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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063490
UUCD1 version UUC-MuM-00920
Ensembl Protein ID ENSMUSP00000032440.4
UniProt Accession Q9D1M0; Q99M12; Q9D712; SEC13_MOUSE
Genbank Protein ID BAB22732.1; BAB26480.1; AAH02128.1
Protein Name Protein SEC13 homolog; SEC13-like protein 1; SEC13-related protein
Genbank Nucleotide ID AK003354; AK009755; BC002128
Gene Name Sec13; Sec13l1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030298.10 ENSMUST00000032440.5 ENSMUSP00000032440.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.50e-29 99.9 55 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd..tllvsGsdDgtikvWD 29
           gH+++v+ +a+  +   ++l+s+s+D ++ +W 
   Q: 55   GHEGPVWQVAWahPMygNILASCSYDRKVIIWK 87
           8***********9666699*************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
Protein Sequence
(Fasta)
MVSVMNTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV 60
WQVAWAHPMY GNILASCSYD RKVIIWKEEN GTWEKTHEHS GHDSSVNSVC WAPHDYGLIL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063490|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATCCTGGGT GACAGCCTGC CGGCTGCGGG CCGGCACCGG AAGTGAAGCG TTTTGAGCTG 60
CCACGTCCGA GGCCGTGGGT CGCCGCTGCT GCAGCTATGG TAAGTGTCGC GATCCCTGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063490|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0012507--C:ER to Golgi transport vesicle membrane
GO:0070062--C:extracellular exosome
GO:0061700--C:GATOR2 complex
GO:0043231--C:intracellular membrane-bounded organelle
GO:0000776--C:kinetochore
GO:0005635--C:nuclear envelope
GO:0031080--C:nuclear pore outer ring
GO:0005654--C:nucleoplasm
GO:0042802--F:identical protein binding
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0051028--P:mRNA transport
GO:0032008--P:positive regulation of TOR signaling
GO:0015031--P:protein transport
KEGG mmu:110379
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000671 Aegilops tauschii 54.15 4.00e-91 327.00
IUUC-Aml-001832 Ailuropoda melanoleuca 97.20 0.00e+00 648.00
IUUC-Atr-002914 Amborella trichopoda 54.85 1.00e-90 325.00
IUUC-Apl-003992 Anas platyrhynchos 94.12 6.00e-171 593.00
IUUC-Aca-005283 Anolis carolinensis 93.79 5.00e-180 623.00
IUUC-Aly-005654 Arabidopsis lyrata 54.67 6.00e-90 323.00
IUUC-Ath-006816 Arabidopsis thaliana 55.33 3.00e-90 325.00
IUUC-Ago-007827 Ashbya gossypii 49.67 5.00e-83 300.00
IUUC-Acl-008205 Aspergillus clavatus 51.16 7.00e-80 290.00
IUUC-Afl-008748 Aspergillus flavus 49.84 1.00e-82 299.00
IUUC-Afu-008791 Aspergillus fumigatus 51.16 7.00e-80 290.00
IUUC-Ani-009152 Aspergillus nidulans 48.89 1.00e-82 299.00
IUUC-Ang-009765 Aspergillus niger 50.81 7.00e-83 300.00
IUUC-Aor-009927 Aspergillus oryzae 50.67 2.00e-79 289.00
IUUC-Ate-010248 Aspergillus terreus 49.52 1.00e-82 299.00
IUUC-Ame-011478 Astyanax mexicanus 86.65 7.00e-168 582.00
IUUC-Bgr-012276 Blumeria graminis 50.00 3.00e-79 288.00
IUUC-Bta-012700 Bos taurus 96.58 0.00e+00 645.00
IUUC-Bci-013722 Botrytis cinerea 49.17 2.00e-81 295.00
IUUC-Bdi-014818 Brachypodium distachyon 54.49 2.00e-91 328.00
IUUC-Bol-015779 Brassica oleracea 56.12 4.00e-90 324.00
IUUC-Bra-016973 Brassica rapa 55.29 9.00e-90 324.00
IUUC-Cel-018479 Caenorhabditis elegans 41.01 2.00e-69 255.00
IUUC-Cja-019956 Callithrix jacchus 97.22 6.00e-168 583.00
