iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023286

Ensembl Protein ID

ENSCSAP00000003177.1

UniProt Accession

A0A0D9R3I8; A0A0D9R3I8_CHLSB

Genbank Protein ID

ENSCSAP00000003177

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AQIB01078863

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000006902.1	ENSCSAT00000004932.1	ENSCSAP00000003177.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.80e-51	174.1	90	280

Active Site

Position(s)	Description	Evidence
97	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
100	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
274		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 90   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSD 178
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 179  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-E 263
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 264  PKVYLLYRPGHYDILYK 280
           ***************96 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE DMTDPCLLQI AVQNPLVSER 60
LELSVLYKEY AEDDNIYQQK IKDLHKKYSY IRKTRPDGNC FYRAFGFSHL EALLDDSKEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATGGCGGC GGAGGAACCT CAGCAGCAGA AGCAGGAGCC GCTGGGCAGC GACTCCGAAG 60
GTACAGCTCC AAGGAGGGAT GTCCGGCCCA GGCTAGTGGG GGCGATGCCG GGCCAGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	95.04	2.00e-153	534.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	6.00e-19	85.10
IUUC-Aca-004648	Anolis carolinensis	82.69	6.00e-135	473.00
IUUC-Aly-005710	Arabidopsis lyrata	43.60	3.00e-50	191.00
IUUC-Ath-007112	Arabidopsis thaliana	43.43	6.00e-50	191.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.80
IUUC-Ame-010662	Astyanax mexicanus	80.15	1.00e-127	448.00
IUUC-Bta-013533	Bos taurus	95.71	2.00e-150	524.00
IUUC-Bol-016100	Brassica oleracea	43.31	3.00e-50	191.00
IUUC-Bra-017705	Brassica rapa	40.22	5.00e-45	174.00
IUUC-Cel-018295	Caenorhabditis elegans	35.78	2.00e-41	162.00
IUUC-Cja-019190	Callithrix jacchus	96.79	1.00e-151	528.00
IUUC-Cfa-020430	Canis familiaris	96.55	4.00e-147	513.00
IUUC-Cpo-022355	Cavia porcellus	96.43	9.00e-152	528.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.66	1.00e-44	173.00
IUUC-Cin-025507	Ciona intestinalis	41.27	3.00e-42	164.00
IUUC-Csv-026273	Ciona savignyi	48.03	1.00e-66	246.00
IUUC-Dre-027843	Danio rerio	76.73	2.00e-124	438.00
IUUC-Dno-029165	Dasypus novemcinctus	99.00	8.00e-118	415.00
IUUC-Dor-030943	Dipodomys ordii	96.43	9.00e-152	528.00
IUUC-Dme-031922	Drosophila melanogaster	54.44	5.00e-76	277.00
IUUC-Ete-032296	Echinops telfairi	96.23	2.00e-89	322.00
IUUC-Eca-033695	Equus caballus	95.40	7.00e-146	509.00
IUUC-Fca-036441	Felis catus	96.55	2.00e-147	514.00
IUUC-Gmo-038908	Gadus morhua	77.66	3.00e-124	437.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.18	5.00e-32	132.00
IUUC-Gga-040460	Gallus gallus	78.93	3.00e-131	460.00
IUUC-Gac-042417	Gasterosteus aculeatus	78.38	4.00e-120	423.00
IUUC-Gma-043712	Glycine max	39.86	7.00e-50	190.00
IUUC-Ggo-044552	Gorilla gorilla	100.00	1.00e-92	332.00
IUUC-Hsa-046766	Homo sapiens	96.79	6.00e-152	529.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	96.43	9.00e-152	528.00
IUUC-Lch-050602	Latimeria chalumnae	78.54	8.00e-117	412.00
IUUC-Laf-053705	Loxodonta africana	96.43	9.00e-152	528.00
IUUC-Mcc-055745	Macaca mulatta	96.89	1.00e-157	548.00
IUUC-Meu-056569	Macropus eugenii	82.86	5.00e-133	466.00
IUUC-Mtr-057712	Medicago truncatula	41.73	7.00e-45	174.00
IUUC-Mvi-060358	Microbotryum violaceum	34.93	3.00e-14	72.40
IUUC-Mmr-061123	Microcebus murinus	95.85	2.00e-125	441.00
IUUC-Mdo-062613	Monodelphis domestica	84.29	3.00e-121	427.00
IUUC-Mmu-063658	Mus musculus	96.43	9.00e-152	528.00
IUUC-Mac-065274	Musa acuminata	37.80	7.00e-39	154.00
IUUC-Mpu-066172	Mustela putorius furo	96.79	6.00e-152	529.00
IUUC-Mlu-066966	Myotis lucifugus	96.07	5.00e-151	526.00
IUUC-Nle-069519	Nomascus leucogenys	88.17	2.00e-93	335.00
IUUC-Ont-071901	Oreochromis niloticus	79.62	1.00e-122	432.00
IUUC-Ola-087331	Oryzias latipes	80.90	5.00e-86	310.00
IUUC-Oga-088064	Otolemur garnettii	96.79	6.00e-152	529.00
IUUC-Oar-089251	Ovis aries	94.68	3.00e-145	507.00
IUUC-Ptr-091430	Pan troglodytes	96.79	2.00e-151	528.00
IUUC-Psi-093823	Pelodiscus sinensis	84.81	2.00e-131	461.00
IUUC-Pma-094366	Petromyzon marinus	75.88	3.00e-102	364.00
IUUC-Pfo-096734	Poecilia formosa	78.08	1.00e-111	395.00
IUUC-Pab-097919	Pongo abelii	96.27	1.00e-124	439.00
IUUC-Pop-099401	Populus trichocarpa	40.81	9.00e-48	183.00
IUUC-Ppe-101977	Prunus persica	41.01	9.00e-50	190.00
IUUC-Pva-102499	Pteropus vampyrus	96.54	7.00e-147	512.00
IUUC-Rno-105233	Rattus norvegicus	96.43	9.00e-152	528.00
IUUC-Sha-107081	Sarcophilus harrisii	93.26	4.00e-146	510.00
IUUC-Sly-111640	Solanum lycopersicum	40.65	3.00e-47	181.00
IUUC-Ssc-116202	Sus scrofa	96.79	6.00e-152	529.00
IUUC-Tru-117664	Takifugu rubripes	74.82	2.00e-120	424.00
IUUC-Tca-121467	Theobroma cacao	40.21	1.00e-48	186.00
IUUC-Tbe-128116	Tupaia belangeri	98.76	2.00e-93	335.00
IUUC-Ttr-128622	Tursiops truncatus	96.07	3.00e-149	520.00
IUUC-Vvi-131389	Vitis vinifera	42.35	3.00e-51	195.00
IUUC-Xma-134191	Xiphophorus maculatus	78.46	1.00e-112	399.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence