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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063731
UUCD1 version UUC-MuM-00070
Ensembl Protein ID ENSMUSP00000114203.1
UniProt Accession Q9R1K5; FZR1_MOUSE
Genbank Protein ID AAD52029.1; AAH06616.1
Protein Name Fizzy-related protein homolog; Cdh1/Hct1 homolog
Genbank Nucleotide ID AF083809; BC006616
Gene Name Fzr1; Fyr; Fzr
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000020235.16 ENSMUST00000140901.7 ENSMUSP00000114203.1
ENSMUSG00000020235.16 ENSMUST00000020457.13 ENSMUSP00000020457.7
ENSMUSG00000020235.16 ENSMUST00000118812.1 ENSMUSP00000112868.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 17601983; 15899874
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.50e-26 91.7 311 341
E3 adaptor/Cullin RING/APC_C/CDC20 1.40e-150 501.8 175 479
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH  +v++l++ +d  ll+sG++D+++ vW+
   Q: 311  GHRQEVCGLKWsTDhQLLASGGNDNKLLVWN 341
           8**********98889**************9 PP
   

   E3 adaptor/Cullin RING/APC_C/CDC20
   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+kvldapel+ddfylnL+dWss nvl+v+Lg++vylwsa+t++v++l+dl  e+d+vtsv w+e+g+l+avGt+kg v+i+D+++ kk
   Q: 175  PFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLsVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKK 263
           689************************************************99************************************ PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelkl.stlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfk 176
           +++l+gh+arvgaL+Wna++lssGsrd++il+rd+r++ l+  ++lq+h+qevCGlkw++d++lLasGGnDn++ vw++ss +P+++++
   Q: 264  LSMLEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPPLQSeRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYT 352
           ******************************************99********************************************* PP
   S: 177  ehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkg 265
           eh aavkaiawsP+q++lLasGGGtaDrci+fwntltg+ l++idtgsqvc+l+wsk+++elvsthG+++n+i +wkypsl++va+l+g
   Q: 353  EHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTG 441
           ***************************************************************************************** PP
   S: 266  heaRvlslalspdgeaivtaagDetlrfwklfdkkkak 303
           h++Rvl+la+spdgeaivt+agDetlrfw++f+k++++
   Q: 442  HSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRST 479
           *********************************99875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
 Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
Protein Sequence
(Fasta)
MDQDYERRLL RQIIIQNENT VPCVSEMRRT LTPANSPVSS PSKHGDRFIP SRAGANWSVN 60
FHRINENEKS PSQNRKAKDA TSDNGKDGLA YSALLKNELL GAGIEKVQDP QTEDRRLQPS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063731|E3,CDC20;E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCTAGGCG CGGTGATGCG CTGGGCGGCG GGGCCGGTCG CGGGCGCGCG CGCGGCCTGC 60
GGGACAGATT GGGGGAGGGA GTCGGGTTGC CACTGAGTTC CGCCATATTA GCTACCGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063731|E3,CDC20;E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0006281--P:DNA repair
GO:0031572--P:G2 DNA damage checkpoint
GO:0070306--P:lens fiber cell differentiation
GO:0007067--P:mitotic nuclear division
GO:0090344--P:negative regulation of cell aging
GO:0008284--P:positive regulation of cell proliferation
GO:0045732--P:positive regulation of protein catabolic process
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination
GO:0040020--P:regulation of meiotic nuclear division
KEGG mmu:56371
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000670 Aegilops tauschii 64.19 2.00e-114 405.00
IUUC-Aml-002003 Ailuropoda melanoleuca 94.15 0.00e+00 948.00
IUUC-Atr-002753 Amborella trichopoda 57.43 1.00e-132 466.00
IUUC-Apl-003212 Anas platyrhynchos 97.97 0.00e+00 1003.00
IUUC-Aly-005442 Arabidopsis lyrata 55.41 2.00e-139 488.00
IUUC-Ath-006938 Arabidopsis thaliana 57.60 8.00e-137 480.00
IUUC-Ago-007784 Ashbya gossypii 49.42 2.00e-96 346.00
IUUC-Acl-008269 Aspergillus clavatus 49.19 2.00e-134 473.00
IUUC-Afl-008432 Aspergillus flavus 50.00 1.00e-133 470.00
IUUC-Afu-008829 Aspergillus fumigatus 50.00 4.00e-135 475.00
IUUC-Ani-009471 Aspergillus nidulans 49.39 2.00e-133 469.00
IUUC-Ang-009711 Aspergillus niger 50.41 4.00e-132 464.00
IUUC-Aor-010118 Aspergillus oryzae 50.00 1.00e-133 470.00
IUUC-Ate-010534 Aspergillus terreus 50.00 3.00e-133 468.00
IUUC-Ame-011011 Astyanax mexicanus 92.15 0.00e+00 881.00
IUUC-Bgr-012013 Blumeria graminis 50.30 7.00e-133 467.00
IUUC-Bta-012586 Bos taurus 98.99 0.00e+00 1012.00
IUUC-Bci-013807 Botrytis cinerea 51.19 4.00e-128 451.00
IUUC-Bdi-014981 Brachypodium distachyon 70.49 4.00e-129 454.00
IUUC-Bol-016301 Brassica oleracea 55.73 1.00e-138 486.00
IUUC-Bra-017453 Brassica rapa 55.73 8.00e-139 486.00
IUUC-Cel-018472 Caenorhabditis elegans 65.24 6.00e-143 501.00
IUUC-Cja-019929 Callithrix jacchus 97.98 0.00e+00 999.00
IUUC-Cfa-020977 Canis familiaris 97.98 0.00e+00 1004.00
IUUC-Cpo-021537 Cavia porcellus 98.58 0.00e+00 1009.00
IUUC-Csa-023389 Chlorocebus sabaeus 98.38 0.00e+00 1004.00
IUUC-Cin-025327 Ciona intestinalis 68.90 0.00e+00 631.00
IUUC-Csv-025921 Ciona savignyi 66.67 0.00e+00 670.00
IUUC-Cgl-026631 Colletotrichum gloeosporioides 50.88 1.00e-133 470.00
IUUC-Cne-026933 Cryptococcus neoformans 51.03 1.00e-127 450.00
IUUC-Cme-027143 Cyanidioschyzon merolae 63.70 5.00e-118 419.00
IUUC-Dre-027470 Danio rerio 91.33 0.00e+00 877.00
IUUC-Dno-029629 Dasypus novemcinctus 89.18 0.00e+00 817.00
IUUC-Dor-030187 Dipodomys ordii 87.30 0.00e+00 872.00
IUUC-Dse-031502 Dothistroma septosporum 49.90 4.00e-128 451.00
IUUC-Dme-031858 Drosophila melanogaster 69.51 0.00e+00 684.00
IUUC-Ete-032562 Echinops telfairi 85.19 0.00e+00 848.00
IUUC-Eca-034210 Equus caballus 98.58 0.00e+00 1010.00
IUUC-Fca-035839 Felis catus 93.51 0.00e+00 936.00
IUUC-Fal-036895 Ficedula albicollis 97.77 0.00e+00 1001.00
IUUC-Fox-037814 Fusarium oxysporum 64.29 2.00e-123 435.00
IUUC-Fso-038420 Fusarium solani 49.61 1.00e-133 469.00
IUUC-Gmo-039544 Gadus morhua 89.54 0.00e+00 856.00
IUUC-Ggr-039774 Gaeumannomyces graminis 50.69 9.00e-134 470.00
IUUC-Gga-041025 Gallus gallus 97.77 0.00e+00 1001.00
IUUC-Gac-041596 Gasterosteus aculeatus 90.32 0.00e+00 867.00
IUUC-Gma-042657 Glycine max 56.40 2.00e-134 472.00
IUUC-Ggo-045599 Gorilla gorilla 97.58 0.00e+00 962.00
IUUC-Hsa-046695 Homo sapiens 97.78 0.00e+00 998.00
IUUC-Hvu-047486 Hordeum vulgare 65.95 2.00e-106 379.00
IUUC-Itr-048192 Ictidomys tridecemlineatus 97.77 0.00e+00 1003.00
IUUC-Kpa-049239 Komagataella pastoris 45.51 5.00e-123 434.00
IUUC-Lch-049827 Latimeria chalumnae 96.75 0.00e+00 956.00
IUUC-Lpe-051568 Leersia perrieri 50.90 2.00e-111 395.00
IUUC-Loc-052856 Lepisosteus oculatus 94.55 0.00e+00 929.00
IUUC-Laf-054321 Loxodonta africana 62.50 7.00e-155 540.00
IUUC-Mcc-055601 Macaca mulatta 98.38 0.00e+00 1004.00
IUUC-Meu-056276 Macropus eugenii 67.92 1.00e-173 602.00
IUUC-Mor-057113 Magnaporthe oryzae 50.00 3.00e-133 469.00
IUUC-Mpo-057599 Magnaporthe poae 50.69 8.00e-134 470.00
IUUC-Mtr-057689 Medicago truncatula 56.67 1.00e-136 479.00
IUUC-Mla-059048 Melampsora laricipopulina 49.70 1.00e-118 420.00
IUUC-Mga-060097 Meleagris gallopavo 91.75 0.00e+00 929.00
IUUC-Mvi-060465 Microbotryum violaceum 51.41 8.00e-131 460.00
IUUC-Mmr-061151 Microcebus murinus 89.11 0.00e+00 876.00
IUUC-Mdo-063062 Monodelphis domestica 97.57 0.00e+00 1002.00
IUUC-Mac-065208 Musa acuminata 57.24 1.00e-128 453.00
IUUC-Mpu-066173 Mustela putorius furo 98.17 0.00e+00 1006.00
IUUC-Mlu-068030 Myotis lucifugus 98.39 0.00e+00 1005.00
IUUC-Nfi-068536 Neosartorya fischeri 50.00 1.00e-135 476.00
IUUC-Ncr-068734 Neurospora crassa 52.57 4.00e-135 475.00
IUUC-Nle-070163 Nomascus leucogenys 98.38 0.00e+00 1004.00
IUUC-Opr-070974 Ochotona princeps 91.78 3.00e-155 540.00
IUUC-Ont-072507 Oreochromis niloticus 87.07 0.00e+00 895.00
IUUC-Oan-073634 Ornithorhynchus anatinus 99.66 2.00e-175 607.00
IUUC-Oba-075417 Oryza barthii 62.86 7.00e-111 394.00
IUUC-Obr-076123 Oryza brachyantha 69.51 5.00e-126 444.00
IUUC-Ogl-077294 Oryza glaberrima 53.88 3.00e-126 445.00
IUUC-Ogu-077996 Oryza glumaepatula 53.66 8.00e-125 440.00
IUUC-Oin-080172 Oryza indica 70.16 5.00e-126 444.00
IUUC-Olo-081068 Oryza longistaminata 70.16 7.00e-126 443.00
IUUC-Ome-081250 Oryza meridionalis 54.34 2.00e-127 449.00
IUUC-Oni-083048 Oryza nivara 53.88 3.00e-126 445.00
IUUC-Opu-083333 Oryza punctata 54.29 1.00e-126 446.00
IUUC-Oru-085001 Oryza rufipogon 53.88 3.00e-126 445.00
IUUC-Osa-086243 Oryza sativa 53.88 3.00e-126 445.00
IUUC-Ola-087094 Oryzias latipes 89.02 0.00e+00 823.00
IUUC-Oga-088911 Otolemur garnettii 98.99 0.00e+00 1012.00
IUUC-Oar-089508 Ovis aries 98.99 0.00e+00 1012.00
IUUC-Ptr-090967 Pan troglodytes 85.53 0.00e+00 674.00
IUUC-Pan-092147 Papio anubis 97.78 0.00e+00 998.00
IUUC-Psi-093702 Pelodiscus sinensis 97.37 0.00e+00 993.00
IUUC-Pma-094581 Petromyzon marinus 83.67 0.00e+00 815.00
IUUC-Pno-095139 Phaeosphaeria nodorum 59.76 6.00e-113 401.00
IUUC-Ppa-095952 Physcomitrella patens 57.17 4.00e-141 494.00
IUUC-Pfo-096309 Poecilia formosa 90.52 0.00e+00 868.00
IUUC-Pab-098762 Pongo abelii 80.65 0.00e+00 776.00
IUUC-Pop-098924 Populus trichocarpa 56.88 3.00e-132 465.00
IUUC-Pca-100565 Procavia capensis 92.60 0.00e+00 890.00
IUUC-Ppe-101924 Prunus persica 57.01 4.00e-136 478.00
IUUC-Pva-102602 Pteropus vampyrus 95.76 0.00e+00 964.00
IUUC-Pgr-103466 Puccinia graminis 50.42 4.00e-118 418.00
IUUC-Ptt-103888 Puccinia triticina 53.71 3.00e-107 382.00
IUUC-Pte-104097 Pyrenophora teres 48.77 4.00e-131 461.00
IUUC-Pyt-104445 Pyrenophora triticirepentis 45.16 4.00e-113 401.00
IUUC-Rno-105028 Rattus norvegicus 99.59 0.00e+00 1013.00
IUUC-Sce-106240 Saccharomyces cerevisiae 39.11 4.00e-95 342.00
IUUC-Sha-107107 Sarcophilus harrisii 83.40 0.00e+00 839.00
IUUC-Sja-107900 Schizosaccharomyces japonicus 48.86 2.00e-115 409.00
IUUC-Spo-108056 Schizosaccharomyces pombe 48.50 2.00e-113 402.00
IUUC-Ssl-108391 Sclerotinia sclerotiorum 52.00 8.00e-131 460.00
IUUC-Smo-108878 Selaginella moellendorffii 58.42 1.00e-144 506.00
IUUC-Sit-110550 Setaria italica 54.30 7.00e-129 454.00
IUUC-Sly-111446 Solanum lycopersicum 55.63 4.00e-134 471.00
IUUC-Stu-112491 Solanum tuberosum 55.39 4.00e-133 468.00
IUUC-Sar-112962 Sorex araneus 80.15 3.00e-119 421.00
IUUC-Sbi-114386 Sorghum bicolor 54.22 2.00e-125 442.00
IUUC-Sre-115222 Sporisorium reilianum 47.64 2.00e-131 462.00
IUUC-Ssc-116171 Sus scrofa 99.19 0.00e+00 1013.00
IUUC-Tgu-116878 Taeniopygia guttata 86.23 0.00e+00 861.00
IUUC-Tru-118222 Takifugu rubripes 89.58 0.00e+00 860.00
IUUC-Tni-119863 Tetraodon nigroviridis 90.12 0.00e+00 860.00
IUUC-Tca-121599 Theobroma cacao 56.92 3.00e-133 468.00
IUUC-Tre-122249 Trichoderma reesei 50.59 9.00e-135 473.00
IUUC-Tvi-122675 Trichoderma virens 50.89 1.00e-134 473.00
IUUC-Tae-123028 Triticum aestivum 55.18 6.00e-126 444.00
IUUC-Tur-126545 Triticum urartu 59.94 1.00e-103 370.00
IUUC-Tme-127151 Tuber melanosporum 54.03 4.00e-146 511.00
IUUC-Tbe-128056 Tupaia belangeri 89.38 5.00e-168 583.00
IUUC-Ttr-129055 Tursiops truncatus 97.38 0.00e+00 989.00
IUUC-Uma-129555 Ustilago maydis 47.45 1.00e-130 460.00
IUUC-Vda-130027 Verticillium dahliae 50.39 4.00e-135 475.00
IUUC-Vvi-131749 Vitis vinifera 54.89 1.00e-133 469.00
IUUC-Xtr-132808 Xenopus tropicalis 92.09 0.00e+00 942.00
IUUC-Xma-133183 Xiphophorus maculatus 90.52 0.00e+00 868.00
IUUC-Yli-134584 Yarrowia lipolytica 64.55 1.00e-130 460.00
IUUC-Zma-135640 Zea mays 68.04 5.00e-125 441.00
Created Date 25-Jun-2017

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