IUUC-Cfa-020752 Canis familiaris 98.14 0.00e+00 653.00
IUUC-Cpo-021871 Cavia porcellus 96.57 0.00e+00 641.00
IUUC-Cre-022797 Chlamydomonas reinhardtii 55.12 2.00e-96 345.00
IUUC-Csa-023393 Chlorocebus sabaeus 97.52 0.00e+00 652.00
IUUC-Cho-024786 Choloepus hoffmanni 76.40 3.00e-135 474.00
IUUC-Cin-025332 Ciona intestinalis 70.78 3.00e-133 468.00
IUUC-Csv-025926 Ciona savignyi 69.16 4.00e-129 454.00
IUUC-Cgl-026413 Colletotrichum gloeosporioides 51.19 2.00e-78 285.00
IUUC-Cne-027054 Cryptococcus neoformans 50.00 2.00e-78 285.00
IUUC-Cme-027165 Cyanidioschyzon merolae 34.94 2.00e-50 194.00
IUUC-Dre-027782 Danio rerio 87.58 1.00e-169 588.00
IUUC-Dno-029628 Dasypus novemcinctus 97.20 0.00e+00 645.00
IUUC-Dor-030650 Dipodomys ordii 80.43 3.00e-146 511.00
IUUC-Dse-031206 Dothistroma septosporum 46.53 1.00e-76 279.00
IUUC-Dme-031854 Drosophila melanogaster 59.74 2.00e-103 369.00
IUUC-Ete-032618 Echinops telfairi 67.60 1.00e-118 419.00
IUUC-Eca-033268 Equus caballus 97.82 0.00e+00 650.00
IUUC-Fca-035918 Felis catus 97.52 0.00e+00 648.00
IUUC-Fal-037551 Ficedula albicollis 93.18 6.00e-160 556.00
IUUC-Fox-037763 Fusarium oxysporum 48.54 3.00e-81 295.00
IUUC-Fso-038341 Fusarium solani 48.52 8.00e-80 290.00
IUUC-Gmo-038638 Gadus morhua 86.92 3.00e-169 587.00
IUUC-Ggr-039865 Gaeumannomyces graminis 48.99 6.00e-78 283.00
IUUC-Gga-040193 Gallus gallus 93.48 1.00e-178 618.00
IUUC-Gma-044311 Glycine max 54.52 8.00e-91 327.00
IUUC-Ggo-045252 Gorilla gorilla 97.20 0.00e+00 650.00
IUUC-Hsa-046565 Homo sapiens 96.89 0.00e+00 647.00
IUUC-Hvu-047835 Hordeum vulgare 55.48 6.00e-93 333.00
IUUC-Itr-048587 Ictidomys tridecemlineatus 98.44 0.00e+00 651.00
IUUC-Kpa-049148 Komagataella pastoris 53.29 1.00e-87 316.00
IUUC-Lch-050421 Latimeria chalumnae 89.44 1.00e-173 602.00
IUUC-Lpe-051187 Leersia perrieri 52.82 1.00e-91 332.00
IUUC-Loc-052167 Lepisosteus oculatus 88.54 3.00e-171 593.00
IUUC-Lma-053250 Leptosphaeria maculans 51.01 5.00e-80 290.00
IUUC-Laf-054304 Loxodonta africana 97.20 0.00e+00 643.00
IUUC-Mcc-055519 Macaca mulatta 97.20 0.00e+00 649.00
IUUC-Meu-056439 Macropus eugenii 95.02 0.00e+00 633.00
IUUC-Mor-057241 Magnaporthe oryzae 48.97 9.00e-78 283.00
IUUC-Mpo-057373 Magnaporthe poae 43.73 3.00e-63 234.00
IUUC-Mtr-058412 Medicago truncatula 54.52 4.00e-89 320.00
IUUC-Mla-058966 Melampsora laricipopulina 49.39 2.00e-86 312.00
IUUC-Mga-060066 Meleagris gallopavo 94.12 6.00e-171 593.00
IUUC-Mvi-060290 Microbotryum violaceum 45.48 4.00e-80 294.00
IUUC-Mmr-060717 Microcebus murinus 98.14 0.00e+00 650.00
IUUC-Mdo-062496 Monodelphis domestica 94.72 0.00e+00 636.00
IUUC-Mac-065307 Musa acuminata 54.95 3.00e-88 318.00
IUUC-Mpu-066601 Mustela putorius furo 98.14 0.00e+00 653.00
IUUC-Mlu-067501 Myotis lucifugus 97.82 0.00e+00 649.00
IUUC-Nfi-068360 Neosartorya fischeri 50.00 2.00e-65 242.00
IUUC-Ncr-068928 Neurospora crassa 49.16 3.00e-82 298.00
IUUC-Nle-069028 Nomascus leucogenys 96.89 0.00e+00 649.00
IUUC-Opr-070446 Ochotona princeps 97.71 2.00e-178 617.00
IUUC-Ont-071587 Oreochromis niloticus 86.60 4.00e-170 590.00
IUUC-Oan-073211 Ornithorhynchus anatinus 92.55 4.00e-180 623.00
IUUC-Ocu-074306 Oryctolagus cuniculus 96.27 0.00e+00 639.00
IUUC-Oba-075069 Oryza barthii 54.15 4.00e-91 327.00
IUUC-Obr-076667 Oryza brachyantha 54.49 1.00e-91 329.00
IUUC-Ogl-077208 Oryza glaberrima 54.15 4.00e-91 327.00
IUUC-Ogu-078513 Oryza glumaepatula 54.15 4.00e-91 327.00
IUUC-Oin-079094 Oryza indica 54.15 4.00e-91 327.00
IUUC-Olo-080473 Oryza longistaminata 54.15 4.00e-91 327.00
IUUC-Ome-081643 Oryza meridionalis 54.15 4.00e-91 327.00
IUUC-Oni-082589 Oryza nivara 54.15 4.00e-91 327.00
IUUC-Opu-083677 Oryza punctata 54.15 4.00e-91 327.00
IUUC-Oru-084537 Oryza rufipogon 54.15 4.00e-91 327.00
IUUC-Osa-085449 Oryza sativa 54.15 4.00e-91 327.00
IUUC-Ola-087226 Oryzias latipes 86.34 1.00e-168 585.00
IUUC-Olu-087893 Ostreococcus lucimarinus 51.37 3.00e-79 288.00
IUUC-Oga-088837 Otolemur garnettii 98.14 0.00e+00 653.00
IUUC-Oar-089594 Ovis aries 96.58 0.00e+00 645.00
IUUC-Ptr-091132 Pan troglodytes 96.89 0.00e+00 647.00
IUUC-Psi-093568 Pelodiscus sinensis 94.48 7.00e-173 599.00
IUUC-Pma-094172 Petromyzon marinus 73.25 2.00e-63 234.00
IUUC-Pno-094955 Phaeosphaeria nodorum 50.85 2.00e-78 285.00
IUUC-Ppa-095578 Physcomitrella patens 55.78 3.00e-92 331.00
IUUC-Pfo-096063 Poecilia formosa 87.27 6.00e-170 589.00
IUUC-Pab-098674 Pongo abelii 96.58 0.00e+00 646.00
IUUC-Pop-099402 Populus trichocarpa 54.67 1.00e-90 326.00
IUUC-Pca-100824 Procavia capensis 78.57 2.00e-144 505.00
IUUC-Ppe-101707 Prunus persica 54.52 1.00e-88 319.00
IUUC-Pva-103161 Pteropus vampyrus 94.10 1.00e-180 625.00
IUUC-Pgr-103573 Puccinia graminis 53.25 1.00e-89 322.00
IUUC-Ptt-103700 Puccinia triticina 51.91 9.00e-83 300.00
IUUC-Pte-104267 Pyrenophora teres 49.66 2.00e-77 282.00
IUUC-Pyt-104535 Pyrenophora triticirepentis 48.30 8.00e-70 256.00
IUUC-Rno-104833 Rattus norvegicus 99.69 0.00e+00 660.00
IUUC-Sce-106437 Saccharomyces cerevisiae 50.99 4.00e-77 281.00
IUUC-Sha-106611 Sarcophilus harrisii 95.02 0.00e+00 633.00
IUUC-Sja-107654 Schizosaccharomyces japonicus 50.00 5.00e-83 300.00
IUUC-Spo-108362 Schizosaccharomyces pombe 52.60 4.00e-86 311.00
IUUC-Smo-109674 Selaginella moellendorffii 54.61 1.00e-92 333.00
IUUC-Sit-110132 Setaria italica 53.82 4.00e-91 327.00
IUUC-Sly-111254 Solanum lycopersicum 53.00 1.00e-86 312.00
IUUC-Stu-112195 Solanum tuberosum 53.31 5.00e-87 313.00
IUUC-Sbi-114229 Sorghum bicolor 53.67 1.00e-91 329.00
IUUC-Sre-114898 Sporisorium reilianum 49.00 7.00e-91 327.00
IUUC-Ssc-115995 Sus scrofa 97.35 4.00e-86 309.00
IUUC-Tgu-116793 Taeniopygia guttata 93.15 3.00e-167 580.00
IUUC-Tru-117797 Takifugu rubripes 86.60 5.00e-169 586.00
IUUC-Tsy-118967 Tarsius syrichta 95.24 1.00e-29 124.00
IUUC-Tni-120366 Tetraodon nigroviridis 86.29 1.00e-168 585.00
IUUC-Tca-121068 Theobroma cacao 54.61 9.00e-89 320.00
IUUC-Tre-121899 Trichoderma reesei 49.83 2.00e-81 295.00
IUUC-Tvi-122380 Trichoderma virens 50.00 1.00e-81 296.00
IUUC-Tae-123998 Triticum aestivum 55.81 9.00e-94 336.00
IUUC-Tur-126202 Triticum urartu 55.15 1.00e-92 332.00
IUUC-Tme-127181 Tuber melanosporum 52.22 3.00e-89 322.00
IUUC-Ttr-128448 Tursiops truncatus 85.40 2.00e-159 555.00
IUUC-Uma-129661 Ustilago maydis 49.57 1.00e-91 329.00
IUUC-Vda-129666 Verticillium dahliae 51.54 6.00e-79 287.00
IUUC-Vpa-130318 Vicugna pacos 97.52 0.00e+00 649.00
IUUC-Vvi-130868 Vitis vinifera 54.00 2.00e-89 322.00
IUUC-Xtr-131859 Xenopus tropicalis 89.75 3.00e-173 600.00
IUUC-Xma-133898 Xiphophorus maculatus 87.27 5.00e-170 590.00
IUUC-Yli-134559 Yarrowia lipolytica 52.53 9.00e-84 303.00
Created Date 25-Jun-2017

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