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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063171
Ensembl Protein ID ENSMUSP00000110688.1
UniProt Accession Q9JMG3; Q53AQ3; TMUB1_MOUSE
Genbank Protein ID BAA92747.1; AAU00155.1; BAB25465.1; AAH19547.1
Protein Name Transmembrane and ubiquitin-like domain-containing protein 1; Hepatocyte odd protein shuttling protein; iHOPS
Genbank Nucleotide ID AB030183; AY603379; AK008109; BC019547
Gene Name Tmub1; Hops
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028958.14 ENSMUST00000115036.7 ENSMUSP00000110688.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 16014383; 18665261; 19254477
Classification
Family E-value Score Start End
ULD/UDP/UBQ/UBQ_Other 1.90e-10 41.6 125 189
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 9    dgs.eltlkvnpsdtVaeLKekiekklgip.pe.qqrLiykGkiL.eddktLadyglkdgstihllekksg 75
           ++s    +  +p+dt++ LK+     + +p  e q+rLiy+G++L +d +tL++++l++++++h+ +++++
   Q: 125  NDSeQVAR-AWPQDTIGSLKR-----TQFPgQEqQVRLIYQGQLLgDDTQTLGSLHLPPNCVLHCHVSTRV 189
           55533333.49**********.....9999855699******************************99986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (PubMed:16014383). May be involved in centrosome assembly (PubMed:18418082). Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (PubMed:22890319).
 iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (PubMed:16014383). May be involved in centrosome assembly (PubMed:18418082). Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (PubMed:22890319).
Protein Sequence
(Fasta)
MGRDLLSTSG SSTGAMALIE GVGDEVTVLF AVLACLLVLA LAWVSTHTTE STDPQPQPPG 60
TTTPAQPSEA MSASDSIREE APGAESPSLR HRGPSAQPEP DTGVTASTPP DSPQEPLLLR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063171|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCAGCAGGG AAGGAGAGGG ACCTCAGGTG TCTGCGACCT CGGTGCCTTC GGCCCGGAAG 60
TGCCCGAGGA GCCGAGATGG AGCTGGTGGA GCTGGGCGGT GAGTCGCTGT GCGTGGCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063171|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0024--Alternative initiation
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF00240--ubiquitin
SMART

SM00213--UBQ
Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0045211--C:postsynaptic membrane
GO:0055037--C:recycling endosome
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG mmu:64295
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001821 Ailuropoda melanoleuca 87.11 3.00e-80 291.00
IUUC-Aca-004375 Anolis carolinensis 46.13 9.00e-34 137.00
IUUC-Bta-012542 Bos taurus 86.99 9.00e-70 256.00
IUUC-Cel-018429 Caenorhabditis elegans 39.81 4.00e-13 70.10
IUUC-Cja-019142 Callithrix jacchus 88.31 7.00e-72 263.00
IUUC-Cfa-020517 Canis familiaris 90.24 7.00e-83 300.00
IUUC-Cpo-021653 Cavia porcellus 85.77 9.00e-67 246.00
IUUC-Csa-023914 Chlorocebus sabaeus 89.43 3.00e-75 274.00
IUUC-Dno-029028 Dasypus novemcinctus 84.77 8.00e-72 263.00
IUUC-Dor-030758 Dipodomys ordii 90.28 5.00e-76 277.00
IUUC-Ete-032267 Echinops telfairi 88.36 7.00e-53 199.00
IUUC-Eca-034010 Equus caballus 85.77 1.00e-70 259.00
IUUC-Fca-035402 Felis catus 89.84 1.00e-82 299.00
IUUC-Fal-037183 Ficedula albicollis 74.42 1.00e-13 68.20
IUUC-Gac-041487 Gasterosteus aculeatus 45.72 7.00e-41 160.00
IUUC-Ggo-045556 Gorilla gorilla 86.59 3.00e-69 254.00
IUUC-Hsa-046639 Homo sapiens 89.43 1.00e-74 272.00
IUUC-Itr-048729 Ictidomys tridecemlineatus 88.72 7.00e-86 310.00
IUUC-Laf-054495 Loxodonta africana 56.50 2.00e-32 131.00
IUUC-Mcc-055870 Macaca mulatta 89.02 1.00e-74 272.00
IUUC-Meu-056759 Macropus eugenii 72.13 3.00e-57 214.00
IUUC-Mdo-062740 Monodelphis domestica 72.13 5.00e-62 230.00
IUUC-Mpu-066100 Mustela putorius furo 87.50 5.00e-81 293.00
IUUC-Mlu-067839 Myotis lucifugus 87.55 2.00e-73 268.00
IUUC-Nle-069603 Nomascus leucogenys 89.02 4.00e-74 271.00
IUUC-Opr-070539 Ochotona princeps 94.04 6.00e-44 169.00
IUUC-Ont-072413 Oreochromis niloticus 44.53 1.00e-39 156.00
IUUC-Ocu-074589 Oryctolagus cuniculus 89.11 3.00e-73 267.00
IUUC-Ola-087411 Oryzias latipes 46.32 7.00e-43 167.00
IUUC-Oga-088156 Otolemur garnettii 86.59 1.00e-75 275.00
IUUC-Oar-089302 Ovis aries 86.80 1.00e-69 256.00
IUUC-Ptr-091176 Pan troglodytes 89.43 1.00e-74 272.00
IUUC-Pab-098432 Pongo abelii 87.80 6.00e-69 254.00
IUUC-Pca-100595 Procavia capensis 70.45 3.00e-48 184.00
IUUC-Pva-102157 Pteropus vampyrus 47.51 2.00e-26 112.00
IUUC-Rno-105447 Rattus norvegicus 96.33 1.00e-91 328.00
IUUC-Sha-106499 Sarcophilus harrisii 73.98 6.00e-66 243.00
IUUC-Ssc-116410 Sus scrofa 87.40 7.00e-74 270.00
IUUC-Tgu-117495 Taeniopygia guttata 70.67 1.00e-25 108.00
IUUC-Tru-118609 Takifugu rubripes 46.21 3.00e-42 165.00
IUUC-Tni-120885 Tetraodon nigroviridis 47.76 3.00e-44 171.00
IUUC-Tbe-127898 Tupaia belangeri 81.40 2.00e-45 173.00
IUUC-Ttr-129209 Tursiops truncatus 88.21 5.00e-76 276.00
IUUC-Uma-129636 Ustilago maydis 44.90 3.30e-01 29.60
Created Date 25-Jun-2017

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