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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046612
Ensembl Protein ID ENSP00000374443.2
UniProt Accession Q99698; O43274; Q5T2U9; Q96TD7; Q96TD8; Q99709; Q9H133; LYST_HUMAN
Genbank Protein ID AAB87737.1; AAB41309.1; AAB39697.1; AAB51608.1; AAB41533.1; CAI14952.1; CAI14952.1; CAI18987.1; CAI18987.1
Protein Name Lysosomal-trafficking regulator; Beige homolog
Genbank Nucleotide ID U84744; U67615; U72192; L77889; U70064; AL390765; AL121997; AL121997; AL390765
Gene Name LYST; CHS; CHS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000143669.13 ENST00000389793.6 ENSP00000374443.2
ENSG00000143669.13 ENST00000487530.2 ENSP00000417168.1
ENSG00000143669.13 ENST00000389794.7 ENSP00000374444.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.00e-06 29.6 3614 3646
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           gHt+++t+l f   +  +l+s s+Dgt+ +WDl 
   Q: 3614 GHTEEITSL-FvckPYSILISVSRDGTCIIWDLN 3646
           8********.99875578**************85 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with CENPJ, LIP8 and ZNF521.
 Interacts with CENPJ, LIP8 and ZNF521.
Protein Sequence
(Fasta)
MSTDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS 60
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPL SADIILTKEK NSSSQRSTQE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046612|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCAAGGGCT TCTAAGAAGC CATCCCAATG ACCTTTTGGC TTTGAGAAGA GCAGTCCTCA 60
TACCAGAGTG TTTGGGGTTT TGGCCTCTTT CAGTGTTTAT TCATTCTTAC GTGGGAAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046612|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR016024--ARM-type_fold
IPR000409--BEACH_dom
IPR030464--LYST
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF02138--Beach
PF14844--PH_BEACH
PF00400--WD40
SMART

SM01026--Beach
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0015630--C:microtubule cytoskeleton
GO:0042742--P:defense response to bacterium
GO:0042832--P:defense response to protozoan
GO:0051607--P:defense response to virus
GO:0032510--P:endosome to lysosome transport via multivesicular body sorting pathway
GO:0030595--P:leukocyte chemotaxis
GO:0007040--P:lysosome organization
GO:0033364--P:mast cell secretory granule organization
GO:0032438--P:melanosome organization
GO:0042267--P:natural killer cell mediated cytotoxicity
GO:0043473--P:pigmentation
GO:0015031--P:protein transport
KEGG hsa:1130
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002188 Ailuropoda melanoleuca 90.62 0.00e+00 6982.00
IUUC-Apl-003779 Anas platyrhynchos 73.01 0.00e+00 5449.00
IUUC-Ame-010834 Astyanax mexicanus 61.57 0.00e+00 4505.00
IUUC-Bta-013274 Bos taurus 90.48 0.00e+00 6895.00
IUUC-Cja-019682 Callithrix jacchus 96.42 0.00e+00 7347.00
IUUC-Cfa-020625 Canis familiaris 90.32 0.00e+00 6822.00
IUUC-Cpo-022515 Cavia porcellus 86.20 0.00e+00 6500.00
IUUC-Csa-023804 Chlorocebus sabaeus 97.14 0.00e+00 7383.00
IUUC-Cin-025176 Ciona intestinalis 44.92 2.00e-85 309.00
IUUC-Csv-026108 Ciona savignyi 53.42 0.00e+00 711.00
IUUC-Dre-027544 Danio rerio 63.10 0.00e+00 3352.00
IUUC-Dno-029030 Dasypus novemcinctus 88.20 0.00e+00 6721.00
IUUC-Dor-031065 Dipodomys ordii 81.93 0.00e+00 2908.00
IUUC-Eca-034391 Equus caballus 90.64 0.00e+00 6918.00
IUUC-Fal-037194 Ficedula albicollis 71.95 0.00e+00 5399.00
IUUC-Gmo-039256 Gadus morhua 74.48 0.00e+00 2305.00
IUUC-Gga-040318 Gallus gallus 72.72 0.00e+00 5412.00
IUUC-Gac-042425 Gasterosteus aculeatus 64.51 0.00e+00 3500.00
IUUC-Ggo-045550 Gorilla gorilla 98.74 0.00e+00 7491.00
IUUC-Laf-054133 Loxodonta africana 89.52 0.00e+00 6744.00
IUUC-Mcc-055373 Macaca mulatta 97.45 0.00e+00 7443.00
IUUC-Mga-059475 Meleagris gallopavo 70.90 0.00e+00 5247.00
IUUC-Mmr-061795 Microcebus murinus 93.58 0.00e+00 7066.00
IUUC-Mlu-067930 Myotis lucifugus 85.29 0.00e+00 3768.00
IUUC-Nle-069205 Nomascus leucogenys 97.06 0.00e+00 7324.00
IUUC-Ont-071764 Oreochromis niloticus 61.88 0.00e+00 4388.00
IUUC-Ocu-074479 Oryctolagus cuniculus 90.26 0.00e+00 6865.00
IUUC-Ptr-091393 Pan troglodytes 99.08 0.00e+00 7536.00
IUUC-Pan-092369 Papio anubis 97.37 0.00e+00 7406.00
IUUC-Pfo-096100 Poecilia formosa 61.05 0.00e+00 4394.00
IUUC-Pab-098733 Pongo abelii 97.19 0.00e+00 7344.00
IUUC-Pca-100429 Procavia capensis 77.83 0.00e+00 2531.00
IUUC-Sha-106595 Sarcophilus harrisii 73.85 0.00e+00 5392.00
IUUC-Sar-113059 Sorex araneus 77.93 0.00e+00 1851.00
IUUC-Ssc-115879 Sus scrofa 84.19 0.00e+00 6187.00
IUUC-Tru-118616 Takifugu rubripes 60.43 0.00e+00 4362.00
IUUC-Tsy-119568 Tarsius syrichta 86.58 0.00e+00 5617.00
IUUC-Tni-120782 Tetraodon nigroviridis 60.22 0.00e+00 4347.00
Created Date 25-Jun-2017

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