iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15644464; 23696092; 24036454

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00018	22.9	319	358

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgH.vfhadClqkwpglknssskefrCPlCr 46
           C iCl++++d + vlpC H +++  C + +        ++ rCP+Cr
   Q: 319  CVICLSEPRD-TTVLPCRHmCMCSGCAKVL------RFQTNRCPICR 358
           ********99.888*****889****8666......8999******8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro). Required for GLUTAMINE DUMPER 1(GDU1)-induced amino acid secretion and for amino acid homeostasis. Ubiquitinates GDU1 (in vitro).

Protein Sequence
(Fasta)

MGNISSSGGE GRRRRRRNHT AAPPPPPPPP SSSLPPPPLP TEIQANPIVF AAVTPYPNPN 60
PNPVYQYPAS YYHHPPPGAM PLPPYDHHLQ HHPPHPYHNH SWAPVAMARY PYAGHMMAQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTGAAA AGACAAAACT CCTTATAATC AACGTAATTA TTAATAACAA GGAGAAAAAA 60
AGTCCAAAGA AAAAAAAAAG AAAGCTTTTT GGGAACATAA ACACCATCGA AGGAGGGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR001841--Znf_RING

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005886--C:plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:1901527--P:abscisic acid-activated signaling pathway involved in stomatal movement
GO:0080144--P:amino acid homeostasis
GO:0009737--P:response to abscisic acid

KEGG

ath:AT3G09770

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000903	Aegilops tauschii	71.26	8.00e-101	358.00
IUUC-Atr-002864	Amborella trichopoda	66.03	1.00e-96	345.00
IUUC-Aly-005561	Arabidopsis lyrata	90.46	1.00e-150	525.00
IUUC-Bdi-014817	Brachypodium distachyon	68.13	5.00e-100	357.00
IUUC-Bol-015790	Brassica oleracea	83.57	4.00e-119	420.00
IUUC-Bra-017806	Brassica rapa	83.10	3.00e-113	400.00
IUUC-Cme-027249	Cyanidioschyzon merolae	38.11	3.00e-40	158.00
IUUC-Gma-044140	Glycine max	72.91	1.00e-104	372.00
IUUC-Lpe-050811	Leersia perrieri	66.91	2.00e-101	362.00
IUUC-Mtr-058351	Medicago truncatula	69.02	2.00e-102	365.00
IUUC-Mmu-064187	Mus musculus	35.58	3.00e-31	129.00
IUUC-Mac-065591	Musa acuminata	70.08	1.00e-98	352.00
IUUC-Obr-076291	Oryza brachyantha	67.53	2.00e-101	362.00
IUUC-Ogl-077178	Oryza glaberrima	67.28	9.00e-101	359.00
IUUC-Ogu-078712	Oryza glumaepatula	72.11	3.00e-102	364.00
IUUC-Oin-080016	Oryza indica	72.11	3.00e-102	364.00
IUUC-Olo-081031	Oryza longistaminata	70.08	3.00e-100	358.00
IUUC-Ome-081566	Oryza meridionalis	67.28	2.00e-100	358.00
IUUC-Oni-082652	Oryza nivara	67.28	2.00e-100	358.00
IUUC-Oru-084456	Oryza rufipogon	67.28	9.00e-101	359.00
IUUC-Osa-086062	Oryza sativa	72.11	3.00e-102	364.00
IUUC-Ppa-095271	Physcomitrella patens	56.47	2.00e-72	266.00
IUUC-Pop-099088	Populus trichocarpa	72.27	5.00e-107	380.00
IUUC-Ppe-101192	Prunus persica	71.80	9.00e-107	379.00
IUUC-Smo-109530	Selaginella moellendorffii	57.63	1.00e-78	285.00
IUUC-Sit-110038	Setaria italica	69.70	4.00e-102	364.00
IUUC-Sly-110839	Solanum lycopersicum	72.29	4.00e-99	353.00
IUUC-Stu-112804	Solanum tuberosum	73.09	4.00e-100	357.00
IUUC-Sar-113137	Sorex araneus	62.75	1.00e-17	83.20
IUUC-Sbi-114265	Sorghum bicolor	67.92	4.00e-101	360.00
IUUC-Tca-121153	Theobroma cacao	69.55	2.00e-103	368.00
IUUC-Tae-123450	Triticum aestivum	69.12	2.00e-102	365.00
IUUC-Tur-126214	Triticum urartu	68.73	8.00e-102	363.00
IUUC-Vvi-131139	Vitis vinifera	71.89	2.00e-99	355.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence