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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046054
Ensembl Protein ID ENSP00000268933.3
UniProt Accession Q9H201; A8K6J3; A8KAB2; Q9BVN6; Q9NWK2; EPN3_HUMAN
Genbank Protein ID AAG45223.1; BAA91378.1; BAF84347.1; BAF85666.1; EAW94607.1; ENSP00000268933
Protein Name Epsin-3; EPS-15-interacting protein 3
Genbank Nucleotide ID AF324241; AK000785; AK291658; AK292977; CH471109; BC001038
Gene Name EPN3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000049283.17 ENST00000268933.7 ENSP00000268933.3
ENSG00000049283.17 ENST00000512291.5 ENSP00000421936.1
ENSG00000049283.17 ENST00000510045.5 ENSP00000421933.1
ENSG00000049283.17 ENST00000574464.5 ENSP00000460911.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 11919637
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UIM 5.20e-07 30.6 236 254
UBD/Alpha-Helix/UIM 2e-05 16.6 209 227
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           dEd++LqlAl+lS+qE+e+
   Q: 236  DEDLQLQLALRLSRQEHEK 254
           7****************96 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+++LqlAla+S++E+e+
   Q: 209  EEELQLQLALAMSREEAEK 227
           79***************95 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MTTSALRRQV KNIVHNYSEA EIKVREATSN DPWGPPSSLM SEIADLTFNT VAFTEVMGML 60
WRRLNDSGKN WRHVYKALTL LDYLLKTGSE RVAHQCRENL YTIQTLKDFQ YIDRDGKDQG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046054|UBD,UIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAGCAGAGG GGATCAGGTC GCCAGCACTG GCTCCAGATG TGCACTTCCT GGGGGCGGCC 60
AACAGGCAGG CCCCCCACCT CTCAATGCAC CACTTGCCTG GCCAGCAGGA AGGGGTTAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046054|UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0446--Lipid-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR027318--Epsin-3_metazoa
IPR003903--UIM_dom
PROSITE

PS50942--ENTH
PS50330--UIM
Pfam

PF01417--ENTH
PF02809--UIM
SMART

SM00273--ENTH
SM00726--UIM
Gene Ontology

GO:0005905--C:clathrin-coated pit
GO:0030136--C:clathrin-coated vesicle
GO:0070062--C:extracellular exosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0008289--F:lipid binding
KEGG hsa:55040
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002202 Ailuropoda melanoleuca 80.10 2.00e-157 548.00
IUUC-Apl-003938 Anas platyrhynchos 61.42 1.00e-86 312.00
IUUC-Aca-005019 Anolis carolinensis 64.76 0.00e+00 643.00
IUUC-Acl-008167 Aspergillus clavatus 53.03 3.00e-38 153.00
IUUC-Afl-008626 Aspergillus flavus 54.92 3.00e-36 145.00
IUUC-Afu-009110 Aspergillus fumigatus 53.03 2.00e-38 154.00
IUUC-Ani-009183 Aspergillus nidulans 53.03 4.00e-37 149.00
IUUC-Ang-009835 Aspergillus niger 54.55 5.00e-39 155.00
IUUC-Aor-009899 Aspergillus oryzae 53.79 2.00e-38 154.00
IUUC-Ate-010292 Aspergillus terreus 55.30 2.00e-39 157.00
IUUC-Ame-011143 Astyanax mexicanus 46.13 3.00e-93 336.00
IUUC-Bgr-012103 Blumeria graminis 40.80 3.00e-45 176.00
IUUC-Bta-012344 Bos taurus 79.06 0.00e+00 812.00
IUUC-Bci-013887 Botrytis cinerea 57.58 7.00e-41 162.00
IUUC-Cja-018801 Callithrix jacchus 95.15 0.00e+00 966.00
IUUC-Cfa-020215 Canis familiaris 89.84 0.00e+00 904.00
IUUC-Cpo-021844 Cavia porcellus 83.61 0.00e+00 808.00
IUUC-Csa-024257 Chlorocebus sabaeus 96.67 0.00e+00 969.00
IUUC-Dre-027620 Danio rerio 46.23 3.00e-98 352.00
IUUC-Dno-029944 Dasypus novemcinctus 79.59 0.00e+00 779.00
IUUC-Dor-030270 Dipodomys ordii 85.33 0.00e+00 899.00
IUUC-Dse-031529 Dothistroma septosporum 49.69 5.00e-43 169.00
IUUC-Eca-033368 Equus caballus 85.69 0.00e+00 916.00
IUUC-Fca-035598 Felis catus 86.12 0.00e+00 783.00
IUUC-Fal-036930 Ficedula albicollis 60.13 8.00e-167 580.00
IUUC-Gmo-039660 Gadus morhua 49.66 6.00e-108 385.00
IUUC-Gga-040600 Gallus gallus 62.93 3.00e-158 551.00
IUUC-Gac-042303 Gasterosteus aculeatus 52.60 3.00e-107 382.00
IUUC-Ggo-045604 Gorilla gorilla 97.18 0.00e+00 1017.00
IUUC-Itr-048835 Ictidomys tridecemlineatus 87.27 0.00e+00 931.00
IUUC-Lch-050652 Latimeria chalumnae 58.01 4.00e-142 498.00
IUUC-Loc-052572 Lepisosteus oculatus 56.31 8.00e-134 471.00
IUUC-Lma-053140 Leptosphaeria maculans 54.48 2.00e-39 158.00
IUUC-Laf-054462 Loxodonta africana 86.47 0.00e+00 930.00
IUUC-Mcc-055207 Macaca mulatta 97.32 0.00e+00 979.00
IUUC-Meu-056064 Macropus eugenii 72.61 0.00e+00 783.00
IUUC-Mla-058947 Melampsora laricipopulina 44.31 8.00e-47 181.00
IUUC-Mga-059375 Meleagris gallopavo 64.00 4.00e-162 564.00
IUUC-Mmr-061041 Microcebus murinus 90.68 0.00e+00 896.00
IUUC-Mdo-062185 Monodelphis domestica 80.19 0.00e+00 843.00
IUUC-Mmu-063485 Mus musculus 81.34 0.00e+00 824.00
IUUC-Mpu-066311 Mustela putorius furo 86.78 0.00e+00 919.00
IUUC-Mlu-067152 Myotis lucifugus 80.81 0.00e+00 659.00
IUUC-Nfi-068548 Neosartorya fischeri 53.03 2.00e-38 154.00
IUUC-Nle-069899 Nomascus leucogenys 95.30 0.00e+00 973.00
IUUC-Opr-070654 Ochotona princeps 86.39 0.00e+00 914.00
IUUC-Ont-071755 Oreochromis niloticus 49.10 4.00e-101 362.00
IUUC-Oan-072854 Ornithorhynchus anatinus 66.43 7.00e-177 613.00
IUUC-Ocu-074810 Oryctolagus cuniculus 89.53 0.00e+00 847.00
IUUC-Olu-087896 Ostreococcus lucimarinus 34.81 1.00e-17 82.80
IUUC-Oga-088099 Otolemur garnettii 82.40 0.00e+00 785.00
IUUC-Oar-090276 Ovis aries 83.58 0.00e+00 867.00
IUUC-Pan-092255 Papio anubis 94.69 0.00e+00 988.00
IUUC-Psi-093981 Pelodiscus sinensis 63.23 2.00e-179 622.00
IUUC-Pno-095066 Phaeosphaeria nodorum 56.88 2.00e-32 133.00
IUUC-Pfo-096086 Poecilia formosa 47.68 1.00e-105 377.00
IUUC-Pab-098401 Pongo abelii 97.99 0.00e+00 1019.00
IUUC-Pca-100477 Procavia capensis 85.51 0.00e+00 926.00
IUUC-Pva-102611 Pteropus vampyrus 75.81 0.00e+00 794.00
IUUC-Pgr-103451 Puccinia graminis 61.24 2.00e-42 166.00
IUUC-Ptt-103708 Puccinia triticina 63.56 5.00e-41 161.00
IUUC-Pte-104048 Pyrenophora teres 54.55 7.00e-39 155.00
IUUC-Pyt-104596 Pyrenophora triticirepentis 54.55 1.00e-38 155.00
IUUC-Rno-105902 Rattus norvegicus 78.35 0.00e+00 780.00
IUUC-Sha-107372 Sarcophilus harrisii 80.19 0.00e+00 843.00
IUUC-Sja-107671 Schizosaccharomyces japonicus 47.73 2.00e-42 167.00
IUUC-Ssl-108625 Sclerotinia sclerotiorum 57.58 8.00e-41 161.00
IUUC-Sar-112960 Sorex araneus 79.85 7.00e-105 374.00
IUUC-Ssc-115921 Sus scrofa 80.90 0.00e+00 812.00
IUUC-Tgu-117395 Taeniopygia guttata 60.98 1.00e-173 603.00
IUUC-Tme-127215 Tuber melanosporum 54.93 2.00e-43 170.00
IUUC-Ttr-128552 Tursiops truncatus 85.10 2.00e-170 592.00
IUUC-Xma-133053 Xiphophorus maculatus 54.01 3.00e-124 439.00
Created Date 25-Jun-2017

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