iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000015522.18	ENSMUST00000102749.10	ENSMUSP00000099810.4
ENSMUSG00000015522.18	ENSMUST00000107161.7	ENSMUSP00000102779.1
ENSMUSG00000015522.18	ENSMUST00000136413.1	ENSMUSP00000116688.1
ENSMUSG00000015522.18	ENSMUST00000090804.11	ENSMUSP00000088313.5
ENSMUSG00000015522.18	ENSMUST00000015666.16	ENSMUSP00000015666.10

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	JASPAR	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	91.66	0.00e+00	1375.00	IUUC-Hsa-046946

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).

Protein Sequence
(Fasta)

MAATTANPEM TSDVPSLGPT IASGNPGPGI QGGGAVVQRA IKRRSGLDFD DEVEVNTKFL 60
RCDDDQMCND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS 120

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Nucleotide Sequence
(Fasta)

GGGGTGGGCG TCCGCCATCT TGGATTCCGC GGTAGCGGTG GCGGCGGTAA GGTGCCTAAT 60
CTGCGGAGTG GCTCTTCCCT CCCCTCCCCC AGCTCGGTGG CGGCTGCCCC TCCCACCGAG 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR011598--bHLH_dom
IPR001067--Nuc_translocat
IPR001610--PAC
IPR000014--PAS
IPR013767--PAS_fold

PROSITE

PS50888--BHLH
PS50112--PAS

Pfam

PF00010--HLH
PF00989--PAS

PRINTS

PR00785--NCTRNSLOCATR

SMART

SM00353--HLH
SM00086--PAC
SM00091--PAS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0005667--C:transcription factor complex
GO:0004874--F:aryl hydrocarbon receptor activity
GO:0017162--F:aryl hydrocarbon receptor binding
GO:0003677--F:DNA binding
GO:0035326--F:enhancer binding
GO:0046982--F:protein heterodimerization activity
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000989--F:transcription factor activity, transcription factor binding
GO:0008134--F:transcription factor binding
GO:0030154--P:cell differentiation
GO:0001892--P:embryonic placenta development
GO:0046886--P:positive regulation of hormone biosynthetic process
GO:0033235--P:positive regulation of protein sumoylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0043619--P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0001666--P:response to hypoxia
GO:0009636--P:response to toxic substance
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:11863

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001940	Ailuropoda melanoleuca	90.14	0.00e+00	1299.00
IUUC-Apl-003615	Anas platyrhynchos	78.88	0.00e+00	1220.00
IUUC-Aca-005047	Anolis carolinensis	76.56	0.00e+00	1171.00
IUUC-Bta-012420	Bos taurus	90.93	0.00e+00	1353.00
IUUC-Cja-019740	Callithrix jacchus	90.64	0.00e+00	1287.00
IUUC-Cfa-020981	Canis familiaris	90.41	0.00e+00	1285.00
IUUC-Cpo-021428	Cavia porcellus	90.98	0.00e+00	1284.00
IUUC-Csa-023451	Chlorocebus sabaeus	91.66	0.00e+00	1348.00
IUUC-Cho-024979	Choloepus hoffmanni	73.63	9.00e-150	524.00
IUUC-Cne-027059	Cryptococcus neoformans	30.59	9.00e-08	53.10
IUUC-Dno-029839	Dasypus novemcinctus	85.66	0.00e+00	1320.00
IUUC-Eca-034359	Equus caballus	86.59	0.00e+00	1270.00
IUUC-Fca-035413	Felis catus	87.00	0.00e+00	1319.00
IUUC-Gga-041165	Gallus gallus	77.20	0.00e+00	1184.00
IUUC-Ggo-045192	Gorilla gorilla	91.69	0.00e+00	1281.00
IUUC-Hsa-046946	Homo sapiens	91.53	0.00e+00	1278.00
IUUC-Itr-048123	Ictidomys tridecemlineatus	91.09	0.00e+00	1368.00
IUUC-Lch-050137	Latimeria chalumnae	65.06	0.00e+00	908.00
IUUC-Laf-053433	Loxodonta africana	90.04	0.00e+00	1328.00
IUUC-Mcc-055174	Macaca mulatta	91.15	0.00e+00	1337.00
IUUC-Mga-059606	Meleagris gallopavo	76.08	0.00e+00	1128.00
IUUC-Mmr-060626	Microcebus murinus	87.75	0.00e+00	1285.00
IUUC-Mdo-062779	Monodelphis domestica	85.10	0.00e+00	1273.00
IUUC-Mpu-066471	Mustela putorius furo	90.34	0.00e+00	1223.00
IUUC-Mlu-066968	Myotis lucifugus	89.78	0.00e+00	1387.00
IUUC-Nle-069762	Nomascus leucogenys	90.96	0.00e+00	1301.00
IUUC-Oan-073371	Ornithorhynchus anatinus	72.40	0.00e+00	1030.00
IUUC-Ocu-074390	Oryctolagus cuniculus	81.68	0.00e+00	1192.00
IUUC-Oga-088408	Otolemur garnettii	90.45	0.00e+00	1348.00
IUUC-Oar-089959	Ovis aries	90.52	0.00e+00	1363.00
IUUC-Ptr-091057	Pan troglodytes	91.66	0.00e+00	1295.00
IUUC-Pan-092602	Papio anubis	90.66	0.00e+00	1329.00
IUUC-Psi-093661	Pelodiscus sinensis	77.52	0.00e+00	1233.00
IUUC-Pab-098708	Pongo abelii	91.53	0.00e+00	1307.00
IUUC-Rno-105732	Rattus norvegicus	94.88	0.00e+00	1399.00
IUUC-Sha-107369	Sarcophilus harrisii	84.95	0.00e+00	1263.00
IUUC-Smo-108833	Selaginella moellendorffii	33.33	2.00e-04	41.20
IUUC-Sar-113492	Sorex araneus	83.33	0.00e+00	667.00
IUUC-Ssc-115814	Sus scrofa	91.40	0.00e+00	1350.00
IUUC-Tgu-116662	Taeniopygia guttata	75.03	0.00e+00	1149.00
IUUC-Tni-120034	Tetraodon nigroviridis	55.36	0.00e+00	707.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence