iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000006676.16	ENSMUST00000006854.12	ENSMUSP00000006854.7
ENSMUSG00000006676.16	ENSMUST00000166103.8	ENSMUSP00000128573.2
ENSMUSG00000006676.16	ENSMUST00000085044.13	ENSMUSP00000082119.7
ENSMUSG00000006676.16	ENSMUST00000193678.5	ENSMUSP00000141738.1
ENSMUSG00000006676.16	ENSMUST00000178075.7	ENSMUSP00000135930.1
ENSMUSG00000006676.16	ENSMUST00000193558.1	ENSMUSP00000142137.1
ENSMUSG00000006676.16	ENSMUST00000194171.5	ENSMUSP00000141628.1
ENSMUSG00000006676.16	ENSMUST00000194863.1	ENSMUSP00000141826.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.30e-115	385.1	539	1256

Active Site

Position(s)	Description	Evidence
548	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1207	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 539  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFTG 625
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 626  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 710
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 711  FLYLPVPLPQKQKVLPIfyfarephskpikflvsvskenssasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldavsptd 797
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 798  vllcfellspelakervvvlevqqrpqvpsipiskcaacqrkqqseeeklkrctrcyrvgycnqfcqkthwpdhkglcrpenigypf 884
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 885  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqspgcttllstssleagdserepiqpselqlvtpvaegdtgahrv 971
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 972  wppadrgpvpstsglssemlasgpiegcpllagervsrpeaavpgyqhssesvnthtpqffiykidasnreqrledkgetplelgdd 1058
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1059 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1145
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1146 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1229
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1230 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1256
           ****************...********996 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity). Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains (By similarity). Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.

Protein Sequence
(Fasta)

MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT KDELLLDWRQ 60
SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW GGVFFAEIQS SCTKVQARKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGGCCGAG CACCGGAACC CCTCCTCTTC CTTTCCCGCC CTCCCCAAAG CTGCCCTTCA 60
CCAAGAGCTC CCACTCTTGC CGGAAGTGCG TCATCAGCTC GGCACCCCGC CTCCCGTAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0051879--F:Hsp90 protein binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0090068--P:positive regulation of cell cycle process
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0031647--P:regulation of protein stability
GO:0034976--P:response to endoplasmic reticulum stress
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mmu:71472

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	88.15	0.00e+00	2216.00
IUUC-Apl-003368	Anas platyrhynchos	70.43	0.00e+00	1679.00
IUUC-Aca-004267	Anolis carolinensis	67.56	0.00e+00	1688.00
IUUC-Ame-010970	Astyanax mexicanus	70.74	0.00e+00	1338.00
IUUC-Bta-012905	Bos taurus	88.08	0.00e+00	2212.00
IUUC-Cja-018789	Callithrix jacchus	86.57	0.00e+00	2299.00
IUUC-Cfa-021004	Canis familiaris	92.35	0.00e+00	2169.00
IUUC-Cpo-021529	Cavia porcellus	89.55	0.00e+00	2294.00
IUUC-Csa-024035	Chlorocebus sabaeus	89.91	0.00e+00	2263.00
IUUC-Cho-025036	Choloepus hoffmanni	83.53	0.00e+00	1232.00
IUUC-Cin-025451	Ciona intestinalis	43.67	8.00e-87	315.00
IUUC-Csv-025931	Ciona savignyi	36.59	9.00e-112	397.00
IUUC-Dre-028556	Danio rerio	69.14	0.00e+00	1310.00
IUUC-Dno-029240	Dasypus novemcinctus	87.22	0.00e+00	2103.00
IUUC-Dor-030495	Dipodomys ordii	94.11	0.00e+00	1229.00
IUUC-Ete-032741	Echinops telfairi	90.57	0.00e+00	1821.00
IUUC-Eca-033661	Equus caballus	91.84	0.00e+00	2353.00
IUUC-Eeu-034648	Erinaceus europaeus	88.31	0.00e+00	785.00
IUUC-Fca-035646	Felis catus	87.97	0.00e+00	2184.00
IUUC-Fal-037094	Ficedula albicollis	68.07	0.00e+00	1788.00
IUUC-Gmo-038869	Gadus morhua	71.78	0.00e+00	844.00
IUUC-Gga-041170	Gallus gallus	65.61	0.00e+00	1728.00
IUUC-Gac-041901	Gasterosteus aculeatus	66.85	0.00e+00	1317.00
IUUC-Ggo-044708	Gorilla gorilla	86.65	0.00e+00	2311.00
IUUC-Hsa-046791	Homo sapiens	92.41	0.00e+00	1996.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	87.43	0.00e+00	2265.00
IUUC-Lch-050456	Latimeria chalumnae	52.46	0.00e+00	1191.00
IUUC-Loc-052861	Lepisosteus oculatus	62.08	0.00e+00	1139.00
IUUC-Laf-053788	Loxodonta africana	90.76	0.00e+00	2257.00
IUUC-Mcc-055693	Macaca mulatta	85.44	0.00e+00	2230.00
IUUC-Meu-055921	Macropus eugenii	78.91	0.00e+00	1518.00
IUUC-Mga-059879	Meleagris gallopavo	68.62	0.00e+00	1725.00
IUUC-Mmr-060802	Microcebus murinus	88.87	0.00e+00	2337.00
IUUC-Mdo-061856	Monodelphis domestica	82.08	0.00e+00	1610.00
IUUC-Mpu-066166	Mustela putorius furo	92.09	0.00e+00	2141.00
IUUC-Nle-070161	Nomascus leucogenys	86.86	0.00e+00	2346.00
IUUC-Opr-071015	Ochotona princeps	91.03	0.00e+00	1878.00
IUUC-Ont-072308	Oreochromis niloticus	69.28	0.00e+00	1365.00
IUUC-Oan-072723	Ornithorhynchus anatinus	64.98	0.00e+00	1631.00
IUUC-Ocu-073938	Oryctolagus cuniculus	87.61	0.00e+00	2209.00
IUUC-Ola-086375	Oryzias latipes	71.33	0.00e+00	1335.00
IUUC-Oga-088297	Otolemur garnettii	87.47	0.00e+00	2257.00
IUUC-Oar-089675	Ovis aries	81.74	0.00e+00	1988.00
IUUC-Ptr-091621	Pan troglodytes	92.32	0.00e+00	1996.00
IUUC-Pan-092118	Papio anubis	86.21	0.00e+00	2251.00
IUUC-Pma-094154	Petromyzon marinus	51.31	1.00e-113	403.00
IUUC-Pfo-097246	Poecilia formosa	60.73	0.00e+00	1018.00
IUUC-Pab-098551	Pongo abelii	91.43	0.00e+00	1969.00
IUUC-Pca-100158	Procavia capensis	86.84	0.00e+00	2231.00
IUUC-Pva-103160	Pteropus vampyrus	91.55	0.00e+00	2296.00
IUUC-Rno-105355	Rattus norvegicus	95.37	0.00e+00	2475.00
IUUC-Sha-107057	Sarcophilus harrisii	76.43	0.00e+00	1781.00
IUUC-Sar-113011	Sorex araneus	87.62	0.00e+00	1450.00
IUUC-Ssc-115761	Sus scrofa	87.09	0.00e+00	2218.00
IUUC-Tgu-116956	Taeniopygia guttata	60.75	0.00e+00	817.00
IUUC-Tru-118739	Takifugu rubripes	67.72	0.00e+00	1344.00
IUUC-Tsy-118827	Tarsius syrichta	85.14	0.00e+00	1240.00
IUUC-Tni-119921	Tetraodon nigroviridis	60.59	0.00e+00	1422.00
IUUC-Tbe-128017	Tupaia belangeri	89.46	0.00e+00	1918.00
IUUC-Ttr-128869	Tursiops truncatus	91.54	0.00e+00	2307.00
IUUC-Uma-129498	Ustilago maydis	30.94	4.00e-87	317.00
IUUC-Vpa-130427	Vicugna pacos	92.74	0.00e+00	895.00
IUUC-Xtr-132734	Xenopus tropicalis	60.77	0.00e+00	1545.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence