iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000005501.14	ENSMUST00000189409.6	ENSMUSP00000140240.1
ENSMUSG00000005501.14	ENSMUST00000040783.10	ENSMUSP00000038533.4
ENSMUSG00000005501.14	ENSMUST00000187758.6	ENSMUSP00000140107.1
ENSMUSG00000005501.14	ENSMUST00000188332.6	ENSMUSP00000140574.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-75	256.2	42	481

Active Site

Position(s)	Description	Evidence
50	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
305	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkg....ellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           G++N+g tCY+ S+LQ+L+++pe+re+l++  +e+l   ++k++       +  +lq+lf++l+  +++a s+ +l++++++++ e  +
   Q: 42   GIRNQGGTCYLSSLLQTLHFTPEFREALFSLGPEELGSLEDKDKPDakvrIIPLQLQRLFAQLLLLDQEAASTIDLTDSFGWTNDE--E 128
           9*****************************777777665543332234458899*******************************8..* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           ++q+D+qE+ ++l+++le++l                            +++++li++l++g++ +qi+c+ec+n+s+r+e+fldl+++
   Q: 129  MRQHDVQELNRILFSALETSL--------------------------VGTSGHDLIHRLYHGTIVNQIVCKECKNISERQEDFLDLTVA 191
           *********************..........................789*************************************** PP
   S: 176  vpgkeetkkeslqdcL.esftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           v++ +      l+d L +++++ee ++ +n y+c +c+++++a k+ kl+klP++L++ L Rf+f+  ++ r k +++++fpl+++l+p
   Q: 192  VKNVS-----GLEDELcNMYVEEEIFDYDNLYHCGTCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKDTSCYTFPLRINLKP 275
           *****.....99***99************************************************************************ PP
   S: 264  fctspeekqkekkkYeLiavvvHsGslssGHYvayvkn................................................... 301
           fc+++e ++  ++ Y+L++v++H+G++ +GHY++y+k+                                                   
   Q: 276  FCEQSELDDM-EYMYDLFSVIIHKGGCYGGHYHVYIKDvdhlgnwqcqeeisdtnvnvkapqseeeandplvvlktillqeeanqipvd 363
           ****998875.9***************************************************************************** PP
   S: 302  ..............................................................................ekgk....Wll 308
                                                                                         +       W+ 
   Q: 364  qlgqkllkktgiswnkkyrkqhgplrkflqlhpqifllstdestvsllrnhltqapsdlqsceqilhtlasespglndD--TscphWFD 450
           ***********************************************************99999999999998888641..24578*** PP
   S: 309  fdDskVtevkeeevleetg..staYvlfYkr 337
           ++DskV++++e+++ ++ +  ++aY+lfY++
   Q: 451  INDSKVHPIREKDITQQFQgkESAYMLFYRK 481
           ***************98889*********97 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MFGNLFEEDY SSVSSSQYGR GKKLKTKGLE PPAPREFTNL SGIRNQGGTC YLSSLLQTLH 60
FTPEFREALF SLGPEELGSL EDKDKPDAKV RIIPLQLQRL FAQLLLLDQE AASTIDLTDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTGGTTGG AAATCACTTT CCAGAGACAC GGCCTCCTCG GCATGGCGGT GCCCGTTCGG 60
AGCGAGTTCG TTTACTCTGT GCTGTGGCCG GGGCGGGGGT CTGGGCTATA GGCAGTAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:227334

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001216	Ailuropoda melanoleuca	78.12	0.00e+00	1786.00
IUUC-Apl-004105	Anas platyrhynchos	62.32	0.00e+00	1498.00
IUUC-Aca-004715	Anolis carolinensis	59.60	0.00e+00	1412.00
IUUC-Ame-011073	Astyanax mexicanus	46.48	0.00e+00	1006.00
IUUC-Bta-012487	Bos taurus	77.93	0.00e+00	1872.00
IUUC-Cja-018937	Callithrix jacchus	80.05	0.00e+00	1949.00
IUUC-Cfa-020645	Canis familiaris	74.33	0.00e+00	1155.00
IUUC-Cpo-022160	Cavia porcellus	77.36	0.00e+00	1868.00
IUUC-Csa-023078	Chlorocebus sabaeus	78.98	0.00e+00	1959.00
IUUC-Cho-025013	Choloepus hoffmanni	63.65	0.00e+00	772.00
IUUC-Csv-026193	Ciona savignyi	55.74	4.00e-59	221.00
IUUC-Dre-027416	Danio rerio	48.64	0.00e+00	1135.00
IUUC-Dno-029639	Dasypus novemcinctus	75.46	0.00e+00	1555.00
IUUC-Dor-030624	Dipodomys ordii	87.71	8.00e-148	518.00
IUUC-Ete-032626	Echinops telfairi	61.59	0.00e+00	721.00
IUUC-Eca-034208	Equus caballus	79.47	0.00e+00	1938.00
IUUC-Eeu-035340	Erinaceus europaeus	45.23	3.00e-83	303.00
IUUC-Fca-035886	Felis catus	69.44	0.00e+00	728.00
IUUC-Fal-036925	Ficedula albicollis	61.98	0.00e+00	1391.00
IUUC-Gmo-038597	Gadus morhua	45.61	0.00e+00	894.00
IUUC-Gga-041171	Gallus gallus	61.56	0.00e+00	1467.00
IUUC-Gac-041362	Gasterosteus aculeatus	45.63	0.00e+00	947.00
IUUC-Ggo-045069	Gorilla gorilla	78.07	0.00e+00	1750.00
IUUC-Hsa-046715	Homo sapiens	79.71	0.00e+00	1941.00
IUUC-Itr-049006	Ictidomys tridecemlineatus	79.66	0.00e+00	1910.00
IUUC-Lch-050182	Latimeria chalumnae	49.76	0.00e+00	1080.00
IUUC-Loc-052705	Lepisosteus oculatus	53.32	0.00e+00	1252.00
IUUC-Laf-054132	Loxodonta africana	77.61	0.00e+00	1912.00
IUUC-Mcc-055734	Macaca mulatta	79.55	0.00e+00	1962.00
IUUC-Meu-056135	Macropus eugenii	86.15	1.00e-111	398.00
IUUC-Mga-060092	Meleagris gallopavo	61.09	0.00e+00	1437.00
IUUC-Mmr-061546	Microcebus murinus	76.43	0.00e+00	1840.00
IUUC-Mdo-061935	Monodelphis domestica	60.62	0.00e+00	1451.00
IUUC-Mpu-066579	Mustela putorius furo	76.15	0.00e+00	1897.00
IUUC-Mlu-068034	Myotis lucifugus	78.33	0.00e+00	1848.00
IUUC-Nle-069082	Nomascus leucogenys	77.15	0.00e+00	1586.00
IUUC-Opr-070953	Ochotona princeps	68.97	0.00e+00	923.00
IUUC-Ont-072435	Oreochromis niloticus	46.92	0.00e+00	1073.00
IUUC-Oan-073339	Ornithorhynchus anatinus	64.52	0.00e+00	1512.00
IUUC-Ocu-073760	Oryctolagus cuniculus	76.72	0.00e+00	1846.00
IUUC-Ola-087015	Oryzias latipes	46.12	0.00e+00	906.00
IUUC-Oga-088960	Otolemur garnettii	79.06	0.00e+00	1934.00
IUUC-Oar-089853	Ovis aries	78.45	0.00e+00	1904.00
IUUC-Ptr-091093	Pan troglodytes	79.63	0.00e+00	1938.00
IUUC-Pan-091962	Papio anubis	78.76	0.00e+00	1947.00
IUUC-Psi-093691	Pelodiscus sinensis	63.65	0.00e+00	1543.00
IUUC-Pma-094428	Petromyzon marinus	64.03	9.00e-90	323.00
IUUC-Pfo-096983	Poecilia formosa	47.58	0.00e+00	1002.00
IUUC-Pab-097860	Pongo abelii	78.85	0.00e+00	1783.00
IUUC-Pca-100514	Procavia capensis	64.43	5.00e-177	615.00
IUUC-Pva-102771	Pteropus vampyrus	77.92	0.00e+00	1766.00
IUUC-Rno-105405	Rattus norvegicus	92.55	0.00e+00	2282.00
IUUC-Sha-107376	Sarcophilus harrisii	62.01	0.00e+00	1425.00
IUUC-Ssc-115819	Sus scrofa	73.65	0.00e+00	1298.00
IUUC-Tgu-117262	Taeniopygia guttata	61.39	0.00e+00	1470.00
IUUC-Tru-117601	Takifugu rubripes	47.36	0.00e+00	1065.00
IUUC-Tsy-118996	Tarsius syrichta	69.55	0.00e+00	1504.00
IUUC-Tni-120682	Tetraodon nigroviridis	43.10	0.00e+00	858.00
IUUC-Tbe-127616	Tupaia belangeri	60.85	0.00e+00	1158.00
IUUC-Ttr-129075	Tursiops truncatus	75.53	0.00e+00	1766.00
IUUC-Vpa-130108	Vicugna pacos	78.02	0.00e+00	1699.00
IUUC-Xtr-132623	Xenopus tropicalis	52.13	0.00e+00	1170.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence