iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026289.15	ENSMUST00000027512.12	ENSMUSP00000027512.6
ENSMUSG00000026289.15	ENSMUST00000113186.7	ENSMUSP00000108811.1
ENSMUSG00000026289.15	ENSMUST00000113190.2	ENSMUSP00000108815.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-30	104.1	422	461
UBD/Beta-Prp	3.50e-62	211.4	333	621

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllks 38
           gH+++v + +f  ++ ++vsGs+D t+k+WDlr+ v++k+
   Q: 422  GHSGKVLSAKFllDNARIVSGSHDRTLKLWDLRSKVCIKT 461
           8***********64489********************985 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           ++++h++ +++v+fsp+++llatg++d+++k+w+++  k+    slsg +a++t+++f++ g +l+ +s+D + ++w ++++   htl+
   Q: 333  VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEAFGDKCefKGSLSGSNAGITSIEFDSAGAYLLAASNDFASRIWTVDDYRLRHTLT 421
           5799***********************************9989********************************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+ +vls +f  ++ ++vsGshdrt+++wdl+++ c++++++g +    c  + +++++++sG+ D+++r+Wd+++++++r+++    
   Q: 422  GHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS----CNDIVCTEQCVMSGHFDKKIRFWDIRSESVVREME--LL 504
           ***************************************9999988....888888889*************************6..69 PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght....dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhns 265
           ++++ l+++++++el+s+s+d  +k+ dl+t+ + +t+ +      +  ++v fsp++ +++ gs++gs+++W + +g++ k+l++++s
   Q: 505  GKITALDLNPERTELLSCSRDDLLKVIDLRTNAVKQTFSAPGfkcgSDWTRVVFSPDGSYVAAGSAEGSLYVWSVLTGKVEKVLSKQHS 593
           **********************************99999988888877777************************************** PP
   S: 266  svisvavlsfgdnvlvlgsedskvniwk 293
           s+i   ++ +++ ++v++++ s++ +w+
   Q: 594  SSINAVAWAPSGLHVVSVDKGSRAVLWA 621
           **************************97 PP

Organism

Mus musculus

Functional Description
(View)

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:18849966, PubMed:12665549, PubMed:24954904, PubMed:24553140, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).

Protein Sequence
(Fasta)

MSSGLRAADF PRWKRHIAEE LRRRDRLQRQ AFEEIILQYT KLLEKSDLHS VLTQKLQAEK 60
HDMPNRHEIS PGHDGAWNDS QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGCCAGGG TGCCTCCCAG CGGCTGCCTC TCATCACCGA CGCTTCCGGC TTCAAGGTTG 60
CGTCATTTGA GAGCGTCCCG CGAAGTCTCG GCCGGGAGCT TGCGCGCGGC CTAGGACGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0005829--C:cytosol
GO:0034045--C:pre-autophagosomal structure membrane
GO:0042802--F:identical protein binding
GO:0000045--P:autophagosome assembly
GO:0016236--P:macroautophagy
GO:0039689--P:negative stranded viral RNA replication
GO:0015031--P:protein transport

KEGG

mmu:77040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000090	Aegilops tauschii	28.57	1.00e-33	137.00
IUUC-Aml-002242	Ailuropoda melanoleuca	82.30	0.00e+00	1002.00
IUUC-Atr-003073	Amborella trichopoda	27.72	2.00e-26	113.00
IUUC-Apl-003384	Anas platyrhynchos	83.95	0.00e+00	1029.00
IUUC-Aca-004962	Anolis carolinensis	86.33	0.00e+00	1063.00
IUUC-Aly-005435	Arabidopsis lyrata	34.45	3.00e-46	179.00
IUUC-Ath-006948	Arabidopsis thaliana	34.78	2.00e-46	180.00
IUUC-Ame-010915	Astyanax mexicanus	77.23	5.00e-150	523.00
IUUC-Bta-012388	Bos taurus	92.60	0.00e+00	1151.00
IUUC-Bdi-014231	Brachypodium distachyon	30.23	3.00e-37	149.00
IUUC-Bol-016174	Brassica oleracea	35.12	9.00e-47	181.00
IUUC-Bra-017165	Brassica rapa	34.45	5.00e-46	179.00
IUUC-Cel-018131	Caenorhabditis elegans	39.33	5.00e-59	222.00
IUUC-Cja-018898	Callithrix jacchus	82.01	0.00e+00	964.00
IUUC-Cfa-020484	Canis familiaris	90.68	0.00e+00	1115.00
IUUC-Cpo-022156	Cavia porcellus	91.80	0.00e+00	1118.00
IUUC-Csa-024019	Chlorocebus sabaeus	89.39	0.00e+00	1082.00
IUUC-Cho-024311	Choloepus hoffmanni	77.69	0.00e+00	931.00
IUUC-Cin-025260	Ciona intestinalis	36.73	7.00e-97	348.00
IUUC-Csv-025836	Ciona savignyi	44.44	1.00e-47	182.00
IUUC-Dre-027702	Danio rerio	74.14	0.00e+00	887.00
IUUC-Dno-029728	Dasypus novemcinctus	91.65	0.00e+00	1157.00
IUUC-Dor-030587	Dipodomys ordii	83.11	3.00e-122	432.00
IUUC-Dme-031595	Drosophila melanogaster	38.21	8.00e-107	381.00
IUUC-Ete-032969	Echinops telfairi	71.76	0.00e+00	750.00
IUUC-Eca-034214	Equus caballus	91.14	0.00e+00	920.00
IUUC-Eeu-034537	Erinaceus europaeus	84.54	0.00e+00	874.00
IUUC-Fca-036005	Felis catus	92.71	0.00e+00	1075.00
IUUC-Fal-037593	Ficedula albicollis	85.92	0.00e+00	1013.00
IUUC-Gmo-039042	Gadus morhua	63.18	0.00e+00	674.00
IUUC-Gga-040986	Gallus gallus	86.01	0.00e+00	1069.00
IUUC-Gac-041351	Gasterosteus aculeatus	71.36	0.00e+00	888.00
IUUC-Gma-043265	Glycine max	34.11	7.00e-48	185.00
IUUC-Ggo-045427	Gorilla gorilla	93.42	0.00e+00	1140.00
IUUC-Hsa-046632	Homo sapiens	91.80	0.00e+00	1127.00
IUUC-Hvu-047655	Hordeum vulgare	29.39	7.00e-25	108.00
IUUC-Itr-048504	Ictidomys tridecemlineatus	90.24	0.00e+00	1096.00
IUUC-Lpe-051254	Leersia perrieri	30.42	4.00e-38	152.00
IUUC-Loc-052610	Lepisosteus oculatus	74.84	0.00e+00	923.00
IUUC-Laf-053936	Loxodonta africana	90.03	0.00e+00	1110.00
IUUC-Mcc-055504	Macaca mulatta	90.43	0.00e+00	1152.00
IUUC-Meu-056516	Macropus eugenii	83.63	0.00e+00	996.00
IUUC-Mtr-058062	Medicago truncatula	31.67	1.00e-43	170.00
IUUC-Mga-059777	Meleagris gallopavo	81.14	0.00e+00	1015.00
IUUC-Mmr-061298	Microcebus murinus	95.66	0.00e+00	1156.00
IUUC-Mdo-062969	Monodelphis domestica	88.75	0.00e+00	1086.00
IUUC-Mac-065022	Musa acuminata	32.33	1.00e-41	163.00
IUUC-Mpu-066196	Mustela putorius furo	93.73	0.00e+00	1131.00
IUUC-Mlu-067651	Myotis lucifugus	89.41	0.00e+00	1096.00
IUUC-Nle-069853	Nomascus leucogenys	90.35	0.00e+00	1105.00
