iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064151

Ensembl Protein ID

ENSMUSP00000086640.5

UniProt Accession

Q6P1F6; 2ABA_MOUSE

Genbank Protein ID

AAH65100.1; AAH80692.1

Protein Name

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha

Genbank Nucleotide ID

BC065100; BC080692

Gene Name

Ppp2r2a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000022052.8	ENSMUST00000089230.5	ENSMUSP00000086640.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-11	45.2	227	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           + +t+ +f  ++ +++v +s  gti+++D+r
   Q: 227  EVITAAEFhpNScNTFVYSSSKGTIRLCDMR 257
           5689999**744799999999********87 PP

Organism

Mus musculus

Functional Description
(View)

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Protein Sequence
(Fasta)

MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 60
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTGACGTC ACCGGCCAGC CAGCGGGCGC CATTTTGAAA GTGGAGTCGC CTGTCCCTGC 60
CGCCGCGGCC GCCGTCGCTG TCCTAGCCGC CGCTGCCGCC GCCACTACTA CCGCCGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS01024--PR55_1
PS01025--PR55_2

PRINTS

PR00600--PP2APR55

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0032502--P:developmental process
GO:0000278--P:mitotic cell cycle
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0006470--P:protein dephosphorylation
GO:0043278--P:response to morphine

KEGG

mmu:71978

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001197	Ailuropoda melanoleuca	100.00	0.00e+00	888.00
IUUC-Atr-002517	Amborella trichopoda	50.00	3.00e-127	448.00
IUUC-Apl-004226	Anas platyrhynchos	98.88	0.00e+00	881.00
IUUC-Aca-005147	Anolis carolinensis	99.11	0.00e+00	880.00
IUUC-Aor-010030	Aspergillus oryzae	55.82	7.00e-132	464.00
IUUC-Ame-011776	Astyanax mexicanus	92.63	0.00e+00	826.00
IUUC-Bta-012702	Bos taurus	100.00	0.00e+00	885.00
IUUC-Bdi-014767	Brachypodium distachyon	50.52	8.00e-126	443.00
IUUC-Bol-015921	Brassica oleracea	50.71	1.00e-135	476.00
IUUC-Bra-017400	Brassica rapa	50.71	3.00e-135	475.00
IUUC-Cel-018618	Caenorhabditis elegans	65.33	3.00e-173	601.00
IUUC-Cja-019036	Callithrix jacchus	100.00	0.00e+00	884.00
IUUC-Cfa-021248	Canis familiaris	100.00	0.00e+00	884.00
IUUC-Cpo-022172	Cavia porcellus	100.00	0.00e+00	884.00
IUUC-Csa-023864	Chlorocebus sabaeus	100.00	0.00e+00	889.00
IUUC-Cin-025380	Ciona intestinalis	77.30	0.00e+00	706.00
IUUC-Dre-027406	Danio rerio	92.00	0.00e+00	818.00
IUUC-Eca-033584	Equus caballus	100.00	0.00e+00	853.00
IUUC-Fca-035565	Felis catus	95.73	0.00e+00	837.00
IUUC-Fal-036821	Ficedula albicollis	98.43	0.00e+00	874.00
IUUC-Gmo-038834	Gadus morhua	92.17	0.00e+00	811.00
IUUC-Gga-041009	Gallus gallus	99.32	0.00e+00	878.00
IUUC-Gma-044088	Glycine max	50.59	9.00e-130	457.00
IUUC-Ggo-044599	Gorilla gorilla	100.00	0.00e+00	884.00
IUUC-Hsa-046718	Homo sapiens	100.00	0.00e+00	884.00
IUUC-Itr-048651	Ictidomys tridecemlineatus	100.00	0.00e+00	889.00
IUUC-Lch-050528	Latimeria chalumnae	96.21	0.00e+00	827.00
IUUC-Loc-052663	Lepisosteus oculatus	88.75	0.00e+00	828.00
IUUC-Laf-053403	Loxodonta africana	99.78	0.00e+00	887.00
IUUC-Mcc-055776	Macaca mulatta	100.00	0.00e+00	880.00
IUUC-Mtr-058561	Medicago truncatula	49.50	7.00e-126	444.00
IUUC-Mga-059946	Meleagris gallopavo	98.88	0.00e+00	881.00
IUUC-Mvi-060503	Microbotryum violaceum	60.61	2.00e-107	382.00
IUUC-Mdo-062340	Monodelphis domestica	99.11	0.00e+00	882.00
IUUC-Mpu-066190	Mustela putorius furo	100.00	0.00e+00	888.00
IUUC-Mlu-068197	Myotis lucifugus	99.76	0.00e+00	850.00
IUUC-Nle-069966	Nomascus leucogenys	97.98	0.00e+00	853.00
IUUC-Ont-071603	Oreochromis niloticus	91.29	0.00e+00	810.00
IUUC-Oan-073540	Ornithorhynchus anatinus	97.65	2.00e-168	584.00
IUUC-Ocu-074222	Oryctolagus cuniculus	100.00	0.00e+00	889.00
IUUC-Obr-076686	Oryza brachyantha	51.87	1.00e-134	473.00
IUUC-Oru-084892	Oryza rufipogon	51.31	2.00e-134	472.00
IUUC-Ola-087128	Oryzias latipes	89.82	0.00e+00	790.00
IUUC-Oga-089168	Otolemur garnettii	99.78	0.00e+00	887.00
IUUC-Oar-089815	Ovis aries	99.55	0.00e+00	885.00
IUUC-Ptr-091110	Pan troglodytes	100.00	0.00e+00	884.00
IUUC-Pan-092884	Papio anubis	100.00	0.00e+00	889.00
IUUC-Ppa-095378	Physcomitrella patens	50.30	6.00e-132	464.00
IUUC-Pfo-097312	Poecilia formosa	90.56	0.00e+00	832.00
IUUC-Pab-098146	Pongo abelii	100.00	0.00e+00	889.00
IUUC-Pca-100882	Procavia capensis	99.60	1.00e-140	493.00
IUUC-Pva-102176	Pteropus vampyrus	92.39	0.00e+00	829.00
IUUC-Rno-105484	Rattus norvegicus	99.78	0.00e+00	889.00
IUUC-Sha-107382	Sarcophilus harrisii	99.52	0.00e+00	850.00
IUUC-Smo-109273	Selaginella moellendorffii	52.09	1.00e-134	473.00
IUUC-Sly-111422	Solanum lycopersicum	51.51	9.00e-130	457.00
IUUC-Sbi-114402	Sorghum bicolor	50.90	8.00e-132	463.00
IUUC-Ssc-115355	Sus scrofa	100.00	0.00e+00	889.00
IUUC-Tgu-116737	Taeniopygia guttata	98.66	0.00e+00	879.00
IUUC-Tru-118130	Takifugu rubripes	91.22	0.00e+00	805.00
IUUC-Tsy-119206	Tarsius syrichta	96.85	0.00e+00	838.00
IUUC-Tni-120009	Tetraodon nigroviridis	91.22	0.00e+00	805.00
IUUC-Tae-125564	Triticum aestivum	50.83	9.00e-127	447.00
IUUC-Ttr-128725	Tursiops truncatus	99.78	0.00e+00	881.00
IUUC-Vpa-130425	Vicugna pacos	95.95	0.00e+00	862.00
IUUC-Vvi-130930	Vitis vinifera	51.51	1.00e-128	452.00
IUUC-Xtr-131852	Xenopus tropicalis	94.03	0.00e+00	868.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence