iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000030374.15	ENSMUST00000019220.15	ENSMUSP00000019220.8
ENSMUSG00000030374.15	ENSMUST00000108495.8	ENSMUSP00000104135.1
ENSMUSG00000030374.15	ENSMUST00000184280.7	ENSMUSP00000139307.1
ENSMUSG00000030374.15	ENSMUST00000184708.7	ENSMUSP00000139171.1
ENSMUSG00000030374.15	ENSMUST00000184694.1	ENSMUSP00000139113.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.50e-27	94.1	549	582
UBD/Beta-Prp	6.70e-47	161.2	597	759

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           gH d v++laf ++  +l+s+s Dgt+++WD+++
   Q: 549  GHGDAVWGLAFsPTsQRLASCSADGTVRIWDPSS 582
           8***********7779***************765 PP

UBD/Beta-Prp

   S: 10   ksvitcvkf.spdksllatgsrdgtikvwdvttgkllrsl.sgheae...vtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
            +  t+v+f s +  ++++++r+g + ++d++ g++l +l s  +++   +++v  +p++++ +t+++Dr i+  d +tgk vh++ +h
   Q: 597  HGIPTSVAFtSTEPAHVVASFRSGDTVLYDLEAGSALLTLeSRGSSGpaqINQVVSHPSQPLTITAHDDRGIRFLDNRTGKSVHSMVAH 685
           56778999*9999999********************77775444333455*************************************** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdgnllvsGslDrtvrlW 164
            d v++l+++p+g +l sGshd  +r+w l++++c++e     ++h++++  v+ hp++ l++s+++D   +++
   Q: 686  LDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEitaHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
           **************************************999999************************988887 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL (By similarity).

Protein Sequence
(Fasta)

MMEERAAAAV ASAASSCRPL GSGTAPNPTA AAPASSPAPG PGPVGKGGGG GGSPGPTAGP 60
EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL QGERKGQENL KTDLVRRIKM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGATAGGG TTATTATGAC AACCGACTTC CTCTGGTCAG AGCCCACTCC CCACCCCAGG 60
TCGTCTTTTT TGTTTTTTGT TTTTTTTTTC TTCACTAAGT GAAAGAGATG GGGGTGTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013258--Striatin_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08232--Striatin
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043197--C:dendritic spine
GO:0016020--C:membrane
GO:0043234--C:protein complex
GO:0000159--C:protein phosphatase type 2A complex
GO:0070016--F:armadillo repeat domain binding
GO:0032403--F:protein complex binding
GO:0051721--F:protein phosphatase 2A binding

KEGG

mmu:97387

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001946	Ailuropoda melanoleuca	80.03	0.00e+00	1002.00
IUUC-Aca-004552	Anolis carolinensis	78.56	0.00e+00	1011.00
IUUC-Acl-008170	Aspergillus clavatus	26.51	1.00e-26	115.00
IUUC-Ate-010457	Aspergillus terreus	26.27	5.00e-27	116.00
IUUC-Bta-012550	Bos taurus	92.08	0.00e+00	1061.00
IUUC-Cja-018978	Callithrix jacchus	93.23	0.00e+00	956.00
IUUC-Cfa-020268	Canis familiaris	94.74	0.00e+00	1085.00
IUUC-Cpo-022102	Cavia porcellus	95.09	0.00e+00	1110.00
IUUC-Csa-023969	Chlorocebus sabaeus	94.74	0.00e+00	1155.00
IUUC-Dre-027638	Danio rerio	61.29	0.00e+00	814.00
IUUC-Dno-029256	Dasypus novemcinctus	96.16	0.00e+00	667.00
IUUC-Dor-031032	Dipodomys ordii	94.86	0.00e+00	1118.00
IUUC-Eca-033515	Equus caballus	94.90	0.00e+00	1121.00
IUUC-Eeu-035033	Erinaceus europaeus	79.34	6.00e-128	451.00
IUUC-Fca-035749	Felis catus	92.97	0.00e+00	1060.00
IUUC-Gmo-039274	Gadus morhua	60.67	0.00e+00	780.00
IUUC-Gac-042099	Gasterosteus aculeatus	59.94	0.00e+00	790.00
IUUC-Ggo-045406	Gorilla gorilla	95.86	0.00e+00	1134.00
IUUC-Hsa-046341	Homo sapiens	95.13	0.00e+00	1136.00
IUUC-Itr-048200	Ictidomys tridecemlineatus	96.70	0.00e+00	1131.00
IUUC-Lch-049604	Latimeria chalumnae	64.67	0.00e+00	826.00
IUUC-Loc-052671	Lepisosteus oculatus	60.99	0.00e+00	817.00
IUUC-Laf-054531	Loxodonta africana	95.89	0.00e+00	1031.00
IUUC-Mcc-055737	Macaca mulatta	89.86	0.00e+00	1094.00
IUUC-Meu-056845	Macropus eugenii	86.55	0.00e+00	1026.00
IUUC-Mmr-061153	Microcebus murinus	95.39	0.00e+00	1169.00
IUUC-Mdo-062739	Monodelphis domestica	81.48	0.00e+00	966.00
IUUC-Mpu-065794	Mustela putorius furo	92.81	0.00e+00	1014.00
IUUC-Nfi-068560	Neosartorya fischeri	26.02	4.00e-26	113.00
IUUC-Nle-069587	Nomascus leucogenys	86.49	0.00e+00	1001.00
IUUC-Opr-071219	Ochotona princeps	73.95	0.00e+00	815.00
IUUC-Ont-071528	Oreochromis niloticus	56.29	0.00e+00	764.00
IUUC-Ocu-073953	Oryctolagus cuniculus	91.27	0.00e+00	954.00
IUUC-Ola-086888	Oryzias latipes	62.62	4.00e-157	548.00
IUUC-Oga-088280	Otolemur garnettii	96.55	0.00e+00	1150.00
IUUC-Oar-090381	Ovis aries	87.88	0.00e+00	982.00
IUUC-Ptr-090704	Pan troglodytes	92.11	0.00e+00	1077.00
IUUC-Pan-092058	Papio anubis	94.74	0.00e+00	1154.00
IUUC-Psi-093535	Pelodiscus sinensis	72.27	0.00e+00	695.00
IUUC-Pfo-096556	Poecilia formosa	60.03	0.00e+00	791.00
IUUC-Pab-098573	Pongo abelii	95.95	0.00e+00	1110.00
IUUC-Pca-100746	Procavia capensis	90.69	0.00e+00	997.00
IUUC-Pva-102823	Pteropus vampyrus	94.61	0.00e+00	1109.00
IUUC-Rno-105418	Rattus norvegicus	98.57	0.00e+00	1167.00
IUUC-Ssc-116050	Sus scrofa	94.00	0.00e+00	892.00
IUUC-Tru-117971	Takifugu rubripes	61.12	0.00e+00	805.00
IUUC-Tni-120522	Tetraodon nigroviridis	62.18	0.00e+00	821.00
IUUC-Tbe-128127	Tupaia belangeri	94.96	0.00e+00	639.00
IUUC-Ttr-128911	Tursiops truncatus	87.99	0.00e+00	1024.00
IUUC-Vda-129673	Verticillium dahliae	25.36	3.00e-28	120.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence