PubMed:12781129). In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of microtubule severing protein mei-1 downstream of unc-89 (PubMed:22621901).
Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:13679922). Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:13679922). Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation (PubMed:12781129). Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation (PubMed:12781129). Regulates microtubule stability in the early embryo (PubMed:12781129). In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of microtubule severing protein mei-1 downstream of unc-89 (PubMed:22621901).
Protein Sequence
(Fasta)
MSGRSGNGGQ QKMRIRPFMA TIDEQYVTQT WELLKRAIQE IQRKNNSGLS FEELYRNAYT 60
MVLHKHGERL YNGLKDVIQD HMASVRIRII ESMNSGSFLE TVAESWADHT VAMVMIRDIL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cel-018641|E3,Cullin|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTTCGAATT ACTCGCGACT TCTCAACTTT GAAGCTGAAA ATAGTTAGTT TTGTTTTTTC 60
TGTTATCAGT GCGCGCTTTT TCTGCAATAA TAACATTCCG CAGTACGATT TTTTCAAATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018641|E3,Cullin|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0031208--F:POZ domain binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0044257--P:cellular protein catabolic process
GO:0044254--P:multicellular organismal protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0071688--P:striated muscle myosin thick filament assembly

KEGG cel:CELE_Y108G3AL.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000335 Aegilops tauschii 39.52 3.00e-159 554.00
IUUC-Aml-002278 Ailuropoda melanoleuca 48.34 0.00e+00 715.00
IUUC-Atr-002616 Amborella trichopoda 43.06 1.00e-173 602.00
IUUC-Apl-004172 Anas platyrhynchos 48.75 0.00e+00 702.00
IUUC-Aca-004309 Anolis carolinensis 48.53 0.00e+00 715.00
IUUC-Aly-005566 Arabidopsis lyrata 41.39 5.00e-168 583.00
IUUC-Ath-007587 Arabidopsis thaliana 41.18 4.00e-168 583.00
IUUC-Acl-008317 Aspergillus clavatus 31.36 5.00e-110 390.00
IUUC-Afl-008727 Aspergillus flavus 31.16 1.00e-109 389.00
IUUC-Afu-008879 Aspergillus fumigatus 32.07 3.00e-101 361.00
IUUC-Ani-009393 Aspergillus nidulans 30.47 3.00e-109 388.00
IUUC-Ang-009626 Aspergillus niger 30.89 3.00e-105 374.00
IUUC-Aor-010207 Aspergillus oryzae 31.16 6.00e-110 390.00
IUUC-Ate-010305 Aspergillus terreus 31.65 5.00e-108 384.00
IUUC-Ame-011805 Astyanax mexicanus 48.46 0.00e+00 713.00
IUUC-Bgr-012098 Blumeria graminis 30.37 9.00e-91 327.00
IUUC-Bta-013445 Bos taurus 48.40 0.00e+00 716.00
IUUC-Bci-013612 Botrytis cinerea 31.87 4.00e-102 364.00
IUUC-Bdi-014269 Brachypodium distachyon 42.75 5.00e-167 580.00
IUUC-Bol-015350 Brassica oleracea 42.05 7.00e-170 589.00
IUUC-Bra-016763 Brassica rapa 42.05 3.00e-170 590.00
IUUC-Cja-019175 Callithrix jacchus 48.40 0.00e+00 716.00
IUUC-Cfa-020905 Canis familiaris 48.43 0.00e+00 704.00
IUUC-Cpo-021293 Cavia porcellus 48.44 0.00e+00 709.00
IUUC-Cre-022776 Chlamydomonas reinhardtii 41.09 4.00e-158 550.00
IUUC-Csa-023800 Chlorocebus sabaeus 48.40 0.00e+00 716.00
IUUC-Cho-024839 Choloepus hoffmanni 45.55 3.00e-166 577.00
IUUC-Cin-025201 Ciona intestinalis 45.38 4.00e-170 590.00
IUUC-Csv-026107 Ciona savignyi 47.11 0.00e+00 678.00
IUUC-Cgl-026630 Colletotrichum gloeosporioides 30.67 1.00e-91 329.00
IUUC-Cne-027048 Cryptococcus neoformans 31.23 1.00e-91 329.00
IUUC-Cme-027254 Cyanidioschyzon merolae 28.80 2.00e-74 272.00
IUUC-Dre-028488 Danio rerio 48.33 0.00e+00 709.00
IUUC-Dno-029784 Dasypus novemcinctus 48.40 0.00e+00 716.00
IUUC-Dor-030682 Dipodomys ordii 43.89 1.00e-169 588.00
IUUC-Dse-031326 Dothistroma septosporum 31.26 2.00e-103 369.00
IUUC-Dme-032112 Drosophila melanogaster 48.31 0.00e+00 722.00
IUUC-Ete-032347 Echinops telfairi 50.58 7.00e-120 423.00
IUUC-Eca-033560 Equus caballus 48.62 0.00e+00 704.00
IUUC-Eeu-034502 Erinaceus europaeus 45.55 6.00e-169 586.00
IUUC-Fca-035544 Felis catus 48.62 0.00e+00 704.00
IUUC-Fal-036751 Ficedula albicollis 48.62 0.00e+00 704.00
IUUC-Fox-037857 Fusarium oxysporum 31.56 3.00e-101 362.00
IUUC-Fso-038163 Fusarium solani 31.21 1.00e-99 356.00
IUUC-Gmo-038830 Gadus morhua 48.33 0.00e+00 713.00
IUUC-Ggr-039999 Gaeumannomyces graminis 28.46 3.00e-92 332.00
IUUC-Gga-040329 Gallus gallus 48.27 0.00e+00 715.00
IUUC-Gac-041510 Gasterosteus aculeatus 47.96 0.00e+00 713.00
IUUC-Gma-043659 Glycine max 42.90 2.00e-166 577.00
IUUC-Ggo-044903 Gorilla gorilla 48.49 0.00e+00 704.00
IUUC-Hsa-046000 Homo sapiens 48.40 0.00e+00 716.00
IUUC-Hvu-047541 Hordeum vulgare 42.23 2.00e-168 585.00
IUUC-Itr-049067 Ictidomys tridecemlineatus 50.00 5.00e-127 446.00
IUUC-Kpa-049372 Komagataella pastoris 31.38 1.00e-98 353.00
IUUC-Lch-050458 Latimeria chalumnae 48.56 0.00e+00 702.00
IUUC-Lpe-051396 Leersia perrieri 42.93 1.00e-172 598.00
IUUC-Loc-052186 Lepisosteus oculatus 48.46 0.00e+00 716.00
IUUC-Lma-053030 Leptosphaeria maculans 32.94 9.00e-108 383.00
IUUC-Laf-053684 Loxodonta africana 48.62 0.00e+00 704.00
IUUC-Mcc-055770 Macaca mulatta 48.40 0.00e+00 716.00
IUUC-Meu-056852 Macropus eugenii 42.80 4.00e-106 377.00
IUUC-Mor-057273 Magnaporthe oryzae 28.89 1.00e-93 336.00
IUUC-Mpo-057403 Magnaporthe poae 28.43 2.00e-92 332.00
IUUC-Mtr-058317 Medicago truncatula 41.86 2.00e-167 581.00
IUUC-Mla-059055 Melampsora laricipopulina 33.50 6.00e-124 437.00
IUUC-Mga-060076 Meleagris gallopavo 48.23 0.00e+00 690.00
IUUC-Mvi-060470 Microbotryum violaceum 29.78 2.00e-109 388.00
IUUC-Mmr-060976 Microcebus murinus 48.40 0.00e+00 716.00
IUUC-Mdo-062741 Monodelphis domestica 48.40 0.00e+00 716.00
IUUC-Mmu-063905 Mus musculus 48.40 0.00e+00 716.00
IUUC-Mac-064718 Musa acuminata 41.97 9.00e-163 565.00
IUUC-Mpu-066356 Mustela putorius furo 48.62 0.00e+00 704.00
IUUC-Mlu-067768 Myotis lucifugus 48.75 0.00e+00 706.00
IUUC-Nfi-068285 Neosartorya fischeri 31.48 2.00e-110 392.00
IUUC-Ncr-068883 Neurospora crassa 30.89 7.00e-100 357.00
IUUC-Nle-069638 Nomascus leucogenys 48.62 0.00e+00 702.00
IUUC-Opr-070333 Ochotona princeps 46.67 2.00e-141 494.00
IUUC-Ont-071601 Oreochromis niloticus 48.59 0.00e+00 735.00
IUUC-Oan-073281 Ornithorhynchus anatinus 45.24 1.00e-162 565.00
IUUC-Ocu-074504 Oryctolagus cuniculus 48.56 0.00e+00 704.00
IUUC-Oba-075459 Oryza barthii 42.65 1.00e-172 598.00
IUUC-Obr-076790 Oryza brachyantha 43.08 3.00e-172 597.00
IUUC-Ogl-077655 Oryza glaberrima 43.06 3.00e-173 600.00
IUUC-Ogu-078100 Oryza glumaepatula 42.65 5.00e-172 596.00
IUUC-Oin-079567 Oryza indica 42.93 8.00e-173 599.00
IUUC-Olo-080930 Oryza longistaminata 43.55 4.00e-174 603.00
IUUC-Ome-081353 Oryza meridionalis 42.95 4.00e-173 600.00
IUUC-Oni-082378 Oryza nivara 43.06 3.00e-173 600.00
IUUC-Opu-084055 Oryza punctata 43.06 9.00e-174 602.00
IUUC-Oru-084410 Oryza rufipogon 42.78 4.00e-173 600.00
IUUC-Osa-085290 Oryza sativa 43.06 2.00e-173 600.00
IUUC-Ola-087562 Oryzias latipes 48.59 0.00e+00 712.00
IUUC-Olu-087866 Ostreococcus lucimarinus 34.33 2.00e-119 422.00
IUUC-Oga-088833 Otolemur garnettii 48.62 0.00e+00 704.00
IUUC-Oar-089958 Ovis aries 48.62 0.00e+00 704.00
IUUC-Ptr-091013 Pan troglodytes 48.40 0.00e+00 716.00
IUUC-Pan-091796 Papio anubis 48.82 0.00e+00 704.00
IUUC-Psi-093564 Pelodiscus sinensis 48.09 0.00e+00 687.00
IUUC-Pma-094678 Petromyzon marinus 31.54 5.00e-85 307.00
IUUC-Pno-094939 Phaeosphaeria nodorum 31.77 9.00e-103 366.00
IUUC-Ppa-095920 Physcomitrella patens 42.13 6.00e-170 589.00
IUUC-Pfo-096588 Poecilia formosa 48.46 0.00e+00 715.00
IUUC-Pab-098164 Pongo abelii 48.40 0.00e+00 716.00
IUUC-Pop-099497 Populus trichocarpa 42.67 3.00e-171 594.00
IUUC-Pca-100702 Procavia capensis 50.00 2.00e-114 405.00
IUUC-Ppe-101971 Prunus persica 42.11 1.00e-163 568.00
IUUC-Pva-103129 Pteropus vampyrus 48.40 0.00e+00 717.00
IUUC-Pgr-103600 Puccinia graminis 31.73 3.00e-97 348.00
IUUC-Ptt-103961 Puccinia triticina 31.38 2.00e-95 342.00
IUUC-Pte-104325 Pyrenophora teres 31.91 3.00e-99 355.00
IUUC-Pyt-104746 Pyrenophora triticirepentis 31.82 6.00e-98 350.00
IUUC-Rno-105935 Rattus norvegicus 48.62 0.00e+00 705.00
IUUC-Sha-106569 Sarcophilus harrisii 46.21 1.00e-174 605.00
IUUC-Sja-107676 Schizosaccharomyces japonicus 35.42 3.00e-128 451.00
IUUC-Spo-108135 Schizosaccharomyces pombe 33.58 1.00e-113 402.00
IUUC-Smo-109555 Selaginella moellendorffii 44.02 2.00e-177 614.00
IUUC-Sit-110763 Setaria italica 42.36 5.00e-168 583.00
IUUC-Sly-111090 Solanum lycopersicum 42.50 6.00e-172 596.00
IUUC-Stu-112351 Solanum tuberosum 42.63 5.00e-173 599.00
IUUC-Sar-113144 Sorex araneus 46.85 2.00e-144 504.00
IUUC-Sbi-114690 Sorghum bicolor 42.49 7.00e-172 596.00
IUUC-Sre-115005 Sporisorium reilianum 31.88 1.00e-101 363.00
IUUC-Ssc-116053 Sus scrofa 46.94 1.00e-144 505.00
IUUC-Tgu-116523 Taeniopygia guttata 48.62 0.00e+00 704.00
IUUC-Tru-118189 Takifugu rubripes 46.81 0.00e+00 665.00
IUUC-Tsy-118962 Tarsius syrichta 46.76 0.00e+00 647.00
IUUC-Tni-120614 Tetraodon nigroviridis 38.13 5.00e-144 503.00
IUUC-Tca-121282 Theobroma cacao 42.39 1.00e-169 588.00
IUUC-Tre-122201 Trichoderma reesei 30.15 7.00e-99 353.00
IUUC-Tvi-122321 Trichoderma virens 30.64 1.00e-99 356.00
IUUC-Tae-124292 Triticum aestivum 42.88 3.00e-168 583.00
IUUC-Tur-126800 Triticum urartu 42.88 2.00e-168 584.00
IUUC-Tme-127053 Tuber melanosporum 33.97 2.00e-124 438.00
IUUC-Tbe-127427 Tupaia belangeri 41.63 7.00e-128 449.00
IUUC-Ttr-128662 Tursiops truncatus 48.09 0.00e+00 683.00
IUUC-Uma-129597 Ustilago maydis 31.41 1.00e-99 356.00
IUUC-Vda-129726 Verticillium dahliae 30.48 1.00e-100 359.00
IUUC-Vpa-130809 Vicugna pacos 46.19 4.00e-92 331.00
IUUC-Vvi-131194 Vitis vinifera 43.57 4.00e-172 597.00
IUUC-Xtr-131887 Xenopus tropicalis 48.27 0.00e+00 711.00
IUUC-Xma-133517 Xiphophorus maculatus 48.72 0.00e+00 715.00
IUUC-Yli-134576 Yarrowia lipolytica 28.97 2.00e-87 315.00
IUUC-Zma-135030 Zea mays 42.88 6.00e-171 592.00
Created Date 25-Jun-2017

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