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Tag Content
UUCD2 ID IUUC-Bta-012914
UUCD1 version UUC-BoT-00840
Ensembl Protein ID ENSBTAP00000027965.3
UniProt Accession Q0VBY8; DDB2_BOVIN
Genbank Protein ID AAI20441.1
Protein Name DNA damage-binding protein 2; Damage-specific DNA-binding protein 2
Genbank Nucleotide ID BC120440
Gene Name DDB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000020999.3 ENSBTAT00000027965.3 ENSBTAP00000027965.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.90e-11 42.9 240 273
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
    H+ +vt +a+ d+ll+++s D t+k+WDlr+
   Q: 240 HKKKVTHVALnpcCDWLLATASVDQTVKIWDLRQ 273
    7888999999975559***************986 PP
   

Organism Bos taurus
Functional Description
(View)

Functional Description



     Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity).
Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity).
Protein Sequence
(Fasta)
MAPRKRPENQ KTPEVVVRPK SKRNRSPREL EPEAKKLCVK GPGSSRRFDS GLWAGLASLR 60
VPPLCSSIVR ALHQHKLGTA AWPSLQQGLQ QSFLNSLASY RIFQKAAPFD RRATSLAWHP 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Bta-012914|E3,WD_repeat|Bos taurus
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Nucleotide Sequence
(Fasta)
CGCTTTTCCT CGTCCCCGCC TTGTTCTCCC CAGAGGCTTC TTAATTCTTC CTCGGCATAG 60
GGCATAGTAC CCCTTCGCAC GGAGGACGCC ATGGCTCCCA GGAAACGCCC AGAAAACCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Bta-012914|E3,WD_repeat|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR033312--DDB2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0030054--C:cell junction
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0003684--F:damaged DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035518--P:histone H2A monoubiquitination
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006290--P:pyrimidine dimer repair
GO:0070914--P:UV-damage excision repair

KEGG bta:519357
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000470 Aegilops tauschii 29.97 7.00e-32 132.00
IUUC-Aml-002203 Ailuropoda melanoleuca 91.75 0.00e+00 780.00
IUUC-Atr-002957 Amborella trichopoda 31.00 5.00e-37 149.00
IUUC-Apl-003832 Anas platyrhynchos 51.32 9.00e-124 437.00
IUUC-Aca-004358 Anolis carolinensis 51.89 2.00e-128 452.00
IUUC-Aly-006296 Arabidopsis lyrata 32.01 4.00e-38 152.00
IUUC-Ath-007115 Arabidopsis thaliana 32.01 1.00e-39 157.00
IUUC-Ame-010817 Astyanax mexicanus 55.22 6.00e-125 441.00
IUUC-Bdi-014261 Brachypodium distachyon 30.79 9.00e-33 134.00
IUUC-Bol-015317 Brassica oleracea 31.10 6.00e-37 148.00
IUUC-Bra-016848 Brassica rapa 31.00 4.00e-37 149.00
IUUC-Cja-018967 Callithrix jacchus 84.78 0.00e+00 726.00
IUUC-Cfa-021238 Canis familiaris 92.43 0.00e+00 752.00
IUUC-Cpo-022063 Cavia porcellus 79.48 0.00e+00 699.00
IUUC-Csa-023382 Chlorocebus sabaeus 84.31 0.00e+00 759.00
IUUC-Cho-024805 Choloepus hoffmanni 61.09 2.00e-92 331.00
IUUC-Dre-028732 Danio rerio 49.18 2.00e-109 389.00
IUUC-Dor-030461 Dipodomys ordii 75.97 2.00e-120 425.00
IUUC-Ete-033038 Echinops telfairi 74.47 0.00e+00 645.00
IUUC-Eca-033772 Equus caballus 89.93 0.00e+00 741.00
IUUC-Eeu-034662 Erinaceus europaeus 68.00 3.00e-71 262.00
IUUC-Fca-036095 Felis catus 90.63 0.00e+00 766.00
IUUC-Gmo-039683 Gadus morhua 50.14 3.00e-106 378.00
IUUC-Gga-040530 Gallus gallus 52.01 5.00e-125 441.00
IUUC-Gac-041517 Gasterosteus aculeatus 50.28 3.00e-98 352.00
IUUC-Gma-043378 Glycine max 31.33 2.00e-38 153.00
IUUC-Ggo-045364 Gorilla gorilla 85.01 0.00e+00 761.00
IUUC-Hsa-046354 Homo sapiens 84.78 0.00e+00 760.00
IUUC-Hvu-047151 Hordeum vulgare 31.29 4.00e-29 122.00
IUUC-Itr-048304 Ictidomys tridecemlineatus 87.11 0.00e+00 759.00
IUUC-Lpe-051256 Leersia perrieri 30.09 3.00e-31 129.00
IUUC-Loc-052398 Lepisosteus oculatus 60.78 4.00e-129 454.00
IUUC-Laf-053562 Loxodonta africana 85.95 0.00e+00 726.00
IUUC-Mcc-055197 Macaca mulatta 64.95 3.00e-153 534.00
IUUC-Meu-056151 Macropus eugenii 75.64 8.00e-122 429.00
IUUC-Mtr-057940 Medicago truncatula 31.40 4.00e-37 149.00
IUUC-Mga-059923 Meleagris gallopavo 51.79 4.00e-132 464.00
IUUC-Mmr-061465 Microcebus murinus 88.49 1.00e-150 525.00
IUUC-Mdo-063063 Monodelphis domestica 67.22 1.00e-159 555.00
IUUC-Mmu-064294 Mus musculus 78.69 0.00e+00 679.00
IUUC-Mac-065598 Musa acuminata 31.48 6.00e-34 138.00
IUUC-Mpu-066831 Mustela putorius furo 90.85 0.00e+00 779.00
IUUC-Mlu-067222 Myotis lucifugus 86.65 0.00e+00 764.00
IUUC-Nle-069581 Nomascus leucogenys 84.54 0.00e+00 761.00
IUUC-Opr-070644 Ochotona princeps 83.96 0.00e+00 717.00
IUUC-Ont-072605 Oreochromis niloticus 51.44 1.00e-116 413.00
IUUC-Oan-072973 Ornithorhynchus anatinus 71.93 6.00e-150 523.00
IUUC-Ocu-074615 Oryctolagus cuniculus 84.07 0.00e+00 742.00
IUUC-Oba-075283 Oryza barthii 29.97 1.00e-31 131.00
IUUC-Obr-076605 Oryza brachyantha 31.02 1.00e-33 137.00
IUUC-Ogl-077512 Oryza glaberrima 29.97 1.00e-31 131.00
IUUC-Ogu-078329 Oryza glumaepatula 29.97 1.00e-31 131.00
IUUC-Oin-079980 Oryza indica 29.97 1.00e-31 130.00
IUUC-Olo-080516 Oryza longistaminata 29.97 5.00e-32 132.00
IUUC-Ome-081415 Oryza meridionalis 29.97 1.00e-31 130.00
IUUC-Oni-082985 Oryza nivara 29.97 1.00e-31 130.00
IUUC-Opu-084159 Oryza punctata 30.89 2.00e-32 133.00
IUUC-Oru-085137 Oryza rufipogon 29.97 7.00e-32 132.00
IUUC-Osa-085614 Oryza sativa 29.97 7.00e-32 132.00
IUUC-Ola-087044 Oryzias latipes 48.22 4.00e-108 385.00
IUUC-Oga-088274 Otolemur garnettii 85.95 0.00e+00 751.00
IUUC-Oar-089826 Ovis aries 99.06 0.00e+00 876.00
IUUC-Ptr-091631 Pan troglodytes 84.78 0.00e+00 760.00
IUUC-Pan-092535 Papio anubis 84.78 0.00e+00 763.00
IUUC-Psi-093815 Pelodiscus sinensis 54.74 9.00e-124 437.00
IUUC-Pma-094474 Petromyzon marinus 49.12 3.00e-97 348.00
IUUC-Ppa-095414 Physcomitrella patens 28.74 6.00e-30 125.00
IUUC-Pfo-096559 Poecilia formosa 45.50 1.00e-101 363.00
IUUC-Pab-098528 Pongo abelii 84.78 0.00e+00 762.00
IUUC-Pop-100064 Populus trichocarpa 29.18 4.00e-35 142.00
IUUC-Pca-100803 Procavia capensis 83.84 0.00e+00 721.00
IUUC-Ppe-101966 Prunus persica 29.88 1.00e-35 144.00
IUUC-Pva-103213 Pteropus vampyrus 89.23 0.00e+00 744.00
IUUC-Rno-105087 Rattus norvegicus 78.92 0.00e+00 699.00
IUUC-Sha-107466 Sarcophilus harrisii 72.58 2.00e-157 548.00
IUUC-Smo-108958 Selaginella moellendorffii 27.51 1.00e-28 121.00
IUUC-Sit-109968 Setaria italica 29.55 6.00e-31 129.00
IUUC-Sly-111495 Solanum lycopersicum 30.49 3.00e-34 140.00
IUUC-Stu-111974 Solanum tuberosum 24.31 4.00e-11 63.50
IUUC-Sar-113272 Sorex araneus 80.24 3.00e-168 584.00
IUUC-Sbi-114706 Sorghum bicolor 28.10 2.00e-27 117.00
IUUC-Ssc-115437 Sus scrofa 90.87 0.00e+00 794.00
IUUC-Tgu-116602 Taeniopygia guttata 51.45 4.00e-122 431.00
IUUC-Tru-118698 Takifugu rubripes 49.58 2.00e-99 356.00
IUUC-Tsy-119027 Tarsius syrichta 83.68 0.00e+00 679.00
IUUC-Tni-119787 Tetraodon nigroviridis 49.16 7.00e-103 367.00
IUUC-Tca-121447 Theobroma cacao 29.13 2.00e-35 143.00
IUUC-Tae-125839 Triticum aestivum 30.18 2.00e-32 133.00
IUUC-Tur-126724 Triticum urartu 30.18 2.00e-32 133.00
IUUC-Tbe-127680 Tupaia belangeri 82.55 3.00e-135 474.00
IUUC-Ttr-128201 Tursiops truncatus 82.90 0.00e+00 691.00
IUUC-Vpa-130451 Vicugna pacos 77.29 1.00e-117 416.00
IUUC-Vvi-131001 Vitis vinifera 31.00 6.00e-38 152.00
IUUC-Xtr-132266 Xenopus tropicalis 62.25 3.00e-131 461.00
IUUC-Xma-133034 Xiphophorus maculatus 50.00 3.00e-114 405.00
Created Date 25-Jun-2017

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