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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046969
UUCD1 version UUC-HoS-00197
Ensembl Protein ID ENSP00000398481.2
UniProt Accession Q86UW7; A4D0X3; B7ZM56; Q658Q2; Q7Z5T7; Q8IZW9; Q8N7M4; Q9H6P4; Q9HCI1; Q9NWK8; CAPS2_HUMAN
Genbank Protein ID AAP22132.1; AAN38707.1; EAL24339.1; AAH54339.1; AAI36602.1; AAI44279.1; BAA91372.1; BAB15210.1; BAB13417.1; CAH56288.1
Protein Name Calcium-dependent secretion activator 2; Calcium-dependent activator protein for secretion 2
Genbank Nucleotide ID AY264289; AF401638; AC004594; BC054339; BC136601; BC144278; AK000768; AK025672; AK098170; AL833058
Gene Name CADPS2; CAPS2; KIAA1591
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000081803.15 ENST00000462699.5 ENSP00000419418.1
ENSG00000081803.15 ENST00000412584.6 ENSP00000400401.2
ENSG00000081803.15 ENST00000449022.6 ENSP00000398481.2
ENSG00000081803.15 ENST00000397721.4 ENSP00000380833.4
ENSG00000081803.15 ENST00000334010.11 ENSP00000333940.7
ENSG00000081803.15 ENST00000615869.4 ENSP00000484355.1
ENSG00000081803.15 ENST00000313070.11 ENSP00000325581.8
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 19690564
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).
 Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).
Protein Sequence
(Fasta)
MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG GGAARSVSPS 60
PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN AKQPTDMARR QQKLNKQQLQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046969|E3,E3 activity/Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATTCAATTCC ACGTGTTGCT TGTTGTAGGC GCCACAGGTT CCCCACCTGC GTCCGGGCGC 60
TCGGGCGGCT CCGCCTCTGC CGGCGGGCTC TGGGGAACCG CTGGGTCGGC GCGCCCGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046969|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0268--Exocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0770--Synapse
KW-0813--Transport
Interpro

IPR000008--C2_dom
IPR033227--CAPS
IPR010439--CAPS_dom
IPR014770--Munc13_1
IPR011993--PH_dom-like
IPR001849--PH_domain
PROSITE

PS51258--MHD1
PS50003--PH_DOMAIN
Pfam

PF06292--DUF1041
PF00169--PH
SMART

SM01145--DUF1041
SM00233--PH
Gene Ontology

GO:0030054--C:cell junction
GO:0030659--C:cytoplasmic vesicle membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0045211--C:postsynaptic membrane
GO:0042734--C:presynaptic membrane
GO:0008289--F:lipid binding
GO:0046872--F:metal ion binding
GO:0009267--P:cellular response to starvation
GO:1990504--P:dense core granule exocytosis
GO:0045921--P:positive regulation of exocytosis
GO:0015031--P:protein transport
GO:0016082--P:synaptic vesicle priming
KEGG hsa:93664
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001725 Ailuropoda melanoleuca 96.71 0.00e+00 2288.00
IUUC-Bgr-012026 Blumeria graminis 34.78 8.60e-01 27.70
IUUC-Cre-022782 Chlamydomonas reinhardtii 26.03 4.40e+00 26.20
IUUC-Eca-034201 Equus caballus 97.10 0.00e+00 2073.00
IUUC-Ggr-039787 Gaeumannomyces graminis 23.46 1.40e-02 36.20
IUUC-Gga-041250 Gallus gallus 90.85 0.00e+00 2253.00
IUUC-Gac-041624 Gasterosteus aculeatus 76.11 0.00e+00 1880.00
IUUC-Lpe-051658 Leersia perrieri 26.32 4.20e-01 27.70
IUUC-Mcc-055130 Macaca mulatta 98.46 0.00e+00 2519.00
IUUC-Mmu-063531 Mus musculus 96.35 0.00e+00 2450.00
IUUC-Ont-072216 Oreochromis niloticus 74.49 0.00e+00 1901.00
IUUC-Oan-072855 Ornithorhynchus anatinus 92.94 0.00e+00 2154.00
IUUC-Pgr-103271 Puccinia graminis 30.61 2.50e+00 28.50
IUUC-Ssc-115989 Sus scrofa 96.84 0.00e+00 2353.00
IUUC-Tgu-116803 Taeniopygia guttata 90.39 0.00e+00 2135.00
IUUC-Tru-118142 Takifugu rubripes 74.30 0.00e+00 1905.00
IUUC-Tre-122055 Trichoderma reesei 31.52 2.20e-02 34.30
Created Date 25-Jun-2017

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