iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088297

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03163964

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000003957.2	ENSOGAT00000003963.2	ENSOGAP00000003526.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.50e-115	384.4	596	1313

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 596  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 682
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 683  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 767
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 768  FLYLPVPLPQKQKVLPVfyfarephskpikflvsvskenssasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldtvspsd 854
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 855  tllcfellspelakervvvlevqqrpqvpsipiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 941
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 942  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrialesqgpgcttllstnsleagdserdsiqppelqlvtpvaegdtgvprv 1028
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1029 waapdrgpgpstsgisseiltsgpielgslaacervsrpeaavpgyqhpseamnahtpqffiykidasnreqrledkgetplelgdd 1115
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1116 cslalvwrnnerlpefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1202
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1203 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1286
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1287 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1313
           ****************...********996 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MSGGASATGQ RRGPPGLEEG TCKKKQKDRA NQESKDGDPR KGGSNFLDSL ASALKSGYLT 60
EIQKMIDGVM GSWTLSPIVV SLFFPSSSGS VSTPREEQNK EGACDLFATP PTELLLDWRQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGGTG GGGCCAGTGC CACAGGCCAG AGGAGAGGGC CCCCAGGACT GGAGGAGGGT 60
ACTTGTAAAA AGAAACAGAA GGATCGAGCA AACCAGGAGA GCAAGGATGG AGATCCTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	90.38	0.00e+00	2305.00
IUUC-Apl-003368	Anas platyrhynchos	67.00	0.00e+00	1703.00
IUUC-Aca-004267	Anolis carolinensis	67.50	0.00e+00	1628.00
IUUC-Ame-010970	Astyanax mexicanus	69.65	0.00e+00	1335.00
IUUC-Bta-012905	Bos taurus	89.18	0.00e+00	2297.00
IUUC-Cel-018257	Caenorhabditis elegans	43.48	3.00e-91	330.00
IUUC-Cja-018789	Callithrix jacchus	90.79	0.00e+00	2422.00
IUUC-Cfa-021004	Canis familiaris	90.10	0.00e+00	2306.00
IUUC-Cpo-021529	Cavia porcellus	86.76	0.00e+00	2327.00
IUUC-Csa-024035	Chlorocebus sabaeus	93.20	0.00e+00	2257.00
IUUC-Cho-025036	Choloepus hoffmanni	80.62	0.00e+00	1222.00
IUUC-Cin-025451	Ciona intestinalis	43.93	1.00e-86	315.00
IUUC-Csv-025931	Ciona savignyi	36.44	3.00e-110	392.00
IUUC-Dre-028556	Danio rerio	68.72	0.00e+00	1317.00
IUUC-Dno-029240	Dasypus novemcinctus	89.55	0.00e+00	2118.00
IUUC-Dor-030495	Dipodomys ordii	95.11	0.00e+00	1244.00
IUUC-Ete-032741	Echinops telfairi	91.90	0.00e+00	1860.00
IUUC-Eca-033661	Equus caballus	90.61	0.00e+00	2390.00
IUUC-Eeu-034648	Erinaceus europaeus	91.24	0.00e+00	825.00
IUUC-Fca-035646	Felis catus	89.87	0.00e+00	2280.00
IUUC-Fal-037094	Ficedula albicollis	68.76	0.00e+00	1740.00
IUUC-Gmo-038869	Gadus morhua	72.04	0.00e+00	842.00
IUUC-Gga-041170	Gallus gallus	65.87	0.00e+00	1695.00
IUUC-Gac-041901	Gasterosteus aculeatus	66.43	0.00e+00	1326.00
IUUC-Ggo-044708	Gorilla gorilla	91.29	0.00e+00	2439.00
IUUC-Hsa-046791	Homo sapiens	95.11	0.00e+00	2062.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	89.30	0.00e+00	2333.00
IUUC-Lch-050456	Latimeria chalumnae	51.02	0.00e+00	1180.00
IUUC-Loc-052861	Lepisosteus oculatus	62.36	0.00e+00	1139.00
IUUC-Laf-053788	Loxodonta africana	88.45	0.00e+00	2294.00
IUUC-Mcc-055693	Macaca mulatta	89.92	0.00e+00	2365.00
IUUC-Meu-055921	Macropus eugenii	78.91	0.00e+00	1524.00
IUUC-Mga-059879	Meleagris gallopavo	65.66	0.00e+00	1744.00
IUUC-Mmr-060802	Microcebus murinus	94.28	0.00e+00	2524.00
IUUC-Mdo-061856	Monodelphis domestica	79.18	0.00e+00	1620.00
IUUC-Mmu-063874	Mus musculus	87.47	0.00e+00	2326.00
IUUC-Mpu-066166	Mustela putorius furo	91.05	0.00e+00	2318.00
IUUC-Nle-070161	Nomascus leucogenys	91.22	0.00e+00	2483.00
IUUC-Opr-071015	Ochotona princeps	92.82	0.00e+00	1934.00
IUUC-Ont-072308	Oreochromis niloticus	69.31	0.00e+00	1363.00
IUUC-Oan-072723	Ornithorhynchus anatinus	66.47	0.00e+00	1594.00
IUUC-Ocu-073938	Oryctolagus cuniculus	90.69	0.00e+00	2290.00
IUUC-Ola-086375	Oryzias latipes	69.65	0.00e+00	1333.00
IUUC-Oar-089675	Ovis aries	94.80	0.00e+00	1647.00
IUUC-Ptr-091621	Pan troglodytes	94.76	0.00e+00	2057.00
IUUC-Pan-092118	Papio anubis	90.67	0.00e+00	2370.00
IUUC-Pma-094154	Petromyzon marinus	51.78	5.00e-114	405.00
IUUC-Pfo-097246	Poecilia formosa	60.27	0.00e+00	1397.00
IUUC-Pab-098551	Pongo abelii	94.13	0.00e+00	2035.00
IUUC-Pca-100158	Procavia capensis	84.64	0.00e+00	2264.00
IUUC-Pva-103160	Pteropus vampyrus	89.58	0.00e+00	2321.00
IUUC-Rno-105355	Rattus norvegicus	87.65	0.00e+00	2343.00
IUUC-Sha-107057	Sarcophilus harrisii	72.42	0.00e+00	1841.00
IUUC-Sar-113011	Sorex araneus	90.11	0.00e+00	1511.00
IUUC-Ssc-115761	Sus scrofa	89.63	0.00e+00	2341.00
IUUC-Tgu-116956	Taeniopygia guttata	61.24	0.00e+00	832.00
IUUC-Tru-118739	Takifugu rubripes	69.46	0.00e+00	1352.00
IUUC-Tsy-118827	Tarsius syrichta	81.39	0.00e+00	1247.00
IUUC-Tni-119921	Tetraodon nigroviridis	61.09	0.00e+00	1391.00
IUUC-Tbe-128017	Tupaia belangeri	91.85	0.00e+00	1974.00
IUUC-Ttr-128869	Tursiops truncatus	88.16	0.00e+00	2300.00
IUUC-Vpa-130427	Vicugna pacos	95.30	0.00e+00	924.00
IUUC-Xtr-132734	Xenopus tropicalis	61.34	0.00e+00	1560.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence