iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064274

UUCD1 version

UUC-MuM-00463

Ensembl Protein ID

ENSMUSP00000124548.1

UniProt Accession

Q5XPI3; Q6PGE0; RN123_MOUSE

Genbank Protein ID

AAU93471.1; AAH57082.1

Protein Name

E3 ubiquitin-protein ligase RNF123; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123; RING-type E3 ubiquitin transferase RNF123

Genbank Nucleotide ID

AY744153; BC057082

Gene Name

Rnf123; Kpc1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000041528.15	ENSMUST00000160249.7	ENSMUSP00000124548.1
ENSMUSG00000041528.15	ENSMUST00000162355.7	ENSMUSP00000125745.1
ENSMUSG00000041528.15	ENSMUST00000159306.7	ENSMUSP00000125695.1
ENSMUSG00000041528.15	ENSMUST00000162753.7	ENSMUSP00000124824.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	93.84	0.00e+00	2454.00	IUUC-Hsa-046786

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Protein Sequence
(Fasta)

MASKGTGMSF SRKSYRLTSD AEKSRVTGIV QEKLLSDYLY RIFSPPDRGP AAATSRKPLN 60
FHNLPEHVDQ LLQVDSEDNE SQGQVEGRLG PSTVVLDHTG GFEGLLLVDD DLLGVIGHSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGTATAGC ACCAGGGCCC ATGGCTATCC CCATCAGGAT TCCTGCAGAA GTTGGCCTCC 60
AGTCCCGCCT GCGGTGCCGA GGTGGGTGTA AATCTAGATG TAGGGGCAGG AGGTAGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50188--B302_SPRY
PS50089--ZF_RING_2

Pfam

PF00622--SPRY

SMART

SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

mmu:84585

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002334	Ailuropoda melanoleuca	93.49	0.00e+00	2295.00
IUUC-Atr-002731	Amborella trichopoda	32.52	1.00e-46	182.00
IUUC-Apl-003337	Anas platyrhynchos	78.96	0.00e+00	2009.00
IUUC-Aca-005266	Anolis carolinensis	79.45	0.00e+00	1614.00
IUUC-Aly-005720	Arabidopsis lyrata	33.98	9.00e-46	179.00
IUUC-Ath-007453	Arabidopsis thaliana	28.09	9.00e-49	189.00
IUUC-Ame-011173	Astyanax mexicanus	67.40	0.00e+00	1433.00
IUUC-Bta-012466	Bos taurus	92.71	0.00e+00	2334.00
IUUC-Bol-016281	Brassica oleracea	25.58	4.00e-94	340.00
IUUC-Bra-016892	Brassica rapa	26.27	5.00e-95	343.00
IUUC-Cja-019535	Callithrix jacchus	93.17	0.00e+00	2338.00
IUUC-Cfa-020260	Canis familiaris	94.24	0.00e+00	2349.00
IUUC-Cpo-021921	Cavia porcellus	92.76	0.00e+00	2387.00
IUUC-Cre-022617	Chlamydomonas reinhardtii	51.53	1.00e-47	185.00
IUUC-Csa-024158	Chlorocebus sabaeus	94.00	0.00e+00	2353.00
IUUC-Cho-025093	Choloepus hoffmanni	81.82	0.00e+00	902.00
IUUC-Cin-025392	Ciona intestinalis	38.40	2.00e-112	399.00
IUUC-Csv-026271	Ciona savignyi	34.55	4.00e-38	151.00
IUUC-Dre-027457	Danio rerio	79.32	0.00e+00	1232.00
IUUC-Dor-030129	Dipodomys ordii	88.31	0.00e+00	2167.00
IUUC-Dme-032022	Drosophila melanogaster	29.56	1.00e-161	564.00
IUUC-Ete-032681	Echinops telfairi	83.27	0.00e+00	819.00
IUUC-Eca-033488	Equus caballus	92.90	0.00e+00	2420.00
IUUC-Eeu-035141	Erinaceus europaeus	95.07	0.00e+00	986.00
IUUC-Fca-036540	Felis catus	94.26	0.00e+00	2320.00
IUUC-Fal-036716	Ficedula albicollis	79.81	0.00e+00	1998.00
IUUC-Gmo-038827	Gadus morhua	72.65	0.00e+00	853.00
IUUC-Gga-040227	Gallus gallus	79.31	0.00e+00	1986.00
IUUC-Gac-041611	Gasterosteus aculeatus	79.23	0.00e+00	929.00
IUUC-Gma-043507	Glycine max	25.31	3.00e-87	317.00
IUUC-Ggo-045274	Gorilla gorilla	93.84	0.00e+00	2345.00
IUUC-Hsa-046786	Homo sapiens	93.84	0.00e+00	2345.00
IUUC-Itr-047988	Ictidomys tridecemlineatus	94.35	0.00e+00	2448.00
IUUC-Lch-050613	Latimeria chalumnae	81.79	0.00e+00	1091.00
IUUC-Lpe-050692	Leersia perrieri	26.96	2.00e-45	178.00
IUUC-Loc-052484	Lepisosteus oculatus	75.88	0.00e+00	1910.00
IUUC-Laf-053359	Loxodonta africana	93.26	0.00e+00	2323.00
IUUC-Mcc-054643	Macaca mulatta	93.99	0.00e+00	2346.00
IUUC-Meu-056856	Macropus eugenii	78.73	0.00e+00	1753.00
IUUC-Mtr-058494	Medicago truncatula	25.53	3.00e-88	320.00
IUUC-Mga-060198	Meleagris gallopavo	66.40	0.00e+00	1302.00
IUUC-Mmr-061762	Microcebus murinus	93.63	0.00e+00	2356.00
IUUC-Mdo-062049	Monodelphis domestica	81.51	0.00e+00	2058.00
IUUC-Mac-064561	Musa acuminata	46.15	5.00e-45	176.00
IUUC-Mpu-066413	Mustela putorius furo	94.03	0.00e+00	2326.00
IUUC-Mlu-067411	Myotis lucifugus	83.01	0.00e+00	2061.00
IUUC-Nle-069644	Nomascus leucogenys	93.68	0.00e+00	2344.00
IUUC-Opr-070465	Ochotona princeps	90.09	0.00e+00	2240.00
IUUC-Ont-072552	Oreochromis niloticus	73.05	0.00e+00	1660.00
IUUC-Ocu-074740	Oryctolagus cuniculus	91.75	0.00e+00	2305.00
IUUC-Oba-075088	Oryza barthii	32.14	2.00e-43	171.00
IUUC-Obr-076657	Oryza brachyantha	27.07	7.00e-44	173.00
IUUC-Ogl-077313	Oryza glaberrima	28.50	3.00e-32	132.00
IUUC-Ogu-078672	Oryza glumaepatula	32.42	3.00e-44	174.00
IUUC-Oin-079756	Oryza indica	32.42	2.00e-44	174.00
IUUC-Olo-080369	Oryza longistaminata	32.42	4.00e-44	174.00
IUUC-Oni-082996	Oryza nivara	32.42	2.00e-44	174.00
IUUC-Opu-083892	Oryza punctata	27.38	1.00e-13	69.70
IUUC-Oru-084434	Oryza rufipogon	32.35	1.00e-46	182.00
IUUC-Osa-085595	Oryza sativa	32.18	5.00e-29	121.00
IUUC-Ola-086405	Oryzias latipes	76.79	0.00e+00	1293.00
IUUC-Oga-088794	Otolemur garnettii	92.91	0.00e+00	2323.00
IUUC-Oar-089775	Ovis aries	85.49	0.00e+00	2155.00
IUUC-Pan-092845	Papio anubis	93.69	0.00e+00	2345.00
IUUC-Psi-093521	Pelodiscus sinensis	75.80	6.00e-115	406.00
IUUC-Ppa-095501	Physcomitrella patens	27.79	1.00e-99	358.00
IUUC-Pfo-097083	Poecilia formosa	74.45	0.00e+00	1890.00
IUUC-Pab-098302	Pongo abelii	92.50	0.00e+00	2296.00
IUUC-Pop-099033	Populus trichocarpa	29.72	7.00e-51	196.00
IUUC-Pca-100742	Procavia capensis	84.02	0.00e+00	2032.00
IUUC-Ppe-101476	Prunus persica	32.19	6.00e-44	173.00
IUUC-Pva-103045	Pteropus vampyrus	91.37	0.00e+00	2214.00
IUUC-Rno-105433	Rattus norvegicus	97.47	0.00e+00	2471.00
IUUC-Sha-107441	Sarcophilus harrisii	82.44	0.00e+00	2086.00
IUUC-Smo-109606	Selaginella moellendorffii	27.72	2.00e-100	360.00
IUUC-Sit-110792	Setaria italica	32.70	4.00e-44	173.00
IUUC-Sly-110982	Solanum lycopersicum	25.96	7.00e-89	322.00
IUUC-Stu-112003	Solanum tuberosum	24.77	2.00e-65	244.00
IUUC-Sar-113146	Sorex araneus	92.45	0.00e+00	1087.00
IUUC-Sbi-113941	Sorghum bicolor	32.39	2.00e-38	154.00
IUUC-Ssc-115635	Sus scrofa	93.17	0.00e+00	2348.00
IUUC-Tgu-116688	Taeniopygia guttata	79.69	0.00e+00	1867.00
IUUC-Tsy-119023	Tarsius syrichta	98.20	0.00e+00	677.00
IUUC-Tca-121219	Theobroma cacao	34.64	3.00e-49	191.00
IUUC-Tbe-127542	Tupaia belangeri	71.87	0.00e+00	1238.00
IUUC-Ttr-128241	Tursiops truncatus	91.14	0.00e+00	2205.00
IUUC-Vvi-131629	Vitis vinifera	34.71	3.00e-49	191.00
IUUC-Xtr-132790	Xenopus tropicalis	77.11	0.00e+00	1988.00
IUUC-Xma-133302	Xiphophorus maculatus	71.79	0.00e+00	1251.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence