iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048737

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTP01034852

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000023944.1	ENSSTOT00000022338.1	ENSSTOP00000017009.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.00e-97	324.4	271	675

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp..................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                    +                                     
   Q: 271  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwltvtA---------Sdktrsykhppitdtvvyqmnecqekdtglvcsrhpsl 350
           7******************************87765554431.........12344555667888889899999888889999999999 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el  
   Q: 351  ssglsggasksrnmeliqprepSSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRVIPAFRGYAQQDAQEFLCELLDKIQHEL-- 437
           999999998888888888877777777************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcL 191
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ + + +        ++++L
   Q: 438  -------ETTGTRLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQFSGKdiasqpcLVTEML 519
           .......7788888999999************************************************8776655577777779***** PP
   S: 192  esftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           ++ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s   ++reki  +v f ++L+++p+c++++
   Q: 520  AKFTETEVLEGKI-YVCDQCNSKRRrfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGC-NNREKIGVHVGFEETLNMEPYCCRET 606
           **********965.*******999999999999999***********************998.7778********************99 PP
   S: 270  ekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 607  LKSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 675
           88876779***************************9999********************...********98 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MLTMDKCKHV GQLQLAPDHS ILNPQKWYCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQNY HSTTRSGRVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTAACAA TGGATAAGTG CAAACACGTT GGGCAGTTGC AGCTTGCTCC AGACCATTCC 60
ATCCTCAATC CTCAGAAATG GTATTGTGTG GACTGCAATA CAACTGAATC TATTTGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	91.57	0.00e+00	1289.00
IUUC-Apl-003673	Anas platyrhynchos	75.87	0.00e+00	1035.00
IUUC-Aca-004434	Anolis carolinensis	73.18	0.00e+00	1014.00
IUUC-Ame-010986	Astyanax mexicanus	64.71	0.00e+00	868.00
IUUC-Bta-012774	Bos taurus	89.47	0.00e+00	1242.00
IUUC-Cja-019619	Callithrix jacchus	89.47	0.00e+00	1252.00
IUUC-Cfa-020957	Canis familiaris	91.01	0.00e+00	1300.00
IUUC-Csa-023177	Chlorocebus sabaeus	88.78	0.00e+00	1243.00
IUUC-Cho-024877	Choloepus hoffmanni	89.68	0.00e+00	857.00
IUUC-Csv-025814	Ciona savignyi	44.54	2.00e-153	536.00
IUUC-Dre-027878	Danio rerio	64.92	0.00e+00	840.00
IUUC-Dno-029832	Dasypus novemcinctus	91.42	0.00e+00	1296.00
IUUC-Ete-032627	Echinops telfairi	86.80	0.00e+00	1216.00
IUUC-Eca-033863	Equus caballus	84.08	0.00e+00	1178.00
IUUC-Eeu-035225	Erinaceus europaeus	83.03	0.00e+00	1156.00
IUUC-Fca-036288	Felis catus	91.01	0.00e+00	1288.00
IUUC-Fal-037207	Ficedula albicollis	74.26	0.00e+00	999.00
IUUC-Gga-040457	Gallus gallus	73.34	0.00e+00	1002.00
IUUC-Ggo-044926	Gorilla gorilla	89.89	0.00e+00	1252.00
IUUC-Hsa-046079	Homo sapiens	89.75	0.00e+00	1254.00
IUUC-Lch-050260	Latimeria chalumnae	67.77	0.00e+00	910.00
IUUC-Laf-054491	Loxodonta africana	88.86	0.00e+00	1187.00
IUUC-Mcc-055694	Macaca mulatta	89.48	0.00e+00	1253.00
IUUC-Mga-059523	Meleagris gallopavo	73.31	0.00e+00	1023.00
IUUC-Mmr-060885	Microcebus murinus	92.43	0.00e+00	1282.00
IUUC-Mdo-063018	Monodelphis domestica	79.10	0.00e+00	1083.00
IUUC-Mmu-064012	Mus musculus	80.59	0.00e+00	1083.00
IUUC-Mpu-066207	Mustela putorius furo	90.17	0.00e+00	1303.00
IUUC-Mlu-066929	Myotis lucifugus	86.92	0.00e+00	1175.00
IUUC-Nle-069313	Nomascus leucogenys	80.31	0.00e+00	1075.00
IUUC-Opr-070375	Ochotona princeps	80.06	0.00e+00	1113.00
IUUC-Ont-071637	Oreochromis niloticus	61.66	0.00e+00	847.00
IUUC-Oan-073030	Ornithorhynchus anatinus	77.49	0.00e+00	833.00
IUUC-Ocu-074836	Oryctolagus cuniculus	86.88	0.00e+00	1206.00
IUUC-Oga-088367	Otolemur garnettii	91.44	0.00e+00	1251.00
IUUC-Oar-089953	Ovis aries	90.17	0.00e+00	1286.00
IUUC-Ptr-090980	Pan troglodytes	89.75	0.00e+00	1253.00
IUUC-Pan-092748	Papio anubis	89.48	0.00e+00	1248.00
IUUC-Psi-094078	Pelodiscus sinensis	75.78	0.00e+00	833.00
IUUC-Pab-098514	Pongo abelii	89.76	0.00e+00	1247.00
IUUC-Pva-102984	Pteropus vampyrus	89.33	0.00e+00	1258.00
IUUC-Rno-106019	Rattus norvegicus	79.83	0.00e+00	1125.00
IUUC-Sha-106965	Sarcophilus harrisii	77.97	0.00e+00	1080.00
IUUC-Ssc-115299	Sus scrofa	91.15	0.00e+00	1300.00
IUUC-Tgu-117160	Taeniopygia guttata	74.01	0.00e+00	1001.00
IUUC-Tru-118156	Takifugu rubripes	60.70	0.00e+00	826.00
IUUC-Tni-119733	Tetraodon nigroviridis	61.44	0.00e+00	840.00
IUUC-Tbe-128084	Tupaia belangeri	83.99	0.00e+00	1186.00
IUUC-Ttr-128928	Tursiops truncatus	92.41	0.00e+00	1308.00
IUUC-Vpa-130706	Vicugna pacos	90.87	0.00e+00	1276.00
IUUC-Xtr-132061	Xenopus tropicalis	71.08	0.00e+00	935.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence