• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP
  • SNP
    • dbSNP
  • mRNA Expression
    • GEO
    • ArrayExpress
    • GXD
  • DNA & RNA Element
    • microRNA
    • TRANSFAC
    • RepTar
    • RAID2
  • PPI
    • IID
  • PTM
    • dbPAF
    • PhosphositePlus
  • Proteomics
    • GPMDB

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046494
UUCD1 version UUC-HoS-00939
Ensembl Protein ID ENSP00000336800.5
UniProt Accession Q9H0H3; B2RDH2; B3KRT7; KLH25_HUMAN
Genbank Protein ID AAV51405.1; CAB66730.1; BAG52499.1; BAG37919.1; AAH28100.1
Protein Name Kelch-like protein 25; Ectoderm-neural cortex protein 2
Genbank Nucleotide ID AY764034; AL136796; AK092231; AK315541; AC021739
Gene Name KLHL25; ENC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000183655.12 ENST00000337975.5 ENSP00000336800.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.40e-19 71.9 46 114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 5.70e-09 35.2 146 177
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkldene 69
           +Dv+l  g++ f++h++vLaasS++F+a+f+++l+es+  ++v+++d + pev++ ll+F Y++++ +ne
   Q: 46   TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESR-DDTVNFQDnLHPEVLELLLDFAYSSRIAINE 114
           7*************************************.*******99*****************99987 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclg++ ++d+++c++L+++  +++l hF+
   Q: 146  PSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFE 177
           89*****************************5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Protein Sequence
(Fasta)
MSVSVHETRK SRSSTGSMNV TLFHKASHPD CVLAHLNTLR KHCMFTDVTL WAGDRAFPCH 60
RAVLAASSRY FEAMFSHGLR ESRDDTVNFQ DNLHPEVLEL LLDFAYSSRI AINEENAESL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046494|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTTTCTGCG GCTGCACTGA AGGGTTCGGC TGCCCATCCG TCACAGAGGC GATGCCTCTG 60
ATTGGCTGCT GCTCTTCGGG CCGGGAGGCG GGGCGGGAAG GCCGGAGAAA CTAGTTTGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046494|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0810--Translation regulation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030565--KLHL25
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006446--P:regulation of translational initiation
KEGG hsa:64410
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002373 Ailuropoda melanoleuca 97.62 0.00e+00 1211.00
IUUC-Apl-003543 Anas platyrhynchos 90.34 0.00e+00 1099.00
IUUC-Aca-004729 Anolis carolinensis 87.61 0.00e+00 1079.00
IUUC-Ame-011020 Astyanax mexicanus 85.23 0.00e+00 1036.00
IUUC-Bta-012955 Bos taurus 95.59 0.00e+00 1191.00
IUUC-Cja-018839 Callithrix jacchus 98.98 0.00e+00 1221.00
IUUC-Cfa-020224 Canis familiaris 97.79 0.00e+00 1208.00
IUUC-Cpo-021593 Cavia porcellus 93.55 0.00e+00 1121.00
IUUC-Csa-023276 Chlorocebus sabaeus 99.66 0.00e+00 1229.00
IUUC-Dre-028053 Danio rerio 85.40 0.00e+00 1013.00
IUUC-Dno-029287 Dasypus novemcinctus 94.91 0.00e+00 1180.00
IUUC-Dor-030908 Dipodomys ordii 88.79 0.00e+00 1077.00
IUUC-Fca-035897 Felis catus 97.96 0.00e+00 1212.00
IUUC-Fal-037036 Ficedula albicollis 90.32 0.00e+00 1104.00
IUUC-Gmo-039345 Gadus morhua 85.23 0.00e+00 1006.00
IUUC-Gga-040404 Gallus gallus 90.15 0.00e+00 1105.00
IUUC-Gac-042447 Gasterosteus aculeatus 84.72 0.00e+00 1020.00
IUUC-Ggo-045060 Gorilla gorilla 99.83 0.00e+00 1231.00
IUUC-Itr-047993 Ictidomys tridecemlineatus 97.96 0.00e+00 1208.00
IUUC-Lch-050211 Latimeria chalumnae 86.56 0.00e+00 1053.00
IUUC-Loc-052578 Lepisosteus oculatus 85.06 0.00e+00 1042.00
IUUC-Lma-053168 Leptosphaeria maculans 29.79 1.00e-04 41.20
IUUC-Laf-053498 Loxodonta africana 95.93 0.00e+00 1141.00
IUUC-Mcc-055033 Macaca mulatta 99.49 0.00e+00 1228.00
IUUC-Meu-056893 Macropus eugenii 93.38 0.00e+00 1160.00
IUUC-Mga-060025 Meleagris gallopavo 90.32 0.00e+00 1104.00
IUUC-Mmr-060658 Microcebus murinus 97.79 0.00e+00 1212.00
IUUC-Mdo-062667 Monodelphis domestica 93.21 0.00e+00 1155.00
IUUC-Mmu-063125 Mus musculus 94.91 0.00e+00 1145.00
IUUC-Mpu-066209 Mustela putorius furo 97.79 0.00e+00 1212.00
IUUC-Mlu-068237 Myotis lucifugus 93.89 0.00e+00 1142.00
IUUC-Nle-069454 Nomascus leucogenys 99.83 0.00e+00 1217.00
IUUC-Ont-072138 Oreochromis niloticus 84.89 0.00e+00 1009.00
IUUC-Oan-073320 Ornithorhynchus anatinus 86.08 0.00e+00 1074.00
IUUC-Ocu-073765 Oryctolagus cuniculus 90.15 0.00e+00 1100.00
IUUC-Oga-088002 Otolemur garnettii 97.79 0.00e+00 1201.00
IUUC-Oar-089481 Ovis aries 95.08 0.00e+00 1186.00
IUUC-Ptr-091200 Pan troglodytes 99.83 0.00e+00 1228.00
IUUC-Psi-093884 Pelodiscus sinensis 89.98 0.00e+00 1092.00
IUUC-Pno-095143 Phaeosphaeria nodorum 27.24 4.00e-15 75.90
IUUC-Pab-098588 Pongo abelii 88.96 0.00e+00 1064.00
IUUC-Pva-102321 Pteropus vampyrus 96.77 0.00e+00 1199.00
IUUC-Rno-104835 Rattus norvegicus 94.74 0.00e+00 1144.00
IUUC-Sha-107528 Sarcophilus harrisii 93.21 0.00e+00 1159.00
IUUC-Ssc-116161 Sus scrofa 97.79 0.00e+00 1208.00
IUUC-Tgu-116569 Taeniopygia guttata 90.15 0.00e+00 1100.00
IUUC-Tni-120525 Tetraodon nigroviridis 75.80 0.00e+00 882.00
IUUC-Ttr-129297 Tursiops truncatus 96.77 0.00e+00 1198.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved