iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	96.89	4.00e-118	421.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to recognize IL6ST.

Protein Sequence
(Fasta)

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120

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Nucleotide Sequence
(Fasta)

GTTTCTTTCC TCTAGCTCCC CCACCGCGCC GAGAGTACCT GGGCGGACCC ACAGTTCGCC 60
ACGCAGGTTG GGAGGCCCAG ATGAGTGATA AGGTAGTAGT TAGCTGCTCC TCCCACCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004860--F:protein kinase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060397--P:JAK-STAT cascade involved in growth hormone signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0009968--P:negative regulation of signal transduction
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination
GO:0045595--P:regulation of cell differentiation
GO:0040008--P:regulation of growth
GO:0001932--P:regulation of protein phosphorylation
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

KEGG

mmu:12702

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	95.11	3.00e-107	380.00
IUUC-Apl-003607	Anas platyrhynchos	82.67	7.00e-97	345.00
IUUC-Aca-005063	Anolis carolinensis	82.46	1.00e-104	371.00
IUUC-Ath-006990	Arabidopsis thaliana	32.94	8.00e-03	36.20
IUUC-Ame-010859	Astyanax mexicanus	57.14	1.00e-70	259.00
IUUC-Bta-012817	Bos taurus	90.83	5.00e-110	390.00
IUUC-Bra-017963	Brassica rapa	28.57	1.00e-01	31.60
IUUC-Cja-019605	Callithrix jacchus	96.00	6.00e-112	396.00
IUUC-Cfa-021231	Canis familiaris	96.00	1.00e-108	385.00
IUUC-Cpo-022003	Cavia porcellus	89.91	4.00e-107	380.00
IUUC-Csa-023511	Chlorocebus sabaeus	96.89	2.00e-111	394.00
IUUC-Dre-028536	Danio rerio	60.43	2.00e-74	271.00
IUUC-Dno-029003	Dasypus novemcinctus	91.56	1.00e-108	385.00
IUUC-Eca-034205	Equus caballus	82.12	8.00e-68	249.00
IUUC-Fca-036317	Felis catus	94.17	8.00e-107	379.00
IUUC-Gmo-038777	Gadus morhua	63.89	7.00e-36	142.00
IUUC-Gga-041258	Gallus gallus	85.33	2.00e-97	348.00
IUUC-Gac-041837	Gasterosteus aculeatus	55.90	1.00e-65	242.00
IUUC-Ggo-045620	Gorilla gorilla	96.89	2.00e-111	394.00
IUUC-Hsa-046909	Homo sapiens	96.89	2.00e-111	394.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	90.60	3.00e-111	394.00
IUUC-Lch-049510	Latimeria chalumnae	67.25	8.00e-84	302.00
IUUC-Loc-052863	Lepisosteus oculatus	63.04	6.00e-80	289.00
IUUC-Laf-054136	Loxodonta africana	91.67	2.00e-109	388.00
IUUC-Mcc-055383	Macaca mulatta	96.89	2.00e-111	394.00
IUUC-Meu-056153	Macropus eugenii	87.61	1.00e-108	385.00
IUUC-Mmr-061185	Microcebus murinus	94.69	8.00e-107	379.00
IUUC-Mdo-061819	Monodelphis domestica	88.89	4.00e-112	396.00
IUUC-Mpu-066691	Mustela putorius furo	96.44	1.00e-108	385.00
IUUC-Mlu-067673	Myotis lucifugus	94.69	3.00e-116	410.00
IUUC-Ont-072406	Oreochromis niloticus	55.02	4.00e-68	250.00
IUUC-Oan-073249	Ornithorhynchus anatinus	75.56	7.00e-94	335.00
IUUC-Ocu-074935	Oryctolagus cuniculus	85.51	8.00e-31	124.00
IUUC-Ola-087373	Oryzias latipes	48.04	4.00e-48	184.00
IUUC-Oga-088041	Otolemur garnettii	91.56	3.00e-108	384.00
IUUC-Oar-089646	Ovis aries	89.52	6.00e-103	366.00
IUUC-Ptr-091502	Pan troglodytes	96.89	2.00e-111	394.00
IUUC-Pan-091934	Papio anubis	96.89	2.00e-111	394.00
IUUC-Pfo-096412	Poecilia formosa	43.23	1.00e-48	186.00
IUUC-Pab-098554	Pongo abelii	96.89	2.00e-111	394.00
IUUC-Rno-105874	Rattus norvegicus	98.67	1.00e-121	428.00
IUUC-Sha-107151	Sarcophilus harrisii	86.84	2.00e-108	384.00
IUUC-Ssc-115722	Sus scrofa	86.05	3.00e-65	240.00
IUUC-Tgu-117151	Taeniopygia guttata	85.33	2.00e-97	347.00
IUUC-Tru-118428	Takifugu rubripes	55.46	2.00e-68	251.00
IUUC-Tni-120590	Tetraodon nigroviridis	55.02	8.00e-67	246.00
IUUC-Ttr-129065	Tursiops truncatus	91.27	9.00e-110	389.00
IUUC-Xtr-132167	Xenopus tropicalis	66.22	4.00e-82	296.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence