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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046983
UUCD1 version UUC-HoS-00014
Ensembl Protein ID ENSP00000306356.4
UniProt Accession O14682; B4DHJ1; E9PFU0; O75464; Q9UPG9; ENC1_HUMAN
Genbank Protein ID AAC39532.1; AAC64498.1; AAC26109.1; BAG58153.1; AAH00418.1
Protein Name Ectoderm-neural cortex protein 1; Kelch-like protein 37; Nuclear matrix protein NRP/B; p53-induced gene 10 protein
Genbank Nucleotide ID AF010314; AF005381; AF059611; AK295128; AC026405
Gene Name ENC1; KLHL37; NRPB; PIG10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000171617.13 ENST00000302351.8 ENSP00000306356.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 6.10e-20 73.0 46 114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 5.40e-08 32.1 146 177
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkldene 69
           +Dv+l+ g++ f++h++vLaa+S++F+a+f+++l+es+  ++v+++  + pev++ ll++ Y++++ +ne
   Q: 46   TDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQ-DSEVNFDNsIHPEVLELLLDYAYSSRVIINE 114
           7************************************9.*******77******************9987 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + Nclg+l ++d+++c++L++   +++l++F+
   Q: 146  PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQ 177
           78*****************************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.
 Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.
Protein Sequence
(Fasta)
MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL HAGNRTFPCH 60
RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL LLDYAYSSRV IINEENAESL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046983|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGTCCAGC CGGGGGTGCC GCACCCACTG GGGAGTGGGG AGGGAGGACA CATAGGAAAT 60
GCCTGGGGCT GGAGTCTCTT TGGCTCTCTG CCAGCAAGAA ACTTAAACGT CCTGGCTTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046983|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR030562--ENC1
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0043025--C:neuronal cell body
GO:0000790--C:nuclear chromatin
GO:0016363--C:nuclear matrix
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0007275--P:multicellular organism development
GO:0017148--P:negative regulation of translation
GO:0007399--P:nervous system development
GO:0010976--P:positive regulation of neuron projection development
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG hsa:8507
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001434 Ailuropoda melanoleuca 99.83 0.00e+00 1192.00
IUUC-Apl-004096 Anas platyrhynchos 97.11 0.00e+00 1166.00
IUUC-Aca-004884 Anolis carolinensis 96.43 0.00e+00 1154.00
IUUC-Ame-011321 Astyanax mexicanus 88.62 0.00e+00 1112.00
IUUC-Bta-013178 Bos taurus 99.66 0.00e+00 1191.00
IUUC-Cja-019494 Callithrix jacchus 99.83 0.00e+00 1192.00
IUUC-Cfa-020824 Canis familiaris 99.83 0.00e+00 1192.00
IUUC-Cpo-021874 Cavia porcellus 99.49 0.00e+00 1189.00
IUUC-Csa-023075 Chlorocebus sabaeus 99.83 0.00e+00 1192.00
IUUC-Cho-024542 Choloepus hoffmanni 99.15 0.00e+00 1186.00
IUUC-Dre-028448 Danio rerio 88.79 0.00e+00 1117.00
IUUC-Dno-029952 Dasypus novemcinctus 99.49 0.00e+00 1189.00
IUUC-Dor-030844 Dipodomys ordii 99.83 0.00e+00 1192.00
IUUC-Ete-032817 Echinops telfairi 91.68 0.00e+00 1088.00
IUUC-Eca-033651 Equus caballus 99.83 0.00e+00 1192.00
IUUC-Fca-036541 Felis catus 99.83 0.00e+00 1192.00
IUUC-Fal-036968 Ficedula albicollis 97.11 0.00e+00 1165.00
IUUC-Gmo-038821 Gadus morhua 88.12 0.00e+00 1103.00
IUUC-Gga-040468 Gallus gallus 97.11 0.00e+00 1166.00
IUUC-Gac-041686 Gasterosteus aculeatus 89.30 0.00e+00 1114.00
IUUC-Ggo-044621 Gorilla gorilla 99.83 0.00e+00 1192.00
IUUC-Itr-048320 Ictidomys tridecemlineatus 99.66 0.00e+00 1191.00
IUUC-Lch-049735 Latimeria chalumnae 92.53 0.00e+00 1106.00
IUUC-Loc-052350 Lepisosteus oculatus 92.19 0.00e+00 1145.00
IUUC-Laf-054117 Loxodonta africana 99.15 0.00e+00 1187.00
IUUC-Mcc-054626 Macaca mulatta 99.83 0.00e+00 1192.00
IUUC-Meu-056763 Macropus eugenii 98.47 0.00e+00 1177.00
IUUC-Mmr-060579 Microcebus murinus 99.83 0.00e+00 1192.00
IUUC-Mdo-061995 Monodelphis domestica 98.47 0.00e+00 1177.00
IUUC-Mmu-064206 Mus musculus 99.32 0.00e+00 1187.00
IUUC-Mpu-066884 Mustela putorius furo 99.83 0.00e+00 1192.00
IUUC-Mlu-067183 Myotis lucifugus 99.83 0.00e+00 1192.00
IUUC-Nle-069928 Nomascus leucogenys 99.83 0.00e+00 1192.00
IUUC-Opr-070238 Ochotona princeps 99.49 0.00e+00 1186.00
IUUC-Ont-072404 Oreochromis niloticus 89.64 0.00e+00 1120.00
IUUC-Oan-073303 Ornithorhynchus anatinus 97.79 0.00e+00 1170.00
IUUC-Ocu-074119 Oryctolagus cuniculus 99.49 0.00e+00 1189.00
IUUC-Ola-087510 Oryzias latipes 89.56 0.00e+00 1070.00
IUUC-Oga-089119 Otolemur garnettii 99.83 0.00e+00 1192.00
IUUC-Oar-090036 Ovis aries 93.04 0.00e+00 1063.00
IUUC-Ptr-091349 Pan troglodytes 99.83 0.00e+00 1192.00
IUUC-Pan-092098 Papio anubis 99.83 0.00e+00 1192.00
IUUC-Pma-094515 Petromyzon marinus 60.00 0.00e+00 673.00
IUUC-Pfo-097496 Poecilia formosa 90.15 0.00e+00 1125.00
IUUC-Pab-098388 Pongo abelii 99.83 0.00e+00 1192.00
IUUC-Pca-100511 Procavia capensis 91.00 0.00e+00 1065.00
IUUC-Pva-102964 Pteropus vampyrus 99.83 0.00e+00 1192.00
IUUC-Rno-106059 Rattus norvegicus 99.49 0.00e+00 1188.00
IUUC-Sha-106470 Sarcophilus harrisii 98.47 0.00e+00 1177.00
IUUC-Sar-113403 Sorex araneus 98.98 0.00e+00 1222.00
IUUC-Ssc-115566 Sus scrofa 99.83 0.00e+00 1192.00
IUUC-Tgu-117331 Taeniopygia guttata 96.94 0.00e+00 1164.00
IUUC-Tru-117890 Takifugu rubripes 89.13 0.00e+00 1112.00
IUUC-Tni-120381 Tetraodon nigroviridis 74.57 0.00e+00 892.00
IUUC-Xtr-131810 Xenopus tropicalis 93.38 0.00e+00 1135.00
Created Date 25-Jun-2017

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