iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046091

UUCD1 version

UUC-HoS-00118

Ensembl Protein ID

ENSP00000226225.2

UniProt Accession

Q13829; B7Z6M4; Q5TZQ1; BACD2_HUMAN

Genbank Protein ID

AAA58385.1; BAH13310.1; BAG35304.1; CAG33100.1; AAV38924.1; AAL38649.1; EAW51077.1; AAH01643.1; AAH01949.1

Protein Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor, alpha-induced protein 1, endothelial

Genbank Nucleotide ID

M80783; AK300584; AK312387; CR456819; BT020121; AY065346; AC002094; BC001643; BC001949

Gene Name

TNFAIP1; BACURD2; EDP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000109079.9	ENST00000226225.6	ENSP00000226225.2
ENSG00000109079.9	ENST00000577535.1	ENSP00000466301.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
miRecords	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	19782033

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	6.00e-07	31.4	29	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgklde 67
            v+l+vgg+ + ++   L+++  +++a+f++ +e  +++++ + i+ +  ++f ++l++l+ +++++
   Q: 29   YVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEvLTDKEGWILID-RCGKHFGTILNYLRDDTITL 94
           599********************************9999******9.**************999876 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Protein Sequence
(Fasta)

MSGDTCLCPA SGAKPKLSGF KGGGLGNKYV QLNVGGSLYY TTVRALTRHD TMLKAMFSGR 60
MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TITLPQNRQE IKELMAEAKY YLIQGLVNMC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTAGCTCT GCTCTCTCCG CGAAGACCCT CGGGGGATTC CGCCTCCACC CTTTCCCGGA 60
TAGAGCGCTA TGCATGCAGG GACTTGTAGT CTCAGGCTCC CCAGCCGGCT GGGCTGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

PROSITE

PS50097--BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0005730--C:nucleolus
GO:0017049--F:GTP-Rho binding
GO:0006915--P:apoptotic process
GO:0016477--P:cell migration
GO:0006260--P:DNA replication
GO:0009790--P:embryo development
GO:0006955--P:immune response
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045740--P:positive regulation of DNA replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0043149--P:stress fiber assembly

KEGG

hsa:7126

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001724	Ailuropoda melanoleuca	97.47	0.00e+00	643.00
IUUC-Apl-003702	Anas platyrhynchos	91.11	1.00e-169	588.00
IUUC-Aca-004408	Anolis carolinensis	82.59	4.00e-147	514.00
IUUC-Afl-008662	Aspergillus flavus	34.48	1.00e-01	31.20
IUUC-Afu-008834	Aspergillus fumigatus	32.50	1.10e+00	27.30
IUUC-Ang-009546	Aspergillus niger	32.20	5.60e-02	31.20
IUUC-Ame-010738	Astyanax mexicanus	76.74	9.00e-123	432.00
IUUC-Bta-013551	Bos taurus	98.10	3.00e-175	607.00
IUUC-Cja-019122	Callithrix jacchus	99.68	0.00e+00	657.00
IUUC-Cfa-020193	Canis familiaris	99.37	0.00e+00	655.00
IUUC-Cpo-022024	Cavia porcellus	97.78	0.00e+00	647.00
IUUC-Csa-024138	Chlorocebus sabaeus	100.00	0.00e+00	658.00
IUUC-Dno-029163	Dasypus novemcinctus	97.78	0.00e+00	649.00
IUUC-Dor-030970	Dipodomys ordii	98.42	0.00e+00	649.00
IUUC-Eca-034114	Equus caballus	98.73	0.00e+00	652.00
IUUC-Eeu-034709	Erinaceus europaeus	97.47	0.00e+00	640.00
IUUC-Fca-036397	Felis catus	98.42	5.00e-176	609.00
IUUC-Fal-037588	Ficedula albicollis	91.40	8.00e-171	592.00
IUUC-Gga-040445	Gallus gallus	90.76	3.00e-169	587.00
IUUC-Ggo-045312	Gorilla gorilla	100.00	0.00e+00	658.00
IUUC-Itr-048608	Ictidomys tridecemlineatus	98.10	0.00e+00	650.00
IUUC-Lch-049970	Latimeria chalumnae	89.03	2.00e-169	588.00
IUUC-Laf-054286	Loxodonta africana	97.47	0.00e+00	645.00
IUUC-Meu-056850	Macropus eugenii	88.71	1.00e-156	545.00
IUUC-Mga-060119	Meleagris gallopavo	93.80	3.00e-134	470.00
IUUC-Mdo-061847	Monodelphis domestica	94.67	6.00e-170	589.00
IUUC-Mmu-063130	Mus musculus	97.15	0.00e+00	644.00
IUUC-Mpu-066060	Mustela putorius furo	98.73	0.00e+00	652.00
IUUC-Mlu-067951	Myotis lucifugus	99.05	0.00e+00	652.00
IUUC-Nle-069523	Nomascus leucogenys	100.00	0.00e+00	658.00
IUUC-Opr-070426	Ochotona princeps	97.78	0.00e+00	647.00
IUUC-Ont-072156	Oreochromis niloticus	69.21	5.00e-130	457.00
IUUC-Oan-073164	Ornithorhynchus anatinus	85.45	3.00e-73	267.00
IUUC-Ocu-074319	Oryctolagus cuniculus	98.73	0.00e+00	654.00
IUUC-Oga-088279	Otolemur garnettii	98.10	0.00e+00	652.00
IUUC-Oar-089368	Ovis aries	98.42	0.00e+00	650.00
IUUC-Ptr-091204	Pan troglodytes	99.68	2.00e-179	620.00
IUUC-Pan-092880	Papio anubis	100.00	0.00e+00	656.00
IUUC-Psi-093768	Pelodiscus sinensis	90.10	1.00e-168	585.00
IUUC-Pab-098414	Pongo abelii	98.42	0.00e+00	642.00
IUUC-Pca-100380	Procavia capensis	92.72	1.00e-174	605.00
IUUC-Pva-102366	Pteropus vampyrus	98.42	0.00e+00	650.00
IUUC-Pgr-103695	Puccinia graminis	25.43	5.00e-03	37.40
IUUC-Ptt-103935	Puccinia triticina	27.96	2.10e-01	29.60
IUUC-Rno-104902	Rattus norvegicus	96.20	0.00e+00	642.00
IUUC-Sha-106996	Sarcophilus harrisii	94.04	7.00e-170	589.00
IUUC-Ssc-116300	Sus scrofa	98.73	0.00e+00	652.00
IUUC-Tgu-116738	Taeniopygia guttata	90.76	8.00e-170	589.00
IUUC-Tru-117840	Takifugu rubripes	72.64	4.00e-116	410.00
IUUC-Tsy-119370	Tarsius syrichta	66.77	4.00e-112	397.00
IUUC-Tni-119857	Tetraodon nigroviridis	70.86	8.00e-130	456.00
IUUC-Tbe-127709	Tupaia belangeri	98.10	0.00e+00	647.00
IUUC-Ttr-129110	Tursiops truncatus	98.10	0.00e+00	651.00
IUUC-Xtr-131870	Xenopus tropicalis	89.34	9.00e-171	592.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence