iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059967

Ensembl Protein ID

ENSMGAP00000014916.1

UniProt Accession

G1NMT4; G1NMT4_MELGA

Protein Name

Inhibitor of growth protein

Gene Name

ING4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000014098.1	ENSMGAT00000015858.1	ENSMGAP00000014916.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.80e-10	38.9	197	244

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 197  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 244
           69*.*******99..********999***********...899996.******97 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

SEAGDYRRKR TDSIENLPFE LQRNFQLMRD LDQRTEDLKS EIDKLATEYI SNARTLSSEE 60
KLGLLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGAGGCTG GGGATTACAG AAGAAAAAGA ACTGATATTA AGATTCTCAA GCTGAATTTC 60
ATCCCTGCCA TAAATTCTCT TTGTAAGCAA TGATGATTTT CAGTTTTATG TGCCTGTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001338	Ailuropoda melanoleuca	93.12	1.00e-117	414.00
IUUC-Atr-002906	Amborella trichopoda	33.74	1.00e-32	132.00
IUUC-Apl-004097	Anas platyrhynchos	96.36	7.00e-121	425.00
IUUC-Aca-004593	Anolis carolinensis	97.57	1.00e-122	431.00
IUUC-Ame-011133	Astyanax mexicanus	80.72	3.00e-112	396.00
IUUC-Bta-012699	Bos taurus	91.90	1.00e-117	414.00
IUUC-Bdi-014504	Brachypodium distachyon	36.07	1.00e-38	152.00
IUUC-Bol-015245	Brassica oleracea	32.23	2.00e-30	125.00
IUUC-Bra-017027	Brassica rapa	32.64	4.00e-31	127.00
IUUC-Cel-018700	Caenorhabditis elegans	47.27	7.00e-08	52.80
IUUC-Cja-019988	Callithrix jacchus	94.33	4.00e-113	400.00
IUUC-Cfa-021282	Canis familiaris	93.52	4.00e-112	396.00
IUUC-Cpo-022011	Cavia porcellus	93.52	2.00e-121	427.00
IUUC-Cre-022920	Chlamydomonas reinhardtii	34.29	1.00e-28	119.00
IUUC-Csa-023203	Chlorocebus sabaeus	94.33	4.00e-113	400.00
IUUC-Cin-025479	Ciona intestinalis	59.66	2.00e-74	271.00
IUUC-Csv-026288	Ciona savignyi	53.44	3.00e-70	257.00
IUUC-Dre-028264	Danio rerio	80.32	1.00e-110	391.00
IUUC-Dno-029766	Dasypus novemcinctus	92.74	2.00e-110	390.00
IUUC-Dor-031136	Dipodomys ordii	91.46	2.00e-91	328.00
IUUC-Dme-032200	Drosophila melanogaster	89.86	2.00e-40	158.00
IUUC-Eca-033565	Equus caballus	93.93	2.00e-121	427.00
IUUC-Eeu-034948	Erinaceus europaeus	76.52	1.00e-94	338.00
IUUC-Fca-036368	Felis catus	93.93	1.00e-112	398.00
IUUC-Fal-037120	Ficedula albicollis	100.00	3.00e-120	423.00
IUUC-Gmo-038982	Gadus morhua	79.84	7.00e-111	392.00
IUUC-Gga-040771	Gallus gallus	97.57	1.00e-122	431.00
IUUC-Gac-042184	Gasterosteus aculeatus	79.59	2.00e-108	384.00
IUUC-Gma-044339	Glycine max	31.15	2.00e-32	131.00
IUUC-Ggo-045559	Gorilla gorilla	94.33	4.00e-113	400.00
IUUC-Hsa-046852	Homo sapiens	94.33	4.00e-113	400.00
IUUC-Hvu-047046	Hordeum vulgare	36.73	1.00e-37	149.00
IUUC-Itr-047978	Ictidomys tridecemlineatus	93.52	4.00e-121	426.00
IUUC-Kpa-049229	Komagataella pastoris	59.18	1.00e-16	79.70
IUUC-Lpe-050822	Leersia perrieri	34.84	5.00e-38	150.00
IUUC-Laf-054057	Loxodonta africana	93.93	1.00e-112	398.00
IUUC-Mcc-055212	Macaca mulatta	88.35	4.00e-107	380.00
IUUC-Meu-056511	Macropus eugenii	92.74	4.00e-112	396.00
IUUC-Mmr-060843	Microcebus murinus	91.90	9.00e-118	415.00
IUUC-Mdo-062357	Monodelphis domestica	93.12	9.00e-121	425.00
IUUC-Mmu-064093	Mus musculus	93.52	2.00e-121	427.00
IUUC-Mac-064625	Musa acuminata	33.61	4.00e-35	140.00
IUUC-Mpu-066923	Mustela putorius furo	82.19	2.00e-89	321.00
IUUC-Mlu-067754	Myotis lucifugus	86.80	7.00e-110	389.00
IUUC-Nle-069062	Nomascus leucogenys	94.33	4.00e-113	400.00
IUUC-Opr-070207	Ochotona princeps	89.83	2.00e-109	387.00
IUUC-Ont-072446	Oreochromis niloticus	80.24	1.00e-109	388.00
IUUC-Ocu-074235	Oryctolagus cuniculus	93.52	4.00e-112	396.00
IUUC-Obr-076266	Oryza brachyantha	34.84	8.00e-37	146.00
IUUC-Ogl-077118	Oryza glaberrima	33.88	7.00e-36	143.00
IUUC-Oin-079049	Oryza indica	34.78	3.00e-35	141.00
IUUC-Ome-081291	Oryza meridionalis	34.29	2.00e-36	145.00
IUUC-Oni-082218	Oryza nivara	34.78	3.00e-35	141.00
IUUC-Opu-084171	Oryza punctata	34.68	1.00e-36	146.00
IUUC-Osa-085563	Oryza sativa	34.29	2.00e-36	145.00
IUUC-Ola-086429	Oryzias latipes	75.40	3.00e-100	357.00
IUUC-Oga-089123	Otolemur garnettii	93.93	1.00e-112	398.00
IUUC-Oar-089524	Ovis aries	91.90	1.00e-117	414.00
IUUC-Ptr-090908	Pan troglodytes	93.93	1.00e-112	398.00
IUUC-Pan-092837	Papio anubis	93.52	3.00e-118	416.00
IUUC-Psi-093828	Pelodiscus sinensis	99.57	8.00e-118	415.00
IUUC-Ppa-096009	Physcomitrella patens	31.76	6.00e-30	123.00
IUUC-Pfo-096617	Poecilia formosa	79.84	1.00e-109	388.00
IUUC-Pab-097978	Pongo abelii	96.19	2.00e-108	384.00
IUUC-Pop-099415	Populus trichocarpa	73.68	1.00e-26	112.00
IUUC-Pca-100475	Procavia capensis	61.54	1.00e-76	278.00
IUUC-Ppe-101441	Prunus persica	33.33	1.00e-35	142.00
IUUC-Pva-102325	Pteropus vampyrus	93.93	2.00e-121	427.00
IUUC-Rno-105178	Rattus norvegicus	91.90	2.00e-126	444.00
IUUC-Sha-106773	Sarcophilus harrisii	93.12	1.00e-120	425.00
IUUC-Smo-109441	Selaginella moellendorffii	32.38	7.00e-38	149.00
IUUC-Sit-109827	Setaria italica	35.66	1.00e-35	142.00
IUUC-Sly-111750	Solanum lycopersicum	34.84	1.00e-35	142.00
IUUC-Stu-112250	Solanum tuberosum	34.84	1.00e-35	142.00
IUUC-Sbi-114826	Sorghum bicolor	34.02	7.00e-37	146.00
IUUC-Sre-115124	Sporisorium reilianum	51.85	7.00e-23	102.00
IUUC-Ssc-115797	Sus scrofa	92.83	2.00e-103	367.00
IUUC-Tgu-117270	Taeniopygia guttata	97.57	1.00e-122	431.00
IUUC-Tru-118253	Takifugu rubripes	79.12	1.00e-109	388.00
IUUC-Tae-123043	Triticum aestivum	37.05	3.00e-37	147.00
IUUC-Tbe-127558	Tupaia belangeri	93.12	1.00e-117	414.00
IUUC-Ttr-128300	Tursiops truncatus	97.27	5.00e-64	236.00
IUUC-Uma-129581	Ustilago maydis	57.63	2.00e-21	97.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence