iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071419

Ensembl Protein ID

ENSONIP00000021428.1

UniProt Accession

I3KJY3; I3KJY3_ORENI

Genbank Protein ID

ENSONIP00000021428

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01036942

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000016994.1	ENSONIT00000021447.1	ENSONIP00000021428.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-22	79.0	616	654
UBD/Beta-Prp	4.40e-40	138.1	485	653

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 616  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 654
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 51   heaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.tl 133
           h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl t +   +  l
   Q: 485  HGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKTPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLATPTPRIKaEL 572
           555677888888874.455555579*******999888888888889*********************************998776588 PP
   S: 134  sghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv 215
           +    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ +
   Q: 573  TSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL 653
           88888888999********************************9.********************************99754 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MIRDLSKMYP PARHPVPHQP GQPFKFTVTE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATTCGAG ATCTGAGCAA GATGTACCCC CCGGCGCGGC ATCCGGTAAG TACAGAACAG 60
TAGCGGTAAG AGCAGTGTGT CAAAACAGCG CAGATTAACA GTCGCGCCTG ATGCGTAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0006355--P:regulation of transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005279	Anolis carolinensis	88.93	0.00e+00	1206.00
IUUC-Bta-012646	Bos taurus	87.64	0.00e+00	1218.00
IUUC-Cel-018361	Caenorhabditis elegans	58.43	9.00e-121	427.00
IUUC-Cja-019079	Callithrix jacchus	88.42	0.00e+00	1248.00
IUUC-Cfa-020987	Canis familiaris	88.59	0.00e+00	1206.00
IUUC-Cpo-021606	Cavia porcellus	86.96	0.00e+00	1189.00
IUUC-Csa-023445	Chlorocebus sabaeus	88.42	0.00e+00	1228.00
IUUC-Cho-024590	Choloepus hoffmanni	76.24	0.00e+00	1062.00
IUUC-Cin-025767	Ciona intestinalis	58.52	4.00e-171	595.00
IUUC-Csv-026174	Ciona savignyi	57.31	3.00e-165	575.00
IUUC-Dno-028979	Dasypus novemcinctus	88.16	0.00e+00	1173.00
IUUC-Dor-030533	Dipodomys ordii	83.31	0.00e+00	1040.00
IUUC-Dme-031576	Drosophila melanogaster	86.31	0.00e+00	667.00
IUUC-Ete-032887	Echinops telfairi	77.40	0.00e+00	1081.00
IUUC-Eeu-035237	Erinaceus europaeus	76.05	0.00e+00	1009.00
IUUC-Fca-036030	Felis catus	88.45	0.00e+00	1223.00
IUUC-Fal-037460	Ficedula albicollis	88.58	0.00e+00	1207.00
IUUC-Gga-040416	Gallus gallus	88.80	0.00e+00	1234.00
IUUC-Gac-041739	Gasterosteus aculeatus	83.21	0.00e+00	1140.00
IUUC-Ggo-045633	Gorilla gorilla	84.89	0.00e+00	1197.00
IUUC-Hsa-046461	Homo sapiens	84.92	0.00e+00	1225.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	88.55	0.00e+00	1235.00
IUUC-Lch-049943	Latimeria chalumnae	86.87	0.00e+00	1145.00
IUUC-Loc-052835	Lepisosteus oculatus	89.70	0.00e+00	1207.00
IUUC-Laf-053425	Loxodonta africana	88.58	0.00e+00	1219.00
IUUC-Mcc-055766	Macaca mulatta	84.92	0.00e+00	1224.00
IUUC-Meu-056209	Macropus eugenii	84.14	0.00e+00	1215.00
IUUC-Mmr-061317	Microcebus murinus	85.34	0.00e+00	1225.00
IUUC-Mdo-062956	Monodelphis domestica	88.67	0.00e+00	1232.00
IUUC-Mmu-063576	Mus musculus	88.29	0.00e+00	1222.00
IUUC-Mlu-067456	Myotis lucifugus	85.38	0.00e+00	1158.00
IUUC-Nle-069495	Nomascus leucogenys	88.45	0.00e+00	1200.00
IUUC-Oan-072842	Ornithorhynchus anatinus	85.96	0.00e+00	1207.00
IUUC-Ocu-074453	Oryctolagus cuniculus	87.26	0.00e+00	1207.00
IUUC-Ola-087090	Oryzias latipes	96.24	0.00e+00	1279.00
IUUC-Oga-087939	Otolemur garnettii	88.67	0.00e+00	1236.00
IUUC-Ptr-091048	Pan troglodytes	88.42	0.00e+00	1228.00
IUUC-Pan-091973	Papio anubis	83.78	0.00e+00	1172.00
IUUC-Pfo-097518	Poecilia formosa	95.22	0.00e+00	1231.00
IUUC-Pva-103037	Pteropus vampyrus	81.44	0.00e+00	1216.00
IUUC-Rno-105314	Rattus norvegicus	87.87	0.00e+00	1153.00
IUUC-Sar-113585	Sorex araneus	79.23	0.00e+00	660.00
IUUC-Ssc-116408	Sus scrofa	88.21	0.00e+00	1244.00
IUUC-Tgu-117068	Taeniopygia guttata	88.46	0.00e+00	1206.00
IUUC-Tru-118782	Takifugu rubripes	90.76	0.00e+00	1186.00
IUUC-Tsy-118884	Tarsius syrichta	75.34	0.00e+00	974.00
IUUC-Tni-120404	Tetraodon nigroviridis	89.43	0.00e+00	1229.00
IUUC-Tbe-128013	Tupaia belangeri	80.91	0.00e+00	1122.00
IUUC-Ttr-129285	Tursiops truncatus	83.75	0.00e+00	1208.00
IUUC-Vpa-130577	Vicugna pacos	74.12	2.00e-160	559.00
IUUC-Xtr-132974	Xenopus tropicalis	86.94	0.00e+00	1177.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence