iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052842

Ensembl Protein ID

ENSLOCP00000021117.1

UniProt Accession

W5NKF8; W5NKF8_LEPOC

Genbank Protein ID

ENSLOCP00000021117

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01026706

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000017089.1	ENSLOCT00000021153.1	ENSLOCP00000021117.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.50e-83	279.7	194	822

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp..............kepkgellkslqklfeelwkskkkavsprellk 75
           +G++NlgNtC++N+v+Q Ls+++ l +l+ e  kek ++ +                 + ++l++++  +++++ +  k+ vsp+ l++
   Q: 194  KGINNLGNTCFFNAVMQNLSQTHMLNDLVSE-MKEKGSKLKIcplmetnldplvvtLPSPEPLTSAMFLFLNCMKEPGKGPVSPKILFN 281
           59*****************************.44444434335666677777777666777**************************** PP
   S: 76   alkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcle 158
           +l+++a++f+gy+qqD+qE+l++lld+++ e +k+ +  + +++++ ++++ d+      + + k+  + ++++++F g+l+++i+c+e
   Q: 282  QLCQKAPRFKGYQQQDSQELLHYLLDAMRMEETKRIKAGILKAFNNPTERTADDetkrkvKAYGKEGVKMNFVDRIFVGELTNTIMCEE 370
           *****************************99988666666666666655555553333335566666666******************* PP
   S: 159  cdnvssreepfldlslpvpgkeetkke.............................................................. 185
           c+++s+ +e f+d+slp+ +++ +k+                                                               
   Q: 371  CEHISTVKEAFIDISLPIIEERVSKPAnpgrgsktnklqereqdqfilsgdntatvtlahlpknskkhstakdkiqqsnlkkherkssf 459
           **********************99888************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 460  gseernndysqtrseedlagepknnykdtgsskvangsqseasekdgshldssndadseasesestskhtlnsssadcfnaggsnqtql 548
           ***************************************************************************************** PP
   S: 186  ...................................................................................slqdcL 191
                                                                                              s+q+cL
   Q: 549  ksdlfhskqkdgnhidhlasamsrlglchnvhesvihthsqeeqtdimsnnkdaskekplisqnpqiafqslshsyvpcskecSVQSCL 637
           ***************************************************************************************** PP
   S: 192  esftkeeelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
            +ft+ e l g+nk+ ce+c++k++                   a+k++ +++lP+v +lhLkRf  +++++s +k+n++v+fpl Ldl
   Q: 638  YQFTSVELLMGNNKLLCENCTEKRQkhlkktitsekkvekvytsARKQMLISSLPPVVTLHLKRF--HQAGMSLRKVNRHVDFPLVLDL 724
           *********************99999***************************************..999******************* PP
   S: 262  spfctspeekqke..kkkYeLiavvvHsGslssGHYvayvkn......................ekgkWllfdDskVtevkeeevleet 326
           +pfc+ ++++  +  ++ Y L+++v HsGs+++GHY ayvk                         g+W++++D++V++v+e++vl   
   Q: 725  APFCSASCKNIVQgeRVLYGLYGIVEHSGSMRGGHYSAYVKIrgphrkleqrrnvagqkeaaaaPPGQWVYVSDTHVQVVPESRVLG-- 811
           ******99886555699*************************99999999999888877777666788*******************.. PP
   S: 327  gstaYvlfYkrr 338
            s+aY+lfY+++
   Q: 812  -SQAYLLFYEEM 822
           .********975 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MRLKDPFSLK ASEMTKRSNR PRKPREEESS DEVSAGMTCQ HVSKAVDLSS VKKAVSQNLW 60
SVCSECLKER TVYDGEPAGP FDILVCLKCG FQQGCNQSDG QHSTKHFQAV HAESHCIVMS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTACAGATGC GGTTAAAAGA TCCATTCTCT TTAAAAGCTT CCGAAATGAC AAAGCGGTCA 60
AACAGGCCAA GAAAGCCTAG AGAGGAAGAG TCCTCAGATG AAGTCAGTGG TAAGGCTTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	58.47	6.00e-132	464.00
IUUC-Apl-003512	Anas platyrhynchos	62.48	0.00e+00	988.00
IUUC-Aca-004284	Anolis carolinensis	58.88	0.00e+00	914.00
IUUC-Ame-010735	Astyanax mexicanus	54.66	1.00e-133	469.00
IUUC-Bta-012880	Bos taurus	58.24	0.00e+00	858.00
IUUC-Bol-015191	Brassica oleracea	30.03	1.00e-28	122.00
IUUC-Cja-019144	Callithrix jacchus	57.42	0.00e+00	894.00
IUUC-Cfa-020971	Canis familiaris	60.67	4.00e-155	541.00
IUUC-Cpo-022497	Cavia porcellus	64.27	2.00e-153	536.00
IUUC-Csa-023910	Chlorocebus sabaeus	58.13	0.00e+00	823.00
IUUC-Cho-024358	Choloepus hoffmanni	46.02	1.00e-79	290.00
IUUC-Dre-028106	Danio rerio	67.18	0.00e+00	1069.00
IUUC-Dno-029456	Dasypus novemcinctus	53.36	4.00e-131	461.00
IUUC-Dor-030438	Dipodomys ordii	48.37	0.00e+00	650.00
IUUC-Ete-032736	Echinops telfairi	49.38	0.00e+00	700.00
IUUC-Eca-034211	Equus caballus	57.95	0.00e+00	899.00
IUUC-Eeu-034797	Erinaceus europaeus	71.68	3.00e-72	265.00
IUUC-Fca-035947	Felis catus	55.46	0.00e+00	808.00
IUUC-Fal-037199	Ficedula albicollis	61.87	0.00e+00	850.00
IUUC-Gmo-039228	Gadus morhua	79.24	0.00e+00	648.00
IUUC-Gga-040823	Gallus gallus	58.38	3.00e-155	541.00
IUUC-Gac-042406	Gasterosteus aculeatus	64.05	0.00e+00	971.00
IUUC-Ggo-045402	Gorilla gorilla	57.95	0.00e+00	878.00
IUUC-Hsa-046430	Homo sapiens	58.14	0.00e+00	882.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	57.67	1.00e-141	496.00
IUUC-Lch-049547	Latimeria chalumnae	60.55	0.00e+00	954.00
IUUC-Laf-053988	Loxodonta africana	58.12	0.00e+00	896.00
IUUC-Mcc-055491	Macaca mulatta	65.65	5.00e-156	544.00
IUUC-Meu-056256	Macropus eugenii	55.21	5.00e-144	504.00
IUUC-Mla-059026	Melampsora laricipopulina	31.84	8.00e-19	88.60
IUUC-Mga-059833	Meleagris gallopavo	55.36	9.00e-158	550.00
IUUC-Mmr-060952	Microcebus murinus	58.29	0.00e+00	878.00
IUUC-Mdo-062642	Monodelphis domestica	61.03	0.00e+00	915.00
IUUC-Mmu-063945	Mus musculus	57.61	0.00e+00	887.00
IUUC-Mpu-065944	Mustela putorius furo	56.35	0.00e+00	852.00
IUUC-Mlu-067049	Myotis lucifugus	56.92	0.00e+00	848.00
IUUC-Nle-069828	Nomascus leucogenys	58.72	0.00e+00	892.00
IUUC-Opr-070672	Ochotona princeps	50.40	1.00e-100	360.00
IUUC-Ont-072121	Oreochromis niloticus	62.11	0.00e+00	960.00
IUUC-Oan-073656	Ornithorhynchus anatinus	60.27	5.00e-176	611.00
IUUC-Ocu-074323	Oryctolagus cuniculus	58.14	0.00e+00	876.00
IUUC-Ola-087238	Oryzias latipes	64.60	0.00e+00	1009.00
IUUC-Oga-088379	Otolemur garnettii	56.06	0.00e+00	830.00
IUUC-Oar-089718	Ovis aries	58.34	0.00e+00	855.00
IUUC-Ptr-091358	Pan troglodytes	58.14	0.00e+00	881.00
IUUC-Pan-092023	Papio anubis	58.17	0.00e+00	885.00
IUUC-Psi-093256	Pelodiscus sinensis	60.77	0.00e+00	910.00
IUUC-Pfo-097285	Poecilia formosa	59.81	0.00e+00	875.00
IUUC-Pab-098539	Pongo abelii	58.75	0.00e+00	899.00
IUUC-Pca-100610	Procavia capensis	53.23	2.00e-116	413.00
IUUC-Pva-102985	Pteropus vampyrus	65.86	2.00e-145	509.00
IUUC-Rno-105538	Rattus norvegicus	57.66	0.00e+00	881.00
IUUC-Sha-107022	Sarcophilus harrisii	63.52	4.00e-158	551.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	30.05	1.00e-18	88.60
IUUC-Sar-113637	Sorex araneus	60.95	2.00e-158	552.00
IUUC-Ssc-115870	Sus scrofa	58.38	0.00e+00	902.00
IUUC-Tgu-116907	Taeniopygia guttata	62.32	0.00e+00	983.00
IUUC-Tru-117835	Takifugu rubripes	64.93	4.00e-139	488.00
IUUC-Tsy-118869	Tarsius syrichta	58.34	0.00e+00	769.00
IUUC-Tni-119716	Tetraodon nigroviridis	79.92	3.00e-120	425.00
IUUC-Tbe-128041	Tupaia belangeri	48.98	2.00e-169	589.00
IUUC-Ttr-128901	Tursiops truncatus	54.62	0.00e+00	836.00
IUUC-Vpa-130331	Vicugna pacos	57.48	0.00e+00	813.00
IUUC-Xtr-131794	Xenopus tropicalis	53.25	0.00e+00	756.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence