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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046381
UUCD1 version UUC-HoS-01165
Ensembl Protein ID ENSP00000215794.7
UniProt Accession Q9UMW8; Q53Y90; Q6IAD9; Q9NY71; UBP18_HUMAN
Genbank Protein ID AAD49967.1; CAB76398.1; CAB66625.1; AAP35481.1; CAJ86437.1; BAG36183.1; CAG33497.1; AAH14896.1
Protein Name Ubl carboxyl-terminal hydrolase 18; 43 kDa ISG15-specific protease; ISG15-specific-processing protease; Ubl thioesterase 18
Genbank Nucleotide ID AF176642; AJ243526; AL136690; BT006835; CT841507; AK313385; CR457216; BC014896
Gene Name USP18; ISG43
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000184979.9 ENST00000215794.7 ENSP00000215794.7
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 20935222; 19615732; 11788588
Classification
Family E-value Score Start End
DUB/USP 6.20e-58 198.3 55 370
Active Site
Position(s) Description Evidence
64 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
318 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +Gl+N+g tC +NS++Q+ ++  ++++ l++    ++++ + +e+  ++  ++  l+e++++s++kav p el  +l+k+++    + q+Da
   Q: 55   VGLHNIGQTCCLNSLIQVFVMNVDFTRILKR---ITVPRGA-DEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKCNVP--LFVQHDA 140
           6******************************...5555443.567889*********************************99..79***** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
             +   l + +++++                          ++ +  + ++ l+ +++k++++c +c+ +ssr++++l+l+l++ + +++ +
   Q: 141  AQLYLKLWNLIKDQI--------------------------TDVHLVERLQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPL 206
           ***************..........................67788899***************************************999* PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls.......pfctspe 269
           ++l+d+L+ f+++ el ++ k++ce+c kk++ ++ lkl++lP++L++hL+Rfs ++  ++ +ki  +++fp++Ld s       + c    
   Q: 207  KTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN--SQTRKICHSLYFPQSLDFSqilpmkrESCDA-- 294
           *****************************************************7755..6888***************554322112222.. PP
   S: 270  ekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkrr 338
            ++++  +YeL+av+ H G ++sGHY++y++n  +gkW++f+Ds++  v++e+++ + g       +taY+l+Y+++
   Q: 295  -EEQSGGQYELFAVIAHVGMADSGHYCVYIRNaVDGKWFCFNDSNICLVSWEDIQCTYGnpnyhwqETAYLLVYMKM 370
           .223389*************************55777*******************888***************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061).
 Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061).
Protein Sequence
(Fasta)
MSKAFGLLRQ ICQSILAESS QSPADLEEKK EEDSNMKREQ PRERPRAWDY PHGLVGLHNI 60
GQTCCLNSLI QVFVMNVDFT RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVRP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046381|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACAGAATGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAGCGAGG GCTGGAAGTC 60
TGGAGCAGGT GCGCGGCTGC AACGGCAGCC GCGGGAAGCT CGGGCCGGCA GGGTTTCCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046381|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0024--Alternative initiation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019785--F:ISG15-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0060338--P:regulation of type I interferon-mediated signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:11274
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001615 Ailuropoda melanoleuca 76.97 2.00e-159 555.00
IUUC-Apl-004006 Anas platyrhynchos 56.88 1.00e-105 375.00
IUUC-Aca-005088 Anolis carolinensis 55.38 7.00e-93 333.00
IUUC-Ame-010606 Astyanax mexicanus 32.28 5.00e-37 148.00
IUUC-Bta-013036 Bos taurus 76.18 1.00e-148 518.00
IUUC-Cja-019052 Callithrix jacchus 83.59 2.00e-158 551.00
IUUC-Cfa-020554 Canis familiaris 81.19 2.00e-165 575.00
IUUC-Cpo-022421 Cavia porcellus 72.27 9.00e-160 556.00
IUUC-Csa-023737 Chlorocebus sabaeus 93.60 7.00e-116 409.00
IUUC-Cho-024807 Choloepus hoffmanni 69.39 3.00e-70 258.00
IUUC-Dre-027408 Danio rerio 31.66 6.00e-43 167.00
IUUC-Dno-029813 Dasypus novemcinctus 66.31 9.00e-127 446.00
IUUC-Dor-030532 Dipodomys ordii 72.19 3.00e-159 554.00
IUUC-Ete-032254 Echinops telfairi 68.73 4.00e-154 537.00
IUUC-Eca-033482 Equus caballus 81.50 3.00e-159 554.00
IUUC-Eeu-034451 Erinaceus europaeus 72.51 6.00e-93 333.00
IUUC-Fca-036313 Felis catus 77.36 2.00e-165 575.00
IUUC-Fal-037216 Ficedula albicollis 52.94 6.00e-106 377.00
IUUC-Gmo-038649 Gadus morhua 32.70 3.00e-40 159.00
IUUC-Gga-041082 Gallus gallus 54.91 4.00e-95 341.00
IUUC-Gac-042439 Gasterosteus aculeatus 35.56 3.00e-50 192.00
IUUC-Itr-047918 Ictidomys tridecemlineatus 77.63 1.00e-171 595.00
IUUC-Loc-052688 Lepisosteus oculatus 34.47 2.00e-46 179.00
IUUC-Laf-054109 Loxodonta africana 77.75 6.00e-179 619.00
IUUC-Mcc-054814 Macaca mulatta 92.78 0.00e+00 727.00
IUUC-Meu-056253 Macropus eugenii 66.43 3.00e-107 381.00
IUUC-Mmr-061613 Microcebus murinus 81.19 4.00e-165 573.00
IUUC-Mdo-061890 Monodelphis domestica 63.39 1.00e-121 429.00
IUUC-Mmu-064329 Mus musculus 70.62 2.00e-147 514.00
IUUC-Mpu-066342 Mustela putorius furo 77.93 9.00e-169 586.00
IUUC-Mlu-067010 Myotis lucifugus 77.47 7.00e-169 586.00
IUUC-Nle-069148 Nomascus leucogenys 95.16 0.00e+00 741.00
IUUC-Opr-070988 Ochotona princeps 72.61 6.00e-68 251.00
IUUC-Ont-072039 Oreochromis niloticus 33.75 3.00e-47 182.00
IUUC-Oan-073740 Ornithorhynchus anatinus 58.06 2.00e-77 281.00
IUUC-Ocu-074498 Oryctolagus cuniculus 75.60 7.00e-156 543.00
IUUC-Ola-086753 Oryzias latipes 35.03 1.00e-46 180.00
IUUC-Oga-088497 Otolemur garnettii 79.39 8.00e-172 596.00
IUUC-Oar-089505 Ovis aries 75.86 4.00e-148 517.00
IUUC-Ptr-091656 Pan troglodytes 98.92 0.00e+00 766.00
IUUC-Pan-092498 Papio anubis 92.51 0.00e+00 722.00
IUUC-Psi-093409 Pelodiscus sinensis 55.71 7.00e-112 397.00
IUUC-Pfo-096507 Poecilia formosa 34.29 2.00e-47 183.00
IUUC-Pab-097828 Pongo abelii 94.43 0.00e+00 635.00
IUUC-Pca-100299 Procavia capensis 75.93 1.00e-105 376.00
IUUC-Pva-102972 Pteropus vampyrus 77.24 6.00e-164 570.00
IUUC-Rno-105738 Rattus norvegicus 70.62 9.00e-154 536.00
IUUC-Sar-112983 Sorex araneus 73.43 1.00e-119 422.00
IUUC-Ssc-116049 Sus scrofa 77.12 1.00e-152 532.00
IUUC-Tgu-117115 Taeniopygia guttata 56.01 5.00e-103 367.00
IUUC-Tru-118022 Takifugu rubripes 31.76 8.00e-41 160.00
IUUC-Tsy-118986 Tarsius syrichta 61.61 6.00e-63 234.00
IUUC-Tni-120306 Tetraodon nigroviridis 31.65 9.00e-39 154.00
IUUC-Tbe-127768 Tupaia belangeri 68.79 8.00e-116 410.00
IUUC-Ttr-128686 Tursiops truncatus 75.00 2.00e-152 531.00
IUUC-Xtr-132032 Xenopus tropicalis 42.77 6.00e-70 257.00
Created Date 25-Jun-2017

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