iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063569

UUCD1 version

UUC-MuM-00032

Ensembl Protein ID

ENSMUSP00000124710.1

UniProt Accession

Q7TPH6; Q6PCM8; MYCB2_MOUSE

Genbank Protein ID

AAP88591.1; AAH59257.1

Protein Name

E3 ubiquitin-protein ligase MYCBP2; Myc-binding protein 2; Pam/highwire/rpm-1 protein; Protein associated with Myc; RING-type E3 ubiquitin transferase MYCBP2

Genbank Nucleotide ID

AY325887; BC059257

Gene Name

Mycbp2; Pam; Phr1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000033004.14	ENSMUST00000159855.7	ENSMUSP00000124710.1
ENSMUSG00000033004.14	ENSMUST00000161278.1	ENSMUSP00000125189.1
ENSMUSG00000033004.14	ENSMUST00000161008.7	ENSMUSP00000124443.1
ENSMUSG00000033004.14	ENSMUST00000160758.7	ENSMUSP00000124601.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20534529; 20203175; 20592256

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	62.76	0.00e+00	727.00	IUUC-Dme-031777

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (By similarity). May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.

Protein Sequence
(Fasta)

MMMCAATASP AAASSGPGGD GFFAAATISS SPAPGALFMP VPDGSVAAAG LGLGLPTTDS 60
RGHYQLLLSG RALADRYRRI YTTALSDRDQ AGSSTGHPAS RNKKILNKKK LKRKQKSKSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCATTGCG GGCAACTCCG GTGGTGGCAG CAGCAGCGGC GGCGGCGGCA CCGCCTCCTC 60
CTCACACTCC GCGGGTGGCG GGGTTAGATG AGCGGCCCCA ACAGCGGCGA GGGCGGCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR017868--Filamin/ABP280_repeat-like
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR012983--PHR
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003646--SH3-like_bac-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51284--DOC
PS50194--FILAMIN_REPEAT
PS00626--RCC1_2
PS50012--RCC1_3
PS50089--ZF_RING_2

Pfam

PF03256--ANAPC10
PF00630--Filamin
PF08005--PHR
PF00415--RCC1
PF08239--SH3_3
PF13639--zf-RING_2

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM00184--RING

Gene Ontology

GO:0030424--C:axon
GO:0016020--C:membrane
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0021785--P:branchiomotor neuron axon guidance
GO:0048667--P:cell morphogenesis involved in neuron differentiation
GO:0021952--P:central nervous system projection neuron axonogenesis
GO:0008045--P:motor neuron axon guidance
GO:0042177--P:negative regulation of protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0051493--P:regulation of cytoskeleton organization
GO:0032880--P:regulation of protein localization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:105689

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001951	Ailuropoda melanoleuca	97.24	0.00e+00	8628.00
IUUC-Apl-003625	Anas platyrhynchos	91.84	0.00e+00	8114.00
IUUC-Aca-005207	Anolis carolinensis	91.35	0.00e+00	8043.00
IUUC-Ame-010649	Astyanax mexicanus	85.04	0.00e+00	7691.00
IUUC-Bta-012670	Bos taurus	95.64	0.00e+00	8533.00
IUUC-Cel-018686	Caenorhabditis elegans	32.47	0.00e+00	660.00
IUUC-Cja-019910	Callithrix jacchus	95.48	0.00e+00	8569.00
IUUC-Cfa-020184	Canis familiaris	96.82	0.00e+00	8685.00
IUUC-Cpo-021334	Cavia porcellus	94.73	0.00e+00	8424.00
IUUC-Csa-023291	Chlorocebus sabaeus	97.20	0.00e+00	8777.00
IUUC-Cho-024927	Choloepus hoffmanni	89.86	0.00e+00	856.00
IUUC-Cin-025345	Ciona intestinalis	53.78	0.00e+00	942.00
IUUC-Csv-026264	Ciona savignyi	50.38	0.00e+00	1095.00
IUUC-Dre-028645	Danio rerio	84.14	0.00e+00	7616.00
IUUC-Dno-029670	Dasypus novemcinctus	94.35	0.00e+00	8416.00
IUUC-Dor-030993	Dipodomys ordii	90.96	0.00e+00	2398.00
IUUC-Dme-031777	Drosophila melanogaster	62.57	0.00e+00	725.00
IUUC-Ete-032613	Echinops telfairi	90.33	0.00e+00	8023.00
IUUC-Eca-034364	Equus caballus	97.07	0.00e+00	8735.00
IUUC-Eeu-035200	Erinaceus europaeus	79.12	0.00e+00	2510.00
IUUC-Fca-036054	Felis catus	94.32	0.00e+00	8488.00
IUUC-Fal-036991	Ficedula albicollis	93.24	0.00e+00	8255.00
IUUC-Gmo-038487	Gadus morhua	85.25	0.00e+00	4133.00
IUUC-Gga-041035	Gallus gallus	92.45	0.00e+00	8260.00
IUUC-Gac-041637	Gasterosteus aculeatus	84.79	0.00e+00	4082.00
IUUC-Ggo-045091	Gorilla gorilla	94.36	0.00e+00	7307.00
IUUC-Hsa-046977	Homo sapiens	95.42	0.00e+00	8557.00
IUUC-Itr-048995	Ictidomys tridecemlineatus	94.00	0.00e+00	2503.00
IUUC-Lch-050171	Latimeria chalumnae	73.46	0.00e+00	1243.00
IUUC-Loc-052822	Lepisosteus oculatus	86.81	0.00e+00	7799.00
IUUC-Laf-054065	Loxodonta africana	96.86	0.00e+00	8711.00
IUUC-Mcc-054947	Macaca mulatta	97.24	0.00e+00	8786.00
IUUC-Meu-056600	Macropus eugenii	89.58	0.00e+00	1516.00
IUUC-Mga-059559	Meleagris gallopavo	91.23	0.00e+00	7438.00
IUUC-Mmr-060973	Microcebus murinus	96.69	0.00e+00	7176.00
IUUC-Mdo-061938	Monodelphis domestica	91.80	0.00e+00	5031.00
IUUC-Mpu-066457	Mustela putorius furo	97.31	0.00e+00	8661.00
IUUC-Mlu-067165	Myotis lucifugus	95.29	0.00e+00	8103.00
IUUC-Nle-069042	Nomascus leucogenys	95.14	0.00e+00	8589.00
IUUC-Opr-070201	Ochotona princeps	82.31	0.00e+00	2817.00
IUUC-Ont-072263	Oreochromis niloticus	83.55	0.00e+00	7418.00
IUUC-Oan-073108	Ornithorhynchus anatinus	91.56	0.00e+00	6917.00
IUUC-Ocu-074359	Oryctolagus cuniculus	95.67	0.00e+00	6999.00
IUUC-Ola-087074	Oryzias latipes	81.29	0.00e+00	5023.00
IUUC-Oga-088322	Otolemur garnettii	95.42	0.00e+00	8569.00
IUUC-Oar-089244	Ovis aries	96.70	0.00e+00	8630.00
IUUC-Ptr-091449	Pan troglodytes	95.00	0.00e+00	8560.00
IUUC-Pan-091756	Papio anubis	96.47	0.00e+00	5074.00
IUUC-Psi-093387	Pelodiscus sinensis	91.33	0.00e+00	6182.00
IUUC-Pma-094327	Petromyzon marinus	71.05	4.00e-119	421.00
IUUC-Ppa-095276	Physcomitrella patens	40.38	7.00e-56	211.00
IUUC-Pfo-097372	Poecilia formosa	84.19	0.00e+00	7524.00
IUUC-Pab-097572	Pongo abelii	96.05	0.00e+00	7200.00
IUUC-Pca-101007	Procavia capensis	91.93	0.00e+00	4009.00
IUUC-Pva-102217	Pteropus vampyrus	89.99	0.00e+00	4274.00
IUUC-Rno-105422	Rattus norvegicus	96.12	0.00e+00	8409.00
IUUC-Sha-107119	Sarcophilus harrisii	86.14	0.00e+00	3929.00
IUUC-Smo-108712	Selaginella moellendorffii	39.60	5.00e-57	214.00
IUUC-Sar-113595	Sorex araneus	94.50	0.00e+00	2315.00
IUUC-Ssc-115690	Sus scrofa	95.37	0.00e+00	8229.00
IUUC-Tgu-116555	Taeniopygia guttata	91.49	0.00e+00	7670.00
IUUC-Tru-117796	Takifugu rubripes	83.22	0.00e+00	7535.00
IUUC-Tsy-118924	Tarsius syrichta	91.96	0.00e+00	5579.00
IUUC-Tni-120759	Tetraodon nigroviridis	82.85	0.00e+00	7452.00
IUUC-Ttr-128814	Tursiops truncatus	93.68	0.00e+00	3643.00
IUUC-Vpa-130430	Vicugna pacos	92.22	0.00e+00	8097.00
IUUC-Xtr-131898	Xenopus tropicalis	86.69	0.00e+00	1567.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence