iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.10e-25	87.0	81	117

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
           H++ vtcl+f  + +l+sG+ Dg i +WD+++ ++lk
   Q: 81   HAGTVTCLKFhGNQHLISGAEDGHICIWDVKRWKCLK 117
           999*******7449****************9998887 PP

Organism

Mus musculus

Functional Description
(View)

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 (By similarity).

Protein Sequence
(Fasta)

MELVAGSYEQ VLFGFTVQRG PAKSGHQETW TPVADFTHHS HTASLSVLAS NSRYVVSGSK 60
DETIHIYDMK RKVEHGALVH HAGTVTCLKF HGNQHLISGA EDGHICIWDV KRWKCLKTFK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTTCCCAA GGCCGGCGGA GCCCACGGCT TCCCAGGACT TGCCTGCTTG ACACAACTTT 60
TCTTTCTCTC TGCTCTGAGA GCCTCCTCCC GCGGCTTCCT TCCTTAAGCT CGTCGCAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0734--Signal transduction inhibitor
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0008283--P:cell proliferation
GO:0009968--P:negative regulation of signal transduction
GO:0060021--P:palate development

KEGG

mmu:68083

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001803	Ailuropoda melanoleuca	74.93	2.00e-167	581.00
IUUC-Atr-003018	Amborella trichopoda	32.59	1.00e-43	170.00
IUUC-Apl-004199	Anas platyrhynchos	68.46	4.00e-121	427.00
IUUC-Aca-005157	Anolis carolinensis	67.32	2.00e-118	418.00
IUUC-Aly-006245	Arabidopsis lyrata	31.76	4.00e-38	151.00
IUUC-Ath-007309	Arabidopsis thaliana	32.08	5.00e-39	154.00
IUUC-Ago-007878	Ashbya gossypii	29.94	4.00e-33	135.00
IUUC-Acl-008015	Aspergillus clavatus	21.05	6.00e-15	75.90
IUUC-Afu-008760	Aspergillus fumigatus	22.94	1.00e-17	84.70
IUUC-Ame-011121	Astyanax mexicanus	51.99	2.00e-105	375.00
IUUC-Bgr-012152	Blumeria graminis	23.04	2.00e-13	70.10
IUUC-Bta-012383	Bos taurus	71.84	8.00e-162	563.00
IUUC-Bdi-014505	Brachypodium distachyon	25.95	1.00e-15	77.00
IUUC-Bol-015458	Brassica oleracea	32.39	3.00e-40	159.00
IUUC-Bra-017790	Brassica rapa	32.70	3.00e-41	162.00
IUUC-Cja-018803	Callithrix jacchus	68.80	3.00e-143	501.00
IUUC-Cfa-020178	Canis familiaris	72.78	3.00e-164	571.00
IUUC-Cpo-021785	Cavia porcellus	70.21	2.00e-159	555.00
IUUC-Cre-022703	Chlamydomonas reinhardtii	31.45	4.00e-36	146.00
IUUC-Csa-023179	Chlorocebus sabaeus	72.09	2.00e-162	565.00
IUUC-Cho-025088	Choloepus hoffmanni	75.77	1.00e-127	449.00
IUUC-Cin-025484	Ciona intestinalis	32.76	2.00e-20	92.40
IUUC-Csv-025887	Ciona savignyi	36.59	2.00e-48	186.00
IUUC-Cne-027021	Cryptococcus neoformans	27.95	3.00e-26	114.00
IUUC-Dre-027360	Danio rerio	58.70	3.00e-110	391.00
IUUC-Dno-029836	Dasypus novemcinctus	75.77	2.00e-161	561.00
IUUC-Dor-030677	Dipodomys ordii	80.00	2.00e-140	491.00
IUUC-Dse-031177	Dothistroma septosporum	22.97	3.00e-17	83.60
IUUC-Dme-032004	Drosophila melanogaster	31.40	3.00e-31	129.00
IUUC-Ete-032837	Echinops telfairi	78.21	4.00e-136	477.00
IUUC-Eca-033291	Equus caballus	74.54	7.00e-170	589.00
IUUC-Eeu-035347	Erinaceus europaeus	78.78	2.00e-135	474.00
IUUC-Fca-036577	Felis catus	72.36	6.00e-159	553.00
IUUC-Fal-036810	Ficedula albicollis	61.54	4.00e-120	424.00
IUUC-Fso-038338	Fusarium solani	28.90	1.00e-16	81.60
IUUC-Gmo-038537	Gadus morhua	63.50	4.00e-106	377.00
IUUC-Gga-040566	Gallus gallus	59.09	6.00e-129	453.00
IUUC-Gac-042422	Gasterosteus aculeatus	57.69	2.00e-117	416.00
IUUC-Gma-044199	Glycine max	30.57	1.00e-33	136.00
IUUC-Ggo-045365	Gorilla gorilla	63.03	5.00e-134	470.00
IUUC-Hsa-046121	Homo sapiens	74.10	9.00e-165	572.00
IUUC-Itr-048361	Ictidomys tridecemlineatus	74.26	1.00e-152	532.00
IUUC-Kpa-049407	Komagataella pastoris	32.01	1.00e-39	157.00
IUUC-Lch-049767	Latimeria chalumnae	64.69	4.00e-122	431.00
IUUC-Lpe-051569	Leersia perrieri	27.02	5.00e-19	88.60
IUUC-Loc-051940	Lepisosteus oculatus	54.34	2.00e-110	392.00
IUUC-Lma-053288	Leptosphaeria maculans	23.58	2.00e-17	83.60
IUUC-Laf-054463	Loxodonta africana	72.09	8.00e-161	559.00
IUUC-Mcc-055412	Macaca mulatta	72.36	6.00e-163	566.00
IUUC-Mtr-057886	Medicago truncatula	31.51	3.00e-31	129.00
IUUC-Mla-058862	Melampsora laricipopulina	24.18	4.00e-19	89.40
IUUC-Mga-060109	Meleagris gallopavo	59.94	5.00e-122	430.00
IUUC-Mvi-060326	Microbotryum violaceum	25.55	3.00e-28	120.00
IUUC-Mmr-060681	Microcebus murinus	72.43	5.00e-160	557.00
IUUC-Mdo-063004	Monodelphis domestica	69.02	2.00e-152	531.00
IUUC-Mac-064987	Musa acuminata	30.57	2.00e-34	139.00
IUUC-Mpu-065847	Mustela putorius furo	72.68	6.00e-171	593.00
IUUC-Mlu-067608	Myotis lucifugus	73.42	1.00e-169	589.00
IUUC-Nfi-068531	Neosartorya fischeri	22.94	1.00e-17	84.70
IUUC-Nle-069302	Nomascus leucogenys	72.90	3.00e-164	571.00
IUUC-Ont-072591	Oreochromis niloticus	60.93	2.00e-101	362.00
IUUC-Oan-073558	Ornithorhynchus anatinus	64.86	1.00e-115	409.00
IUUC-Ocu-074558	Oryctolagus cuniculus	72.63	8.00e-151	526.00
IUUC-Ogl-076960	Oryza glaberrima	27.50	3.00e-25	108.00
IUUC-Ogu-078660	Oryza glumaepatula	28.44	1.00e-22	100.00
IUUC-Oin-079790	Oryza indica	27.67	1.00e-28	120.00
IUUC-Ome-081631	Oryza meridionalis	25.26	2.00e-14	72.80
IUUC-Oni-083082	Oryza nivara	27.36	1.00e-24	107.00
IUUC-Opu-083394	Oryza punctata	26.50	1.00e-26	113.00
IUUC-Oru-084461	Oryza rufipogon	26.71	7.00e-23	101.00
IUUC-Osa-085655	Oryza sativa	27.69	8.00e-22	97.10
IUUC-Ola-086955	Oryzias latipes	63.04	5.00e-118	417.00
IUUC-Olu-087657	Ostreococcus lucimarinus	28.22	3.00e-22	99.80
IUUC-Oga-088108	Otolemur garnettii	71.04	3.00e-157	547.00
IUUC-Oar-090019	Ovis aries	70.53	7.00e-161	560.00
IUUC-Ptr-091544	Pan troglodytes	73.17	6.00e-165	573.00
IUUC-Pan-092562	Papio anubis	72.36	2.00e-162	565.00
IUUC-Psi-094025	Pelodiscus sinensis	62.30	4.00e-99	354.00
IUUC-Pma-094322	Petromyzon marinus	55.47	1.00e-95	342.00
IUUC-Ppa-095541	Physcomitrella patens	34.57	4.00e-40	158.00
IUUC-Pfo-096667	Poecilia formosa	59.38	2.00e-95	342.00
IUUC-Pab-098064	Pongo abelii	72.63	4.00e-163	567.00
IUUC-Pop-099969	Populus trichocarpa	34.81	5.00e-39	154.00
IUUC-Pca-101053	Procavia capensis	78.19	2.00e-155	541.00
IUUC-Ppe-101839	Prunus persica	34.08	1.00e-42	166.00
IUUC-Pva-102963	Pteropus vampyrus	73.02	1.00e-157	549.00
IUUC-Pgr-103276	Puccinia graminis	27.83	1.00e-18	87.80
IUUC-Pte-104117	Pyrenophora teres	25.37	5.00e-16	79.30
IUUC-Pyt-104649	Pyrenophora triticirepentis	25.00	2.00e-15	77.40
IUUC-Rno-105975	Rattus norvegicus	83.51	0.00e+00	662.00
IUUC-Sce-106226	Saccharomyces cerevisiae	26.99	6.00e-32	132.00
IUUC-Sha-106907	Sarcophilus harrisii	66.49	1.00e-154	539.00
IUUC-Sja-107867	Schizosaccharomyces japonicus	25.73	2.00e-22	99.80
IUUC-Spo-108377	Schizosaccharomyces pombe	28.62	2.00e-24	106.00
IUUC-Smo-109068	Selaginella moellendorffii	30.87	2.00e-33	136.00
IUUC-Sit-110114	Setaria italica	26.42	4.00e-20	92.00
IUUC-Sly-111581	Solanum lycopersicum	33.87	3.00e-38	152.00
IUUC-Stu-112770	Solanum tuberosum	33.55	3.00e-37	149.00
IUUC-Sbi-114797	Sorghum bicolor	25.77	1.00e-15	77.40
IUUC-Sre-114941	Sporisorium reilianum	27.99	1.00e-34	140.00
IUUC-Ssc-116346	Sus scrofa	72.31	8.00e-155	539.00
IUUC-Tgu-116628	Taeniopygia guttata	65.02	2.00e-125	441.00
IUUC-Tru-117646	Takifugu rubripes	60.73	3.00e-106	378.00
IUUC-Tsy-119593	Tarsius syrichta	56.59	3.00e-124	438.00
IUUC-Tni-119872	Tetraodon nigroviridis	60.26	6.00e-113	400.00
IUUC-Tca-121500	Theobroma cacao	33.44	4.00e-39	155.00
IUUC-Tre-122151	Trichoderma reesei	23.94	2.00e-17	83.60
IUUC-Tae-125015	Triticum aestivum	27.22	2.00e-22	100.00
IUUC-Tbe-127959	Tupaia belangeri	76.55	6.00e-135	473.00
IUUC-Ttr-129125	Tursiops truncatus	71.92	1.00e-160	559.00
IUUC-Uma-129567	Ustilago maydis	30.56	1.00e-32	134.00
IUUC-Vpa-130157	Vicugna pacos	79.39	6.00e-78	283.00
IUUC-Vvi-131065	Vitis vinifera	33.55	6.00e-36	144.00
IUUC-Xtr-132601	Xenopus tropicalis	61.09	3.00e-109	388.00
IUUC-Xma-133142	Xiphophorus maculatus	61.72	3.00e-102	365.00
IUUC-Yli-134580	Yarrowia lipolytica	30.80	2.00e-32	133.00
IUUC-Zma-135330	Zea mays	29.28	2.00e-28	119.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence