iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
circBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.70e-13	49.2	435	467

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 6    vtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
            tc++   s  +l+vsG+ D  +++ Dlr+++ 
   Q: 435  FTCVNIrdSPpNLMVSGNMDRRVRIHDLRSDKI 467
           589999973359*****************9875 PP

Organism

Mus musculus

Functional Description
(View)

Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity).

Protein Sequence
(Fasta)

MDDHNLEEFR RHWQEELAQS QALRRRRRLE AGERRSPRRP EAGARGEPAS GYLGLAQGLL 60
EGAGRPPAPR PGRGGDRKDT SSRSRSPPDR DATEPEPLVD QLIRDLNELD DVPFFDVRLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTACGGAC ACTTCCGGCG GATGGACAGT CCGTCCCCAT TCTGGCAGCC CCTGGGTGCC 60
GCGTCGGCCT GGGCGCGTCA AGCATGGACG ACCACAACCT GGAGGAGTTC CGCCGGCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0060712--P:spongiotrophoblast layer development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:231672

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	86.49	0.00e+00	942.00
IUUC-Apl-003239	Anas platyrhynchos	60.33	0.00e+00	689.00
IUUC-Aca-004756	Anolis carolinensis	59.11	8.00e-135	473.00
IUUC-Ame-011198	Astyanax mexicanus	47.33	3.00e-57	215.00
IUUC-Bta-012430	Bos taurus	54.16	1.00e-141	496.00
IUUC-Cja-019131	Callithrix jacchus	74.58	0.00e+00	843.00
IUUC-Cfa-021022	Canis familiaris	78.20	0.00e+00	915.00
IUUC-Cpo-021898	Cavia porcellus	78.44	0.00e+00	933.00
IUUC-Csa-023452	Chlorocebus sabaeus	77.59	0.00e+00	910.00
IUUC-Cho-024759	Choloepus hoffmanni	72.12	0.00e+00	796.00
IUUC-Dre-028123	Danio rerio	46.11	3.00e-147	515.00
IUUC-Dno-029045	Dasypus novemcinctus	87.75	0.00e+00	853.00
IUUC-Dor-030433	Dipodomys ordii	77.68	0.00e+00	774.00
IUUC-Ete-032465	Echinops telfairi	81.25	0.00e+00	766.00
IUUC-Eca-034134	Equus caballus	86.99	0.00e+00	909.00
IUUC-Eeu-035047	Erinaceus europaeus	75.76	0.00e+00	777.00
IUUC-Fca-036574	Felis catus	87.14	0.00e+00	895.00
IUUC-Fal-037665	Ficedula albicollis	59.48	1.00e-174	606.00
IUUC-Gmo-039137	Gadus morhua	39.53	5.00e-68	251.00
IUUC-Gga-040711	Gallus gallus	62.20	0.00e+00	664.00
IUUC-Gac-041675	Gasterosteus aculeatus	52.63	2.00e-55	208.00
IUUC-Ggo-045331	Gorilla gorilla	81.10	0.00e+00	832.00
IUUC-Hsa-046240	Homo sapiens	77.96	0.00e+00	899.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	88.21	0.00e+00	890.00
IUUC-Loc-052631	Lepisosteus oculatus	50.26	2.00e-167	582.00
IUUC-Laf-054127	Loxodonta africana	78.32	7.00e-63	232.00
IUUC-Mcc-055083	Macaca mulatta	78.13	0.00e+00	893.00
IUUC-Mga-060113	Meleagris gallopavo	61.02	0.00e+00	652.00
IUUC-Mmr-061780	Microcebus murinus	83.83	0.00e+00	938.00
IUUC-Mdo-063066	Monodelphis domestica	59.51	0.00e+00	711.00
IUUC-Mpu-066913	Mustela putorius furo	86.77	0.00e+00	914.00
IUUC-Mlu-067924	Myotis lucifugus	82.64	0.00e+00	932.00
IUUC-Nle-069558	Nomascus leucogenys	77.87	0.00e+00	850.00
IUUC-Opr-070506	Ochotona princeps	86.13	0.00e+00	909.00
IUUC-Ont-071514	Oreochromis niloticus	45.91	3.00e-148	518.00
IUUC-Ocu-074477	Oryctolagus cuniculus	85.98	0.00e+00	879.00
IUUC-Ola-087416	Oryzias latipes	45.06	3.00e-147	515.00
IUUC-Oga-088643	Otolemur garnettii	81.94	0.00e+00	939.00
IUUC-Oar-090172	Ovis aries	85.57	0.00e+00	892.00
IUUC-Ptr-090870	Pan troglodytes	78.09	0.00e+00	903.00
IUUC-Pan-092017	Papio anubis	77.13	0.00e+00	899.00
IUUC-Psi-093794	Pelodiscus sinensis	62.63	0.00e+00	654.00
IUUC-Pfo-096192	Poecilia formosa	50.29	4.00e-149	521.00
IUUC-Pab-097882	Pongo abelii	77.09	0.00e+00	890.00
IUUC-Pca-100902	Procavia capensis	73.62	9.00e-141	493.00
IUUC-Pva-103139	Pteropus vampyrus	82.80	0.00e+00	951.00
IUUC-Rno-105798	Rattus norvegicus	95.46	0.00e+00	1011.00
IUUC-Sha-106576	Sarcophilus harrisii	62.02	0.00e+00	676.00
IUUC-Ssc-115923	Sus scrofa	73.03	0.00e+00	879.00
IUUC-Tgu-116667	Taeniopygia guttata	55.73	3.00e-117	415.00
IUUC-Tru-118323	Takifugu rubripes	43.85	6.00e-144	504.00
IUUC-Tsy-118818	Tarsius syrichta	75.59	6.00e-109	387.00
IUUC-Tni-120438	Tetraodon nigroviridis	42.65	2.00e-139	489.00
IUUC-Tbe-127784	Tupaia belangeri	91.26	5.00e-111	394.00
IUUC-Ttr-128288	Tursiops truncatus	73.41	0.00e+00	799.00
IUUC-Vpa-130307	Vicugna pacos	81.10	0.00e+00	772.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence