iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19959993; 16847351; 23593021

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Component of the synapsis initiation complex (SIC) necessary for the synaptonemal complex assembly. Stabilizes the ZIP2 component to the chromosomes. The SIC complex loads onto chromosomes and nucleates ZIP1 polymerization, a molecular zipper that acts to bring homologous chromosomes in close apposition, which is required for meiotic crossover. May also be involved in double strand break repair.

Protein Sequence
(Fasta)

MGGYLAIVFI PQTNTKSMRE KKQKCLKQVR RLSLISPKKY IMPDSIFEQP FVYCGVCHRR 60
TSHGDPLRLT SCAHILCSQH SPLTSKVCPI CRSSDISIIN LVESKQLPTD IRIFFEPLPP 120

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Nucleotide Sequence
(Fasta)

ATGGGCGGCT ATTTGGCGAT CGTGTTCATT CCCCAAACTA ACACGAAGAG CATGAGAGAG 60
AAAAAACAAA AGTGCTTGAA ACAGGTAAGA CGTTTATCAT TGATATCACC AAAGAAATAT 120

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Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0469--Meiosis
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF14634--zf-RING_5

Gene Ontology

GO:0000794--C:condensed nuclear chromosome
GO:0000228--C:nuclear chromosome
GO:0000795--C:synaptonemal complex
GO:0003682--F:chromatin binding
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016925--P:protein sumoylation
GO:0007131--P:reciprocal meiotic recombination
GO:0007129--P:synapsis
GO:0007130--P:synaptonemal complex assembly

KEGG

sce:YLR394W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001729	Ailuropoda melanoleuca	27.34	2.00e-06	44.70
IUUC-Aca-004727	Anolis carolinensis	28.36	3.00e-03	33.50
IUUC-Aly-006377	Arabidopsis lyrata	30.10	3.00e-03	34.70
IUUC-Cel-018486	Caenorhabditis elegans	24.82	1.00e-05	42.00
IUUC-Cja-019592	Callithrix jacchus	26.62	4.00e-05	40.00
IUUC-Cfa-020989	Canis familiaris	27.34	6.00e-06	42.70
IUUC-Cpo-022199	Cavia porcellus	25.90	7.00e-05	39.30
IUUC-Cin-025593	Ciona intestinalis	27.52	1.00e-05	41.60
IUUC-Cgl-026603	Colletotrichum gloeosporioides	25.81	1.90e-02	32.70
IUUC-Dse-031174	Dothistroma septosporum	30.16	2.00e-04	39.30
IUUC-Dme-031890	Drosophila melanogaster	28.03	3.00e-06	43.10
IUUC-Fca-035686	Felis catus	28.06	7.00e-07	45.80
IUUC-Hsa-045890	Homo sapiens	26.62	3.00e-05	40.40
IUUC-Lch-049529	Latimeria chalumnae	22.58	1.00e-03	34.70
IUUC-Loc-052078	Lepisosteus oculatus	62.50	5.00e-03	36.20
IUUC-Meu-055940	Macropus eugenii	32.61	4.00e-04	35.00
IUUC-Mtr-057645	Medicago truncatula	34.33	1.50e-02	32.30
IUUC-Mvi-060212	Microbotryum violaceum	26.32	4.00e-04	37.70
IUUC-Mdo-062669	Monodelphis domestica	32.61	1.00e-03	34.70
IUUC-Mpu-066296	Mustela putorius furo	25.32	7.00e-05	39.70
IUUC-Mlu-067434	Myotis lucifugus	28.26	9.00e-03	32.00
IUUC-Ncr-068660	Neurospora crassa	29.03	1.00e-03	37.00
IUUC-Nle-069857	Nomascus leucogenys	26.62	3.00e-05	40.40
IUUC-Opr-070576	Ochotona princeps	27.16	7.00e-03	32.30
IUUC-Oan-073188	Ornithorhynchus anatinus	27.86	4.00e-05	39.70
IUUC-Ptr-090600	Pan troglodytes	26.62	1.00e-05	41.60
IUUC-Pab-098207	Pongo abelii	26.62	5.00e-05	39.70
IUUC-Pgr-103435	Puccinia graminis	25.37	5.00e-03	33.90
IUUC-Ptt-103949	Puccinia triticina	29.33	1.50e-02	32.30
IUUC-Sha-107359	Sarcophilus harrisii	32.61	2.00e-03	34.30
IUUC-Sre-114928	Sporisorium reilianum	25.00	4.00e-08	50.10
IUUC-Tre-122240	Trichoderma reesei	38.00	5.00e-03	35.00
IUUC-Tae-123863	Triticum aestivum	38.10	2.00e-04	35.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence