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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063519
UUCD1 version UUC-MuM-00545
Ensembl Protein ID ENSMUSP00000092602.2
UniProt Accession Q6ZPT1; Q505G5; KLHL9_MOUSE
Genbank Protein ID BAC98148.1; AAH94556.1; CAM14922.1
Protein Name Kelch-like protein 9
Genbank Nucleotide ID AK129338; BC094556; AL928605
Gene Name Klhl9; Kiaa1354
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000070923.4 ENSMUST00000094993.2 ENSMUSP00000092602.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.20e-15 58.7 50 118
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 6.60e-08 31.8 151 182
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvg..geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+lv g  +e f++h++++a++S++F+a+f+++++e++   ++++++v    ++ +++F+Yt kl++n
   Q: 50   CDVTLVPGdgEEIFPVHRAMMASASDYFKAMFTGGMKEKD-LMCIKLHGVNKVGLKKIIDFIYTAKLSLN 118
           8******99778889************************9.**************************987 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Nc+++ r+A++y++ ++ +++++filk+F+
   Q: 151  LDNCVEVGRIANTYNLIEVDKYVNNFILKNFP 182
           69*****************************6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).
Protein Sequence
(Fasta)
MKVSLGNGDM GVSAHLQPCK SGTTRFFTSN THSSVVLQGF DQLRIEGLLC DVTLVPGDGE 60
EIFPVHRAMM ASASDYFKAM FTGGMKEKDL MCIKLHGVNK VGLKKIIDFI YTAKLSLNMD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063519|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTTCCGGAA GGTCGGGCTG GCTCTCGGTG CTAGGCCGCC GTTCTAGGCC CAAGTCGGGA 60
TTCCAGGCCC TGCTCCAAGC CAAGTCCGTA GCCGCGACGA CACAGCGGGG ATCGCAGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063519|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030496--C:midbody
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000910--P:cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
KEGG mmu:242521
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003784 Anas platyrhynchos 95.76 0.00e+00 1215.00
IUUC-Bta-013439 Bos taurus 98.38 0.00e+00 1250.00
IUUC-Cho-024873 Choloepus hoffmanni 98.38 0.00e+00 1253.00
IUUC-Cin-025654 Ciona intestinalis 64.54 0.00e+00 809.00
IUUC-Csv-026204 Ciona savignyi 66.61 0.00e+00 795.00
IUUC-Dre-028773 Danio rerio 90.73 0.00e+00 1154.00
IUUC-Fca-036091 Felis catus 94.78 0.00e+00 1183.00
IUUC-Gmo-039422 Gadus morhua 84.69 0.00e+00 1051.00
IUUC-Gga-040612 Gallus gallus 95.60 0.00e+00 1212.00
IUUC-Gac-042629 Gasterosteus aculeatus 91.22 0.00e+00 1159.00
IUUC-Ggo-044475 Gorilla gorilla 95.30 0.00e+00 1197.00
IUUC-Hsa-046683 Homo sapiens 98.70 0.00e+00 1254.00
IUUC-Itr-048813 Ictidomys tridecemlineatus 98.87 0.00e+00 1257.00
IUUC-Loc-052719 Lepisosteus oculatus 92.01 0.00e+00 1206.00
IUUC-Mcc-054723 Macaca mulatta 98.51 0.00e+00 1224.00
IUUC-Meu-056474 Macropus eugenii 91.03 0.00e+00 1154.00
IUUC-Mor-057229 Magnaporthe oryzae 37.68 3.00e-07 49.30
IUUC-Mmr-061352 Microcebus murinus 98.67 0.00e+00 1223.00
IUUC-Mdo-061869 Monodelphis domestica 91.24 0.00e+00 1178.00
IUUC-Mpu-065703 Mustela putorius furo 98.87 0.00e+00 1256.00
IUUC-Mlu-067082 Myotis lucifugus 98.06 0.00e+00 1247.00
IUUC-Opr-070825 Ochotona princeps 98.52 0.00e+00 1234.00
IUUC-Ont-071620 Oreochromis niloticus 92.01 0.00e+00 1168.00
IUUC-Oan-073694 Ornithorhynchus anatinus 87.20 0.00e+00 1018.00
IUUC-Ocu-074027 Oryctolagus cuniculus 98.87 0.00e+00 1256.00
IUUC-Ola-086565 Oryzias latipes 91.68 0.00e+00 1166.00
IUUC-Oga-088341 Otolemur garnettii 98.69 0.00e+00 1246.00
IUUC-Ptr-091283 Pan troglodytes 99.09 0.00e+00 1117.00
IUUC-Pan-092737 Papio anubis 95.27 0.00e+00 1190.00
IUUC-Psi-094003 Pelodiscus sinensis 95.60 0.00e+00 1212.00
IUUC-Pfo-096698 Poecilia formosa 87.60 0.00e+00 1128.00
IUUC-Pab-098052 Pongo abelii 98.70 0.00e+00 1254.00
IUUC-Rno-105991 Rattus norvegicus 99.51 0.00e+00 1261.00
IUUC-Ssc-116052 Sus scrofa 98.70 0.00e+00 1254.00
IUUC-Tru-117586 Takifugu rubripes 91.22 0.00e+00 1165.00
IUUC-Tsy-119119 Tarsius syrichta 98.54 0.00e+00 1250.00
IUUC-Tni-119722 Tetraodon nigroviridis 89.23 0.00e+00 1127.00
IUUC-Ttr-128192 Tursiops truncatus 98.70 0.00e+00 1255.00
Created Date 25-Jun-2017

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