IUUC-Opr-070350	Ochotona princeps	94.89	3.00e-121	429.00
IUUC-Ont-072489	Oreochromis niloticus	72.01	0.00e+00	879.00
IUUC-Oan-072703	Ornithorhynchus anatinus	84.22	0.00e+00	994.00
IUUC-Ocu-074205	Oryctolagus cuniculus	92.31	0.00e+00	1153.00
IUUC-Oba-075619	Oryza barthii	30.45	3.00e-37	149.00
IUUC-Obr-076632	Oryza brachyantha	30.21	7.00e-38	151.00
IUUC-Ogl-077671	Oryza glaberrima	30.45	3.00e-37	149.00
IUUC-Ogu-078052	Oryza glumaepatula	30.45	3.00e-37	149.00
IUUC-Oin-079611	Oryza indica	30.13	4.00e-35	142.00
IUUC-Olo-080408	Oryza longistaminata	30.45	7.00e-37	148.00
IUUC-Ome-081560	Oryza meridionalis	30.45	3.00e-37	149.00
IUUC-Oni-082145	Oryza nivara	30.45	3.00e-37	149.00
IUUC-Opu-083918	Oryza punctata	30.13	1.00e-36	147.00
IUUC-Oru-084858	Oryza rufipogon	30.13	6.00e-35	142.00
IUUC-Osa-086277	Oryza sativa	30.13	4.00e-35	142.00
IUUC-Ola-086816	Oryzias latipes	69.85	4.00e-99	353.00
IUUC-Olu-087622	Ostreococcus lucimarinus	33.44	1.00e-44	173.00
IUUC-Oga-088765	Otolemur garnettii	88.60	0.00e+00	1031.00
IUUC-Oar-090196	Ovis aries	89.38	0.00e+00	1006.00
IUUC-Ptr-091676	Pan troglodytes	91.96	0.00e+00	1128.00
IUUC-Pan-092068	Papio anubis	94.06	0.00e+00	1144.00
IUUC-Psi-093367	Pelodiscus sinensis	83.44	0.00e+00	1020.00
IUUC-Ppa-095699	Physcomitrella patens	33.78	8.00e-41	161.00
IUUC-Pfo-096067	Poecilia formosa	70.75	0.00e+00	862.00
IUUC-Pab-098111	Pongo abelii	93.74	0.00e+00	1144.00
IUUC-Pop-099116	Populus trichocarpa	31.44	1.00e-42	167.00
IUUC-Pca-100680	Procavia capensis	82.12	0.00e+00	938.00
IUUC-Ppe-101790	Prunus persica	31.44	5.00e-44	172.00
IUUC-Pva-102871	Pteropus vampyrus	90.58	0.00e+00	1051.00
IUUC-Rno-106088	Rattus norvegicus	97.59	0.00e+00	1180.00
IUUC-Sha-106984	Sarcophilus harrisii	85.64	0.00e+00	1043.00
IUUC-Smo-109404	Selaginella moellendorffii	31.44	3.00e-41	162.00
IUUC-Sit-110828	Setaria italica	31.58	6.00e-41	162.00
IUUC-Sly-111009	Solanum lycopersicum	31.00	3.00e-44	172.00
IUUC-Stu-112370	Solanum tuberosum	31.00	7.00e-45	174.00
IUUC-Sar-113659	Sorex araneus	58.65	9.00e-85	306.00
IUUC-Sbi-114819	Sorghum bicolor	30.62	3.00e-39	156.00
IUUC-Ssc-116241	Sus scrofa	88.40	0.00e+00	1078.00
IUUC-Tgu-116576	Taeniopygia guttata	84.08	0.00e+00	1056.00
IUUC-Tru-118336	Takifugu rubripes	64.05	0.00e+00	731.00
IUUC-Tsy-119006	Tarsius syrichta	90.19	0.00e+00	1081.00
IUUC-Tni-120300	Tetraodon nigroviridis	71.19	0.00e+00	852.00
IUUC-Tca-121002	Theobroma cacao	32.67	4.00e-45	176.00
IUUC-Tae-124868	Triticum aestivum	29.19	1.00e-34	140.00
IUUC-Tur-126463	Triticum urartu	28.57	7.00e-34	139.00
IUUC-Tbe-127631	Tupaia belangeri	92.07	0.00e+00	904.00
IUUC-Ttr-129005	Tursiops truncatus	81.68	2.00e-157	549.00
IUUC-Vpa-130246	Vicugna pacos	85.24	0.00e+00	853.00
IUUC-Vvi-130878	Vitis vinifera	33.44	6.00e-44	172.00
IUUC-Xtr-132798	Xenopus tropicalis	72.36	0.00e+00	863.00
IUUC-Xma-133264	Xiphophorus maculatus	70.00	0.00e+00	860.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence