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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Cel-018385
UUCD1 version UUC-CaE-00381
Ensembl Protein ID F32A6.3c
UniProt Accession Q19954; A3RMR9; A3RMS0; VPS41_CAEEL
Genbank Protein ID CCD65714.1; CCD65718.1; CCD65724.1; CCD70397.1
Protein Name Vacuolar protein sorting-associated protein 41 homolog
Genbank Nucleotide ID FO080679; FO080679; FO080679; FO081274
Gene Name vps-41; F32A6.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00017974 F32A6.3b F32A6.3b
WBGene00017974 F32A6.3c F32A6.3c
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 28.45 7.00e-90 330.00 IUUC-Hsa-047030
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). Has a role in the negative regulation of apoptosis. Required for uptake of exogenous dsRNA which is used in experimental RNA silencing.
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). Has a role in the negative regulation of apoptosis. Required for uptake of exogenous dsRNA which is used in experimental RNA silencing.
Protein Sequence
(Fasta)
MDETHENEAS DSFDPVFENS YHDDVTFNTE DDDEPPLEPR FKYERLKGEE TLPFMKTATF 60
TSIDLHDKFI AIGTATGLIY ILDHHGYGNF DSVPPLKPHR CAVSKVKFDE TGSYVLSCAN 120
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Protein Fasta Sequence



>IUUC-Cel-018385|E3,RING|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
AGAACCAATG GACGAAACAC ACGAGAATGA GGCGTCCGAT TCCTTTGATC CAGTGTTCGA 60
AAATTCCTAC CATGATGACG TCACATTCAA CACAGAAGAC GACGATGAGC CACCATTAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018385|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016024--ARM-type_fold
IPR000547--Clathrin_H-chain/VPS_repeat
IPR011990--TPR-like_helical_dom
IPR016902--VPS41
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50236--CHCR
PS50089--ZF_RING_2

Pfam

PF00637--Clathrin

SMART

SM00299--CLH

Gene Ontology

GO:0030136--C:clathrin-coated vesicle
GO:0033263--C:CORVET complex
GO:0005769--C:early endosome
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0030897--C:HOPS complex
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005773--C:vacuole
GO:0051020--F:GTPase binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0006623--P:protein targeting to vacuole
GO:0035542--P:regulation of SNARE complex assembly
GO:0006624--P:vacuolar protein processing
GO:0007034--P:vacuolar transport
GO:0042144--P:vacuole fusion, non-autophagic
GO:0016192--P:vesicle-mediated transport

KEGG cel:CELE_F32A6.3
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000207 Aegilops tauschii 23.74 2.00e-56 213.00
IUUC-Aml-001435 Ailuropoda melanoleuca 28.99 6.00e-96 344.00
IUUC-Atr-002975 Amborella trichopoda 26.37 4.00e-74 271.00
IUUC-Apl-003254 Anas platyrhynchos 28.49 2.00e-93 335.00
IUUC-Aca-005067 Anolis carolinensis 29.06 8.00e-97 347.00
IUUC-Aly-005839 Arabidopsis lyrata 26.56 5.00e-77 281.00
IUUC-Ath-006625 Arabidopsis thaliana 26.35 2.00e-76 279.00
IUUC-Ago-007960 Ashbya gossypii 20.65 3.00e-32 132.00
IUUC-Acl-008174 Aspergillus clavatus 22.49 3.00e-32 133.00
IUUC-Afl-008524 Aspergillus flavus 23.91 2.00e-31 130.00
IUUC-Afu-009054 Aspergillus fumigatus 22.69 3.00e-30 126.00
IUUC-Ani-009250 Aspergillus nidulans 23.94 9.00e-29 121.00
IUUC-Ang-009665 Aspergillus niger 24.24 2.00e-30 127.00
IUUC-Aor-010230 Aspergillus oryzae 23.80 1.00e-32 134.00
IUUC-Ate-010464 Aspergillus terreus 23.54 1.00e-29 124.00
IUUC-Ame-011311 Astyanax mexicanus 27.03 3.00e-70 258.00
IUUC-Bgr-012099 Blumeria graminis 24.30 2.00e-25 110.00
IUUC-Bta-013327 Bos taurus 29.38 6.00e-96 344.00
IUUC-Bci-013660 Botrytis cinerea 22.79 4.00e-31 129.00
IUUC-Bdi-014641 Brachypodium distachyon 24.61 2.00e-64 239.00
IUUC-Bol-015685 Brassica oleracea 25.08 1.00e-76 280.00
IUUC-Bra-016918 Brassica rapa 25.22 1.00e-75 276.00
IUUC-Cja-018994 Callithrix jacchus 28.59 2.00e-91 329.00
IUUC-Cfa-020405 Canis familiaris 29.14 7.00e-95 340.00
IUUC-Cpo-022163 Cavia porcellus 29.02 4.00e-94 337.00
IUUC-Cre-022626 Chlamydomonas reinhardtii 19.12 2.00e-11 63.50
IUUC-Csa-023134 Chlorocebus sabaeus 28.81 2.00e-94 338.00
IUUC-Cho-024913 Choloepus hoffmanni 24.24 3.00e-57 215.00
IUUC-Cin-025239 Ciona intestinalis 27.18 7.00e-89 320.00
IUUC-Cgl-026706 Colletotrichum gloeosporioides 24.93 6.00e-27 115.00
IUUC-Cne-026799 Cryptococcus neoformans 22.96 3.00e-69 255.00
IUUC-Cme-027200 Cyanidioschyzon merolae 18.29 8.00e-04 38.10
IUUC-Dre-028115 Danio rerio 27.63 5.00e-92 330.00
IUUC-Dor-030947 Dipodomys ordii 27.43 8.00e-85 306.00
IUUC-Dse-031544 Dothistroma septosporum 22.09 1.00e-25 111.00
IUUC-Dme-031830 Drosophila melanogaster 24.34 3.00e-73 268.00
IUUC-Ete-033051 Echinops telfairi 32.31 3.00e-31 129.00
IUUC-Eca-033501 Equus caballus 28.79 3.00e-95 342.00
IUUC-Eeu-034555 Erinaceus europaeus 24.41 4.00e-31 129.00
IUUC-Fca-035809 Felis catus 29.14 1.00e-93 336.00
IUUC-Fal-037056 Ficedula albicollis 28.57 8.00e-94 337.00
IUUC-Fox-037949 Fusarium oxysporum 22.38 3.00e-27 116.00
IUUC-Fso-038282 Fusarium solani 22.88 2.00e-24 107.00
IUUC-Gmo-038540 Gadus morhua 27.40 4.00e-85 308.00
IUUC-Ggr-039733 Gaeumannomyces graminis 25.62 1.00e-28 121.00
IUUC-Gga-040446 Gallus gallus 28.49 7.00e-94 337.00
IUUC-Gac-041462 Gasterosteus aculeatus 27.75 6.00e-86 310.00
IUUC-Gma-043148 Glycine max 25.14 2.00e-73 269.00
IUUC-Hsa-047030 Homo sapiens 28.79 7.00e-95 340.00
IUUC-Hvu-047693 Hordeum vulgare 24.57 8.00e-63 234.00
IUUC-Itr-048318 Ictidomys tridecemlineatus 28.94 5.00e-95 340.00
IUUC-Kpa-049224 Komagataella pastoris 21.06 6.00e-29 122.00
IUUC-Lch-049444 Latimeria chalumnae 28.00 1.00e-93 336.00
IUUC-Lpe-050942 Leersia perrieri 26.71 2.00e-42 166.00
IUUC-Loc-052260 Lepisosteus oculatus 27.99 2.00e-93 335.00
IUUC-Lma-053173 Leptosphaeria maculans 23.34 4.00e-26 113.00
IUUC-Laf-054185 Loxodonta africana 28.76 1.00e-94 339.00
IUUC-Mcc-054816 Macaca mulatta 28.93 2.00e-94 339.00
IUUC-Meu-056483 Macropus eugenii 33.46 2.00e-39 156.00
IUUC-Mor-056979 Magnaporthe oryzae 25.06 7.00e-29 122.00
IUUC-Mpo-057312 Magnaporthe poae 24.87 6.00e-28 119.00
IUUC-Mtr-057630 Medicago truncatula 25.19 2.00e-75 276.00
IUUC-Mla-058930 Melampsora laricipopulina 27.22 3.00e-17 80.10
IUUC-Mga-059942 Meleagris gallopavo 28.57 1.00e-93 336.00
IUUC-Mvi-060386 Microbotryum violaceum 24.61 2.00e-58 219.00
IUUC-Mmr-060640 Microcebus murinus 29.04 4.00e-95 341.00
IUUC-Mdo-062934 Monodelphis domestica 25.72 1.00e-65 243.00
IUUC-Mmu-063488 Mus musculus 28.40 7.00e-94 337.00
IUUC-Mac-064975 Musa acuminata 26.74 1.00e-73 270.00
IUUC-Mpu-065777 Mustela putorius furo 28.91 5.00e-95 341.00
IUUC-Mlu-068052 Myotis lucifugus 29.16 7.00e-97 347.00
IUUC-Nfi-068436 Neosartorya fischeri 23.13 5.00e-32 132.00
IUUC-Ncr-068840 Neurospora crassa 24.68 7.00e-28 119.00
IUUC-Nle-070063 Nomascus leucogenys 28.67 5.00e-93 334.00
IUUC-Opr-070385 Ochotona princeps 28.64 7.00e-46 177.00
IUUC-Ont-072367 Oreochromis niloticus 27.13 5.00e-87 314.00
IUUC-Oan-073085 Ornithorhynchus anatinus 28.55 4.00e-88 318.00
IUUC-Ocu-074672 Oryctolagus cuniculus 29.02 7.00e-96 343.00
IUUC-Oba-075574 Oryza barthii 25.52 2.00e-66 246.00
IUUC-Obr-076203 Oryza brachyantha 25.52 5.00e-66 244.00
IUUC-Ogl-077909 Oryza glaberrima 25.52 2.00e-66 246.00
IUUC-Ogu-078053 Oryza glumaepatula 25.55 1.00e-65 243.00
IUUC-Oin-079700 Oryza indica 25.52 2.00e-66 246.00
IUUC-Olo-080707 Oryza longistaminata 25.20 3.00e-69 255.00
IUUC-Oni-082754 Oryza nivara 25.44 1.00e-65 243.00
IUUC-Opu-083854 Oryza punctata 25.66 1.00e-66 246.00
IUUC-Oru-085071 Oryza rufipogon 25.92 6.00e-66 244.00
IUUC-Osa-085370 Oryza sativa 25.52 2.00e-66 246.00
IUUC-Ola-086362 Oryzias latipes 27.57 5.00e-84 304.00
IUUC-Oga-088078 Otolemur garnettii 28.59 1.00e-91 330.00
IUUC-Oar-089679 Ovis aries 29.14 6.00e-96 343.00
IUUC-Ptr-091680 Pan troglodytes 28.79 7.00e-95 340.00
IUUC-Pan-092816 Papio anubis 30.78 5.00e-69 254.00
IUUC-Psi-093890 Pelodiscus sinensis 29.14 8.00e-96 343.00
IUUC-Pma-094654 Petromyzon marinus 28.21 1.00e-95 343.00
IUUC-Pno-095071 Phaeosphaeria nodorum 22.49 6.00e-27 115.00
IUUC-Ppa-095198 Physcomitrella patens 23.76 2.00e-59 223.00
IUUC-Pfo-097465 Poecilia formosa 26.81 9.00e-85 306.00
IUUC-Pab-098686 Pongo abelii 28.79 9.00e-95 340.00
IUUC-Pop-099281 Populus trichocarpa 26.19 1.00e-74 273.00
IUUC-Pca-100990 Procavia capensis 28.08 1.00e-75 276.00
IUUC-Ppe-101500 Prunus persica 25.86 3.00e-75 275.00
IUUC-Pva-102809 Pteropus vampyrus 28.89 3.00e-95 341.00
IUUC-Pgr-103404 Puccinia graminis 22.34 5.00e-63 234.00
IUUC-Ptt-103952 Puccinia triticina 22.12 3.00e-60 226.00
IUUC-Pte-104216 Pyrenophora teres 31.43 1.00e-21 98.20
IUUC-Rno-105949 Rattus norvegicus 28.63 4.00e-89 321.00
IUUC-Sce-106462 Saccharomyces cerevisiae 25.64 1.00e-23 103.00
IUUC-Sha-106689 Sarcophilus harrisii 28.10 5.00e-95 341.00
IUUC-Sja-107696 Schizosaccharomyces japonicus 20.45 1.00e-22 100.00
IUUC-Spo-108173 Schizosaccharomyces pombe 22.36 3.00e-46 179.00
IUUC-Smo-109505 Selaginella moellendorffii 26.29 4.00e-73 268.00
IUUC-Sit-110176 Setaria italica 26.28 9.00e-75 274.00
IUUC-Sly-111671 Solanum lycopersicum 25.55 1.00e-77 283.00
IUUC-Sar-113073 Sorex araneus 30.66 2.00e-65 242.00
IUUC-Sbi-114139 Sorghum bicolor 24.95 1.00e-67 249.00
IUUC-Sre-115158 Sporisorium reilianum 25.11 9.00e-69 254.00
IUUC-Ssc-115894 Sus scrofa 29.53 6.00e-97 347.00
IUUC-Tgu-117481 Taeniopygia guttata 28.57 2.00e-94 338.00
IUUC-Tru-118468 Takifugu rubripes 26.58 1.00e-85 310.00
IUUC-Tni-120478 Tetraodon nigroviridis 26.52 1.00e-86 313.00
IUUC-Tca-121780 Theobroma cacao 26.71 8.00e-75 274.00
IUUC-Tre-121900 Trichoderma reesei 24.94 9.00e-30 124.00
IUUC-Tvi-122343 Trichoderma virens 23.35 8.00e-30 125.00
IUUC-Tae-123578 Triticum aestivum 24.51 1.00e-63 236.00
IUUC-Tur-126430 Triticum urartu 24.40 8.00e-60 224.00
IUUC-Tme-127007 Tuber melanosporum 26.01 1.00e-26 114.00
IUUC-Tbe-128073 Tupaia belangeri 28.53 6.00e-79 287.00
IUUC-Ttr-128879 Tursiops truncatus 28.47 3.00e-93 335.00
IUUC-Uma-129356 Ustilago maydis 23.98 8.00e-68 251.00
IUUC-Vda-129676 Verticillium dahliae 23.00 4.00e-28 119.00
IUUC-Vvi-131744 Vitis vinifera 26.67 1.00e-71 263.00
IUUC-Xtr-132093 Xenopus tropicalis 26.35 4.00e-83 301.00
IUUC-Xma-133199 Xiphophorus maculatus 26.58 5.00e-84 304.00
IUUC-Yli-134385 Yarrowia lipolytica 22.25 6.00e-18 85.50
IUUC-Zma-135567 Zea mays 25.05 6.00e-65 241.00
Created Date 25-Jun-2017

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