iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.50e-15	58.4	95	169
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.60e-09	36.9	203	233

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvg...geeffahkivLaasSsvFyalflmeleesksklmveikd......vqpevfrallkFlYtgklde 67
           +D++l+ g   g+ef+ah++vLaa+ ++F  l++++++es+ +++ve++        +p+ ++a+++++Ytg+++ 
   Q: 95   CDITLCFGgagGREFRAHRSVLAAATEYFTPLLSGQFSESR-SGRVEMRKwssepgPEPDTVEAVIEYMYTGRIRV 169
           8******7788******************************.*******4456799*****************975 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           l+Nc++i ++A++y++++L+++a d+i ++F
   Q: 203  LSNCVAIHSLAHMYTLSQLALKAADMIRRNF 233
           69****************************9 PP

Organism

Mus musculus

Functional Description
(View)

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Protein Sequence
(Fasta)

MAAAVAAAAA AAAAAASFQV LEMESMETAV AGSASLAAEV RGSGTVDFVT GAGISTLVDT 60
GGSDPGPEAE DFECSTHCSE LSWRQNEQRR QGLFCDITLC FGGAGGREFR AHRSVLAAAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGGCGTC AAGATGGCGG CGGCTGTGGC GGCGGCAGCT GCCGCTGCGG CCGCGGCTGC 60
ATCTTTTCAA GTGCTGGAGA TGGAGAGCAT GGAGACTGCC GTCGCCGGTT CCGCGAGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

mmu:217194

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002239	Ailuropoda melanoleuca	95.64	0.00e+00	1326.00
IUUC-Apl-003928	Anas platyrhynchos	84.42	0.00e+00	1042.00
IUUC-Aca-004801	Anolis carolinensis	82.12	0.00e+00	1108.00
IUUC-Ame-010943	Astyanax mexicanus	76.01	0.00e+00	908.00
IUUC-Bta-012341	Bos taurus	99.40	4.00e-97	346.00
IUUC-Cja-019924	Callithrix jacchus	96.68	0.00e+00	1385.00
IUUC-Cfa-021076	Canis familiaris	96.83	0.00e+00	1390.00
IUUC-Cpo-022193	Cavia porcellus	91.49	0.00e+00	1294.00
IUUC-Csa-023614	Chlorocebus sabaeus	96.94	0.00e+00	1377.00
IUUC-Cho-024806	Choloepus hoffmanni	82.67	0.00e+00	928.00
IUUC-Dre-028622	Danio rerio	75.16	0.00e+00	997.00
IUUC-Dno-029965	Dasypus novemcinctus	94.12	0.00e+00	1346.00
IUUC-Dor-030136	Dipodomys ordii	97.72	0.00e+00	1089.00
IUUC-Eca-034191	Equus caballus	94.93	0.00e+00	1334.00
IUUC-Eeu-034746	Erinaceus europaeus	95.24	0.00e+00	1367.00
IUUC-Fca-035702	Felis catus	90.45	0.00e+00	1253.00
IUUC-Fal-037360	Ficedula albicollis	83.68	0.00e+00	1027.00
IUUC-Gmo-038582	Gadus morhua	74.81	0.00e+00	1008.00
IUUC-Ggr-039747	Gaeumannomyces graminis	25.93	2.00e-08	52.80
IUUC-Gga-040375	Gallus gallus	83.54	0.00e+00	1128.00
IUUC-Gac-042523	Gasterosteus aculeatus	76.59	0.00e+00	1001.00
IUUC-Ggo-045632	Gorilla gorilla	98.30	0.00e+00	1095.00
IUUC-Hsa-046817	Homo sapiens	96.83	0.00e+00	1386.00
IUUC-Itr-048433	Ictidomys tridecemlineatus	96.97	0.00e+00	1391.00
IUUC-Lch-049985	Latimeria chalumnae	78.71	0.00e+00	1036.00
IUUC-Loc-052594	Lepisosteus oculatus	76.18	0.00e+00	996.00
IUUC-Lma-053111	Leptosphaeria maculans	31.65	1.00e-04	40.00
IUUC-Laf-054357	Loxodonta africana	96.83	0.00e+00	1391.00
IUUC-Mcc-055454	Macaca mulatta	97.70	0.00e+00	1345.00
IUUC-Meu-056012	Macropus eugenii	87.82	3.00e-175	607.00
IUUC-Mga-060048	Meleagris gallopavo	84.52	0.00e+00	859.00
IUUC-Mdo-062082	Monodelphis domestica	88.22	0.00e+00	1286.00
IUUC-Mpu-066511	Mustela putorius furo	96.68	0.00e+00	1389.00
IUUC-Mlu-067301	Myotis lucifugus	94.81	0.00e+00	1343.00
IUUC-Nfi-068503	Neosartorya fischeri	33.33	8.00e-03	34.30
IUUC-Nle-069912	Nomascus leucogenys	96.83	0.00e+00	1386.00
IUUC-Opr-070762	Ochotona princeps	97.53	0.00e+00	837.00
IUUC-Ont-071916	Oreochromis niloticus	77.36	0.00e+00	996.00
IUUC-Oan-072932	Ornithorhynchus anatinus	77.04	0.00e+00	823.00
IUUC-Ocu-074172	Oryctolagus cuniculus	98.08	0.00e+00	1083.00
IUUC-Ola-086483	Oryzias latipes	77.21	0.00e+00	992.00
IUUC-Oga-088112	Otolemur garnettii	95.70	0.00e+00	1323.00
IUUC-Oar-090129	Ovis aries	96.68	0.00e+00	1388.00
IUUC-Ptr-090571	Pan troglodytes	98.29	0.00e+00	1095.00
IUUC-Pan-092073	Papio anubis	96.68	0.00e+00	1385.00
IUUC-Psi-093836	Pelodiscus sinensis	85.74	0.00e+00	1082.00
IUUC-Pno-095007	Phaeosphaeria nodorum	31.08	8.00e-05	41.20
IUUC-Pfo-096477	Poecilia formosa	77.21	0.00e+00	994.00
IUUC-Pab-098473	Pongo abelii	96.68	0.00e+00	1385.00
IUUC-Pca-100239	Procavia capensis	94.91	0.00e+00	822.00
IUUC-Pyt-104638	Pyrenophora triticirepentis	38.10	7.00e-05	41.20
IUUC-Rno-104859	Rattus norvegicus	99.57	0.00e+00	1451.00
IUUC-Sha-106746	Sarcophilus harrisii	87.18	0.00e+00	1268.00
IUUC-Ssl-108438	Sclerotinia sclerotiorum	38.10	1.00e-05	43.50
IUUC-Tgu-117183	Taeniopygia guttata	83.02	0.00e+00	1129.00
IUUC-Tru-118655	Takifugu rubripes	75.61	0.00e+00	988.00
IUUC-Tsy-119430	Tarsius syrichta	98.12	0.00e+00	1328.00
IUUC-Tni-119698	Tetraodon nigroviridis	76.43	0.00e+00	869.00
IUUC-Vda-129848	Verticillium dahliae	33.33	1.00e-03	37.40
IUUC-Vpa-130715	Vicugna pacos	95.51	0.00e+00	1373.00
IUUC-Xtr-132276	Xenopus tropicalis	77.41	0.00e+00	997.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence