iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071369

Ensembl Protein ID

ENSONIP00000016788.1

UniProt Accession

I3K6P3; I3K6P3_ORENI

Genbank Protein ID

ENSONIP00000016788

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AERX01023283

Gene Name

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000013354.1	ENSONIT00000016803.1	ENSONIP00000016788.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	56.77	3.00e-118	423.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oreochromis niloticus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MLLRQSPAQS RQPCGPVLRP RDSPASSELE PHSPTRVSPS LRSPLNDMYP EESRGSGGVA 60
TVDFLEGTYD YAAPTPAPTP LYSHSTTGCY SAPLDAHGPL SDGSLQSLGS GPTSPLVFVP 120

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Nucleotide Sequence
(Fasta)

ATGTTGCTCA GGCAGAGCCC AGCGCAGAGC AGACAGCCGT GCGGACCAGT ACTCAGACCC 60
AGGGACAGCC CAGCCTCCTC AGAGCTGGAG CCCCACTCTC CAACTCGCGT CTCGCCATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	60.89	2.00e-125	442.00
IUUC-Apl-003688	Anas platyrhynchos	51.80	2.00e-126	446.00
IUUC-Aca-005222	Anolis carolinensis	51.10	4.00e-134	472.00
IUUC-Ame-010731	Astyanax mexicanus	60.81	4.00e-163	568.00
IUUC-Bta-013112	Bos taurus	59.13	2.00e-126	446.00
IUUC-Cja-019408	Callithrix jacchus	57.91	3.00e-127	449.00
IUUC-Cfa-020694	Canis familiaris	57.95	8.00e-126	444.00
IUUC-Cpo-021426	Cavia porcellus	50.00	4.00e-122	432.00
IUUC-Csa-023736	Chlorocebus sabaeus	57.94	3.00e-128	451.00
IUUC-Dre-027698	Danio rerio	59.90	4.00e-165	575.00
IUUC-Dno-029477	Dasypus novemcinctus	60.86	2.00e-124	439.00
IUUC-Dor-030572	Dipodomys ordii	61.34	5.00e-121	427.00
IUUC-Ete-032849	Echinops telfairi	44.51	8.00e-82	297.00
IUUC-Eca-033605	Equus caballus	50.27	3.00e-126	445.00
IUUC-Eeu-034683	Erinaceus europaeus	56.50	1.00e-52	200.00
IUUC-Fca-035928	Felis catus	61.10	1.00e-124	439.00
IUUC-Fal-036754	Ficedula albicollis	53.03	8.00e-139	487.00
IUUC-Gmo-038872	Gadus morhua	72.36	2.00e-159	555.00
IUUC-Gga-040988	Gallus gallus	52.66	1.00e-135	476.00
IUUC-Gac-042015	Gasterosteus aculeatus	74.88	0.00e+00	723.00
IUUC-Ggo-044749	Gorilla gorilla	58.04	9.00e-127	447.00
IUUC-Hsa-046944	Homo sapiens	58.04	6.00e-127	447.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	49.36	6.00e-125	441.00
IUUC-Loc-052414	Lepisosteus oculatus	59.62	2.00e-179	622.00
IUUC-Mcc-054781	Macaca mulatta	58.04	1.00e-126	447.00
IUUC-Meu-056232	Macropus eugenii	52.03	5.00e-126	444.00
IUUC-Mga-059319	Meleagris gallopavo	52.48	3.00e-135	475.00
IUUC-Mmr-061636	Microcebus murinus	56.74	7.00e-54	204.00
IUUC-Mdo-062661	Monodelphis domestica	53.15	6.00e-130	457.00
IUUC-Mmu-063330	Mus musculus	58.04	9.00e-126	444.00
IUUC-Mpu-065757	Mustela putorius furo	50.45	9.00e-129	454.00
IUUC-Mlu-067712	Myotis lucifugus	58.14	2.00e-127	449.00
IUUC-Nle-069283	Nomascus leucogenys	58.04	9.00e-127	447.00
IUUC-Opr-070391	Ochotona princeps	57.44	4.00e-126	445.00
IUUC-Oan-073734	Ornithorhynchus anatinus	43.79	4.00e-55	208.00
IUUC-Ocu-074292	Oryctolagus cuniculus	50.81	1.00e-127	450.00
IUUC-Ola-087052	Oryzias latipes	80.10	0.00e+00	780.00
IUUC-Oga-088586	Otolemur garnettii	58.33	2.00e-125	443.00
IUUC-Oar-090156	Ovis aries	55.26	2.00e-125	442.00
IUUC-Ptr-091321	Pan troglodytes	58.04	9.00e-127	447.00
IUUC-Pan-092851	Papio anubis	58.04	1.00e-126	447.00
IUUC-Psi-093434	Pelodiscus sinensis	51.71	1.00e-136	480.00
IUUC-Pfo-097379	Poecilia formosa	75.20	0.00e+00	782.00
IUUC-Pab-097735	Pongo abelii	58.04	1.00e-126	447.00
IUUC-Pva-102125	Pteropus vampyrus	51.92	8.00e-127	447.00
IUUC-Rno-106121	Rattus norvegicus	57.08	5.00e-126	445.00
IUUC-Sha-107547	Sarcophilus harrisii	52.88	2.00e-128	452.00
IUUC-Sar-113650	Sorex araneus	43.69	8.00e-75	274.00
IUUC-Tgu-117175	Taeniopygia guttata	51.53	1.00e-137	483.00
IUUC-Tru-117545	Takifugu rubripes	78.04	0.00e+00	777.00
IUUC-Tsy-119586	Tarsius syrichta	53.87	1.00e-107	384.00
IUUC-Tni-120121	Tetraodon nigroviridis	69.52	0.00e+00	769.00
IUUC-Tbe-127548	Tupaia belangeri	52.99	6.00e-99	355.00
IUUC-Ttr-128374	Tursiops truncatus	54.16	6.00e-113	401.00
IUUC-Vpa-130464	Vicugna pacos	47.81	3.00e-78	285.00
IUUC-Xtr-132171	Xenopus tropicalis	52.68	9.00e-129	454.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence