iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.50e-52	172.1	106	144
UBD/Beta-Prp	2.70e-74	250.4	2	190

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H ++v+c +f +d +l+vs+sdD+t+k+WD ++  +++s
   Q: 106  HINWVRCAKFsPDgRLIVSASDDKTVKLWDKTSRECVHS 144
           999********999******************9999886 PP

UBD/Beta-Prp

   S: 31   dgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtir 119
           d+t+ +w +++++   ++ gh+++vt+v+fsp+g +l++gs+D+t+++w ++      ++++h+++v+s++f+ +g+ lv++s+d+t++
   Q: 2    DSTLMIWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQLLVTASDDKTVK 90
           99***********************************************7775555567899*************************** PP
   S: 120  vwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwd 208
           vw ++ +  l   l++h  +v+c++++pdg+l+vs+s+D+tv+lWd  + ++++   + h + v+ ++f+++g++++++++d+tvk+wd
   Q: 91   VWSTHRQRFLF-SLTQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKTSRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
           **999988888.9*******************************************98.****************************** PP
   S: 209  lqtgecvrtlngh 221
            +t + v+ ++ h
   Q: 178  TRTHRLVQHYQLH 190
           *****99999877 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDSTLMIWHM KPQSRAYRFT GHKDAVTCVN FSPSGHLLAS GSRDKTVRIW VPNVKGESTV 60
FRAHTATVRS VHFCSDGQLL VTASDDKTVK VWSTHRQRFL FSLTQHINWV RCAKFSPDGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACTCAA CCCTCATGAT CTGGCACATG AAGCCCCAGT CACGTGCCTA CCGCTTCACG 60
GGCCACAAGG ACGCCGTGAC TTGTGTGAAT TTCTCCCCAT CGGGACACCT GCTTGCCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005814--C:centriole
GO:0036064--C:ciliary basal body
GO:0000922--C:spindle pole
GO:0003431--P:growth plate cartilage chondrocyte development
GO:0007052--P:mitotic spindle organization
GO:1905515--P:non-motile cilium assembly
GO:0010825--P:positive regulation of centrosome duplication
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001513	Ailuropoda melanoleuca	87.30	0.00e+00	638.00
IUUC-Apl-003466	Anas platyrhynchos	72.70	1.00e-157	549.00
IUUC-Aca-004323	Anolis carolinensis	67.08	1.00e-153	536.00
IUUC-Bta-012484	Bos taurus	86.76	0.00e+00	663.00
IUUC-Cja-019067	Callithrix jacchus	85.79	0.00e+00	649.00
IUUC-Cfa-020439	Canis familiaris	86.72	0.00e+00	663.00
IUUC-Cpo-021403	Cavia porcellus	85.71	0.00e+00	649.00
IUUC-Cre-022724	Chlamydomonas reinhardtii	48.88	2.00e-97	348.00
IUUC-Csa-023479	Chlorocebus sabaeus	86.22	0.00e+00	632.00
IUUC-Cho-024354	Choloepus hoffmanni	82.98	2.00e-92	331.00
IUUC-Csv-025955	Ciona savignyi	61.92	1.00e-135	475.00
IUUC-Dor-030399	Dipodomys ordii	85.68	0.00e+00	648.00
IUUC-Eca-034425	Equus caballus	87.84	0.00e+00	635.00
IUUC-Eeu-034607	Erinaceus europaeus	72.97	1.00e-147	516.00
IUUC-Fca-035627	Felis catus	87.57	0.00e+00	642.00
IUUC-Fal-037381	Ficedula albicollis	70.46	6.00e-154	536.00
IUUC-Gmo-038489	Gadus morhua	64.58	4.00e-138	484.00
IUUC-Gga-040559	Gallus gallus	70.62	3.00e-151	527.00
IUUC-Gac-041453	Gasterosteus aculeatus	66.40	3.00e-145	508.00
IUUC-Ggo-044773	Gorilla gorilla	86.76	0.00e+00	630.00
IUUC-Hsa-045823	Homo sapiens	87.03	0.00e+00	635.00
IUUC-Itr-048560	Ictidomys tridecemlineatus	87.30	0.00e+00	666.00
IUUC-Lch-050558	Latimeria chalumnae	65.41	5.00e-150	523.00
IUUC-Loc-052836	Lepisosteus oculatus	66.75	4.00e-153	534.00
IUUC-Laf-053974	Loxodonta africana	77.51	5.00e-163	566.00
IUUC-Mcc-055494	Macaca mulatta	84.53	2.00e-179	621.00
IUUC-Meu-056646	Macropus eugenii	75.00	3.00e-111	395.00
IUUC-Mga-059295	Meleagris gallopavo	63.37	1.00e-147	516.00
IUUC-Mmr-061040	Microcebus murinus	87.30	0.00e+00	660.00
IUUC-Mdo-062519	Monodelphis domestica	78.64	2.00e-158	551.00
IUUC-Mmu-063759	Mus musculus	98.21	4.00e-167	580.00
IUUC-Mpu-066442	Mustela putorius furo	87.30	0.00e+00	648.00
IUUC-Mlu-068163	Myotis lucifugus	86.22	0.00e+00	644.00
IUUC-Nle-070160	Nomascus leucogenys	86.22	0.00e+00	631.00
IUUC-Opr-070192	Ochotona princeps	83.78	1.00e-175	608.00
IUUC-Ont-072539	Oreochromis niloticus	77.49	9.00e-134	469.00
IUUC-Ocu-074624	Oryctolagus cuniculus	85.95	0.00e+00	651.00
IUUC-Ola-087268	Oryzias latipes	58.31	1.00e-133	469.00
IUUC-Oga-088964	Otolemur garnettii	82.84	0.00e+00	640.00
IUUC-Oar-090202	Ovis aries	87.30	0.00e+00	636.00
IUUC-Ptr-091164	Pan troglodytes	87.03	0.00e+00	635.00
IUUC-Pan-092805	Papio anubis	85.95	0.00e+00	631.00
IUUC-Psi-093359	Pelodiscus sinensis	84.56	3.00e-143	501.00
IUUC-Ppa-095677	Physcomitrella patens	49.08	2.00e-77	281.00
IUUC-Pab-098376	Pongo abelii	87.03	0.00e+00	665.00
IUUC-Pca-101122	Procavia capensis	83.24	0.00e+00	628.00
IUUC-Pva-103104	Pteropus vampyrus	65.95	9.00e-133	466.00
IUUC-Sha-106840	Sarcophilus harrisii	80.68	2.00e-100	358.00
IUUC-Smo-108731	Selaginella moellendorffii	47.01	1.00e-75	276.00
IUUC-Sar-113262	Sorex araneus	67.41	1.00e-117	416.00
IUUC-Ssc-115392	Sus scrofa	89.93	6.00e-163	566.00
IUUC-Tgu-117340	Taeniopygia guttata	70.65	4.00e-151	527.00
IUUC-Tsy-119404	Tarsius syrichta	78.38	2.00e-170	591.00
IUUC-Tbe-127788	Tupaia belangeri	67.03	3.00e-138	484.00
IUUC-Ttr-128608	Tursiops truncatus	82.43	2.00e-170	591.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence