iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-44	148.8	202	238
UBD/Beta-Prp	2.60e-63	214.3	297	490

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH ++v+c+a  ++   +v+Gs D tik+WDl +g+l
   Q: 202  GHLGWVRCIAVePGnQWFVTGSADRTIKIWDLASGKL 238
           8***********77799***************99987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
           +p  ++l+t srd+t ++wdv+t+  +++lsgh+++v++v+++  ++ ++tgs D ti++wdl +gk+ +tl++h++sv+++ ++p  +
   Q: 297  HPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPLHY 385
           67778899999999999999999999999999999999999999999999999999999999999999999999999999999999999 PP
   S: 108  klvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.......tgghtdsvyslsfd 189
           +++sGs d+ i+ w+ + g  ++  lsgh++++n+++v+  + +lvsG++++t+ lWd +tg   ++        + + ++ +   +fd
   Q: 386  TFASGSPDN-IKQWKFPDGGFIQ-NLSGHNAIINTLAVNT-DGVLVSGADNGTMHLWDWRTGYNFQRVhaavqpgSLDSESGIFACAFD 471
           999999665.8999999999999.9999999999999998.678899999999999999999888888765555533355555555599 PP
   S: 190  sngkelvsgsldgtvklwd 208
           ++  +l+++  d+t+k++ 
   Q: 472  RSESRLLTAEADKTIKVYR 490
           9999999999999999986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Protein Sequence
(Fasta)

MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 60
SKENLKEKGP QNAPDSYPHK QYPANQGQDV EYLVTGTHPY PPGPGVALTA DTKIQRMPSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCGGCGAC AGGCCCCAAT CTCCGGAAGG AGCGGCAGAA TAGTGGCGGC GATTTCTGCG 60
TCGAGCATTT GGAGTTTCTT CGCTGCTGAA CGGGTAGACT AAACGGCGGC GACATGGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005662--C:DNA replication factor A complex
GO:0001650--C:fibrillar center
GO:0031965--C:nuclear membrane
GO:0016607--C:nuclear speck
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0000398--P:mRNA splicing, via spliceosome
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0034504--P:protein localization to nucleus

KEGG

rno:60376

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000084	Aegilops tauschii	46.99	5.00e-129	454.00
IUUC-Aml-001605	Ailuropoda melanoleuca	95.71	0.00e+00	1025.00
IUUC-Atr-002757	Amborella trichopoda	49.59	4.00e-130	458.00
IUUC-Apl-003198	Anas platyrhynchos	88.95	0.00e+00	959.00
IUUC-Aca-004683	Anolis carolinensis	88.37	0.00e+00	944.00
IUUC-Aly-005775	Arabidopsis lyrata	60.53	2.00e-125	442.00
IUUC-Ath-007460	Arabidopsis thaliana	54.05	3.00e-126	445.00
IUUC-Ago-007884	Ashbya gossypii	47.31	3.00e-106	378.00
IUUC-Acl-008153	Aspergillus clavatus	64.02	1.00e-127	449.00
IUUC-Afl-008384	Aspergillus flavus	64.63	1.00e-128	452.00
IUUC-Afu-009045	Aspergillus fumigatus	64.63	2.00e-128	452.00
IUUC-Ani-009229	Aspergillus nidulans	62.03	7.00e-128	450.00
IUUC-Ang-009812	Aspergillus niger	64.98	2.00e-122	431.00
IUUC-Aor-010059	Aspergillus oryzae	64.63	1.00e-128	452.00
IUUC-Ate-010351	Aspergillus terreus	63.37	1.00e-135	476.00
IUUC-Ame-011613	Astyanax mexicanus	58.76	7.00e-154	536.00
IUUC-Bgr-012042	Blumeria graminis	63.72	1.00e-134	473.00
IUUC-Bta-012406	Bos taurus	94.56	0.00e+00	1012.00
IUUC-Bci-013760	Botrytis cinerea	63.04	6.00e-134	470.00
IUUC-Bdi-014776	Brachypodium distachyon	51.58	3.00e-130	458.00
IUUC-Bol-016189	Brassica oleracea	53.17	8.00e-126	443.00
IUUC-Bra-018044	Brassica rapa	53.17	1.00e-125	443.00
IUUC-Cel-018651	Caenorhabditis elegans	53.03	4.00e-155	541.00
IUUC-Cja-019974	Callithrix jacchus	95.72	0.00e+00	1034.00
IUUC-Cfa-021085	Canis familiaris	95.34	0.00e+00	1026.00
IUUC-Cpo-021458	Cavia porcellus	94.76	0.00e+00	1021.00
IUUC-Cre-022880	Chlamydomonas reinhardtii	60.18	5.00e-124	437.00
IUUC-Csa-023883	Chlorocebus sabaeus	96.30	0.00e+00	1039.00
IUUC-Cho-024623	Choloepus hoffmanni	93.92	0.00e+00	989.00
IUUC-Cin-025190	Ciona intestinalis	59.96	0.00e+00	644.00
IUUC-Csv-026367	Ciona savignyi	59.32	0.00e+00	654.00
IUUC-Cgl-026499	Colletotrichum gloeosporioides	64.69	6.00e-140	490.00
IUUC-Cne-027069	Cryptococcus neoformans	63.12	2.00e-126	446.00
IUUC-Cme-027233	Cyanidioschyzon merolae	31.08	4.00e-35	142.00
IUUC-Dre-028260	Danio rerio	77.91	0.00e+00	831.00
IUUC-Dno-029112	Dasypus novemcinctus	96.11	0.00e+00	1036.00
IUUC-Dor-031118	Dipodomys ordii	94.63	0.00e+00	798.00
IUUC-Dse-031493	Dothistroma septosporum	46.29	9.00e-126	443.00
IUUC-Dme-032138	Drosophila melanogaster	59.53	4.00e-171	593.00
IUUC-Ete-032411	Echinops telfairi	83.17	0.00e+00	828.00
IUUC-Eca-033521	Equus caballus	94.76	0.00e+00	1022.00
IUUC-Eeu-035249	Erinaceus europaeus	80.73	0.00e+00	655.00
IUUC-Fca-036358	Felis catus	94.95	0.00e+00	1022.00
IUUC-Fal-036933	Ficedula albicollis	89.53	0.00e+00	959.00
IUUC-Fox-037713	Fusarium oxysporum	56.93	5.00e-140	491.00
IUUC-Fso-038380	Fusarium solani	64.04	6.00e-139	487.00
IUUC-Gmo-039133	Gadus morhua	78.56	0.00e+00	832.00
IUUC-Ggr-039915	Gaeumannomyces graminis	66.36	3.00e-132	465.00
IUUC-Gga-041176	Gallus gallus	87.60	0.00e+00	948.00
IUUC-Gac-042344	Gasterosteus aculeatus	76.74	0.00e+00	829.00
IUUC-Gma-043328	Glycine max	50.40	1.00e-133	469.00
IUUC-Ggo-044478	Gorilla gorilla	96.11	0.00e+00	1037.00
IUUC-Hsa-046037	Homo sapiens	96.30	0.00e+00	1038.00
IUUC-Hvu-047349	Hordeum vulgare	50.51	2.00e-132	466.00
IUUC-Itr-048390	Ictidomys tridecemlineatus	96.31	0.00e+00	1038.00
IUUC-Kpa-049343	Komagataella pastoris	58.77	2.00e-118	419.00
IUUC-Lch-049830	Latimeria chalumnae	82.95	0.00e+00	891.00
IUUC-Lpe-051442	Leersia perrieri	48.97	2.00e-129	456.00
IUUC-Loc-051794	Lepisosteus oculatus	81.89	0.00e+00	852.00
IUUC-Lma-053137	Leptosphaeria maculans	45.03	9.00e-127	447.00
IUUC-Laf-053471	Loxodonta africana	95.13	0.00e+00	1018.00
IUUC-Mcc-055627	Macaca mulatta	96.11	0.00e+00	1036.00
IUUC-Meu-056148	Macropus eugenii	81.02	0.00e+00	862.00
IUUC-Mor-056960	Magnaporthe oryzae	61.28	7.00e-137	480.00
IUUC-Mtr-057816	Medicago truncatula	47.55	1.00e-126	446.00
IUUC-Mla-059031	Melampsora laricipopulina	60.39	2.00e-127	449.00
IUUC-Mga-059337	Meleagris gallopavo	87.94	0.00e+00	948.00
IUUC-Mvi-060217	Microbotryum violaceum	63.58	4.00e-129	454.00
IUUC-Mmr-061018	Microcebus murinus	96.12	0.00e+00	1034.00
IUUC-Mdo-062863	Monodelphis domestica	90.31	0.00e+00	942.00
IUUC-Mmu-063988	Mus musculus	98.44	0.00e+00	1050.00
IUUC-Mac-064459	Musa acuminata	48.33	8.00e-122	430.00
IUUC-Mpu-066559	Mustela putorius furo	95.53	0.00e+00	1027.00
IUUC-Mlu-067361	Myotis lucifugus	91.98	0.00e+00	973.00
IUUC-Nfi-068492	Neosartorya fischeri	64.94	1.00e-128	453.00
IUUC-Ncr-068808	Neurospora crassa	59.63	4.00e-137	481.00
IUUC-Nle-069875	Nomascus leucogenys	96.50	0.00e+00	1041.00
IUUC-Opr-070462	Ochotona princeps	96.24	3.00e-155	541.00
IUUC-Ont-071365	Oreochromis niloticus	76.94	0.00e+00	830.00
IUUC-Oan-072708	Ornithorhynchus anatinus	90.08	0.00e+00	969.00
IUUC-Ocu-074594	Oryctolagus cuniculus	95.73	0.00e+00	1027.00
IUUC-Oba-075570	Oryza barthii	59.61	1.00e-127	449.00
IUUC-Obr-076366	Oryza brachyantha	64.83	1.00e-91	329.00
IUUC-Ogl-077153	Oryza glaberrima	59.61	7.00e-127	447.00
IUUC-Ogu-078540	Oryza glumaepatula	59.61	2.00e-127	449.00
IUUC-Oin-079612	Oryza indica	57.29	1.00e-125	442.00
IUUC-Olo-081077	Oryza longistaminata	57.29	1.00e-125	442.00
IUUC-Ome-081236	Oryza meridionalis	57.03	1.00e-125	442.00
IUUC-Oni-082499	Oryza nivara	59.61	2.00e-127	449.00
IUUC-Opu-083499	Oryza punctata	57.29	2.00e-125	442.00
IUUC-Oru-084276	Oryza rufipogon	59.61	2.00e-127	449.00
IUUC-Osa-085849	Oryza sativa	59.61	2.00e-127	449.00
IUUC-Ola-086655	Oryzias latipes	76.21	0.00e+00	819.00
IUUC-Olu-087637	Ostreococcus lucimarinus	57.77	4.00e-119	421.00
IUUC-Oga-087934	Otolemur garnettii	95.74	0.00e+00	1028.00
IUUC-Oar-090185	Ovis aries	93.22	0.00e+00	998.00
IUUC-Ptr-091198	Pan troglodytes	96.50	0.00e+00	1041.00
IUUC-Pan-092622	Papio anubis	96.30	0.00e+00	1039.00
IUUC-Psi-093320	Pelodiscus sinensis	88.78	0.00e+00	952.00
IUUC-Pma-094638	Petromyzon marinus	76.50	0.00e+00	833.00
IUUC-Pno-094826	Phaeosphaeria nodorum	46.90	1.00e-106	379.00
IUUC-Ppa-095576	Physcomitrella patens	63.99	3.00e-124	438.00
IUUC-Pfo-096894	Poecilia formosa	77.22	0.00e+00	834.00
IUUC-Pab-098020	Pongo abelii	96.50	0.00e+00	1041.00
IUUC-Pop-099180	Populus trichocarpa	48.62	1.00e-127	449.00
IUUC-Pca-100909	Procavia capensis	89.59	0.00e+00	810.00
IUUC-Ppe-101346	Prunus persica	47.44	1.00e-126	446.00
IUUC-Pva-102167	Pteropus vampyrus	77.67	0.00e+00	785.00
IUUC-Pgr-103516	Puccinia graminis	50.10	7.00e-131	460.00
IUUC-Ptt-103738	Puccinia triticina	50.83	2.00e-131	462.00
IUUC-Pte-104352	Pyrenophora teres	58.19	3.00e-131	461.00
IUUC-Pyt-104632	Pyrenophora triticirepentis	58.77	3.00e-132	465.00
IUUC-Sce-106204	Saccharomyces cerevisiae	50.15	3.00e-103	368.00
IUUC-Sha-106943	Sarcophilus harrisii	89.36	0.00e+00	931.00
IUUC-Sja-107659	Schizosaccharomyces japonicus	65.08	1.00e-129	456.00
IUUC-Spo-108049	Schizosaccharomyces pombe	63.72	8.00e-134	470.00
IUUC-Smo-109043	Selaginella moellendorffii	61.38	1.00e-126	446.00
IUUC-Sit-110431	Setaria italica	58.12	1.00e-130	459.00
IUUC-Sly-111391	Solanum lycopersicum	48.74	2.00e-121	429.00
IUUC-Stu-112364	Solanum tuberosum	55.59	1.00e-95	342.00
IUUC-Sar-113450	Sorex araneus	97.13	0.00e+00	714.00
IUUC-Sbi-113829	Sorghum bicolor	50.31	2.00e-130	458.00
IUUC-Sre-115153	Sporisorium reilianum	61.16	4.00e-121	428.00
IUUC-Ssc-115798	Sus scrofa	94.57	0.00e+00	1013.00
IUUC-Tgu-117417	Taeniopygia guttata	89.67	0.00e+00	958.00
IUUC-Tru-117615	Takifugu rubripes	75.83	0.00e+00	783.00
IUUC-Tsy-119480	Tarsius syrichta	96.67	0.00e+00	1035.00
IUUC-Tni-119847	Tetraodon nigroviridis	75.39	0.00e+00	811.00
IUUC-Tca-121287	Theobroma cacao	47.75	2.00e-127	449.00
IUUC-Tre-122010	Trichoderma reesei	65.20	3.00e-143	501.00
IUUC-Tvi-122475	Trichoderma virens	61.46	5.00e-142	497.00
IUUC-Tae-124397	Triticum aestivum	50.31	3.00e-134	471.00
IUUC-Tur-126116	Triticum urartu	42.15	6.00e-101	361.00
IUUC-Tme-126992	Tuber melanosporum	65.55	5.00e-136	478.00
IUUC-Tbe-127803	Tupaia belangeri	84.81	0.00e+00	736.00
IUUC-Ttr-128933	Tursiops truncatus	95.15	0.00e+00	1019.00
IUUC-Uma-129447	Ustilago maydis	59.38	1.00e-116	413.00
IUUC-Vda-129780	Verticillium dahliae	63.82	4.00e-138	484.00
IUUC-Vpa-130557	Vicugna pacos	89.13	2.00e-118	419.00
IUUC-Vvi-130918	Vitis vinifera	47.13	1.00e-122	432.00
IUUC-Xtr-132409	Xenopus tropicalis	84.53	0.00e+00	877.00
IUUC-Xma-133420	Xiphophorus maculatus	77.33	0.00e+00	837.00
IUUC-Yli-134362	Yarrowia lipolytica	47.51	4.00e-121	428.00
IUUC-Zma-135804	Zea mays	56.88	1.00e-125	442.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence