iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045951

UUCD1 version

UUC-HoS-01063

Ensembl Protein ID

ENSP00000363019.3

UniProt Accession

P51668; A6NLF6; A8K786; UB2D1_HUMAN

Genbank Protein ID

CAA55019.1; AAM81086.1; CAC82177.1; BAF84590.1; CAC82097.1; AAP35690.1; EAW54169.1; AAH05980.1; AAH15997.1; ENSP00000363019

Protein Name

Ubiquitin-conjugating enzyme E2 D1; (E3-independent) E2 ubiquitin-conjugating enzyme D1; E2 ubiquitin-conjugating enzyme D1; Stimulator of Fe transport; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1

Genbank Nucleotide ID

X78140; AF257220; AJ272367; AK291901; AJ293565; BT007041; AC016396; BC005980; BC015997; AF020761

Gene Name

UBE2D1; SFT; UBC5A; UBCH5; UBCH5A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000072401.14	ENST00000373910.8	ENSP00000363019.3
ENSG00000072401.14	ENST00000615793.1	ENSP00000479814.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	17576800; 20704751; 15590664; 20145714; 20133640; 19892745; 19706544; 19592251; 19587678; 16243356; 18312418; 19300455; 19264966; 19219073; 19218198; 17786241; 18687884; 19118899; 19103148; 18643997; 18633460; 18451177; 17420289; 17341663; 16522193; 12393902; 12670957; 20357004; 17132228; 24403071
UBD/UBC-like/UBD_UBC	UBD_UBC	23671280

Classification

Family	E-value	Score	Start	End
E2/UBC	4.00e-56	190.3	5	139
UBD/UBC-like/UBD_UBC	8.70e-84	280.2	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++kel++l++dpp+++sa+pv + dl++w+++i+Gp+d+ Y+ggvF l+++fp+dYPfkPPk+ f+tki+hPn+++nG++Cl+il+  ++W
   Q: 5    RIQKELSDLQRDPPAHCSAGPVGD-DLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILR--SQW 93
           9***********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           spal+v++vllsi+sll++pnp++pl  ++a+++k+++e+y++++r
   Q: 94   SPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAR 139
           ******************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaa 92
           ri+kel+dl+rd++a++sa++v+ddlf+++ati+gppds+y+ggvfflt+++ptdypfkppk+af+tkiyhpninsngsicldilrsqws+a
   Q: 5    RIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPA 96
           8******************************************************************************************* PP
   S: 93   ltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           lt+skvlls+csll+d++pddplv++ia+iyk+dkeky+r+arewt
   Q: 97   LTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWT 142
           *********************************************8 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

Protein Sequence
(Fasta)

MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF FLTVHFPTDY 60
PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120

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Nucleotide Sequence
(Fasta)

AAACAAAAGA GTCTCGCCGG CGTCCCCGCC CGCACACTCG CGCACACTCG CGCTCGGGCG 60
CACACGGAGC AGGGACCGGC GCCCGGAGCG AGCCAGGGAG CGGCTAACCG GGGACCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0030509--P:BMP signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0031398--P:positive regulation of protein ubiquitination
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7321

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001563	Ailuropoda melanoleuca	100.00	1.00e-85	308.00
IUUC-Apl-003639	Anas platyrhynchos	99.29	4.00e-81	292.00
IUUC-Aca-005254	Anolis carolinensis	100.00	1.00e-85	308.00
IUUC-Bta-013467	Bos taurus	100.00	1.00e-85	308.00
IUUC-Cja-019302	Callithrix jacchus	100.00	1.00e-85	308.00
IUUC-Cfa-021087	Canis familiaris	100.00	1.00e-85	308.00
IUUC-Csa-023668	Chlorocebus sabaeus	100.00	1.00e-85	308.00
IUUC-Cho-024987	Choloepus hoffmanni	100.00	1.00e-85	308.00
IUUC-Dno-030067	Dasypus novemcinctus	100.00	1.00e-85	308.00
IUUC-Dor-030474	Dipodomys ordii	100.00	1.00e-85	308.00
IUUC-Ete-032540	Echinops telfairi	100.00	1.00e-85	308.00
IUUC-Eca-034167	Equus caballus	100.00	1.00e-85	308.00
IUUC-Gga-040873	Gallus gallus	100.00	1.00e-85	308.00
IUUC-Itr-048743	Ictidomys tridecemlineatus	100.00	1.00e-85	308.00
IUUC-Laf-053673	Loxodonta africana	99.29	3.00e-81	293.00
IUUC-Mcc-055719	Macaca mulatta	100.00	1.00e-85	308.00
IUUC-Mga-060138	Meleagris gallopavo	99.29	4.00e-81	292.00
IUUC-Mmr-061212	Microcebus murinus	100.00	1.00e-85	308.00
IUUC-Mdo-062402	Monodelphis domestica	100.00	1.00e-81	294.00
IUUC-Mmu-063779	Mus musculus	100.00	1.00e-85	308.00
IUUC-Mpu-065724	Mustela putorius furo	100.00	1.00e-85	308.00
IUUC-Mlu-067573	Myotis lucifugus	99.29	4.00e-81	292.00
IUUC-Nle-069950	Nomascus leucogenys	100.00	1.00e-85	308.00
IUUC-Oan-073149	Ornithorhynchus anatinus	95.92	4.00e-82	296.00
IUUC-Oga-088915	Otolemur garnettii	100.00	1.00e-85	308.00
IUUC-Oar-090418	Ovis aries	97.95	3.00e-83	300.00
IUUC-Ptr-091575	Pan troglodytes	100.00	1.00e-85	308.00
IUUC-Pan-092922	Papio anubis	100.00	1.00e-85	308.00
IUUC-Pab-098137	Pongo abelii	100.00	1.00e-85	308.00
IUUC-Pca-100678	Procavia capensis	100.00	1.00e-85	308.00
IUUC-Pva-102770	Pteropus vampyrus	100.00	1.00e-85	308.00
IUUC-Rno-106124	Rattus norvegicus	100.00	1.00e-85	308.00
IUUC-Sha-106489	Sarcophilus harrisii	95.86	9.00e-82	295.00
IUUC-Sar-113557	Sorex araneus	100.00	7.00e-81	291.00
IUUC-Tgu-117399	Taeniopygia guttata	100.00	7.00e-84	302.00
IUUC-Ttr-128363	Tursiops truncatus	100.00	1.00e-85	308.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence