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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046453
Ensembl Protein ID ENSP00000264864.6
UniProt Accession Q8TCG2; Q9NUW2; P4K2B_HUMAN
Genbank Protein ID AAL47580.1; AAL04154.1; AAM12049.1; BAA92006.1; AAH51749.1
Protein Name Phosphatidylinositol 4-kinase type 2-beta; Phosphatidylinositol 4-kinase type II-beta
Genbank Nucleotide ID AY065990; AF411320; AY091514; AK001967; BC051749
Gene Name PI4K2B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000038210.12 ENST00000264864.7 ENSP00000264864.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVar
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UFD/MUB 29.97 6.00e-19 92.40 IUUC-Ath-007357
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
 Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
Protein Sequence
(Fasta)
MEDPSEPDRL ASADGGSPEE EEDGEREPLL PRIAWAHPRR GAPGSAVRLL DAAGEEGEAG 60
DEELPLPPGD VGVSRSSSAE LDRSRPAVSV TIGTSEMNAF LDDPEFADIM LRAEQAIEVG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046453|ULD,MUB|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGGCGCGA GGTGGGGCGC GGCCGGCGGC GAGGCGGGAC AACCGCTGGG CGGGCGCCAA 60
GCGTGCCCGT GCGCTGGTGA GGTGGCGTCC GTTCTACCCG GTCGCTCCCG TTCCGCGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046453|ULD,MUB|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR000403--PI3/4_kinase_cat_dom
Pfam

PF00454--PI3_PI4_kinase
Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0005802--C:trans-Golgi network
GO:0004430--F:1-phosphatidylinositol 4-kinase activity
GO:0005524--F:ATP binding
GO:0007032--P:endosome organization
GO:0007030--P:Golgi organization
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046854--P:phosphatidylinositol phosphorylation
KEGG hsa:55300
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000880 Aegilops tauschii 27.56 2.00e-14 74.70
IUUC-Aml-002168 Ailuropoda melanoleuca 81.22 0.00e+00 766.00
IUUC-Atr-002849 Amborella trichopoda 26.69 1.00e-14 75.50
IUUC-Apl-003641 Anas platyrhynchos 84.46 0.00e+00 692.00
IUUC-Aca-004310 Anolis carolinensis 76.16 0.00e+00 695.00
IUUC-Aly-005869 Arabidopsis lyrata 29.62 1.00e-18 88.20
IUUC-Ath-007357 Arabidopsis thaliana 29.97 9.00e-20 92.00
IUUC-Ago-007834 Ashbya gossypii 38.19 5.00e-60 225.00
IUUC-Acl-008056 Aspergillus clavatus 37.91 5.00e-48 186.00
IUUC-Afl-008443 Aspergillus flavus 32.82 2.00e-65 244.00
IUUC-Afu-008894 Aspergillus fumigatus 31.46 3.00e-57 216.00
IUUC-Ani-009242 Aspergillus nidulans 46.49 5.00e-44 172.00
IUUC-Ang-009698 Aspergillus niger 35.92 6.00e-72 265.00
IUUC-Aor-010129 Aspergillus oryzae 32.82 1.00e-65 244.00
IUUC-Ate-010366 Aspergillus terreus 33.33 7.00e-63 235.00
IUUC-Ame-011505 Astyanax mexicanus 59.84 2.00e-136 478.00
IUUC-Bgr-012207 Blumeria graminis 33.56 9.00e-63 235.00
IUUC-Bta-013130 Bos taurus 80.95 0.00e+00 738.00
IUUC-Bci-013857 Botrytis cinerea 31.42 5.00e-61 229.00
IUUC-Bdi-014227 Brachypodium distachyon 28.11 2.00e-14 74.30
IUUC-Bol-015769 Brassica oleracea 30.07 5.00e-19 89.70
IUUC-Bra-017779 Brassica rapa 29.51 1.00e-17 85.10
IUUC-Cel-018333 Caenorhabditis elegans 38.52 4.00e-65 241.00
IUUC-Cja-019512 Callithrix jacchus 93.97 0.00e+00 893.00
IUUC-Cfa-020046 Canis familiaris 90.91 0.00e+00 735.00
IUUC-Cpo-022524 Cavia porcellus 88.28 0.00e+00 694.00
IUUC-Cre-022842 Chlamydomonas reinhardtii 23.05 5.00e-06 45.10
IUUC-Csa-024215 Chlorocebus sabaeus 96.88 0.00e+00 886.00
IUUC-Cho-024651 Choloepus hoffmanni 75.60 2.00e-168 585.00
IUUC-Cin-025197 Ciona intestinalis 62.24 7.00e-150 523.00
IUUC-Csv-026330 Ciona savignyi 63.45 3.00e-149 521.00
IUUC-Cgl-026422 Colletotrichum gloeosporioides 34.43 4.00e-64 239.00
IUUC-Dre-028161 Danio rerio 79.38 0.00e+00 660.00
IUUC-Dno-029087 Dasypus novemcinctus 80.00 0.00e+00 744.00
IUUC-Dor-031108 Dipodomys ordii 81.54 0.00e+00 724.00
IUUC-Dse-031283 Dothistroma septosporum 32.64 4.00e-61 229.00
IUUC-Dme-032030 Drosophila melanogaster 60.98 5.00e-86 311.00
IUUC-Ete-032358 Echinops telfairi 69.43 8.00e-110 390.00
IUUC-Eca-034170 Equus caballus 87.89 0.00e+00 712.00
IUUC-Eeu-034549 Erinaceus europaeus 86.26 2.00e-94 339.00
IUUC-Fca-035541 Felis catus 82.38 0.00e+00 754.00
IUUC-Fal-037138 Ficedula albicollis 84.54 0.00e+00 689.00
IUUC-Fox-037982 Fusarium oxysporum 44.17 8.00e-43 169.00
IUUC-Fso-038407 Fusarium solani 45.55 4.00e-42 166.00
IUUC-Gmo-039406 Gadus morhua 60.49 5.00e-158 550.00
IUUC-Ggr-040017 Gaeumannomyces graminis 43.00 2.00e-40 160.00
IUUC-Gga-040594 Gallus gallus 83.42 0.00e+00 682.00
IUUC-Gac-041355 Gasterosteus aculeatus 76.09 0.00e+00 634.00
IUUC-Gma-043404 Glycine max 28.43 9.00e-17 82.00
IUUC-Ggo-044615 Gorilla gorilla 99.17 0.00e+00 879.00
IUUC-Hvu-047413 Hordeum vulgare 27.05 4.00e-13 70.10
IUUC-Itr-048839 Ictidomys tridecemlineatus 90.28 0.00e+00 754.00
IUUC-Kpa-049368 Komagataella pastoris 38.11 2.00e-68 253.00
IUUC-Lch-049861 Latimeria chalumnae 79.47 0.00e+00 679.00
IUUC-Lpe-051715 Leersia perrieri 25.98 7.00e-14 72.40
IUUC-Loc-052304 Lepisosteus oculatus 78.79 0.00e+00 671.00
IUUC-Lma-053303 Leptosphaeria maculans 34.59 1.00e-66 248.00
IUUC-Laf-053826 Loxodonta africana 83.26 0.00e+00 761.00
IUUC-Mcc-055372 Macaca mulatta 98.44 0.00e+00 793.00
IUUC-Meu-056312 Macropus eugenii 77.63 5.00e-178 617.00
IUUC-Mor-056958 Magnaporthe oryzae 46.49 2.00e-40 161.00
IUUC-Mpo-057554 Magnaporthe poae 41.83 3.00e-40 160.00
IUUC-Mtr-057995 Medicago truncatula 28.67 6.00e-17 82.80
IUUC-Mla-059000 Melampsora laricipopulina 39.22 3.00e-49 190.00
IUUC-Mga-059856 Meleagris gallopavo 82.82 0.00e+00 682.00
IUUC-Mvi-060280 Microbotryum violaceum 43.65 5.00e-34 140.00
IUUC-Mmr-061773 Microcebus murinus 85.98 0.00e+00 778.00
IUUC-Mdo-061817 Monodelphis domestica 84.69 0.00e+00 696.00
IUUC-Mmu-064384 Mus musculus 80.49 0.00e+00 753.00
IUUC-Mpu-066590 Mustela putorius furo 78.16 0.00e+00 749.00
IUUC-Mlu-067287 Myotis lucifugus 76.29 0.00e+00 697.00
IUUC-Nfi-068333 Neosartorya fischeri 32.66 8.00e-60 225.00
IUUC-Ncr-068800 Neurospora crassa 33.33 8.00e-65 242.00
IUUC-Nle-069534 Nomascus leucogenys 98.13 0.00e+00 888.00
IUUC-Opr-071136 Ochotona princeps 71.65 0.00e+00 627.00
IUUC-Ont-071667 Oreochromis niloticus 77.63 0.00e+00 653.00
IUUC-Oan-073489 Ornithorhynchus anatinus 85.27 0.00e+00 684.00
IUUC-Ocu-074482 Oryctolagus cuniculus 91.60 0.00e+00 761.00
IUUC-Oba-075598 Oryza barthii 25.42 6.00e-14 72.40
IUUC-Obr-076060 Oryza brachyantha 27.21 9.00e-15 75.90
IUUC-Ogl-077532 Oryza glaberrima 28.57 4.00e-16 79.70
IUUC-Ogu-079016 Oryza glumaepatula 25.42 6.00e-14 72.80
IUUC-Oin-079936 Oryza indica 27.05 1.00e-13 71.60
IUUC-Olo-080229 Oryza longistaminata 29.08 3.00e-18 87.00
IUUC-Ome-081235 Oryza meridionalis 25.63 1.00e-14 74.70
IUUC-Oni-082942 Oryza nivara 25.42 6.00e-14 72.80
IUUC-Opu-084094 Oryza punctata 27.53 8.00e-17 82.40
IUUC-Oru-084647 Oryza rufipogon 27.05 2.00e-13 71.20
IUUC-Osa-086157 Oryza sativa 27.05 1.00e-13 71.60
IUUC-Ola-086957 Oryzias latipes 76.29 0.00e+00 629.00
IUUC-Olu-087862 Ostreococcus lucimarinus 24.43 7.00e-10 57.40
IUUC-Oga-088698 Otolemur garnettii 85.28 0.00e+00 787.00
IUUC-Oar-090389 Ovis aries 77.98 0.00e+00 739.00
IUUC-Ptr-090638 Pan troglodytes 98.32 0.00e+00 890.00
IUUC-Pan-092030 Papio anubis 88.64 0.00e+00 783.00
IUUC-Psi-093599 Pelodiscus sinensis 79.36 0.00e+00 692.00
IUUC-Pma-094719 Petromyzon marinus 66.86 9.00e-137 479.00
IUUC-Pno-094843 Phaeosphaeria nodorum 30.69 8.00e-54 205.00
IUUC-Pfo-096221 Poecilia formosa 78.15 0.00e+00 651.00
IUUC-Pab-097653 Pongo abelii 97.51 0.00e+00 883.00
IUUC-Pop-099957 Populus trichocarpa 27.33 1.00e-15 78.20
IUUC-Pca-100747 Procavia capensis 72.43 4.00e-71 262.00
IUUC-Ppe-101716 Prunus persica 26.30 3.00e-14 73.90
IUUC-Pva-102926 Pteropus vampyrus 80.26 0.00e+00 741.00
IUUC-Pte-104342 Pyrenophora teres 41.41 7.00e-38 152.00
IUUC-Rno-105311 Rattus norvegicus 81.60 0.00e+00 759.00
IUUC-Sce-106456 Saccharomyces cerevisiae 34.43 2.00e-58 220.00
IUUC-Sha-106794 Sarcophilus harrisii 85.64 0.00e+00 706.00
IUUC-Sja-107883 Schizosaccharomyces japonicus 37.02 8.00e-60 224.00
IUUC-Spo-108111 Schizosaccharomyces pombe 34.06 7.00e-61 228.00
IUUC-Ssl-108516 Sclerotinia sclerotiorum 31.65 2.00e-60 227.00
IUUC-Smo-108951 Selaginella moellendorffii 29.43 3.00e-13 70.10
IUUC-Sit-110146 Setaria italica 28.83 2.00e-16 80.90
IUUC-Sly-111242 Solanum lycopersicum 27.21 1.00e-16 81.60
IUUC-Stu-111951 Solanum tuberosum 27.92 3.00e-17 83.60
IUUC-Sar-113055 Sorex araneus 84.46 0.00e+00 694.00
IUUC-Sbi-114147 Sorghum bicolor 28.11 9.00e-16 79.00
IUUC-Sre-114896 Sporisorium reilianum 45.39 3.00e-31 130.00
IUUC-Ssc-115853 Sus scrofa 68.22 5.00e-157 547.00
IUUC-Tgu-116711 Taeniopygia guttata 83.63 0.00e+00 688.00
IUUC-Tru-118416 Takifugu rubripes 77.78 0.00e+00 628.00
IUUC-Tsy-119014 Tarsius syrichta 92.06 0.00e+00 776.00
IUUC-Tni-120317 Tetraodon nigroviridis 78.50 0.00e+00 643.00
IUUC-Tca-121419 Theobroma cacao 27.92 9.00e-17 82.00
IUUC-Tre-122021 Trichoderma reesei 43.14 2.00e-41 164.00
IUUC-Tvi-122384 Trichoderma virens 41.67 8.00e-38 152.00
IUUC-Tae-122680 Triticum aestivum 27.92 5.00e-15 76.30
IUUC-Tur-126000 Triticum urartu 26.77 3.00e-13 70.10
IUUC-Tme-127049 Tuber melanosporum 37.80 1.00e-67 251.00
IUUC-Tbe-127365 Tupaia belangeri 81.84 0.00e+00 654.00
IUUC-Ttr-129032 Tursiops truncatus 82.79 0.00e+00 786.00
IUUC-Uma-129477 Ustilago maydis 43.42 4.00e-30 127.00
IUUC-Vda-129801 Verticillium dahliae 33.19 3.00e-63 236.00
IUUC-Vpa-130255 Vicugna pacos 83.33 0.00e+00 663.00
IUUC-Vvi-131314 Vitis vinifera 26.69 2.00e-17 84.30
IUUC-Xtr-132347 Xenopus tropicalis 75.22 0.00e+00 689.00
IUUC-Xma-133726 Xiphophorus maculatus 78.92 0.00e+00 659.00
IUUC-Yli-134389 Yarrowia lipolytica 38.50 2.00e-71 264.00
IUUC-Zma-134858 Zea mays 28.11 2.00e-14 73.90
Created Date 25-Jun-2017

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