iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045677

UUCD1 version

UUC-HoS-00134

Ensembl Protein ID

ENSP00000369427.2

UniProt Accession

Q16576; Q5JP00; RBBP7_HUMAN

Genbank Protein ID

AAC50231.1; CAA51360.1; BAG52439.1; ENSP00000369424

Protein Name

Histone-binding protein RBBP7; Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46

Genbank Nucleotide ID

U35143; X72841; AK091911; AL929302

Gene Name

RBBP7; RBAP46

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000102054.17	ENST00000380087.6	ENSP00000369427.2
ENSG00000102054.17	ENST00000380084.8	ENSP00000369424.4
ENSG00000102054.17	ENST00000404022.5	ENSP00000386068.1
ENSG00000102054.17	ENST00000444437.5	ENSP00000402796.1
ENSG00000102054.17	ENST00000416035.1	ENSP00000392714.1
ENSG00000102054.17	ENST00000493145.1	ENSP00000417507.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-37	126.7	271	305

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           Ht++v+cl+f   s+ +l++Gs D+t+ +WDlr  
   Q: 271  HTAEVNCLSFnpySEFILATGSADKTVALWDLRNL 305
           **********96554568*************9875 PP

Organism

Homo sapiens

Functional Description
(View)

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Protein Sequence
(Fasta)

MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY 60
ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGEFGGFGSV TGKIECEIKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCTCGGCG CCGGAGCCGT TGGCTCCCAG ACCCGCCTCT CCGCCTCCTC TCACTTTTCC 60
CAGGGCGGAT GCGCCTGCGC TCAGCTGCCT GGGCGGGCTG GGAGGCGCGG GTTGAAAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0004407--F:histone deacetylase activity
GO:0003723--F:RNA binding
GO:0008283--P:cell proliferation
GO:0070370--P:cellular heat acclimation
GO:0034080--P:CENP-A containing nucleosome assembly
GO:0006260--P:DNA replication
GO:0007275--P:multicellular organism development
GO:0030308--P:negative regulation of cell growth
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0048545--P:response to steroid hormone
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:5931

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001256	Ailuropoda melanoleuca	99.05	0.00e+00	867.00
IUUC-Apl-003357	Anas platyrhynchos	92.07	0.00e+00	809.00
IUUC-Bta-013455	Bos taurus	99.53	0.00e+00	877.00
IUUC-Cja-019957	Callithrix jacchus	99.29	0.00e+00	868.00
IUUC-Cfa-020917	Canis familiaris	99.05	0.00e+00	869.00
IUUC-Cpo-022173	Cavia porcellus	100.00	0.00e+00	881.00
IUUC-Csa-023738	Chlorocebus sabaeus	100.00	0.00e+00	881.00
IUUC-Dno-029206	Dasypus novemcinctus	99.76	0.00e+00	879.00
IUUC-Dor-030733	Dipodomys ordii	86.02	0.00e+00	737.00
IUUC-Eca-034138	Equus caballus	99.05	0.00e+00	868.00
IUUC-Fca-035977	Felis catus	99.05	0.00e+00	868.00
IUUC-Fal-037538	Ficedula albicollis	90.05	0.00e+00	797.00
IUUC-Gga-040764	Gallus gallus	93.65	0.00e+00	828.00
IUUC-Itr-048060	Ictidomys tridecemlineatus	100.00	0.00e+00	868.00
IUUC-Kpa-049258	Komagataella pastoris	36.65	9.00e-71	260.00
IUUC-Laf-053973	Loxodonta africana	98.83	0.00e+00	869.00
IUUC-Mcc-055687	Macaca mulatta	100.00	0.00e+00	881.00
IUUC-Mga-059209	Meleagris gallopavo	90.82	0.00e+00	795.00
IUUC-Mmr-061008	Microcebus murinus	99.29	0.00e+00	870.00
IUUC-Mdo-062817	Monodelphis domestica	96.24	0.00e+00	850.00
IUUC-Mmu-063773	Mus musculus	99.76	0.00e+00	879.00
IUUC-Mpu-066722	Mustela putorius furo	99.05	0.00e+00	867.00
IUUC-Mlu-067813	Myotis lucifugus	99.05	0.00e+00	868.00
IUUC-Nle-070023	Nomascus leucogenys	99.29	0.00e+00	869.00
IUUC-Oan-073579	Ornithorhynchus anatinus	95.29	0.00e+00	842.00
IUUC-Ocu-074778	Oryctolagus cuniculus	99.76	0.00e+00	879.00
IUUC-Oga-088987	Otolemur garnettii	92.20	0.00e+00	785.00
IUUC-Oar-090250	Ovis aries	98.82	0.00e+00	862.00
IUUC-Ptr-091598	Pan troglodytes	99.76	0.00e+00	869.00
IUUC-Pan-092412	Papio anubis	100.00	0.00e+00	881.00
IUUC-Psi-093162	Pelodiscus sinensis	95.13	0.00e+00	773.00
IUUC-Pab-097865	Pongo abelii	100.00	0.00e+00	881.00
IUUC-Pva-102369	Pteropus vampyrus	99.05	0.00e+00	869.00
IUUC-Rno-105892	Rattus norvegicus	100.00	0.00e+00	881.00
IUUC-Sha-107575	Sarcophilus harrisii	95.29	0.00e+00	840.00
IUUC-Sar-113236	Sorex araneus	90.84	0.00e+00	768.00
IUUC-Ssc-116352	Sus scrofa	99.05	0.00e+00	870.00
IUUC-Tsy-118854	Tarsius syrichta	99.29	0.00e+00	869.00
IUUC-Tbe-128010	Tupaia belangeri	88.15	0.00e+00	762.00
IUUC-Ttr-128558	Tursiops truncatus	87.38	0.00e+00	743.00
IUUC-Vpa-130664	Vicugna pacos	99.29	0.00e+00	865.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence