iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.90e-17	62.0	260	298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           H+++++ ++f  s+ ++l ++s Dg++  WD +t+ ++k
   Q: 260  HEAEMWEVHFhpSNpDHLFTCSEDGSLWHWDASTDAPEK 298
           99999******8778****************99988776 PP

Organism

Mus musculus

Functional Description
(View)

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity).

Protein Sequence
(Fasta)

MEEIYAKFVS QKISKTRWRP VPSGSLQTTE TFATGSWDNE ENCVSLWSIG DFGNLDSDGG 60
FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF LHHPNNQTLS VNQQWPAAHY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGGGCC TGAGGAGCGC GCAGTGTGCT TTCTGCTGAA CCTTCTTGCT GGTTTCAGCA 60
TGGAGGAAAT TTATGCTAAG TTCGTGTCTC AGAAAATTAG CAAAACCCGC TGGCGGCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0031080--C:nuclear pore outer ring
GO:0051301--P:cell division
GO:0007059--P:chromosome segregation
GO:0007067--P:mitotic nuclear division
GO:0051028--P:mRNA transport
GO:0015031--P:protein transport

KEGG

mmu:69912

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001593	Ailuropoda melanoleuca	92.89	0.00e+00	705.00
IUUC-Atr-002526	Amborella trichopoda	26.83	2.00e-10	60.10
IUUC-Apl-003533	Anas platyrhynchos	74.63	6.00e-140	489.00
IUUC-Aca-004965	Anolis carolinensis	70.26	5.00e-157	546.00
IUUC-Aly-006431	Arabidopsis lyrata	30.18	7.00e-14	71.60
IUUC-Ath-007253	Arabidopsis thaliana	30.36	8.00e-14	71.20
IUUC-Ame-011694	Astyanax mexicanus	63.24	2.00e-119	422.00
IUUC-Bta-013161	Bos taurus	92.11	0.00e+00	717.00
IUUC-Bdi-014758	Brachypodium distachyon	27.62	8.00e-11	61.20
IUUC-Bra-017838	Brassica rapa	27.27	1.00e-07	50.80
IUUC-Cel-018567	Caenorhabditis elegans	23.66	1.00e-08	54.30
IUUC-Cja-020000	Callithrix jacchus	81.14	4.00e-174	603.00
IUUC-Cfa-021112	Canis familiaris	93.16	0.00e+00	719.00
IUUC-Cpo-022095	Cavia porcellus	90.53	0.00e+00	696.00
IUUC-Csa-023460	Chlorocebus sabaeus	93.68	0.00e+00	719.00
IUUC-Cho-024279	Choloepus hoffmanni	91.47	2.00e-169	588.00
IUUC-Cin-025360	Ciona intestinalis	35.97	5.00e-61	228.00
IUUC-Csv-026301	Ciona savignyi	36.93	4.00e-53	201.00
IUUC-Dre-028097	Danio rerio	62.70	2.00e-134	472.00
IUUC-Dno-029131	Dasypus novemcinctus	91.32	0.00e+00	698.00
IUUC-Dor-030496	Dipodomys ordii	82.68	1.00e-178	619.00
IUUC-Dme-031834	Drosophila melanogaster	27.61	2.00e-40	159.00
IUUC-Ete-032448	Echinops telfairi	88.82	3.00e-158	551.00
IUUC-Eca-034409	Equus caballus	92.37	0.00e+00	717.00
IUUC-Eeu-035343	Erinaceus europaeus	77.11	5.00e-157	547.00
IUUC-Fca-036177	Felis catus	93.68	0.00e+00	724.00
IUUC-Fal-037657	Ficedula albicollis	68.95	1.00e-151	528.00
IUUC-Gmo-038946	Gadus morhua	65.96	2.00e-140	491.00
IUUC-Gga-041070	Gallus gallus	73.42	3.00e-159	554.00
IUUC-Gac-042442	Gasterosteus aculeatus	65.87	1.00e-144	505.00
IUUC-Gma-043812	Glycine max	25.54	1.00e-11	63.90
IUUC-Ggo-045223	Gorilla gorilla	93.42	0.00e+00	726.00
IUUC-Hsa-045956	Homo sapiens	93.68	0.00e+00	726.00
IUUC-Itr-048116	Ictidomys tridecemlineatus	95.28	0.00e+00	729.00
IUUC-Lch-050035	Latimeria chalumnae	70.63	2.00e-158	551.00
IUUC-Laf-053404	Loxodonta africana	88.68	0.00e+00	673.00
IUUC-Mcc-055813	Macaca mulatta	94.21	0.00e+00	723.00
IUUC-Meu-056388	Macropus eugenii	75.68	1.00e-159	555.00
IUUC-Mga-060193	Meleagris gallopavo	72.37	1.00e-166	578.00
IUUC-Mmr-060818	Microcebus murinus	93.16	0.00e+00	714.00
IUUC-Mdo-062822	Monodelphis domestica	88.95	0.00e+00	684.00
IUUC-Mpu-066865	Mustela putorius furo	94.12	0.00e+00	647.00
IUUC-Mlu-067329	Myotis lucifugus	92.11	0.00e+00	692.00
IUUC-Nle-069093	Nomascus leucogenys	94.21	0.00e+00	726.00
IUUC-Opr-070481	Ochotona princeps	83.99	0.00e+00	637.00
IUUC-Ont-072445	Oreochromis niloticus	66.67	6.00e-146	509.00
IUUC-Oan-073029	Ornithorhynchus anatinus	76.58	1.00e-168	585.00
IUUC-Ocu-074275	Oryctolagus cuniculus	91.58	0.00e+00	709.00
IUUC-Ola-086862	Oryzias latipes	63.23	9.00e-132	463.00
IUUC-Oga-088952	Otolemur garnettii	93.14	0.00e+00	717.00
IUUC-Oar-089300	Ovis aries	92.89	0.00e+00	722.00
IUUC-Ptr-091389	Pan troglodytes	93.95	0.00e+00	726.00
IUUC-Pan-092174	Papio anubis	93.95	0.00e+00	721.00
IUUC-Psi-093326	Pelodiscus sinensis	76.54	7.00e-158	549.00
IUUC-Pfo-096331	Poecilia formosa	65.15	1.00e-142	499.00
IUUC-Pab-098306	Pongo abelii	93.68	0.00e+00	724.00
IUUC-Pop-099166	Populus trichocarpa	31.91	2.00e-11	63.50
IUUC-Pca-100455	Procavia capensis	89.33	8.00e-72	264.00
IUUC-Ppe-101380	Prunus persica	29.78	3.00e-12	66.20
IUUC-Pva-102578	Pteropus vampyrus	93.16	0.00e+00	705.00
IUUC-Rno-105146	Rattus norvegicus	97.37	0.00e+00	713.00
IUUC-Sha-107640	Sarcophilus harrisii	89.24	0.00e+00	687.00
IUUC-Sar-113681	Sorex araneus	93.37	4.00e-108	384.00
IUUC-Sbi-113809	Sorghum bicolor	24.64	6.00e-05	42.00
IUUC-Ssc-116129	Sus scrofa	92.11	0.00e+00	709.00
IUUC-Tgu-117456	Taeniopygia guttata	67.14	2.00e-77	281.00
IUUC-Tru-117630	Takifugu rubripes	68.16	3.00e-99	354.00
IUUC-Tsy-119331	Tarsius syrichta	94.74	0.00e+00	730.00
IUUC-Tni-120077	Tetraodon nigroviridis	64.81	4.00e-136	477.00
IUUC-Tca-121814	Theobroma cacao	30.64	5.00e-10	58.90
IUUC-Tae-123605	Triticum aestivum	27.53	5.00e-10	58.50
IUUC-Tbe-127359	Tupaia belangeri	84.35	1.00e-178	619.00
IUUC-Ttr-128461	Tursiops truncatus	93.68	0.00e+00	715.00
IUUC-Vpa-130162	Vicugna pacos	94.21	0.00e+00	715.00
IUUC-Vvi-131114	Vitis vinifera	28.18	8.00e-11	61.20
IUUC-Xtr-132446	Xenopus tropicalis	68.34	7.00e-153	533.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence